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Book: A complete ABA curriculum for individuals on the autism spectrum with a developmental age of 1-4 years

Knapp, Julie / Turnbull, Carolline

a step-by-step treatment manual including supporting materials for teaching 140 foundational skills

2014

Author's details	Julie Knapp, Ph.D., BCBA-O and Carolline Turnbull, BA, BCaBA
Keywords	Autistic children/Education (Early childhood)/Curricula ; Children with autism spectrum disorders
Subject code	371.94
Language	English
Size	493 Seiten, Diagramme
Publisher	Jessica Kingsley Publishers
Publishing place	London
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references ; "Includes CD of printable curriculum programs annd colorful teaching materials" - Umschlag
Accompanying material	1 CD-ROM
HBZ-ID	HT018943353
ISBN	978-1-84905-978-7 ; 978-0-85700-887-9 ; 1-84905-978-0 ; 0-85700-887-0
Database	Catalogue ZB MED Medicine, Health

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Article: Practical Observations on Ship Fever as It Prevailed in Philadelphia and Its Environs, in the Months of June, July, and August, 1847.

Turnbull, Laurence

Medical examiner (Philadelphia, Pa.)

2023 Volume 3, Issue 33, Page(s) 528–531

Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Compassion through tele-empathy: technology-mediated symptom transference.

Ho, Ashley Jane / Turnbull, Julie / Fossat, Yan

Future healthcare journal

2019 Volume 4, Issue 3, Page(s) 219–220

Language	English
Publishing date	2019-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	3016427-8
ISSN	2514-6653 ; 2514-6645
ISSN (online)	2514-6653
ISSN	2514-6645
DOI	10.7861/futurehosp.4-3-219
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mitochondrial donation - hope for families with mitochondrial DNA disease.

Craven, Lyndsey / Murphy, Julie L / Turnbull, Doug M

Emerging topics in life sciences

2020 Volume 4, Issue 2, Page(s) 151–154

Abstract: In 2015, the UK became the first country to approve the use of mitochondrial donation. This novel in vitro fertilisation treatment was developed to prevent transmission of mitochondrial DNA (mtDNA) disease and ultimately give more reproductive choice to ... ...

Abstract	In 2015, the UK became the first country to approve the use of mitochondrial donation. This novel in vitro fertilisation treatment was developed to prevent transmission of mitochondrial DNA (mtDNA) disease and ultimately give more reproductive choice to women at risk of having severely affected offspring. The policy change was a major advance that surmounted many scientific, legislative and clinical challenges. Further challenges have since been addressed and there is now an NHS clinical service available to families with pathogenic mtDNA mutations that provides reproductive advice and options, and a research study to look at the outcome at 18 months of children born after mitochondrial donation.
MeSH term(s)	DNA, Mitochondrial/genetics ; Female ; Fertilization in Vitro ; Humans ; Mitochondria/genetics ; Mitochondrial Diseases/therapy ; Mitochondrial Replacement Therapy/methods ; Oocyte Donation ; Point Mutation ; Policy Making ; Pregnancy ; United Kingdom
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2020-06-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2882721-1
ISSN	2397-8554 ; 2397-8554 ; 2397-8562
ISSN (online)	2397-8554
ISSN	2397-8554 ; 2397-8562
DOI	10.1042/ETLS20190196
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving Certified Registered Nurse Anesthetists' Adherence to a Standardized Intraoperative Lung Protective Ventilation Protocol.

Wilson, Megan G / Adams, Cara N / Turnbull, Matthew D / Falyar, Christian R / Harris, Erica M / Thompson, Julie A / Simmons, Virginia C

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2023 Volume 38, Issue 6, Page(s) 845–850

Abstract: Purpose: The use of lung protective ventilation (LPV) during general anesthesia is an effective strategy among certified registered nurse anesthetists (CRNAs) to reduce and prevent the incidence of postoperative pulmonary complications. The purpose of ... ...

Abstract	Purpose: The use of lung protective ventilation (LPV) during general anesthesia is an effective strategy among certified registered nurse anesthetists (CRNAs) to reduce and prevent the incidence of postoperative pulmonary complications. The purpose of this project was to implement a LPV protocol, assess CRNA provider adherence, and investigate differences in ventilation parameters and postoperative oxygen requirements. Design: This quality improvement project was conducted using a pre- and postimplementation design. Methods: Sixty patients undergoing robotic laparoscopic abdominal surgery and 35 CRNAs at a community hospital participated. An evidence-based intraoperative LPV protocol was developed, CRNA education was provided, and the protocol was implemented. Pre- and postimplementation, CRNA knowledge, and confidence were assessed. Ventilation data were collected at 1-minute intervals intraoperatively and oxygen requirements were recorded in the postanesthesia care unit (PACU). Findings: Use of intraoperative LPV strategies increased 2.4%. Overall CRNA knowledge (P = .588), confidence (P = .031), and practice (P < .001) improved from pre- to postimplementation. Driving pressures decreased from pre- to postimplementation (P < .001). Supplemental oxygen use on admission to the PACU decreased from 93.3% to 70.0%. Conclusions: Educational interventions and implementation of a standardized protocol can improve the use of intraoperative LPV strategies and patient outcomes.
MeSH term(s)	Humans ; Nurse Anesthetists ; RNA, Complementary ; Respiration, Artificial ; Lung ; Postoperative Complications/prevention & control ; Oxygen
Chemical Substances	RNA, Complementary ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2022.12.005
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Article ; Online: Genome Sequencing of a Historic Staphylococcus aureus Collection Reveals New Enterotoxin Genes and Sheds Light on the Evolution and Genomic Organization of This Key Virulence Gene Family.

