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Article ; Online: Hereditary angioedema in children and adolescents.

Mansour, Eli / Veronez, Camila L / Craig, Timothy / Grumach, Anete Sevciovic

2022 Volume 50, Issue S Pt 1, Page(s) 1–6

Abstract: Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More ...

Abstract	Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Family history can help with the diagnosis; however, approximately 25% of the cases are
MeSH term(s)	Adolescent ; Adult ; Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/genetics ; Child ; Child, Preschool ; Complement C1 Inhibitor Protein/genetics ; Complement C1 Inhibitor Protein/therapeutic use ; Humans
Chemical Substances	Complement C1 Inhibitor Protein
Language	English
Publishing date	2022-04-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v50iSP1.535
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Article: Asthma and COVID-19: a systematic review.

Mendes, Natália F / Jara, Carlos P / Mansour, Eli / Araújo, Eliana P / Velloso, Licio A

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2021 Volume 17, Issue 1, Page(s) 5

Abstract: Background: Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tract, asthma has been cited as a ... ...

Abstract	Background: Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tract, asthma has been cited as a potential risk factor for severe COVID-19. However, conflicting results have been published over the last few months and the putative association between these two diseases is still unproven. Methods: Here, we systematically reviewed all reports on COVID-19 published since its emergence in December 2019 to June 30, 2020, looking into the description of asthma as a premorbid condition, which could indicate its potential involvement in disease progression. Results: We found 372 articles describing the underlying diseases of 161,271 patients diagnosed with COVID-19. Asthma was reported as a premorbid condition in only 2623 patients accounting for 1.6% of all patients. Conclusions: As the global prevalence of asthma is 4.4%, we conclude that either asthma is not a premorbid condition that contributes to the development of COVID-19 or clinicians and researchers are not accurately describing the premorbidities in COVID-19 patients.
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-020-00509-y
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Article: Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19.

Moraes, Carla Roberta Peachazepi / Borba-Junior, Ivanio Teixeira / De Lima, Franciele / Silva, Jéssica Ribeiro Alves / Bombassaro, Bruna / Palma, André C / Mansour, Eli / Velloso, Lício Augusto / Orsi, Fernanda Andrade / Costa, Fábio Trindade Maranhão / De Paula, Erich Vinicius

Frontiers in physiology

2023 Volume 14, Page(s) 1113968

Abstract: Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of additional ... ...

Abstract	Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of additional mediators of barrier integrity in this process, as well as the potential of serum from COVID-19 patients to induce EB disruption in cell monolayers. In a cohort from a clinical trial consisting of thirty patients with COVID-19 that required hospital admission due to hypoxia we demonstrate that i) levels of soluble Tie2 were increase, and of soluble VE-cadherin were decreased when compared to healthy individuals; ii) sera from these patients induce barrier disruption in monolayers of endothelial cells; and iii) that the magnitude of this effect is proportional to disease severity and to circulating levels of VEGF-A and Ang-2. Our study confirms and extends previous findings on the pathogenesis of acute lung injury in COVID-19, reinforcing the concept that EB is a relevant component of this disease. Our results pave the way for future studies that can refine our understanding of the pathogenesis of acute lung injury in viral respiratory disorders, and contribute to the identification of new biomarkers and therapeutic targets for these conditions.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1113968
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Article ; Online: Podoplanin and CLEC-2 levels in patients with COVID-19.

Borba-Junior, Ivanio Teixeira / Lima, Franciele / Vitoria Rodrigues Oliveira, Davi Sidarta / Peachazepi Moraes, Carla Roberta / Annichino-Bizzacchi, Joyce M / Bombassaro, Bruna / Palma, André C / Maranhao Costa, Fabio Trindade / Moretti, Maria Luiza / Mansour, Eli / Velloso, Licio Augusto / Orsi, Fernanda Andrade / De Paula, Erich Vinicius

Research and practice in thrombosis and haemostasis

2023 , Page(s) 100282

Abstract: Introduction: Podoplanin (: Aim: To explore the role of podoplanin and CLEC-2 in COVID-19.: Methods: Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex- ... ...

Abstract	Introduction: Podoplanin ( Aim: To explore the role of podoplanin and CLEC-2 in COVID-19. Methods: Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex-matched healthy individuals. Podoplanin expression in lungs from patients who died of COVID-19 was obtained from two independent public databases of single-cell RNAseq from which data from control lungs were also available. Results: Circulating podoplanin levels were lower in COVID-19, while no difference was observed in CLEC-2 levels. Podoplanin levels were significantly inversely correlated with markers of coagulation, fibrinolysis and innate immunity. scRNAseq data confirmed that Conclusion: Circulating levels of podoplanin are lower in COVID-19, and the magnitude of this reduction is correlated with hemostasis activation. We also demonstrate the downregulation of
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2023.100282
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Article ; Online: Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19.

de Lima, Franciele / Moraes, Carla Roberta Peachazepi / Barbosa, Mayck Silva / Bombassaro, Bruna / Palma, André C / Dertkigil, Sergio San Juan / Moretti, Maria Luiza / Orsi, Fernanda Andrade / Annichino-Bizzacchi, Joyce M / Mansour, Eli / Velloso, Licio A / De Paula, Erich Vinicius

Experimental biology and medicine (Maywood, N.J.)

