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Article ; Online: Increased Intestinal Permeability and Decreased Resiliency of the Intestinal Barrier in Alcoholic Liver Disease.

Swanson, Garth R / Garg, Kanika / Shaikh, Maliha / Keshavarzian, Ali

Clinical and translational gastroenterology

2024 Volume 15, Issue 4, Page(s) e00689

Abstract: Introduction: Only 20%-30% of individuals with alcohol use disorder (AUD) develop alcoholic liver disease (ALD). While the development of gut-derived endotoxemia is understood to be a required cofactor, increased intestinal permeability in ALD is not ... ...

Abstract	Introduction: Only 20%-30% of individuals with alcohol use disorder (AUD) develop alcoholic liver disease (ALD). While the development of gut-derived endotoxemia is understood to be a required cofactor, increased intestinal permeability in ALD is not completely understood. Methods: We recruited 178 subjects-58 healthy controls (HCs), 32 with ALD, 53 with AUD but no liver disease (ALC), and 35 with metabolic dysfunction-associated steatotic liver disease (MASLD). Intestinal permeability was assessed by a sugar cocktail as a percentage of oral dose. The permeability test was repeated after an aspirin challenge in a subset. Results: Five-hour urinary lactulose/mannitol ratio (primarily representing small intestinal permeability) was not statistically different in HC, ALC, ALD, and MASLD groups ( P = 0.40). Twenty-four-hour urinary sucralose (representing whole gut permeability) was increased in ALD ( F = 5.3, P < 0.01) and distinguished ALD from ALC; 24-hour sucralose/lactulose ratio (primarily representing colon permeability) separated the ALD group ( F = 10.2, P < 0.01) from the MASLD group. After aspirin challenge, intestinal permeability increased in all groups and ALD had the largest increase. Discussion: In a group of patients, we confirmed that (i) the ALD group has increased intestinal permeability compared with the HC, ALC, or MASLD group. In addition, because small bowel permeability (lactulose/mannitol ratio) is normal, the disruption of intestinal barrier seems to be primarily in the large intestine; (ii) decreased resiliency of intestinal barrier to injurious agents (such as NSAID) might be the mechanism for gut leak in subset of AUD who develop ALD.
MeSH term(s)	Humans ; Male ; Liver Diseases, Alcoholic/metabolism ; Middle Aged ; Female ; Permeability ; Lactulose/urine ; Lactulose/administration & dosage ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Adult ; Mannitol/urine ; Mannitol/administration & dosage ; Case-Control Studies ; Aspirin/administration & dosage ; Intestinal Absorption/drug effects ; Sucrose/administration & dosage ; Sucrose/analogs & derivatives ; Alcoholism/complications ; Alcoholism/metabolism ; Aged ; Intestinal Barrier Function
Chemical Substances	Lactulose (4618-18-2) ; Mannitol (3OWL53L36A) ; Aspirin (R16CO5Y76E) ; Sucrose (57-50-1) ; trichlorosucrose (96K6UQ3ZD4)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2581516-7
ISSN	2155-384X ; 2155-384X
ISSN (online)	2155-384X
ISSN	2155-384X
DOI	10.14309/ctg.0000000000000689
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advancements in the dominion of fate and transport of pharmaceuticals and personal care products in the environment-a bibliometric study.

Ashraf, Maliha / Ahammad, Shaikh Ziauddin / Chakma, Sumedha

Environmental science and pollution research international

2023 Volume 30, Issue 23, Page(s) 64313–64341

Abstract: The study on the fate and transport of Pharmaceuticals and Personal Care Products, PPCPs (FTP) in the environment, has received particular attention for over two decades. The PPCPs threaten ecology and human health even at low concentrations due to their ...

