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  1. Article ; Online: Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound.

    Dann, Melissa M / Clark, Sydney Q / Trzaskalski, Natasha A / Earl, Conner C / Schepers, Luke E / Pulente, Serena M / Lennord, Ebonee N / Annamalai, Karthik / Gruber, Joseph M / Cox, Abigail D / Lorenzen-Schmidt, Ilka / Seymour, Richard / Kim, Kyoung-Han / Goergen, Craig J / Mulvihill, Erin E

    American journal of physiology. Heart and circulatory physiology

    2022  Volume 322, Issue 3, Page(s) H359–H372

    Abstract: Ischemic heart disease is the leading cause of death in the United States, Canada, and worldwide. Severe disease is characterized by coronary artery occlusion, loss of blood flow to the myocardium, and necrosis of tissue, with subsequent remodeling of ... ...

    Abstract Ischemic heart disease is the leading cause of death in the United States, Canada, and worldwide. Severe disease is characterized by coronary artery occlusion, loss of blood flow to the myocardium, and necrosis of tissue, with subsequent remodeling of the heart wall, including fibrotic scarring. The current study aims to demonstrate the efficacy of quantitating infarct size via two-dimensional (2-D) echocardiographic akinetic length and four-dimensional (4-D) echocardiographic infarct volume and surface area as in vivo analysis techniques. We further describe and evaluate a new surface area strain analysis technique for estimating myocardial infarction (MI) size after ischemic injury. Experimental MI was induced in mice via left coronary artery ligation. Ejection fraction and infarct size were measured through 2-D and 4-D echocardiography. Infarct size established via histology was compared with ultrasound-based metrics via linear regression analysis. Two-dimensional echocardiographic akinetic length (
    MeSH term(s) Algorithms ; Animals ; Cardiac Output ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Imaging, Three-Dimensional/methods ; Imaging, Three-Dimensional/standards ; Male ; Mice ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Sensitivity and Specificity ; Ultrasonography/methods ; Ultrasonography/standards
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00476.2021
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  2. Article ; Online: Use of noise cancellation earphones in out-of-booth audiometric evaluations.

    Clark, John Greer / Brady, Matthew / Earl, Brian R / Scheifele, Peter M / Snyder, Lianna / Clark, Suzanne Duchesne

    International journal of audiology

    2017  Volume 56, Issue 12, Page(s) 989–996

    Abstract: Objective: To assess the utility of noise cancelation earphones (NCE) in audiometric evaluations.: Design: Degree of noise reduction of Bose QuietComfort 15 NCE was assessed through probe-microphone measures and sound-field audiometry. Occlusion ... ...

    Abstract Objective: To assess the utility of noise cancelation earphones (NCE) in audiometric evaluations.
    Design: Degree of noise reduction of Bose QuietComfort 15 NCE was assessed through probe-microphone measures and sound-field audiometry. Occlusion effects from NCE were assessed for potential effects on bone-conduction thresholds.
    Study sample: Twenty participants were tested to determine average occlusion effect values during bone-conduction testing with and without NCE. Noise reduction values of the NCE were assessed on a single subject through probe-microphone measures and sound-field testing.
    Results: NCE sufficiently reduced ambient noise to levels acceptable for air-conduction testing as well as for bone-conduction testing for most patients when adding minimal adjustment to acceptable levels as outlined by the ANSI S3.1-1999 standard. In addition, NCE did not create a clinically significant change in the occlusion effect for bone-conduction testing.
    Conclusion: NCE placed over insert earphones provide a sound pressure level at the tympanic membrane that is below ANSI standards for routine air-conduction testing and result in sufficient ambient noise reduction for bone-conduction testing with most patients. There is no clinically significant occlusion effect from NCE during routine bone-conduction audiometry. These findings support the utility of using NCE for offsite audiometric testing.
    MeSH term(s) Adult ; Audiometry, Pure-Tone/instrumentation ; Audiometry, Pure-Tone/methods ; Auditory Perception ; Auditory Threshold ; Bone Conduction ; Ear Protective Devices ; Equipment Design ; Female ; Humans ; Male ; Noise/adverse effects ; Noise/prevention & control ; Young Adult
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073098-6
    ISSN 1708-8186 ; 1499-2027
    ISSN (online) 1708-8186
    ISSN 1499-2027
    DOI 10.1080/14992027.2017.1362118
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  3. Article ; Online: A synthetic Pur-based peptide binds and alters G-quadruplex secondary structure present in the expanded RNA repeat of C9orf72 ALS/FTD.

