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Article ; Online: Elucidating Vaccine Trafficking Mechanisms using Multimodal Imaging.

Hartwell, Brittany L / Martin, Jacob / Chang, Jason Y H / Kumarapperuma, Sidath C / Ruprecht, Ruth M / Irvine, Darrell J

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue 29 Suppl 1, Page(s) 1068

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.547
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Article: Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans.

Naps, Michelle S / Leong, Shirley H / Hartwell, Emily E / Rentsch, Christopher T / Kranzler, Henry R

Alcohol (Hanover, York County, Pa.)

2023 Volume 47, Issue 3, Page(s) 438–447

Abstract: ... linear regression models. A serum bicarbonate concentration <17 mEq/L was considered to represent possible ... topiramate-associated reductions in serum bicarbonate concentration were <2 mEq/L in the low (≤88.75), medium ... Concentrations <17 mEq/L occurred in 1.1% of topiramate-treated patients and 0.3% of controls and were not ...

Abstract	Background: Topiramate, which is increasingly being used to treat alcohol use disorder (AUD), is commonly associated with reduced serum bicarbonate concentrations. However, estimates of the prevalence and magnitude of this effect are from small samples and do not address whether topiramate's effects on acid-base balance differ in the presence of an AUD or by topiramate dosage. Methods: Veterans Health Administration electronic health record (EHR) data were used to identify patients with a minimum of 180 days of topiramate prescription for any indication and a propensity score-matched control group. We differentiated patients into two subgroups based on the presence of a diagnosis of AUD in the EHR. Baseline alcohol consumption was determined using Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) scores in the EHR. Analysis also included a three-level measure representing mean daily dosage. The topiramate-associated changes in serum bicarbonate concentration were estimated in difference-in-differences linear regression models. A serum bicarbonate concentration <17 mEq/L was considered to represent possible clinically significant metabolic acidosis. Results: The cohort comprised 4287 topiramate-treated patients and 5992 propensity score-matched controls with a mean follow-up period of 417 days. The mean topiramate-associated reductions in serum bicarbonate concentration were <2 mEq/L in the low (≤88.75), medium (>88.75 and ≤141.70), and high (>141.70) mg/day dosage tertiles, irrespective of AUD history. Concentrations <17 mEq/L occurred in 1.1% of topiramate-treated patients and 0.3% of controls and were not associated with alcohol consumption or an AUD diagnosis. Conclusions: The excess prevalence of metabolic acidosis associated with topiramate treatment does not differ with dosage, alcohol consumption, or the presence of an AUD. Baseline and periodic serum bicarbonate concentration measurements are recommended during topiramate therapy. Patients prescribed topiramate should be educated about the symptoms of metabolic acidosis and urged to report their occurrence promptly to a healthcare provider.
MeSH term(s)	Humans ; Topiramate ; Bicarbonates ; Alcoholism ; Veterans ; Acidosis/chemically induced ; Acidosis/diagnosis ; Acidosis/epidemiology
Chemical Substances	Topiramate (0H73WJJ391) ; Bicarbonates
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
DOI	10.1111/acer.15011
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Article: Prevalence of metabolically healthy obesity in the United States: A cross-sectional evaluation of the National Health and Nutrition Examination Survey.

Braun, Ashlea C / Hartwell, Micah L / Montgomery, McKale R / Emerson, Sam R / Morris, Katherine T / Greiner, Benjamin H

Obesity research & clinical practice

2022 Volume 16, Issue 6, Page(s) 536–538

Language	English
Publishing date	2022-10-28
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2022.10.009
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Article ; Online: A recommendation for earlier screening of type 2 diabetes mellitus within the US population: A cross-sectional analysis of NHIS data.

Greiner, Benjamin / Mercer, Heather / Raymond, Charissa / Sonstein, Lindsay / Hartwell, Micah

Diabetes research and clinical practice

2020 Volume 168, Page(s) 108376

Abstract: Diabetes is a leading cause of morbidity and mortality in the US. Current USPSTF guidelines recommend screening asymptomatic, overweight patients greater than 40 years. Our study showed that ¼ of patients with type 2 diabetes were diagnosed prior to 40 ... ...

Abstract	Diabetes is a leading cause of morbidity and mortality in the US. Current USPSTF guidelines recommend screening asymptomatic, overweight patients greater than 40 years. Our study showed that ¼ of patients with type 2 diabetes were diagnosed prior to 40 years. Therefore, we recommend lowering the screening age for diabetes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Data Analysis ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Risk Assessment ; United States ; Young Adult
Language	English
Publishing date	2020-08-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2020.108376
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Article ; Online: Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.

Kember, Rachel L / Hartwell, Emily E / Xu, Heng / Rotenberg, James / Almasy, Laura / Zhou, Hang / Gelernter, Joel / Kranzler, Henry R

Biological psychiatry

2022 Volume 93, Issue 6, Page(s) 536–545

Abstract: Background: Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRSs) and phenome-wide association studies are useful in ... ...