Abstract	The study on the fate and transport of Pharmaceuticals and Personal Care Products, PPCPs (FTP) in the environment, has received particular attention for over two decades. The PPCPs threaten ecology and human health even at low concentrations due to their synergistic effects and long-range transport. The research aims to provide an inclusive map of the scientific background of FTP research over the last 25 years, from 1996 to 2020, to identify the main characteristics, evolution, salient research themes, trends, and research hotspots in the field of interest. Bibliometric networks were synthesized and analyzed for 577 journal articles extracted from the Scopus database. Consequently, seven major themes of FTP research were identified as follows: (i) PPCPs category; (ii) hazardous effects; (iii) occurrence of PPCPs; (iv) PPCPs in organisms; (v) remediation; (vi) FTP-governing processes; and (vii) assessment in the environment. The themes gave an in-depth picture of the sources of PPCPs and their transport and fate processes in the environment, which originated from sewage treatment plants and transported further to sediment/soils/groundwater/oceans that act as the PPCPs' major sink. The article provided a rigorous analysis of the research landscape in the FTP study conducted during the specified years. The prominent research themes, content analysis, and research hotspots identified in the study may serve as the basis of real-time guidance to lead future research areas and a prior review for policymakers and practitioners.
MeSH term(s)	Humans ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Cosmetics/analysis ; Ecology ; Pharmaceutical Preparations
Chemical Substances	Water Pollutants, Chemical ; Cosmetics ; Pharmaceutical Preparations
Language	English
Publishing date	2023-04-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26796-7
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Article ; Online: Correction to: Novel role of the Mu‑opioid receptor in pancreatic cancer: potential link between opioid use and cancer progression.

Haque, Muhammad R / Barlass, Usman / Armstrong, Andrew / Shaikh, Maliha / Bishehsari, Faraz

Molecular and cellular biochemistry

2022 Volume 477, Issue 5, Page(s) 1347

Language	English
Publishing date	2022-02-25
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04400-9
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Zs.A 892: Show issues

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Article ; Online: Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice.

Forsyth, Christopher B / Shaikh, Maliha / Engen, Phillip A / Preuss, Fabian / Naqib, Ankur / Palmen, Breanna A / Green, Stefan J / Zhang, Lijuan / Bogin, Zlata R / Lawrence, Kristi / Sharma, Deepak / Swanson, Garth R / Bishehsari, Faraz / Voigt, Robin M / Keshavarzian, Ali

Frontiers in aging

2024 Volume 5, Page(s) 1352299

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3076785-4
ISSN	2673-6217 ; 2673-6217
ISSN (online)	2673-6217
ISSN	2673-6217
DOI	10.3389/fragi.2024.1352299
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Article: A Comparison of the Effectiveness of Neurodynamic Sliding Technique and Self-Myofascial Release Technique for Reducing Hamstring Tightness in Healthy Individuals: A Prospective Study.

Shaikh, Amreen Afsarpatel / Quraishi, Maliha Fatima / Chitapure, Tajuddin / Joshi, Priyanka Abhay / Shaikh, Saba Afsar / Nandgaonkar, Nikita / Sable, Komal

Cureus

2023 Volume 15, Issue 6, Page(s) e40613

Abstract: Background: Hamstring tightness is prevalent among college-going students aged 18-25 years, leading to an increased risk of recurrent injury, reduced athletic performance, post-exercise soreness, and decreased coordination. Myofascial release and ... ...

Abstract	Background: Hamstring tightness is prevalent among college-going students aged 18-25 years, leading to an increased risk of recurrent injury, reduced athletic performance, post-exercise soreness, and decreased coordination. Myofascial release and neurodynamic sliding technique are two interventions used to alleviate this issue. Myofascial release is a concept that involves pain originating from the muscle and fascia. The neurodynamic sliding technique is a method of producing sliding movement of neural structures relative to their mechanical interfaces. Methods: This study involved 70 individuals with hamstring tightness who met the inclusion and exclusion criteria. Participants were assigned to Group A or Group B using a convenient sampling method. Group A received neurodynamic sliding technique treatment, while Group B received a self-myofascial release. Both interventions were administered for two months. The outcome measures used in this study were active knee extension and lower extremity functional scale, which were evaluated before and after the intervention. Results and implications: Within-group comparisons indicated that both Group A and Group B showed significant improvements in hamstring flexibility. Between-group comparisons of active knee extension (AKE) and lower extremity functional scale (LEFS) immediately after the intervention showed statistically significant results. These findings suggest that both the neurodynamic sliding technique and self-myofascial release are effective in improving hamstring flexibility. This study has implications for clinical practice, as both interventions may be used to address hamstring tightness. Conclusion: Our study found that both the neurodynamic sliding technique and self-myofascial release can improve hamstring flexibility. However, the neurodynamic sliding technique was found to be more effective than self-myofascial release. Further research is necessary to determine the optimal protocol for these interventions and their effectiveness in clinical populations with hamstring tightness or injury.
Language	English
Publishing date	2023-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40613
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Article: Dreadful infectious disease outbreaks threaten flood-ravaged pakistan: short communication.