    Wortman, Margaret J / Dagdanova, Ayuna V / Clark, Andrea M / Godfrey, Earl W / Pascal, Steven M / Johnson, Edward M / Daniel, Dianne C

    Biochimica et biophysica acta. Molecular cell research

    2020  Volume 1867, Issue 6, Page(s) 118674

    Abstract: Increased Pur-alpha (Pura) protein levels in animal models alleviate certain cellular symptoms of the disease spectrum amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). Pura is a member of the Pur family of evolutionarily conserved guanine- ...

    Abstract Increased Pur-alpha (Pura) protein levels in animal models alleviate certain cellular symptoms of the disease spectrum amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). Pura is a member of the Pur family of evolutionarily conserved guanine-rich polynucleotide binding proteins containing a repeated signature PUR domain of 60-80 amino acids. Here we have employed a synthetic peptide, TZIP, similar to a Pur domain, but with sequence alterations based on a consensus of evolutionarily conserved Pur family binding domains and having an added transporter sequence. A major familial form of ALS/FTD, C9orf72 (C9), is due to a hexanucleotide repeat expansion (HRE) of (GGGGCC), a Pur binding element. We show by circular dichroism that RNA oligonucleotides containing this purine-rich sequence consist largely of parallel G-quadruplexes. TZIP peptide binds this repeat sequence in both DNA and RNA. It binds the RNA element, including the G-quadruplexes, with a high degree of specificity versus a random oligonucleotide. In addition, TZIP binds both linear and G-quadruplex repeat RNA to form higher order G-quadruplex secondary structures. This change in conformational form by Pur-based peptide represents a new mechanism for regulating G quadruplex secondary structure within the C9 repeat. TZIP modulation of C9 RNA structural configuration may alter interaction of the complex with other proteins. This Pur-based mechanism provides new targets for therapy, and it may help to explain Pura alleviation of certain cellular pathological aspects of ALS/FTD.
    MeSH term(s) C9orf72 Protein/chemistry ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; Circular Dichroism ; DNA Repeat Expansion/drug effects ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; G-Quadruplexes/drug effects ; Humans ; Models, Molecular ; Molecular Mimicry ; Peptides/chemical synthesis ; Peptides/pharmacology ; RNA/chemistry ; RNA/metabolism ; Thermodynamics ; Transcription Factors/chemistry ; Transcription Factors/metabolism
    Chemical Substances C9orf72 Protein ; C9orf72 protein, human ; DNA-Binding Proteins ; PURA protein, human ; Peptides ; Transcription Factors ; RNA (63231-63-0)
    Language English
    Publishing date 2020-02-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2020.118674
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  4. Article: Regional analysis of planting date and cultivar maturity recommendations that improve soybean oil yield and meal protein concentration.

    Salmerón, Montserrat / Bourland, Fred M / Buehring, Normie W / Earnest, Larry / Fritschi, Felix B / Gbur, Edward E / Golden, Bobby R / Hathcoat, Daniel / Lofton, Josh / McClure, Angela Thompson / Miller, Travis D / Neely, Clark / Shannon, Grover / Udeigwe, Theophilus K / Verbree, David A / Vories, Earl D / Wiebold, William J / Purcell, Larry C

    Frontiers in plant science

    2022  Volume 13, Page(s) 954111

    Abstract: Planting date and cultivar maturity group (MG) are major management factors affecting soybean [ ...

    Abstract Planting date and cultivar maturity group (MG) are major management factors affecting soybean [
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.954111
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  5. Article ; Online: GIGYF1 disruption associates with autism and impaired IGF-1R signaling.

    Chen, Guodong / Yu, Bin / Tan, Senwei / Tan, Jieqiong / Jia, Xiangbin / Zhang, Qiumeng / Zhang, Xiaolei / Jiang, Qian / Hua, Yue / Han, Yaoling / Luo, Shengjie / Hoekzema, Kendra / Bernier, Raphael A / Earl, Rachel K / Kurtz-Nelson, Evangeline C / Idleburg, Michaela J / Madan-Khetarpal, Suneeta / Clark, Rebecca / Sebastian, Jessica /
    Fernandez-Jaen, Alberto / Alvarez, Sara / King, Staci D / Ramos, Luiza Lp / Santos, Mara Lucia Sf / Martin, Donna M / Brooks, Dan / Symonds, Joseph D / Cutcutache, Ioana / Pan, Qian / Hu, Zhengmao / Yuan, Ling / Eichler, Evan E / Xia, Kun / Guo, Hui

    The Journal of clinical investigation

    2022  Volume 132, Issue 19

    Abstract: Autism spectrum disorder (ASD) represents a group of neurodevelopmental phenotypes with a strong genetic component. An excess of likely gene-disruptive (LGD) mutations in GIGYF1 was implicated in ASD. Here, we report that GIGYF1 is the second-most ... ...

