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  1. Article ; Online: Unveiling the heavy-metal ion critical role in γ-dicalcium silicate: from solidification to early hydration.

    Lu, Heyu / Liu, Zhaohui / Zhi, Xiao / Ye, Jiayuan / Wan, Jieshuo / Ai, Daizhixuan / Li, Neng

    RSC advances

    2024  Volume 14, Issue 16, Page(s) 11400–11410

    Abstract: The heavy-metal ion critical role in γ-dicalcium silicate (γ- ... ...

    Abstract The heavy-metal ion critical role in γ-dicalcium silicate (γ-C
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01214c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: STING, a critical contributor to SARS-CoV-2 immunopathology.

    Li, Heyu / Zhou, Fangfang / Zhang, Long

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 106

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-00967-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts.

    Cai, Xinjia / Zhang, Heyu / Wang, Yanjin / Zhang, Jianyun / Li, Tiejun

    International journal of oral science

    2024  Volume 16, Issue 1, Page(s) 16

    Abstract: Odontogenic keratocyst (OKC) is a common jaw cyst with a high recurrence rate. OKC combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin syndrome. Moreover, OKC needs to be ... ...

    Abstract Odontogenic keratocyst (OKC) is a common jaw cyst with a high recurrence rate. OKC combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin syndrome. Moreover, OKC needs to be differentiated from orthokeratinized odontogenic cyst and other jaw cysts. Because of the different prognosis, differential diagnosis of several cysts can contribute to clinical management. We collected 519 cases, comprising a total of 2 157 hematoxylin and eosin-stained images, to develop digital pathology-based artificial intelligence (AI) models for the diagnosis and prognosis of OKC. The Inception_v3 neural network was utilized to train and test models developed from patch-level images. Finally, whole slide image-level AI models were developed by integrating deep learning-generated pathology features with several machine learning algorithms. The AI models showed great performance in the diagnosis (AUC = 0.935, 95% CI: 0.898-0.973) and prognosis (AUC = 0.840, 95%CI: 0.751-0.930) of OKC. The advantages of multiple slides model for integrating of histopathological information are demonstrated through a comparison with the single slide model. Furthermore, the study investigates the correlation between AI features generated by deep learning and pathological findings, highlighting the interpretative potential of AI models in the pathology. Here, we have developed the robust diagnostic and prognostic models for OKC. The AI model that is based on digital pathology shows promise potential for applications in odontogenic diseases of the jaw.
    MeSH term(s) Humans ; Artificial Intelligence ; Diagnosis, Differential ; Odontogenic Cysts/diagnostic imaging ; Basal Cell Nevus Syndrome ; Odontogenic Tumors/pathology ; Prognosis
    Language English
    Publishing date 2024-02-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2569849-7
    ISSN 2049-3169 ; 1674-2818
    ISSN (online) 2049-3169
    ISSN 1674-2818
    DOI 10.1038/s41368-024-00287-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.

    Zhu, Guanglang / Li, Yang / Gao, Hongxia / Li, Xu / Fan, Heyu / Fan, Longhua

    Journal of cardiovascular translational research

    2024  

    Abstract: In this study, we investigated the protective role of Mzb1 in atherosclerotic plaque vulnerability. To explore the impact of Mzb1, we analyzed Mzb1 expression, assessed apoptosis, and evaluated mitochondrial function in atherosclerosis (AS) mouse models ... ...

    Abstract In this study, we investigated the protective role of Mzb1 in atherosclerotic plaque vulnerability. To explore the impact of Mzb1, we analyzed Mzb1 expression, assessed apoptosis, and evaluated mitochondrial function in atherosclerosis (AS) mouse models and human vascular smooth muscle cells (HVSMCs). We observed a significant decrease in Mzb1 expression in AS mouse models and ox-LDL-treated HVSMCs. Downregulation of Mzb1 increased ox-LDL-induced apoptosis and cholesterol levels of HVSMCs, while Mzb1 overexpression alleviated these effect. Mzb1 was found to enhance mitochondrial function, as evidenced by restored ATP synthesis, mitochondrial membrane potential, and reduced mtROS production. Moreover, Mzb1 overexpression attenuated atherosclerotic plaque vulnerability in ApoE
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2422411-X
    ISSN 1937-5395 ; 1937-5387
    ISSN (online) 1937-5395
    ISSN 1937-5387
    DOI 10.1007/s12265-024-10483-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: STING, a critical contributor to SARS-CoV-2 immunopathology

    Heyu Li / Fangfang Zhou / Long Zhang

    Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-

    2022  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside.

