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Article ; Online: Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Heindl, Stefan / Eggenstein, Evelyn / Keller, Simone / Kneissl, Julia / Keller, Gisela / Mutze, Kathrin / Rauser, Sandra / Gasteiger, Georg / Drexler, Ingo / Hapfelmeier, Alexander / Höfler, Heinz / Luber, Birgit

Journal of cancer research and clinical oncology

2012 Volume 138, Issue 5, Page(s) 843–858

Abstract: ... of the cell adhesion molecule E-cadherin as well as MET activation were examined by Western blot analysis, flow cytometry and ... with cetuximab responsiveness. MET activation as well as mutations of KRAS and CDH1 (gene encoding E-cadherin ...

Abstract	Purpose: The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. Reliable biomarkers for the identification of patients who are likely to benefit from the treatment are not available. The aim of the study was to examine the drug sensitivity of five gastric cancer cell lines towards cetuximab as a single agent and to establish predictive markers for chemosensitivity in this cell culture model. The effect of a combination of cetuximab with chemotherapy was compared between a sensitive and a nonsensitive cell line. Methods: EGFR expression, activation and localisation, the presence and subcellular localisation of the cell adhesion molecule E-cadherin as well as MET activation were examined by Western blot analysis, flow cytometry and immunofluorescence staining. Cells were treated with varying concentrations of cetuximab and cisplatin and 5-fluorouracil in tumour-relevant concentrations. The biological endpoint was cell viability, which was measured by XTT cell proliferation assay. Response to treatment was evaluated using statistical methods. Results: We assessed the activity of cetuximab in five gastric cancer cell lines (AGS, KATOIII, MKN1, MKN28 and MKN45). The viability of two cell lines, MKN1 and MKN28, was significantly reduced by cetuximab treatment. High EGFR expression and low levels of receptor activation were associated with cetuximab responsiveness. MET activation as well as mutations of KRAS and CDH1 (gene encoding E-cadherin) was associated with cetuximab resistance. Conclusion: These data indicate that our examinations may be clinically relevant, and the candidate markers should therefore be tested in clinical studies.
MeSH term(s)	Antibodies, Monoclonal, Humanized/pharmacology ; Antigens, CD ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Biomarkers, Tumor ; Blotting, Western ; Cadherins/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cetuximab ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; ErbB Receptors/metabolism ; Flow Cytometry ; Fluorescent Antibody Technique, Indirect ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Mutation ; Phosphorylation ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Proto-Oncogene Proteins p21(ras) ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; ras Proteins/genetics
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antigens, CD ; Biomarkers, Tumor ; CDH1 protein, human ; Cadherins ; KRAS protein, human ; Proto-Oncogene Proteins ; ErbB Receptors (EC 2.7.10.1) ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2) ; Cetuximab (PQX0D8J21J) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2012-01-31
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-011-1128-4
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Book: Braukunst und Brauereien im Dachauer Land

Gasteiger, Robert

eines erbarn Handtwerchs der Pierpreuen ; 100 Jahre Museumsverein Dachau

2009

Institution	Museumsverein Dachau
Author's details	[im Auftr. des Museumsvereins Dachau e.V. und des Museums- und Heimatvereins Altomünster. Hrsg.:] Robert Gasteiger ; Wilhelm Liebhart
Subject code	647.95433634074 ; 641.2309433634074
Language	German
Size	374 S., Ill., Kt., 23 x 24 cm
Publisher	Museumsverein Dachau
Publishing place	Dachau
Publishing country	Germany
Document type	Book
HBZ-ID	HT016570812
ISBN	978-3-926355-17-1 ; 3-926355-17-4
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108/1560	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach.

Gasteiger, Norina / Gasteiger, Chiara / Vedhara, Kavita / Broadbent, Elizabeth

Vaccine

2022 Volume 40, Issue 25, Page(s) 3461–3465

Abstract: Demographics and media discourse impact vaccine hesitancy. We explored the New Zealand public's perceptions of COVID-19 vaccines and associated media portrayal, and determined predictive factors associated with willingness to receive vaccines. A ... ...

Abstract	Demographics and media discourse impact vaccine hesitancy. We explored the New Zealand public's perceptions of COVID-19 vaccines and associated media portrayal, and determined predictive factors associated with willingness to receive vaccines. A community cohort (N = 340) completed online surveys. A logistic regression explored whether characteristics predict willingness to receive the vaccine. Textual data were analysed thematically. Willingness to receive the vaccine was high (90%). Having a postgraduate degree (p =.026), trying to receive an influenza vaccine (p <.001) and fewer concerns (p <.001) predicted willingness. Health keyworkers (p <.001) were less willing. Participants wanted the vaccine for protection and returning to normality. Reasons against receiving vaccines regarded safety, efficacy, and an unclear roll-out plan. The media was reported to generally provide good/positive coverage, but also engage in unbalanced reporting and spreading misinformation. Education strategies should include collaborations between media and scientists and focus on distributing easy-to-access information. Health keyworkers should be reassured of testing/safety.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Humans ; Influenza Vaccines ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines
Language	English
Publishing date	2022-05-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.04.092
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis.

