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  1. Article: Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies.

    Lovisa, Sara

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 737570

    Abstract: The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during wound healing and in pathological conditions such as fibrosis and cancer, continues to gain the attention of the research community, as testified by the exponential ... ...

    Abstract The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during wound healing and in pathological conditions such as fibrosis and cancer, continues to gain the attention of the research community, as testified by the exponential trend of publications since its discovery in the seventies. From the first description as a mesenchymal transformation, the concept of EMT has been substantially refined as an in-depth comprehension of its functional role has recently emerged thanks to the implementation of novel mouse models as well as the use of sophisticated mathematical modeling and bioinformatic analysis. Nevertheless, attempts to targeting EMT in fibrotic diseases are at their infancy and continue to pose several challenges. The aim of this mini review is to recapitulate the most recent concepts in the EMT field and to summarize the different strategies which have been exploited to target EMT in fibrotic disorders.
    Language English
    Publishing date 2021-09-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.737570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Preclinical models and emerging technologies to study the effects of the tumor microenvironment on cancer heterogeneity and drug resistance.

    Adriani, Giulia / Cappello, Paola / Lovisa, Sara

    Frontiers in oncology

    2023  Volume 13, Page(s) 1289756

    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1289756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Trading Justice for Peace? Reframing reconciliation in TRC processes in South Africa, Canada and Nordic countries

    Henkeman, Stanley / Guðmarsdóttir, Sigríður / Regan, Paulette / Solomons, Demaine / Johnsen, Tore / Nordquist, Kjell-Åke / Thesnaar, Christo H. / Sjöberg, Lovisa M. / Sara, Mikkel N. / MacDonald, David B. / Lightfoot, Sheryl / Klaasen, John / Lindmark, Daniel / Shaffer, Elizabeth / Baron, Eugene / Verwoerd, Wilhelm / Wale, Kim / Quinn, Joanna R.

    2021  

    Keywords South Africa ; Canada ; Norway ; Truth and Reconciliation Commission ; Justice ; reconciliation ; liberation
    Language 0|e
    Size 1 electronic resource (336 pages)
    Publisher AOSIS
    Publishing place Durbanville
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021614402
    ISBN 9781776342105 ; 1776342100
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Editorial

    Giulia Adriani / Paola Cappello / Sara Lovisa

    Frontiers in Oncology, Vol

    Preclinical models and emerging technologies to study the effects of the tumor microenvironment on cancer heterogeneity and drug resistance

    2023  Volume 13

    Keywords tumor microenvironment ; tumor heterogeneity ; scRNA seq ; spatial biology ; preclinical tumor models ; 3D tumor models ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Multiple Faces of Integrin-ECM Interactions in Inflammatory Bowel Disease.

    Garlatti, Valentina / Lovisa, Sara / Danese, Silvio / Vetrano, Stefania

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Inflammatory Bowel Disease (IBD) comprises a series of chronic and relapsing intestinal diseases, with Crohn's disease and ulcerative colitis being the most common. The abundant and uncontrolled deposition of extracellular matrix, namely fibrosis, is one ...

    Abstract Inflammatory Bowel Disease (IBD) comprises a series of chronic and relapsing intestinal diseases, with Crohn's disease and ulcerative colitis being the most common. The abundant and uncontrolled deposition of extracellular matrix, namely fibrosis, is one of the major hallmarks of IBD and is responsible for the progressive narrowing and closure of the intestine, defined as stenosis. Although fibrosis is usually considered the product of chronic inflammation, the substantial failure of anti-inflammatory therapies to target and reduce fibrosis in IBD suggests that fibrosis might be sustained in an inflammation-independent manner. Pharmacological therapies targeting integrins have recently shown great promise in the treatment of IBD. The efficacy of these therapies mainly relies on their capacity to target the integrin-mediated recruitment and functionality of the immune cells at the damage site. However, by nature, integrins also act as mechanosensitive molecules involved in the intracellular transduction of signals and modifications originating from the extracellular matrix. Therefore, understanding integrin signaling in the context of IBD may offer important insights into mechanisms of matrix remodeling, which are uncoupled from inflammation and could underlie the onset and persistency of intestinal fibrosis. In this review, we present the currently available knowledge on the role of integrins in the etiopathogenesis of IBD, highlighting their role in the context of immune-dependent and independent mechanisms.
    MeSH term(s) Animals ; Extracellular Matrix/immunology ; Extracellular Matrix/pathology ; Fibrosis ; Humans ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/pathology ; Integrins/immunology ; Mechanotransduction, Cellular/immunology
    Chemical Substances Integrins
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition.

    Lovisa, Sara / Kalluri, Raghu

    Trends in molecular medicine

    2018  Volume 24, Issue 5, Page(s) 432–434

    Abstract: The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal ... ...

    Abstract The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.
    MeSH term(s) Endothelial Cells ; Endothelium ; Fatty Acids ; Oxidation-Reduction ; Signal Transduction
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2018-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2018.03.003
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The Multiple Faces of Integrin–ECM Interactions in Inflammatory Bowel Disease

    Valentina Garlatti / Sara Lovisa / Silvio Danese / Stefania Vetrano

    International Journal of Molecular Sciences, Vol 22, Iss 10439, p

    2021  Volume 10439

    Abstract: Inflammatory Bowel Disease (IBD) comprises a series of chronic and relapsing intestinal diseases, with Crohn’s disease and ulcerative colitis being the most common. The abundant and uncontrolled deposition of extracellular matrix, namely fibrosis, is one ...