    Cai, Xinjia / Zhang, Jianyun / Zhang, Heyu / Li, Tiejun

    Journal of Zhejiang University. Science. B

    2023  Volume 24, Issue 10, Page(s) 868–882

    Abstract: Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is ... ...

    Title translation 口腔白斑癌变生物标志物： 从基础科研到临床应用.
    Abstract Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.
    MeSH term(s) Humans ; Mouth Neoplasms ; Carcinoma, Squamous Cell ; Quality of Life ; Leukoplakia, Oral ; Biomarkers ; Head and Neck Neoplasms
    Chemical Substances Biomarkers
    Language Chinese
    Publishing date 2023-05-13
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 2247290-3
    ISSN 1862-1783 ; 1673-1581
    ISSN (online) 1862-1783
    ISSN 1673-1581
    DOI 10.1631/jzus.B2200589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection.

    Cai, Xinjia / Zhang, Heyu / Zhang, Jianyun / Li, Tiejun

    Journal of visualized experiments : JoVE

    2023  , Issue 198

    Abstract: Oral submucous fibrosis (OSF) is a common type of potentially malignant disorder in the oral cavity. The atrophy of epithelium and fibrosis of the lamina propria and the submucosa are often found on histopathological slides. Epithelial dysplasia, ... ...

    Abstract Oral submucous fibrosis (OSF) is a common type of potentially malignant disorder in the oral cavity. The atrophy of epithelium and fibrosis of the lamina propria and the submucosa are often found on histopathological slides. Epithelial dysplasia, epithelial atrophy, and senescent fibroblasts have been proposed to be associated with the malignant transformation of OSF. However, because of the heterogeneity of potentially malignant oral disorders and oral squamous cell carcinoma, it is difficult to identify the specific molecular mechanisms of malignant transformation in OSF. Here, we present a method to obtain a small number of epithelial or mesenchymal cells carrying morphological data and spatial information by laser capture microdissection on formalin-fixed paraffin-embedded tissue slides. Using a microscope, we can precisely capture microscale (~500 cells) dysplastic or atrophic epithelial tissue and fibrotic subepithelial tissue. The extracted cells can be evaluated by genome or transcriptome sequencing to acquire genomic and transcriptomic data with morphological and spatial information. This approach removes the heterogeneity of bulk OSF tissue sequencing and the interference caused by cells in non-lesioned areas, allowing for precise spatial-omics analysis of OSF tissue.
    MeSH term(s) Humans ; Oral Submucous Fibrosis/genetics ; Laser Capture Microdissection ; Carcinoma, Squamous Cell ; Mouth Neoplasms ; Atrophy
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A critical review of characteristics of domestic wastewater and key treatment techniques in Chinese villages.

    Zhang, Jing / Jiang, Yungeng / Zhang, Heyu / Feng, Dan / Bu, Hongling / Li, Linlin / Lu, Shaoyong

    The Science of the total environment

    2024  Volume 927, Page(s) 172155

    Abstract: As of 2022, China's rural sewage treatment rate is only approximately 31 %. Rapid rural development has led to higher demand. However, China's rural areas are complex and face many problems, such as uneven economic development, population distribution, ... ...

    Abstract As of 2022, China's rural sewage treatment rate is only approximately 31 %. Rapid rural development has led to higher demand. However, China's rural areas are complex and face many problems, such as uneven economic development, population distribution, and water availability. Long-lasting and low-cost wastewater treatment measures are needed for application in rural areas. The quantity and quality of rural domestic wastewater in China were characterized first. Next, the hot topic of domestic wastewater in Chinese villages was confirmed via bibliometric analysis using CiteSpace, and the treatment technologies for rural domestic wastewater were compared. Specifically, the technical status and challenges of the most common technology in rural domestic wastewater treatment, constructed wetlands, were summarized.
    MeSH term(s) Wastewater ; China ; Waste Disposal, Fluid/methods ; Wetlands ; Rural Population ; Water Purification/methods ; East Asian People
    Chemical Substances Wastewater
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Genomic alterations in oral multiple primary cancers.

