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  1. Article: Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction.

    Jesrani, Ameet Kumar / Faiq, Syed M / Rashid, Rahma / Kalwar, Tariq Ali / Mohsin, Rehan / Aziz, Tahir / Khan, Nida Amin / Mubarak, Muhammed

    World journal of transplantation

    2024  Volume 14, Issue 1, Page(s) 89255

    Abstract: ... creatinine in all patients was 2.86 ± 1.68 mg/dL and the mean estimated GFR was 35.38 ± 17.27 mL/min/1.73 m ...

    Abstract Background: Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term survival. Conventional and novel ultrasound-based investigations are being increasingly used for this purpose with variable results.
    Aim: To compare the diagnostic performance of resistive index (RI) and shear wave elastography (SWE) in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological results.
    Methods: This is a cross-sectional and comparative study. A total of 154 kidney transplant recipients were included in this study, which was conducted at the Departments of Transplantation and Radiology, Sindh Institute of Urology and Transplan tation, Karachi, Pakistan, from August 2022 to February 2023. All consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate (GFR) after three months of transplantation were enrolled in this study. SWE and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic utility.
    Results: The mean age of all patients was 35.32 ± 11.08 years. Among these, 126 (81.8%) were males and 28 (18.2%) were females. The mean serum creatinine in all patients was 2.86 ± 1.68 mg/dL and the mean estimated GFR was 35.38 ± 17.27 mL/min/1.73 m
    Conclusion: The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft damage. It can be of great help during the routine follow-up of kidney transplant recipients for screening and early detection of chronic changes and selecting patients for allograft biopsy.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v14.i1.89255
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  2. Article ; Online: Management of Tacrolimus-Induced Toxicity With Normal Serum Levels After Liver Transplant.

    Majid, Zain / Khan, Shoaib Ahmed / Hanif, Farina M / Laeeq, Mudassir / Tasneem, Abbas Ali / Luck, Nasir Hassan / Mubarak, Muhammad

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2024  Volume 22, Issue Suppl 1, Page(s) 338–341

    Abstract: Drug-induced liver injury after liver transplant occurs in 1.7% of patients. Tacrolimus is an effective immunosuppressant that is used to treat acute rejection. Although rare, it can cause toxicity, which is demonstrated by cholestatic liver injury. Here, ...

    Abstract Drug-induced liver injury after liver transplant occurs in 1.7% of patients. Tacrolimus is an effective immunosuppressant that is used to treat acute rejection. Although rare, it can cause toxicity, which is demonstrated by cholestatic liver injury. Here, we present a case of a young male patient who was diagnosed with Wilson disease, had penicillaminechelating therapy, and underwent living related liver transplant. Within 1 month posttransplant, he developed deranged, predominantly cholestatic pattern liver function tests. Laboratory parameters showed total bilirubin of 1.12 mg/ dL, alanine aminotransferase of 553 IU/L, gammaglutamyltransferase of 624 IU/L, and tacrolimus level of 10.2 ng/mL. After thorough evaluation, a liver biopsy was performed. Liver biopsy showed hepatocellular necrosis with centrilobular cholestasis without any evidence of graft rejection. However, with normal level of tacrolimus, the biopsy was suggestive of drug-induced liver injury. Thus, tacrolimus dose was reduced, resulting in improved liver function tests and patient discharge from the hospital. Tacrolimus is an effective immunosuppressant after liver transplant and has the ability to treat early acute rejection. The patient's liver biopsy showed hepatocellular necrosis with centrilobular cholestasis without any evidence of graft rejection. Cholestatic liver injury after tacrolimus usually resolves after dose reduction or by switching to another agent. With demonstrated tacrolimus-induced toxicity in liver transplant recipients, despite normal serum levels, transplant physicians should keep high index of suspicion regarding toxicity in the posttransplant setting.
    MeSH term(s) Humans ; Male ; Tacrolimus/adverse effects ; Liver Transplantation/adverse effects ; Immunosuppressive Agents/adverse effects ; Cholestasis/chemically induced ; Cholestasis/diagnosis ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/surgery ; Graft Rejection/diagnosis ; Graft Rejection/prevention & control ; Necrosis/drug therapy
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; Immunosuppressive Agents
    Language English
    Publishing date 2024-02-23
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.MESOT2023.P8
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    Zs.A 6632: Show issues Location:
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  3. Article ; Online: Author Correction: Insights into isotherms, kinetics, and thermodynamics of adsorption of acid blue 113 from an aqueous solution of nutraceutical industrial fennel seed spent.