Abstract	Background: Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRSs) and phenome-wide association studies are useful in evaluating pleiotropic effects. However, the comparatively low prevalence of SUDs in population samples and the lack of detailed information available in electronic health records limit these data sets' informativeness for such analyses. Methods: We used the deeply phenotyped Yale-Penn sample (n = 10,610 with genetic data; 46.3% African ancestry, 53.7% European ancestry) to examine pleiotropy for 4 major substance-related traits: alcohol use disorder, opioid use disorder, smoking initiation, and lifetime cannabis use. The sample includes both affected and control subjects interviewed using the Semi-Structured Assessment for Drug Dependence and Alcoholism, a comprehensive psychiatric interview. Results: In African ancestry individuals, PRS for alcohol use disorder, and in European individuals, PRS for alcohol use disorder, opioid use disorder, and smoking initiation were associated with their respective primary DSM diagnoses. These PRSs were also associated with additional phenotypes involving the same substance. Phenome-wide association study analyses of PRS in European individuals identified associations across multiple phenotypic domains, including phenotypes not commonly assessed in phenome-wide association study analyses, such as family environment and early childhood experiences. Conclusions: Smaller, deeply phenotyped samples can complement large biobank genetic studies with limited phenotyping by providing greater phenotypic granularity. These efforts allow associations to be identified between specific features of disorders and genetic liability for SUDs, which help to inform our understanding of the pleiotropic pathways underlying them.
MeSH term(s)	Child, Preschool ; Humans ; Alcoholism/epidemiology ; Alcoholism/genetics ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/genetics ; Alcohol Drinking/genetics ; Risk Factors ; Phenotype ; Multifactorial Inheritance/genetics ; Genome-Wide Association Study ; Genetic Predisposition to Disease
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2022.08.010
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Zs.A 720: Show issues

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Book ; Conference proceedings: Advances in carbon dioxide effects research

Allen, Leon H.

proceedings of a symposium ... at Cincinnati, Ohio, 7 - 12 november 1993

(ASA special publication ; 61)

1997

Author's details	ed.: L. H. Allen
Series title	ASA special publication ; 61
Collection
Keywords	Pflanzen ; Photosynthese ; Kohlendioxidaustausch ; Atmung ; Atmosphäre ; Kohlendioxid ; Anreicherung ; Kohlendioxidbelastung ; Cincinnati <Ohio, 1993>
Subject	Kohlendioxid ; Aufkonzentrieren ; Kohlendioxyd ; Kohlenstoffdioxid ; CO2 ; R 744 ; R-744 ; R744 ; Erdatmosphäre ; Respiration ; Flora ; Pflanze ; Landpflanzen ; Fotosynthese
Size	XVIII, 228 S. : Ill., graph. Darst.
Publishing place	Madison, Wis
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT008058625
ISBN	0-89118-133-4 ; 978-0-89118-133-0
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Shelf mark	Loan status	Location
988/18	available for loan (reading room)	Freihandmagazin (U1)

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Article: Periodic density fluctuation during the yeast cell cycle and the selection of synchronous cultures.

Hartwell, L H

Journal of bacteriology

2006 Volume 104, Issue 3, Page(s) 1280–1285

Abstract: Yeast cells undergo periodic fluctuations in density during the cell division cycle such that a minimum in density occurs at the time of cell separation whereas a maximum occurs between the time of deoxyribonucleic acid replication and nuclear division. ... ...

Abstract	Yeast cells undergo periodic fluctuations in density during the cell division cycle such that a minimum in density occurs at the time of cell separation whereas a maximum occurs between the time of deoxyribonucleic acid replication and nuclear division. Synchronous cultures can be selected from asynchronously growing cell cultures by withdrawing the cells of least or greatest density after banding in Renografin-sucrose density gradients. This technique is rapid, reproducible, and almost unlimited in capacity.
Language	English
Publishing date	2006-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/jb.104.3.1280-1285.1970
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Article ; Online: Does polygenic risk for substance-related traits predict ages of onset and progression of symptoms?

Kranzler, Henry R / Feinn, Richard / Xu, Heng / Ho, Brendan L / Saini, Divya / Nicastro, Olivia R / Jacoby, Anya / Toikumo, Sylvanus / Gelernter, Joel / Hartwell, Emily E / Kember, Rachel L

Addiction (Abingdon, England)

2023 Volume 118, Issue 9, Page(s) 1675–1686

Abstract: Background and aims: Genetic risk can influence disease progression. We measured the impact of genetic risk for substance use disorders (SUDs) on substance use onset and progression of symptoms.: Design, setting, participants: Using findings from ... ...