Shaikh, Omer Ahmed / Rahim, Maliha / Essarani, Manisha / Nadeem, Soeba / Ochani, Sidhant / Hasibuzzaman, Md Al / Ullah, Kaleem

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 6, Page(s) 3237–3238

Abstract: A rise in the incidence of water-borne, communicable illnesses, and viral outbreaks in Pakistan follows periods of heavy rainfall. Due to climate change, floods and droughts have had devastating effects on human health by facilitating the spread of ... ...

Abstract	A rise in the incidence of water-borne, communicable illnesses, and viral outbreaks in Pakistan follows periods of heavy rainfall. Due to climate change, floods and droughts have had devastating effects on human health by facilitating the spread of infectious illnesses including cholera, malaria, typhoid, dengue fever, and viral hepatitis A. Food instability, starvation, malnutrition, and a lack of potable water are only some of the indirect effects of flooding on health. Recently, one of the worst floods in history devastated Pakistan, affecting more than 333 million people along with a significant portion of the nation submerged. Malaria, dengue fever, and other ailments are on the rise in Pakistan, threatening to overwhelm the country's healthcare infrastructure. There is an urgent need for preventative measures in Pakistan to cope with dreadful outbreaks.
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000754
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Article ; Online: Novel role of the Mu-opioid receptor in pancreatic cancer: potential link between opioid use and cancer progression.

Haque, Muhammad R / Barlass, Usman / Armstrong, Andrew / Shaikh, Maliha / Bishehsari, Faraz

Molecular and cellular biochemistry

2022 Volume 477, Issue 5, Page(s) 1339–1345

Abstract: Opioids are the most popular drugs for both acute and chronic pain management. The G protein-coupled mu-opioid receptor (MOR) is the therapeutic target for most clinically used opioids, including morphine. A mounting number of publications suggest a ... ...

Abstract	Opioids are the most popular drugs for both acute and chronic pain management. The G protein-coupled mu-opioid receptor (MOR) is the therapeutic target for most clinically used opioids, including morphine. A mounting number of publications suggest a relationship between the MOR and possible cancer progression and recurrence extending to managing chronic cancer pain. In this study, we studied the possible link between opioid use and pancreatic cancer (PC) progression. We found increased MOR expression in murine and human PC cell lines, human PC-derived organoids, and in the undifferentiated or poorly differentiated areas of surgically resected PC tissues. Direct stimulation of MOR by morphine (MOR agonist) caused a significant dose-dependent increase in proliferation, invasion, and levels of stemness markers in PC cells. In a co-culture system, MOR stimulation of macrophages also resulted in increased proliferation of PC cells. MOR overexpression increased proliferation and cancer stemness, whereas knock-down of MOR followed opposite results in the PC cells. Morphine induced chemoresistance to conventional chemotherapeutic agents used for PC treatment. Overall, our results suggest that MOR is expressed in pancreatic cancer and may be involved in tumor progression and chemoresistance.
MeSH term(s)	Analgesics, Opioid/adverse effects ; Analgesics, Opioid/pharmacology ; Animals ; Cell Line ; Humans ; Mice ; Morphine/adverse effects ; Morphine/pharmacology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/etiology ; Receptors, Opioid, mu/genetics ; Receptors, Opioid, mu/metabolism
Chemical Substances	Analgesics, Opioid ; Receptors, Opioid, mu ; Morphine (76I7G6D29C)
Language	English
Publishing date	2022-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04377-5
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Article ; Online: Evidence of a genetic background predisposing to complex regional pain syndrome type 1.

Shaikh, Samiha S / Goebel, Andreas / Lee, Michael C / Nahorski, Michael S / Shenker, Nicholas / Pamela, Yunisa / Drissi, Ichrak / Brown, Christopher / Ison, Gillian / Shaikh, Maliha F / Kuttikat, Anoop / Woods, William A / Dixit, Abhishek / Stouffer, Kaitlin / Clarke, Murray Ch / Menon, David K / Woods, C Geoffrey

Journal of medical genetics

2024 Volume 61, Issue 2, Page(s) 163–170

Abstract: Background: Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared ...