    Taqui, Syed Noeman / Syed, Akheel Ahmed / Mubarak, Nabisab Mujawar / Farade, Rizwan Abutaleeb / Khan, M A Majeed / Kalam, Md Abul / Dehghani, Mohammad Hadi / Soudagar, Manzoore Elahi Mohammad / Rather, Rauoof Ahmad / Shamshuddin, Sathgatta Zaheeruddin Mohamed / Karri, Rama Rao

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2474

    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53033-z
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  4. Article: Modified Endoscope Holder for Two Handed Endoscopic Ear Surgery.

    Parab, Sapna R / Khan, Mubarak M

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2020  Volume 72, Issue 3, Page(s) 335–341

    Abstract: We have been doing Endoscopic ear surgeries since 2013. Inorder to overcome the disadvantage of the single handed endoscopic ear surgery technique, we have developed the endoscope holders, ... ...

    Abstract We have been doing Endoscopic ear surgeries since 2013. Inorder to overcome the disadvantage of the single handed endoscopic ear surgery technique, we have developed the endoscope holders, Justtach
    Language English
    Publishing date 2020-04-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-020-01841-w
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    Zs.A 5300: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Simple Economical Solution for Personal Protection Equipment (Face Mask/Shield) for Health Care Staff During COVID 19.

    Khan, Mubarak M / Parab, Sapna R

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2020  Volume 74, Issue Suppl 2, Page(s) 2676–2680

    Abstract: Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. It has taken a toll of lots of lives since its outbreak. Infection prevention at present is an appropriate control measure in addition to other ... ...

    Abstract Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. It has taken a toll of lots of lives since its outbreak. Infection prevention at present is an appropriate control measure in addition to other measure like hand hygiene and personal protective equipment (PPE). In our country with a large population, supplying PPE to all the health care workers of all hospitals definitely is an economic burden. Hence we have come up with an economic and simple solution for face mask.
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-020-01863-4
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    Zs.A 5300: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Safety Guidelines for Sterility of Face Shields During COVID 19 Pandemic.

    Khan, Mubarak M / Parab, Sapna R

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2020  Volume 73, Issue 1, Page(s) 85–86

    Abstract: Face shields are personal protective equipment devices that are to be used by many health care workers during COVID 19 pandemic for protection of the facial area and associated mucous membranes (eyes, nose, mouth) from droplet spread of infection. Face ... ...

    Abstract Face shields are personal protective equipment devices that are to be used by many health care workers during COVID 19 pandemic for protection of the facial area and associated mucous membranes (eyes, nose, mouth) from droplet spread of infection. Face shields are generally not used alone, but in conjunction with other protective equipment like cap, mask, goggle, and are therefore classified as adjunctive personal protective equipment. In the wake of scarcity of face shields during the COVID 19 Pandemic, consideration of innovating newer methods of manufacturing must be considered to overcome the present day scarcity without jeopardising the safety of front line Heath care workers. All initial fast innovations comes with advantages and disadvantages, hence we thought of putting down simple guidelines for new emerged face shield use.
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-020-01865-2
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    Zs.A 5300: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Antibacterial and Antibiofilm Activity of

    Khan, Asif Ullah / Hussain, Tahir / Abdullah / Khan, Mubarak Ali / Almostafa, Mervt M / Younis, Nancy S / Yahya, Galal

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 14

    Abstract: The significance of nanomaterials in biomedicines served as the inspiration for the design of this study. In this particular investigation, we carried out the biosynthesis of calcium oxide nanoparticles (CaONPs) by employing a green-chemistry strategy ... ...