Hoerner, Elisabeth / Stundner, Ottokar / Seisl, Anna / Fiegl, Heidi / Gasteiger, Lukas

Regional anesthesia and pain medicine

2024

Abstract: Introduction: Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on ...

Abstract	Introduction: Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics. Methods: We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH. Results: Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points. Discussion: The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2023-105229
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Article ; Online: The more the merrier! Barriers and facilitators to the general public's use of a COVID-19 contact tracing app in New Zealand.

Gasteiger, Norina / Gasteiger, Chiara / Vedhara, Kavita / Broadbent, Elizabeth

Informatics for health & social care

2021 Volume 47, Issue 2, Page(s) 132–143

Abstract: Contact tracing for infectious diseases can be partially automated using mobile applications. However, the success of these tools is dependent on significant uptake and frequent use by the public. This study explored the barriers and facilitators to the ... ...

Abstract	Contact tracing for infectious diseases can be partially automated using mobile applications. However, the success of these tools is dependent on significant uptake and frequent use by the public. This study explored the barriers and facilitators to the New Zealand (NZ) general public's use of the COVID-19 contact
MeSH term(s)	Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Contact Tracing ; Humans ; Mobile Applications ; New Zealand/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2431238-1
ISSN	1753-8165 ; 1753-8157
ISSN (online)	1753-8165
ISSN	1753-8157
DOI	10.1080/17538157.2021.1951274
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Article ; Online: Crystallization of short-acting and intermediate-acting local anesthetics when mixed with adjuvants: a semiquantitative light microscopy analysis.

Hoerner, Elisabeth / Stundner, Ottokar / Fiegl, Heidi / Gasteiger, Lukas

Regional anesthesia and pain medicine

2023 Volume 48, Issue 10, Page(s) 508–512

Abstract: Introduction: The addition of adjuvants to short-acting local anesthetics (LA) is common practice in clinical routine to speed up block onset and decrease pain on injection. In a previous study, we observed the development of microscopic crystal ... ...

Abstract	Introduction: The addition of adjuvants to short-acting local anesthetics (LA) is common practice in clinical routine to speed up block onset and decrease pain on injection. In a previous study, we observed the development of microscopic crystal precipitations after bupivacaine or ropivacaine were mixed with adjuvants; this follow-up study is intended to clarify whether crystallization (A) also occurs in short-acting or intermediate-acting LA-adjuvant mixtures, (B) changes over time, and (C) is associated with the solutions' pH. Methods: Lidocaine 2%, prilocaine 2%, mepivacaine 2%, procaine 2% and chloroprocaine 2% were individually mixed with clonidine, dexamethasone, dexmedetomidine, epinephrine, fentanyl, morphine or sodium bicarbonate 8.4% in clinically established ratios. For each mixture, we measured initial pH and recorded crystallization patterns at 0, 15, 30 and 60 min using a standardized, semiquantitative light microscopy approach. Results: Lidocaine 2% and mepivacaine 2% plus sodium bicarbonate 8.4%, and mepivacaine 2% plus dexamethasone developed delayed grade 5 crystallization over 1 hour. Prilocaine-based, procaine-based and chloroprocaine-based mixtures showed much less pronounced crystallization, with a maximum of grade 2. Initial pH and grade of crystallization showed weak monotonic relationships at time points t
MeSH term(s)	Humans ; Anesthetics, Local ; Mepivacaine ; Sodium Bicarbonate ; Crystallization ; Follow-Up Studies ; Microscopy ; Procaine ; Bupivacaine ; Lidocaine ; Prilocaine ; Dexamethasone
Chemical Substances	Anesthetics, Local ; chloroprocaine (5YVB0POT2H) ; Mepivacaine (B6E06QE59J) ; Sodium Bicarbonate (8MDF5V39QO) ; Procaine (4Z8Y51M438) ; Bupivacaine (Y8335394RO) ; Lidocaine (98PI200987) ; Prilocaine (046O35D44R) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2023-104398
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Article ; Online: Community-based support to improve mental health and wellbeing in older sexually and gender diverse people: a scoping review.

Gasteiger, Chiara / Collens, Paula / du Preez, Elizabeth

Aging & mental health

2023 Volume 28, Issue 4, Page(s) 692–700

Abstract: Objectives: This scoping review seeks to identify what community-based support is used by older sexually and gender diverse (SGD) people, that aims to improve mental health/wellbeing.: Methods: A scoping review was conducted using the Arksey and O' ... ...