Abstract	Background: Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared with those who do not have the condition. Methods: Exome sequencing was performed to seek altered non-synonymous SNP allele frequencies in a discovery cohort of well-characterised patients with chronic CRPS-1 (n Results: In the discovery cohort, the rare allele frequencies of four non-synonymous SNPs were statistically increased. The replication cohort confirmed this finding. In a chronic pain cohort, these alleles were not overexpressed. In total, 25 out of 84 (29.8%) patients with CRPS-1 expressed a rare allele. The SNPs were rs41289586 in Conclusion: A single SNP in each of the genes
MeSH term(s)	Male ; Female ; Humans ; Complex Regional Pain Syndromes/genetics ; Complex Regional Pain Syndromes/epidemiology ; Gene Frequency ; Polymorphism, Single Nucleotide/genetics ; Alleles ; Genetic Background
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmg-2023-109236
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Article: Risk factors associated with disease recurrence in patients with T4 staged Squamous Cell Carcinoma of the Oral Cavity treated with surgery and postoperative radiotherapy.

Hassan, Nabeel Humayun / Ayub, Bushra / Qureshi, Talha Ahmed / Shaikh, Shafqat Ali / Kazi, Maliha / Usman, Rahila / Haroon, Umer Saeed

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 72, Issue 12, Page(s) 2399–2403

Abstract: Objective: To determine the association of clinical and pathological parameters on recurrence of treated stage T4squamous cell carcinoma of oral cavity patients managed with surgery followed by concomitant chemo and radiation therapy.: Methods: The ... ...

Abstract	Objective: To determine the association of clinical and pathological parameters on recurrence of treated stage T4squamous cell carcinoma of oral cavity patients managed with surgery followed by concomitant chemo and radiation therapy. Methods: The retrospective, cohort study was conducted at Patel Hospital, Karachi, and comprised data of patients diagnosed with oral squamous cell carcinoma and admitted between January 1, 2014, and January 30, 2019. Patients of either gender aged 20-80 years who had a minimum follow-up of one year were included. Data was collected using the Head and Neck Cancer registry form and the medical record files. The subjects were also contacted by telephone when needed. The study end-points were disease-free survival and overall survival. Data was analysed using SPSS 21. Results: Out of the 83 patients, 65(78%) were male. The overall median(range) age was 46(20-80) years, and 43(52%) of them were aged 31-50 years. Overall, 15(18%) patients had positive margins and 48(58%) had proven cervical node metastasis on histopathology. Overall survival was 42.2% with the median(range) follow-up time was 14(9-21) months and 5-year disease-free survival was 45.8% with the median (range) follow-up time was 13(7-19). The factor that affected the final outcome was found to be the increasing nodal ratio (p=0.043). Conclusion: Among T4 oral squamous cell carcinoma patients treated with surgery and adjuvant therapy, the rate of disease recurrence was found to be high. Tumours with a high cervical nodal disease burden and/or margin involved were at substantially higher risk of recurrence.
MeSH term(s)	Humans ; Male ; Female ; Carcinoma, Squamous Cell/radiotherapy ; Squamous Cell Carcinoma of Head and Neck/therapy ; Squamous Cell Carcinoma of Head and Neck/pathology ; Mouth Neoplasms/radiotherapy ; Mouth Neoplasms/surgery ; Retrospective Studies ; Cohort Studies ; Neoplasm Staging ; Head and Neck Neoplasms ; Risk Factors ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Radiotherapy, Adjuvant
Language	English
Publishing date	2023-05-25
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.3374
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Article ; Online: Impact of alcohol-induced intestinal microbiota dysbiosis in a rodent model of Alzheimer's disease.

Frausto, Dulce M / Engen, Phillip A / Naqib, Ankur / Jackson, Aeja / Tran, Laura / Green, Stefan J / Shaikh, Maliha / Forsyth, Christopher B / Keshavarzian, Ali / Voigt, Robin M

Frontiers in aging

2022 Volume 3, Page(s) 916336

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-08-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3076785-4
ISSN	2673-6217 ; 2673-6217
ISSN (online)	2673-6217
ISSN	2673-6217
DOI	10.3389/fragi.2022.916336
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