Dicks, Jo / Turnbull, Jake D / Russell, Julie / Parkhill, Julian / Alexander, Sarah

Journal of bacteriology

2021 Volume 203, Issue 10

Abstract: We take advantage of a historic collection of ... ...

Abstract	We take advantage of a historic collection of 133
MeSH term(s)	Animals ; Databases, Genetic ; Enterotoxins/genetics ; Evolution, Molecular ; Genes, Bacterial ; Genome, Bacterial ; High-Throughput Nucleotide Sequencing ; Humans ; Multigene Family ; Phylogeny ; Plasmids ; Pseudogenes ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/classification ; Staphylococcus aureus/genetics ; Staphylococcus aureus/pathogenicity ; Virulence/genetics ; Virulence Factors/genetics ; Whole Genome Sequencing
Chemical Substances	Enterotoxins ; Virulence Factors
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/JB.00587-20
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Article ; Online: Assessing the Measurement Properties of the Self-Administered Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R): A Rasch Analysis.

Mehdipour, Ava / Teshler, Lizabeth / Dal Bello-Haas, Vanina / Richardson, Julie / Beauchamp, Marla / Turnbull, John / Chum, Marvin / Johnston, Wendy / O'Connell, Colleen / Luth, Westerly / Kuspinar, Ayse

Physical therapy

2023 Volume 103, Issue 11

Abstract: Objective: The self-administered version of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is used to monitor function and disease progression in individuals with amyotrophic lateral sclerosis (ALS). However, the ... ...

Abstract	Objective: The self-administered version of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is used to monitor function and disease progression in individuals with amyotrophic lateral sclerosis (ALS). However, the performance of the self-administered ALSFRS-R has not been assessed using Rasch Measurement Theory. Therefore, the purpose of this study was to examine the psychometric properties of the self-administered ALSFRS-R using Rasch analysis. Methods: Rasch analysis was performed on self-administered ALSFRS-R data from individuals with ALS across Canada. The following 6 aspects of Rasch analysis were examined using RUMM2030: fit via residuals and chi-square statistics, targeting via person-item threshold maps, dependency via item residual correlations, unidimensionality through principal components analysis of residuals, reliability via person separation index, and stability through differential item functioning analyses for sex, age, and language. Results: Analysis was performed on 122 participants (mean age: 52.9 years; 62.8% men). The overall scale demonstrated good fit, reliability, and stability; however, multidimensionality was found. To address this issue, items were divided into 3 subscales (bulbar, motor, and respiratory function), and Rasch analysis was performed for each subscale. The subscales demonstrated good fit, reliability, stability, and unidimensionality. However, there were still issues with item dependency for all subscale and targeting for bulbar and respiratory subscales. Conclusions: The self-administered ALSFRS-R is reliable, internally valid, and stable across sex, age, and language subgroups; however, it is recommended that the ALSFRS-R be scored by subscale. Future studies can look at revising and/or adding items to tackle misfit, redundancy, and ceiling effects. Impact: Self-administered measures are simple to administer and inexpensive. The self-administered ALSFRS-R was found to be psychometrically sound and can be used as a tool to monitor disease progression and function in ALS.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Amyotrophic Lateral Sclerosis ; Reproducibility of Results ; Language ; Psychometrics ; Disease Progression
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzad109
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Article ; Online: Mitochondrial morphology and function: two for the price of one!

Faitg, Julie / Davey, Tracey / Turnbull, Doug M / White, Kathryn / Vincent, Amy E

Journal of microscopy

2020 Volume 278, Issue 2, Page(s) 89–106

Abstract: Mitochondrial shape and function are known to be linked; therefore, there is a need to combine three-dimensional EM structural analysis with functional analysis. Cytochrome c oxidase labelling is one approach to examine mitochondrial function at the EM ... ...