Abstract	Background and aims: Genetic risk can influence disease progression. We measured the impact of genetic risk for substance use disorders (SUDs) on substance use onset and progression of symptoms. Design, setting, participants: Using findings from genome-wide association studies (GWASs) of alcohol use disorder (AUD), opioid use disorder (OUD) and smoking trajectory (SMK) as discovery samples, we calculated polygenic risk scores (PRSs) in a deeply phenotyped independent target sample. Participants in the target sample were recruited from 2000 to 2020 from US inpatient or outpatient settings or through advertisements and comprised 5692 European-ancestry individuals (EUR) (56.2% male) and 4918 African-ancestry individuals (AFR) (54.9% male). Measurements: This study measured age of first substance use, regular use, reported problems and dependence diagnosis and progression from regular use to onset of problems and dependence for alcohol, opioids and smoking. We examined the contribution of PRS to each milestone and progression measure. Findings: EUR and males reported an earlier onset and shorter progression times than AFR and females, respectively. Among EUR, higher AUD PRS predicted earlier onset and more rapid progression to alcohol-related milestones (P < 0.001). Although the AUD PRS was a stronger moderator of problem onset among females (P = 0.017), it was more predictive of the progression to problems among males (P = 0.005). OUD and SMK PRS in EUR also predicted earlier onset of the respective milestones (P < 0.001). Among AFR, where power is lower due to the smaller discovery sample, AUD PRS predicted age of regular alcohol use (P = 0.039) and dependence (P = 0.001) and progression from regular use to diagnosis (P = 0.045), while SMK PRS predicted earlier age of initiation (P = 0.036). Conclusions: Genetic risk for SUDs appears to predict substance use milestones and symptom progression among European-ancestry individuals and, to a lesser extent, African-ancestry individuals.
MeSH term(s)	Female ; Humans ; Male ; Genome-Wide Association Study ; Alcoholism/epidemiology ; Alcoholism/genetics ; Alcohol Drinking/epidemiology ; Alcohol Drinking/genetics ; Risk Factors ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/genetics ; Ethanol ; Multifactorial Inheritance ; Genetic Predisposition to Disease
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.16210
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Article ; Online: An Evaluation of Research Publications for General Surgery Residents And its Influence on the Future Pursuit of Fellowship or Academic Career.

Fladie, Ian / Wise, Audrey / Carr, Marvin / Johnson, Austin L / Kinder, Nicholas / Jackson, Erin / Shweikeh, Faris / Hartwell, Micah / Vassar, Matt

Journal of surgical education

2022 Volume 80, Issue 3, Page(s) 352–359

Abstract: ... of peer-reviewed publications, H-indices, fellowships, and whether the graduate pursued a career ... The number of publications before residency positively correlated with having a higher h-index (r = 0.4 ...

Abstract	Introduction: Traditionally, the Accreditation Council for Graduate Medical Education (ACGME) requires residency programs to implement research and other scholarly activities into their training curriculum. Encouraging residents to publish during residency is believed to promote research throughout their careers; however, the rate of research outcomes among general surgery residents remains unknown. Our study aims to determine associated factors that influence publication rates before, during, and after general surgery residency. Methods: This observational study employed a cross-sectional design. We examined whether research outcomes during general surgery residency was associated with academic advancement or continued research involvement after residency. We identified 321 general surgery residency programs on the Doximity website and randomly selected 50 to include in our sample. Of these programs, graduate rosters for 31 programs were located and subsequently included. Of the 405 residency graduates identified, we recorded the number of peer-reviewed publications, H-indices, fellowships, and whether the graduate pursued a career in private practice or academia. Results: Among the 405 physicians analyzed, 3815 total publications were identified with a mean of 9.4 (SD 11.8) per person. The most reported study design was observational studies (46.5%; 1775/3815) and the least reported was systematic reviews/meta-analyses (1.4%; 52/3815). The number of publications before residency positively correlated with having a higher h-index (r = 0.4). We also found that physicians who completed a fellowship had more publications during residency (mean = 4.7, SD = 6.5) than those not pursuing a fellowship (mean = 1.5, SD = 2.7; t= -4.3. p ≤ 0.001). We observed a statistically significant increase in the likelihood a physician pursued a career in academic medicine if they pursued a fellowship (OR: 3.77, 95% CI: 2.0-7.2) and if they had published research as a primary author (OR 1.25, 95% CI: 1.0-1.5). Conclusion: Increased research productivity was associated with continued academic pursuits and an increased likelihood of pursuing fellowship training after residency.
MeSH term(s)	Humans ; Fellowships and Scholarships ; Cross-Sectional Studies ; Education, Medical, Graduate ; Internship and Residency ; Efficiency ; Career Choice
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2022.10.004
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Article: Navigating Minority and Gender Discrimination, Substance Use Disorder, Financial Distress, and Workplace Politics: Lessons for Work-Life Wellness in Academic Medicine: Part 2 of 3.

Ahmed, Rami / Hartwell, Jennifer L / Farley, Heather / MacRae, Julia / Rogers, David A / Lawrence, Elizabeth C / Brazeau, Chantal Mlr / Park, Eliza M / Cassidy, Anna / Hartsock, Jane / Holmes, Emily / Schroeder, Kristen / Barach, Paul

Kansas journal of medicine

2023 Volume 16, Page(s) 159–164

Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ISSN	1948-2035
ISSN	1948-2035
DOI	10.17161/kjm.vol16.19953
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