2023 Volume 248, Issue 4, Page(s) 309–316

Abstract: Heme-oxygenase 1 (HO-1) is an enzyme with well-known anti-inflammatory and antioxidant properties, whose levels have been previously associated with disease severity in the context of sterile and infectious diseases. Moreover, the heme/HO-1 pathway has ... ...

Abstract	Heme-oxygenase 1 (HO-1) is an enzyme with well-known anti-inflammatory and antioxidant properties, whose levels have been previously associated with disease severity in the context of sterile and infectious diseases. Moreover, the heme/HO-1 pathway has been associated with prothrombotic changes in other diseases. Accordingly, the potential of modulating HO-1 levels for the treatment of COVID-19 was extensively speculated during the COVID-19 pandemic, but very few actual data were generated. The aim of our study was to explore the association of HO-1, heme, and hemopexin (HPX) levels with COVID-19 severity and with markers of inflammation and coagulation activation. The study was conducted in 30 consecutive patients with COVID-19 admitted due to hypoxemia, and 30 healthy volunteers matched by sex, age, and geographic region. HO-1 and HPX levels were measured by enzyme immunoassay (ELISA) and heme levels were measured by a colorimetric method. A comprehensive panel of coagulation and fibrinolysis activation was also used. Patients with COVID-19 presented increased levels of HO-1 when compared to controls (5741 ± 2696 vs 1953 ± 612 pg/mL, respectively,
MeSH term(s)	Humans ; Biomarkers ; COVID-19 ; Heme ; Hemopexin/metabolism ; Pandemics ; Patient Acuity ; Heme Oxygenase-1/metabolism
Chemical Substances	Biomarkers ; Heme (42VZT0U6YR) ; Hemopexin (9013-71-2) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2023-02-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702221139185
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Article: The Significance of Routine Computer Tomography in Evaluation of Asymptomatic Postoperative War Trauma Patients Transferred from Syria for Further Treatment.

Kakiashvili, Eli / Mansour, Muhammad / Weiss, Michael / Barhoum, Masad / Khatib, Kamal / Bickel, Amitai

The Israel Medical Association journal : IMAJ

2018 Volume 20, Issue 4, Page(s) 211–212

MeSH term(s)	Adult ; Humans ; Israel ; Male ; Postoperative Period ; Relief Work ; Syria ; Tomography, X-Ray Computed/methods ; War-Related Injuries/diagnostic imaging ; War-Related Injuries/surgery ; Warfare ; Young Adult
Language	English
Publishing date	2018-04-06
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19.

Bueno, Larissa C M / Paim, Layde R / Minin, Eduarda O Z / da Silva, Luís Miguel / Mendes, Paulo R / Kiyota, Tatiana A / Schreiber, Angelica Z / Bombassaro, Bruna / Mansour, Eli / Moretti, Maria Luiza / Chow, Jonathan Tak-Sum / Salmena, Leonardo / Coelho-Filho, Otavio R / Velloso, Licio A / Nadruz, Wilson / Schreiber, Roberto

Viruses

2022 Volume 14, Issue 7

Abstract: Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the association between circulating miRNAs and lung injury associated with COVID-19.
MeSH term(s)	COVID-19/genetics ; Computational Biology/methods ; Humans ; Lung Injury ; MicroRNAs/metabolism ; SARS-CoV-2
Chemical Substances	MIRN150 microRNA, human ; MIRN212 microRNA, human ; MicroRNAs
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14071363
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Article: Are pediatricians familiar with hereditary angioedema?

Chong-Neto, Herberto José / Aroni, Bárbara Padilha / Mansour, Eli / Toledo, Eliana / Serpa, Faradiba Sarquis / Arruda, Luisa Karla / Giavina-Bianchi, Pedro / Valle, Solange Oliveira Rodrigues / de Moraes, Caroline Guth de Freitas Batista / Kruk, Tatielly / Chong-Silva, Débora Carla / Solé, Dirceu / Silva, Luciana Rodrigues / Grumach, Anete S / Rosário Filho, Nelson Augusto / Campos, Régis de Albuquerque

The World Allergy Organization journal

2023 Volume 16, Issue 6, Page(s) 100783

Abstract: Background: Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of subcutaneous or mucosal edema caused by excess bradykinin. The aim of the present study was to assess the knowledge of pediatricians about ... ...