    Abstract Autism spectrum disorder (ASD) represents a group of neurodevelopmental phenotypes with a strong genetic component. An excess of likely gene-disruptive (LGD) mutations in GIGYF1 was implicated in ASD. Here, we report that GIGYF1 is the second-most mutated gene among known ASD high-confidence risk genes. We investigated the inheritance of 46 GIGYF1 LGD variants, including the highly recurrent mutation c.333del:p.L111Rfs*234. Inherited GIGYF1 heterozygous LGD variants were 1.8 times more common than de novo mutations. Among individuals with ASD, cognitive impairments were less likely in those with GIGYF1 LGD variants relative to those with other high-confidence gene mutations. Using a Gigyf1 conditional KO mouse model, we showed that haploinsufficiency in the developing brain led to social impairments without significant cognitive impairments. In contrast, homozygous mice showed more severe social disability as well as cognitive impairments. Gigyf1 deficiency in mice led to a reduction in the number of upper-layer cortical neurons, accompanied by a decrease in proliferation and increase in differentiation of neural progenitor cells. We showed that GIGYF1 regulated the recycling of IGF-1R to the cell surface. KO of GIGYF1 led to a decreased level of IGF-1R on the cell surface, disrupting the IGF-1R/ERK signaling pathway. In summary, our findings show that GIGYF1 is a regulator of IGF-1R recycling. Haploinsufficiency of GIGYF1 was associated with autistic behavior, likely through interference with IGF-1R/ERK signaling pathway.
    MeSH term(s) Animals ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/metabolism ; Autistic Disorder/genetics ; Autistic Disorder/metabolism ; Mice ; Neurons/metabolism ; Phenotype ; Signal Transduction
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI159806
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  6. Book ; Online: Optimising Trotter-Suzuki Decompositions for Quantum Simulation Using Evolutionary Strategies

    Jones, Benjamin D. M. / O'Brien, George O. / White, David R. / Campbell, Earl T. / Clark, John A.

    2019  

    Abstract: One of the most promising applications of near-term quantum computing is the simulation of quantum systems, a classically intractable task. Quantum simulation requires computationally expensive matrix exponentiation; Trotter-Suzuki decomposition of this ... ...

    Abstract One of the most promising applications of near-term quantum computing is the simulation of quantum systems, a classically intractable task. Quantum simulation requires computationally expensive matrix exponentiation; Trotter-Suzuki decomposition of this exponentiation enables efficient simulation to a desired accuracy on a quantum computer. We apply the Covariance Matrix Adaptation Evolutionary Strategy (CMA-ES) algorithm to optimise the Trotter-Suzuki decompositions of a canonical quantum system, the Heisenberg Chain; we reduce simulation error by around 60%. We introduce this problem to the computational search community, show that an evolutionary optimisation approach is robust across runs and problem instances, and find that optimisation results generalise to the simulation of larger systems.

    Comment: A version of this paper is to appear in GECCO'19
    Keywords Computer Science - Neural and Evolutionary Computing ; Quantum Physics
    Subject code 006
    Publishing date 2019-04-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA.

    Erskine, Elliot / Morris, Ryan J / Schor, Marieke / Earl, Chris / Gillespie, Rachel M C / Bromley, Keith M / Sukhodub, Tetyana / Clark, Lauren / Fyfe, Paul K / Serpell, Louise C / Stanley-Wall, Nicola R / MacPhee, Cait E

    Molecular microbiology

    2018  Volume 110, Issue 6, Page(s) 897–913

    Abstract: Bacterial biofilms are communities of microbial cells encased within a self-produced polymeric matrix. In the Bacillus subtilis biofilm matrix, the extracellular fibres of TasA are essential. Here, a recombinant expression system allows interrogation of ... ...