    Abstract Inflammatory Bowel Disease (IBD) comprises a series of chronic and relapsing intestinal diseases, with Crohn’s disease and ulcerative colitis being the most common. The abundant and uncontrolled deposition of extracellular matrix, namely fibrosis, is one of the major hallmarks of IBD and is responsible for the progressive narrowing and closure of the intestine, defined as stenosis. Although fibrosis is usually considered the product of chronic inflammation, the substantial failure of anti-inflammatory therapies to target and reduce fibrosis in IBD suggests that fibrosis might be sustained in an inflammation-independent manner. Pharmacological therapies targeting integrins have recently shown great promise in the treatment of IBD. The efficacy of these therapies mainly relies on their capacity to target the integrin-mediated recruitment and functionality of the immune cells at the damage site. However, by nature, integrins also act as mechanosensitive molecules involved in the intracellular transduction of signals and modifications originating from the extracellular matrix. Therefore, understanding integrin signaling in the context of IBD may offer important insights into mechanisms of matrix remodeling, which are uncoupled from inflammation and could underlie the onset and persistency of intestinal fibrosis. In this review, we present the currently available knowledge on the role of integrins in the etiopathogenesis of IBD, highlighting their role in the context of immune-dependent and independent mechanisms.
    Keywords integrin ; inflammatory bowel disease ; IBD ; intestinal fibrosis ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Revisiting fibrosis in inflammatory bowel disease: the gut thickens.

    D'Alessio, Silvia / Ungaro, Federica / Noviello, Daniele / Lovisa, Sara / Peyrin-Biroulet, Laurent / Danese, Silvio

    Nature reviews. Gastroenterology & hepatology

    2021  Volume 19, Issue 3, Page(s) 169–184

    Abstract: Intestinal fibrosis, which is usually the consequence of chronic inflammation, is a common complication of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In the past few years, substantial advances have been made in ... ...

    Abstract Intestinal fibrosis, which is usually the consequence of chronic inflammation, is a common complication of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In the past few years, substantial advances have been made in the areas of pathogenesis, diagnosis and management of intestinal fibrosis. Of particular interest have been inflammation-independent mechanisms behind the gut fibrotic process, genetic and environmental risk factors (such as the role of the microbiota), and the generation of new in vitro and in vivo systems to study fibrogenesis in the gut. A huge amount of work has also been done in the area of biomarkers to predict or detect intestinal fibrosis, including novel cross-sectional imaging techniques. In parallel, researchers are embarking on developing and validating clinical trial end points and protocols to test novel antifibrotic agents, although no antifibrotic therapies are currently available. This Review presents the state of the art on the most recently identified pathogenic mechanisms of this serious IBD-related complication, focusing on possible targets of antifibrotic therapies, management strategies, and factors that might predict fibrosis progression or response to treatment.
    MeSH term(s) Chronic Disease ; Colitis, Ulcerative ; Crohn Disease/drug therapy ; Fibrosis ; Humans ; Inflammation/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/therapy
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-021-00543-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6020: Show issues Location:
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  9. Article ; Online: Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease.

    Lovisa, Sara / Genovese, Giannicola / Danese, Silvio

    Journal of Crohn's & colitis

    2018  Volume 13, Issue 5, Page(s) 659–668

    Abstract: Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to ...

    Abstract Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.
    MeSH term(s) Animals ; Colitis, Ulcerative/pathology ; Crohn Disease/pathology ; Disease Models, Animal ; Epithelial-Mesenchymal Transition ; Fibrosis ; Humans ; Inflammatory Bowel Diseases/pathology ; Intestinal Fistula/etiology ; Intestinal Fistula/pathology ; Intestines/pathology ; Mice
    Language English
    Publishing date 2018-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjy201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6634: Show issues Location:
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  10. Article: The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind?

    Loponte, Sara / Lovisa, Sara / Deem, Angela K / Carugo, Alessandro / Viale, Andrea

    Cancers

    2019  Volume 11, Issue 10

    Abstract: Tumor functional heterogeneity has been recognized for decades, and technological advancements are fueling renewed interest in uncovering the cell-intrinsic and extrinsic factors that influence tumor development and therapeutic response. Intratumoral ... ...

    Abstract Tumor functional heterogeneity has been recognized for decades, and technological advancements are fueling renewed interest in uncovering the cell-intrinsic and extrinsic factors that influence tumor development and therapeutic response. Intratumoral heterogeneity is now arguably one of the most-studied topics in tumor biology, leading to the discovery of new paradigms and reinterpretation of old ones, as we aim to understand the profound implications that genomic, epigenomic, and functional heterogeneity hold with regard to clinical outcomes. In spite of our improved understanding of the biological complexity of cancer, characterization of tumor metabolic heterogeneity has lagged behind, lost in a century-old controversy debating whether glycolysis or mitochondrial respiration is more influential. But is tumor metabolism really so simple? Here, we review historical and current views of intratumoral heterogeneity, with an emphasis on summarizing the emerging data that begin to illuminate just how vast the spectrum of metabolic strategies a tumor can employ may be, and what this means for how we might interpret other tumor characteristics, such as mutational landscape, contribution of microenvironmental influences, and treatment resistance.
    Language English
    Publishing date 2019-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11101574
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