Abstract	Background: Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of subcutaneous or mucosal edema caused by excess bradykinin. The aim of the present study was to assess the knowledge of pediatricians about hereditary angioedema. Methods: An online survey with 12 HAE-related and 14 demographics-related questions was e-mailed to all pediatricians who were members of the Brazilian Society of Pediatrics (n = 17 145) once a week during the months of June and July 2021. The electronic questionnaire assessed clinical manifestations, diagnosis, and treatment of hereditary angioedema in children and adolescents. Results: Four hundred and fifty-five pediatricians responded to the questionnaire (2.6%), of whom 55 (12.1%) were board certified in Allergy and Immunology (A/I), while 400 (87.9%) were not (N-A/I). Three hundred and sixty-eight (80.9%) were female, 289 (55.7%) were under 50 years of age, 286 (62.9%) graduated from Medical School more than 10 years previously, 83 (18.2%) held an MSc/PhD degree, and 253 (55.6%) were living in the Southeast Region of Brazil. The median number of correct answers to the questions related to HAE among A/I was 7 out of 12 (58.3%), with median ranging from 4.5 to 8 correct answers, while for N-A/I it was 3 (25%), with median ranging from 2.5 to 4 correct answers (p < 0.001). Conclusion: Knowledge about HAE among Brazilian pediatricians, whether board certified in Allergy and Immunology or not, was unsatisfactory. HAE is a rare disease, largely unknown among physicians; therefore, increasing awareness may lead to improvement in diagnosis and treatment.
Language	English
Publishing date	2023-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2023.100783
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Article: Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019.

Camargo, Rafael L / Bombassaro, Bruna / Monfort-Pires, Milena / Mansour, Eli / Palma, Andre C / Ribeiro, Luciana C / Ulaf, Raisa G / Bernardes, Ana Flavia / Nunes, Thyago A / Agrela, Marcus V / Dertkigil, Rachel P / Dertkigil, Sergio S / Araujo, Eliana P / Nadruz, Wilson / Moretti, Maria Luiza / Velloso, Licio A / Sposito, Andrei C

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 847809

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs angiotensin-converting enzyme 2 (ACE2) as its receptor for cell entrance, and studies have suggested that upon viral binding, ACE2 catalytic activity could be inhibited; therefore, ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs angiotensin-converting enzyme 2 (ACE2) as its receptor for cell entrance, and studies have suggested that upon viral binding, ACE2 catalytic activity could be inhibited; therefore, impacting the regulation of the renin-angiotensin-aldosterone system (RAAS). To date, only few studies have evaluated the impact of SARS-CoV-2 infection on the blood levels of the components of the RAAS. The objective of this study was to determine the blood levels of ACE, ACE2, angiotensin-II, angiotensin (1-7), and angiotensin (1-9) at hospital admission and discharge in a group of patients presenting with severe or critical evolution of coronavirus disease 2019 (COVID-19). We showed that ACE, ACE2, angiotensin (1-7), and angiotensin (1-9) were similar in patients with critical and severe COVID-19. However, at admission, angiotensin-II levels were significantly higher in patients presenting as critical, compared to patients presenting with severe COVID-19. We conclude that blood levels of angiotensin-II are increased in hospitalized patients with COVID-19 presenting the critical outcome of the disease. We propose that early measurement of Ang-II could be a useful biomarker for identifying patients at higher risk for extremely severe progression of the disease.
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.847809
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Article ; Online: Hereditary angioedema: how to approach it at the emergency department?

Serpa, Faradiba Sarquis / Mansour, Eli / Aun, Marcelo Vivolo / Giavina-Bianchi, Pedro / Chong Neto, Herberto José / Arruda, Luisa Karla / Campos, Regis Albuquerque / Motta, Antônio Abílio / Toledo, Eliana / Grumach, Anete Sevciovic / Valle, Solange Oliveira Rodrigues

Einstein (Sao Paulo, Brazil)

2021 Volume 19, Page(s) eRW5498

Abstract: Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management. The mechanisms involved in angioedema without urticaria may be ... ...

Abstract	Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management. The mechanisms involved in angioedema without urticaria may be histamine- or bradykinin-mediated. The most common causes of histamine-mediated angioedema are foods, medications, insect sting and idiopathic. When the mediator is bradykinin, the triggers are angiotensin-converting enzyme inhibitors and factors related to acquired angioedema with deficiency of C1-inhibitor or hereditary angioedema, which are less common, but very important because of the possibility of fatal outcome. Hereditary angioedema is a rare disease characterized by attacks of edema that affect the subcutaneous tissue and mucous membranes of various organs, manifesting mainly by angioedema and abdominal pain. This type of angioedema does not respond to the usual treatment with epinephrine, antihistamines and corticosteroids. Thus, if not identified and treated appropriately, these patients have an estimated risk of mortality from laryngeal edema of 25% to 40%. Hereditary angioedema treatment has changed dramatically in recent years with the development of new and efficient drugs for attack management: plasma-derived C1 inhibitor, recombinant human C1-inhibitor, bradykinin B2 receptor antagonist (icatibant), and the kallikrein inhibitor (ecallantide). In Brazil, plasma-derived C1 inhibitor and icatibant have already been approved for use. Proper management of these patients in the emergency department avoids unnecessary surgery and, especially, fatal outcomes.
MeSH term(s)	Angioedema/diagnosis ; Angioedema/drug therapy ; Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/drug therapy ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Brazil ; Emergency Service, Hospital ; Humans
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors
Language	Portuguese
Publishing date	2021-04-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.31744/einstein_journal/2021RW5498
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