    Abstract Bacterial biofilms are communities of microbial cells encased within a self-produced polymeric matrix. In the Bacillus subtilis biofilm matrix, the extracellular fibres of TasA are essential. Here, a recombinant expression system allows interrogation of TasA, revealing that monomeric and fibre forms of TasA have identical secondary structure, suggesting that fibrous TasA is a linear assembly of globular units. Recombinant TasA fibres form spontaneously, and share the biological activity of TasA fibres extracted from B. subtilis, whereas a TasA variant restricted to a monomeric form is inactive and subjected to extracellular proteolysis. The biophysical properties of both native and recombinant TasA fibres indicate that they are not functional amyloid-like fibres. A gel formed by TasA fibres can recover after physical shear force, suggesting that the biofilm matrix is not static and that these properties may enable B. subtilis to remodel its local environment in response to external cues. Using recombinant fibres formed by TasA orthologues we uncover species variability in the ability of heterologous fibres to cross-complement the B. subtilis tasA deletion. These findings are indicative of specificity in the biophysical requirements of the TasA fibres across different species and/or reflect the precise molecular interactions needed for biofilm matrix assembly.
    MeSH term(s) Amyloidogenic Proteins/chemistry ; Amyloidogenic Proteins/genetics ; Amyloidogenic Proteins/metabolism ; Bacillus subtilis/metabolism ; Bacillus subtilis/physiology ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Chemical Substances Amyloidogenic Proteins ; Bacterial Proteins ; Recombinant Proteins ; TasA protein, Bacillus subtilis
    Language English
    Publishing date 2018-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.13985
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  8. Article ; Online: Voxelotor improves red blood cell functionality in children with sickle cell anaemia: An ancillary study of the HOPE-KIDS 1 trial.

    Chonat, Satheesh / Fields, Earl / Baratz, Hannah / Watt, Amanda / Pochron, Mira / Dixon, Sandy / Tonda, Margaret / Brown, Clark / Archer, David

    EJHaem

    2024  Volume 5, Issue 1, Page(s) 125–130

    Abstract: Introduction: Sickle haemoglobin (HbS) polymerisation perturbs red blood cell (RBC) rheology and drives sickle cell disease (SCD) pathophysiology. Voxelotor is an HbS polymerisation inhibitor that increases haemoglobin (Hb)-oxygen affinity.: Methods/ ... ...

    Abstract Introduction: Sickle haemoglobin (HbS) polymerisation perturbs red blood cell (RBC) rheology and drives sickle cell disease (SCD) pathophysiology. Voxelotor is an HbS polymerisation inhibitor that increases haemoglobin (Hb)-oxygen affinity.
    Methods/results: In this 48-week, prospective, single-centre translational study, 10 children aged 4-11 years with SCD were treated with voxelotor. Improvements in RBC deformability were observed using osmotic/oxygen gradient ektacytometry, with increases in minimal and maximal elongation index and reductions in point of sickling. Increased Hb and reduced markers of haemolysis were also observed.
    Conclusion: These findings suggest that voxelotor treatment is associated with reduced RBC sickling and haemolysis in children with SCD.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.831
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  9. Article ; Online: Public and private tapwater: Comparative analysis of contaminant exposure and potential risk, Cape Cod, Massachusetts, USA.

    Bradley, Paul M / LeBlanc, Denis R / Romanok, Kristin M / Smalling, Kelly L / Focazio, Michael J / Cardon, Mary C / Clark, Jimmy M / Conley, Justin M / Evans, Nicola / Givens, Carrie E / Gray, James L / Earl Gray, L / Hartig, Phillip C / Higgins, Christopher P / Hladik, Michelle L / Iwanowicz, Luke R / Loftin, Keith A / Blaine McCleskey, R / McDonough, Carrie A /
    Medlock-Kakaley, Elizabeth K / Weis, Christopher P / Wilson, Vickie S

    Environment international

    2021  Volume 152, Page(s) 106487

    Abstract: Background: Humans are primary drivers of environmental contamination worldwide, including in drinking-water resources. In the United States (US), federal and state agencies regulate and monitor public-supply drinking water while private-supply ... ...