    Abstract The significance of nanomaterials in biomedicines served as the inspiration for the design of this study. In this particular investigation, we carried out the biosynthesis of calcium oxide nanoparticles (CaONPs) by employing a green-chemistry strategy and making use of an extract of
    MeSH term(s) Ficus ; Staphylococcus aureus ; Reducing Agents/pharmacology ; Escherichia coli ; Metal Nanoparticles/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/pharmacology ; Biofilms ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction ; Microbial Sensitivity Tests
    Chemical Substances lime (C7X2M0VVNH) ; Reducing Agents ; Plant Extracts ; Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28145553
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  8. Article ; Online: Simple Economical Solution for Personal Protection Equipment (Face Mask/Shield) for Health Care Staff During COVID 19

    Khan, Mubarak M. / Parab, Sapna R.

    Indian Journal of Otolaryngology and Head & Neck Surgery ; ISSN 2231-3796 0973-7707

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12070-020-01863-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Safety Guidelines for Sterility of Face Shields During COVID 19 Pandemic

    Khan, Mubarak M. / Parab, Sapna R.

    Indian Journal of Otolaryngology and Head & Neck Surgery ; ISSN 2231-3796 0973-7707

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12070-020-01865-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: CDCA8, a mitosis-related gene, as a prospective pan-cancer biomarker: implications for survival prognosis and oncogenic immunology.

    Hu, Hanjie / Umair, Muhammad / Khan, Sikandar Ali / Sani, Aliya Irshad / Iqbal, Sahar / Khalid, Fatima / Sultan, Rizwana / Abdel-Maksoud, Mostafa A / Mubarak, Ayman / Dawoud, Turki M / Malik, Abdul / Saleh, Ibrahim A / Al Amri, Abdul Aziz / Algarzae, Norah Khaled / Kodous, Ahmad S / Hameed, Yasir

    American journal of translational research

    2024  Volume 16, Issue 2, Page(s) 432–445

    Abstract: Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the ... ...

    Abstract Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers.
    Methods: Bioinformatics and molecular experiments.
    Results: Analyzing TCGA data via TIMER2 and GEPIA2 databases revealed significant up-regulation of CDCA8 in 23 cancer types compared to normal tissues. Prognostically, elevated CDCA8 expression correlated with poorer overall survival in KIRC, LUAD, and SKCM, emphasizing its potential as a prognostic marker. UALCAN analysis demonstrated CDCA8 up-regulation based on clinical variables, such as cancer stage, race, and gender, in these cancers. Epigenetic exploration indicated reduced CDCA8 promoter methylation levels in Kidney Renal Clear Cell Carcinoma (KIRC), Lung Adenocarcinoma (LUAD), and Skin Cutaneous Melanoma (SKCM) tissues compared to normal controls. Promoter methylation and mutational analyses showcased a hypomethylation and low mutation rate for CDCA8 in these cancers. Correlation analysis revealed positive associations between CDCA8 expression and infiltrating immune cells, particularly CD8+ and CD4+ T cells. Protein-protein interaction (PPI) network analysis unveiled key interacting proteins, while gene enrichment analysis highlighted their involvement in crucial cellular processes and pathways. Additionally, exploration of CDCA8-associated drugs through DrugBank presented potential therapeutic options for KIRC, LUAD, and SKCM. In vitro validation using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) confirmed elevated CDCA8 expression in LUAD cell lines (A549 and H1299) compared to control cell lines (Beas-2B and NL-20).
    Conclusion: This study provides concise insights into CDCA8's multifaceted role in KIRC, LUAD, and SKCM, covering expression patterns, diagnostic and prognostic relevance, epigenetic regulation, mutational landscape, immune infiltration, and therapeutic implications.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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