Abstract	Mitochondrial shape and function are known to be linked; therefore, there is a need to combine three-dimensional EM structural analysis with functional analysis. Cytochrome c oxidase labelling is one approach to examine mitochondrial function at the EM level. However, previous efforts to apply this method have had several issues including inconsistent results, disruption to mitochondrial ultrastructure, and a lack of optimisation for volume EM methods. We have used short fixation and microwave processing to address these issues. We show that our method gives consistent cytochrome c oxidase labelling and improves labelling penetration across tissue volume. We also quantify mitochondrial morphology metrics, including in volume EM, to show that ultrastructure is unaltered by the processing. This work represents a technical advance that allows the correlation of mitochondrial function and morphology with greater resolution and volume than has previously been feasible. LAY SUMMARY: Transmission electron microscopy (TEM) is a high-resolution technique used for the study of cells and their components, such as mitochondria. However, the two-dimensional nature of TEM means that quantification of these structures is difficult without making assumptions about their shape; a problem that was solved by the advent of three-dimensional EM approaches. Mitochondrial shape and function are known to be linked therefore there is a need to combine three-dimensional EM structural analysis with functional analysis. To do this we used electron microscopy to visualise a reaction that assesses the activity of cytochrome c oxidase in the mitochondrial respiratory chain. The reaction deposits a dark staining on mitochondrial cristae where cytochrome c oxidase is functioning and a lack of staining where it is not. We first optimised this technique for TEM, showing that the tissue was evenly stained and exhibited no effect on mitochondrial shape when compared to conventionally processed tissue. We then demonstrated that this was also true of a sample processed for three-dimensional EM imaging. This work presents an advance in three-dimensional EM imaging that allows us to look at both mitochondrial function and shape and to detect subtle changes in shape.
MeSH term(s)	Animals ; Electron Transport Complex IV/metabolism ; Imaging, Three-Dimensional/methods ; Mice ; Microscopy, Electron, Transmission/methods ; Mitochondria/physiology ; Mitochondria/ultrastructure ; Staining and Labeling/methods ; Tissue Fixation/methods
Chemical Substances	Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2020-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219263-9
ISSN	1365-2818 ; 0022-2720
ISSN (online)	1365-2818
ISSN	0022-2720
DOI	10.1111/jmi.12891
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Article ; Online: Workshop report: the clinical application of data from multiplex assays of variant effect (MAVEs), 12 July 2023.

Allen, Sophie / Garrett, Alice / Muffley, Lara / Fayer, Shawn / Foreman, Julia / Adams, David J / Hurles, Matthew / Rubin, Alan F / Roth, Frederick P / Starita, Lea M / Biesecker, Leslie G / Turnbull, Clare

European journal of human genetics : EJHG

2024 Volume 32, Issue 5, Page(s) 593–600

MeSH term(s)	Humans ; Genetic Testing/standards ; Genetic Testing/methods
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Journal Article ; Congress
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-024-01566-2
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Article ; Online: Emergency department staff views of NHS 111 First: qualitative interview study in England.

MacLellan, Jennifer / Turnbull, Joanne / Prichard, Jane / Pope, Catherine

Emergency medicine journal : EMJ

2023 Volume 40, Issue 9, Page(s) 636–640

Abstract: ... England between October 2020 and July 2021 as part of a larger multimethod study examining the impact ...

Abstract	Background: NHS 111 is a phone and online urgent care triage and assessment system that aims to reduce UK ED demand. In 2020, 111 First was introduced to triage patients before entry to the ED and to offer direct booking for patients needing ED or urgent care into same-day arrival time slots. 111 First continues to be used post pandemic, but concerns about patient safety, delays or inequities in accessing care have been voiced. This paper examines ED and urgent care centre (UCC) staff experiences of NHS 111 First. Method: Semistructured telephone interviews were conducted with ED/UCC practitioners across England between October 2020 and July 2021 as part of a larger multimethod study examining the impact of NHS 111 online. We purposively recruited from areas with high need/demand likely to be using NHS 111 services. Interviews were transcribed verbatim and coded inductively by the primary researcher. We coded all items to capture experiences of 111 First within the full project coding tree and from this constructed two explanatory themes which were refined by the wider research team. Results: We recruited 27 participants (10 nurses, 9 doctors and 8 administrator/managers) working in ED/UCCs serving areas with high deprivation and mixed sociodemographic profiles. Participants reported local triage/streaming systems predating 111 First continued to operate so that, despite prebooked arrival slots at the ED, all attendances were funnelled into a single queue. This was described by participants as a source of frustration for staff and patients. Interviewees perceived remote algorithm-based assessments as less robust than in-person assessments which drew on more nuanced clinical expertise. Discussion: While remote preassessment of patients before they present at ED is attractive, existing triage and streaming systems based on acuity, and staff views about the superiority of clinical acumen, are likely to remain barriers to the effective use of 111 First as a demand management strategy.
MeSH term(s)	Humans ; Emergency Service, Hospital ; England ; Qualitative Research ; State Medicine/organization & administration ; Triage/methods
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2022-212947
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