    Zhou, Xuan / Cai, Xinjia / Jing, Fengyang / Li, Xuefen / Zhang, Jianyun / Zhang, Heyu / Li, Tiejun

    International journal of oral science

    2024  Volume 16, Issue 1, Page(s) 13

    Abstract: Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n = 202) and oral MPCs (n = 34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in MPCs. Moreover, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.
    MeSH term(s) Female ; Humans ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Lymphatic Metastasis/genetics ; Phylogeny ; Neoplasm Recurrence, Local ; Squamous Cell Carcinoma of Head and Neck ; Genomics ; Head and Neck Neoplasms ; Neoplasms, Multiple Primary/genetics
    Language English
    Publishing date 2024-02-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2569849-7
    ISSN 2049-3169 ; 1674-2818
    ISSN (online) 2049-3169
    ISSN 1674-2818
    DOI 10.1038/s41368-023-00265-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on Leydig cells.

    Li, Zihan / Zhu, Chengshan / Yin, Cong / Li, Heyu / Liu, Yimei / Li, Juan

    Journal of ethnopharmacology

    2024  Volume 325, Page(s) 117817

    Abstract: Ethnopharmacological relevance: Cordyceps sobolifera (CS) has been traditionally utilized as an ethnic remedy for various health conditions, including chronic kidney diseases, anti-fatigue interventions, and management of chronic inflammation. Notably, ... ...

    Abstract Ethnopharmacological relevance: Cordyceps sobolifera (CS) has been traditionally utilized as an ethnic remedy for various health conditions, including chronic kidney diseases, anti-fatigue interventions, and management of chronic inflammation. Notably, CS is recognized for its substantial content of bioactive compounds, among which nucleosides prominently feature as constituents with diverse therapeutic advantages.
    Aim of the study: This study aims to investigate the effects of CS on testosterone secretion in Leydig cells and explore the underlying mechanism.
    Materials and methods: Leydig cells were isolated from rat testes to establish a primary rat Leydig cells model. Cell proliferation and testosterone secretion were assessed via the methyl-piperidino-pyrazole (MTT) assay and enzyme-linked immunosorbent assay (ELISA), respectively. Samples earmarked for RNA sequencing (RNA-Seq) analysis facilitated the identification of significantly differentially expressed genes (DEGs), and we conducted Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) functional annotation and enrichment analyses. The veracity of our findings was validated through quantitative real time polymerase chain reaction (qRT-PCR) and western blotting.
    Results: The results showed that CS and guanosine could promote Leydig cell proliferation and bolster testosterone secretion. Our integrative analysis of metabolomics and transcriptomics has unveiled the potential mechanisms governing testosterone synthesis. Specifically, metabolomics has illuminated striking correlations within cholesterol metabolism, and bile secretion. Concurrently, transcriptomics has underscored the pivotal roles played by the cyclic adenosine monophosphate (cAMP) signaling pathway and steroid hormone biosynthesis. Furthermore, our investigation has demonstrated CS's aptitude in elevating the expression of proteins and genes. Notably, our findings have elucidated that these effects can be mitigated by protein kinase A (PKA) and adenylate cyclase (AC) specific inhibitors.
    Conclusion: This study delineates the cAMP-PKA pathways as plausible mechanisms underpinning the testosterone-enhancing properties of CS, with guanosine emerging as a fundamental bioactive constituent.
    MeSH term(s) Male ; Rats ; Animals ; Testosterone/metabolism ; Leydig Cells ; Multiomics ; Cyclic AMP/metabolism ; Guanosine/metabolism ; Guanosine/pharmacology ; Hypocreales
    Chemical Substances Testosterone (3XMK78S47O) ; Cyclic AMP (E0399OZS9N) ; Guanosine (12133JR80S)
    Language English
    Publishing date 2024-02-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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