Abstract	Objectives: This scoping review seeks to identify what community-based support is used by older sexually and gender diverse (SGD) people, that aims to improve mental health/wellbeing. Methods: A scoping review was conducted using the Arksey and O'Malley framework. APA PsycInfo, Embase, MEDLINE, PubMed, and Scopus were searched. Key information was extracted and entered into a structured coding sheet before being summarized. Results: Seventeen studies were included (41% observational qualitative and 35% observational quantitative). The most commonly used community-based support was lesbian, gay, bisexual and transgender (LGBT) social groups. A range of practices were reported in five studies, including in SGD affirming religious congregations and mind-body practices. Two studies reported the use of formal programmes, with one based on a group initiative. Positive outcomes included feeling connected, improved social support and mental health, and coping with illness. Five studies reported null or negative findings, including a lack of acceptance. Most studies used categories for sex and gender inaccurately, and lacked detail when describing community-based support. Conclusion: The use of community-based support by older SGD people is underexplored. More interventions designed for and by this community are needed, along with experimental research to draw conclusions on effectiveness to improve mental health or wellbeing.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Bisexuality/psychology ; Homosexuality, Female/psychology ; Mental Health ; Sexual and Gender Minorities ; Social Support ; Observational Studies as Topic
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2023.2269097
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Article: Examining the relationship between health literacy and individual and sociodemographic factors in secondary school students.

Pendl, Dominik / Maitz, Katharina Maria / Gasteiger-Klicpera, Barbara

Zeitschrift fur Gesundheitswissenschaften = Journal of public health

2023 , Page(s) 1–12

Abstract: ... health inequalities by fostering relevant internet skills, i.e. the skills needed to facilitate effective and critical ...

Abstract	Aim: Health literacy (HL) is an important factor in health promotion, especially regarding children and adolescents. The present study aims to identify the individual and sociodemographic factors related to secondary school students' HL. This should make it possible to find specific strategies to improve HL. Subject and methods: Data on the sociodemographic background (migrant background, number of books at home and spoken language at home), self-efficacy, online reading behaviour, subjective HL (adapted version of the European Health Literacy [HLS-EU] questionnaire) and the eHealth Literacy Scale (eHEALS) of 544 Austrian secondary school students (age 11-16, 46% girls) were collected. Regression analyses were conducted to test the hypotheses regarding those factors which influence students' subjective HL and eHL. Results: Students subjective HL ( Conclusion: Students' online reading behaviour and age are important factors linked to HL. Educational activities may serve to reduce health inequalities by fostering relevant internet skills, i.e. the skills needed to facilitate effective and critical use of internet information.
Language	English
Publishing date	2023-02-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1149070-6
ISSN	2198-1833 ; 0943-1853
ISSN	2198-1833 ; 0943-1853
DOI	10.1007/s10389-023-01836-1
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Article ; Online: WITHDRAWN: Comment on "Comparison of the clinical performance of the i-gelTM, LMA SupremeTM, and Ambu AuraGainTM in adult patients during general anesthesia: a prospective and randomized study"

Hoerner, Elisabeth / Gasteiger, Lukas / Keller, Christian

Korean journal of anesthesiology

2022

Abstract: Ahead of Print article withdrawn by publisher. ...

Abstract	Ahead of Print article withdrawn by publisher.
Language	English
Publishing date	2022-10-05
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2557340-8
ISSN	2005-7563 ; 2005-7563
ISSN (online)	2005-7563
ISSN	2005-7563
DOI	10.4097/kja.22558
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Book ; Online: Collective Robustness Certificates

Schuchardt, Jan / Bojchevski, Aleksandar / Gasteiger, Johannes / Günnemann, Stephan

Exploiting Interdependence in Graph Neural Networks

2023

Abstract: ... a classifier that simultaneously outputs multiple predictions (a vector of labels) based on a single input, i.e ... of predictions that are simultaneously guaranteed to remain stable under perturbation, i.e. cannot be attacked ...

Abstract	In tasks like node classification, image segmentation, and named-entity recognition we have a classifier that simultaneously outputs multiple predictions (a vector of labels) based on a single input, i.e. a single graph, image, or document respectively. Existing adversarial robustness certificates consider each prediction independently and are thus overly pessimistic for such tasks. They implicitly assume that an adversary can use different perturbed inputs to attack different predictions, ignoring the fact that we have a single shared input. We propose the first collective robustness certificate which computes the number of predictions that are simultaneously guaranteed to remain stable under perturbation, i.e. cannot be attacked. We focus on Graph Neural Networks and leverage their locality property - perturbations only affect the predictions in a close neighborhood - to fuse multiple single-node certificates into a drastically stronger collective certificate. For example, on the Citeseer dataset our collective certificate for node classification increases the average number of certifiable feature perturbations from $7$ to $351$. Comment: Accepted at ICLR 2021 (https://openreview.net/forum?id=ULQdiUTHe3y). Uploaded to arxiv to fix Google Scholar indexing
Keywords	Computer Science - Machine Learning ; Computer Science - Cryptography and Security
Subject code	006
Publishing date	2023-02-06
Publishing country	us
Document type	Book ; Online
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