    Abstract Background: Humans are primary drivers of environmental contamination worldwide, including in drinking-water resources. In the United States (US), federal and state agencies regulate and monitor public-supply drinking water while private-supply monitoring is rare; the current lack of directly comparable information on contaminant-mixture exposures and risks between private- and public-supplies undermines tapwater (TW) consumer decision-making.
    Methods: We compared private- and public-supply residential point-of-use TW at Cape Cod, Massachusetts, where both supplies share the same groundwater source. TW from 10 private- and 10 public-supply homes was analyzed for 487 organic, 38 inorganic, 8 microbial indicators, and 3 in vitro bioactivities. Concentrations were compared to existing protective health-based benchmarks, and aggregated Hazard Indices (HI) of regulated and unregulated TW contaminants were calculated along with ratios of in vitro exposure-activity cutoffs.
    Results: Seventy organic and 28 inorganic constituents were detected in TW. Median detections were comparable, but median cumulative concentrations were substantially higher in public supply due to 6 chlorine-disinfected samples characterized by disinfection byproducts and corresponding lower heterotrophic plate counts. Public-supply applicable maximum contaminant (nitrate) and treatment action (lead and copper) levels were exceeded in private-supply TW samples only. Exceedances of health-based HI screening levels of concern were common to both TW supplies.
    Discussion: These Cape Cod results indicate comparable cumulative human-health concerns from contaminant exposures in private- and public-supply TW in a shared source-water setting. Importantly, although this study's analytical coverage exceeds that currently feasible for water purveyors or homeowners, it nevertheless is a substantial underestimation of the full breadth of contaminant mixtures documented in the environment and potentially present in drinking water.
    Conclusion: Regardless of the supply, increased public engagement in source-water protection and drinking-water treatment, including consumer point-of-use treatment, is warranted to reduce risks associated with long-term TW contaminant exposures, especially in vulnerable populations.
    MeSH term(s) Environmental Monitoring ; Groundwater ; Humans ; Massachusetts ; United States ; Water ; Water Pollutants, Chemical/analysis ; Water Purification ; Water Supply
    Chemical Substances Water Pollutants, Chemical ; Water (059QF0KO0R)
    Language English
    Publishing date 2021-03-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2021.106487
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  10. Article: Public and private tapwater: Comparative analysis of contaminant exposure and potential risk, Cape Cod, Massachusetts, USA

    Bradley, Paul M / LeBlanc, Denis R / Romanok, Kristin M / Smalling, Kelly L / Focazio, Michael J / Cardon, Mary C / Clark, Jimmy M / Conley, Justin M / Evans, Nicola / Givens, Carrie E / Gray, James L / Earl Gray, L / Hartig, Phillip C / Higgins, Christopher P / Hladik, Michelle L / Iwanowicz, Luke R / Loftin, Keith A / Blaine McCleskey, R / McDonough, Carrie A /
    Medlock-Kakaley, Elizabeth K / Weis, Christopher P / Wilson, Vickie S

    Environment international. 2021 July, v. 152

    2021  

    Abstract: Humans are primary drivers of environmental contamination worldwide, including in drinking-water resources. In the United States (US), federal and state agencies regulate and monitor public-supply drinking water while private-supply monitoring is rare; ... ...

    Abstract Humans are primary drivers of environmental contamination worldwide, including in drinking-water resources. In the United States (US), federal and state agencies regulate and monitor public-supply drinking water while private-supply monitoring is rare; the current lack of directly comparable information on contaminant-mixture exposures and risks between private- and public-supplies undermines tapwater (TW) consumer decision-making.We compared private- and public-supply residential point-of-use TW at Cape Cod, Massachusetts, where both supplies share the same groundwater source. TW from 10 private- and 10 public-supply homes was analyzed for 487 organic, 38 inorganic, 8 microbial indicators, and 3 in vitro bioactivities. Concentrations were compared to existing protective health-based benchmarks, and aggregated Hazard Indices (HI) of regulated and unregulated TW contaminants were calculated along with ratios of in vitro exposure-activity cutoffs.Seventy organic and 28 inorganic constituents were detected in TW. Median detections were comparable, but median cumulative concentrations were substantially higher in public supply due to 6 chlorine–disinfected samples characterized by disinfection byproducts and corresponding lower heterotrophic plate counts. Public-supply applicable maximum contaminant (nitrate) and treatment action (lead and copper) levels were exceeded in private-supply TW samples only. Exceedances of health-based HI screening levels of concern were common to both TW supplies.These Cape Cod results indicate comparable cumulative human-health concerns from contaminant exposures in private- and public-supply TW in a shared source-water setting. Importantly, although this study’s analytical coverage exceeds that currently feasible for water purveyors or homeowners, it nevertheless is a substantial underestimation of the full breadth of contaminant mixtures documented in the environment and potentially present in drinking water.Regardless of the supply, increased public engagement in source-water protection and drinking-water treatment, including consumer point-of-use treatment, is warranted to reduce risks associated with long-term TW contaminant exposures, especially in vulnerable populations.
    Keywords citizen participation ; copper ; disinfection ; drinking water ; environment ; groundwater ; human health ; lead ; nitrates ; pollution ; risk ; Massachusetts
    Language English
    Dates of publication 2021-07
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2021.106487
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