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  1. Article: A case report of prolonged COVID-19-positive RT-PCR for five months.

    Siami, Zeinab / Jamalimoghadamsiahkali, Saeidreza / Khavandegar, Armin

    Clinical case reports

    2022  Volume 10, Issue 7, Page(s) e6113

    Abstract: The COVID-19 gold standard assessment tool remained the RT-PCR of upper respiratory tract specimen extracted by the nasopharyngeal swab. A positive result would decrease through a three-week course and eventually be undetectable. The maximum duration of ... ...

    Abstract The COVID-19 gold standard assessment tool remained the RT-PCR of upper respiratory tract specimen extracted by the nasopharyngeal swab. A positive result would decrease through a three-week course and eventually be undetectable. The maximum duration of viral shedding is 83 days. Besides, COVID-19 RT-PCR remained positive for 74 days in a patient suffering from lymphoma. In this study, we have presented a 56-year-old male patient, a known case of lymphoma since 2015, who experienced many episodes of chemotherapy with a five-month positive RT-PCR COVID-19 laboratory test and finally was intubated and then died of opportunistic pulmonary infections. COVID-19 patients with concurrent lymphoma failed to remove the virus thoroughly, despite providing appropriate treatment regimens.
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preparation, characterization and in vitro evaluation of insulin-PHBV nanoparticles / alginate hydrogel composite system for prolonged delivery of insulin.

    Bayrami, Samane / Chamani, Mehdi / JamaliMoghadamSiahkali, SaeidReza / SeyedAlinaghi, SeyedAhmad / Shirmard, Leila Rezaie / Bayrami, Sepide / Javar, Hamid Akbari / Ghahremani, Mohammad Hossein / Amini, Mohsen / Tehrani, Morteza Rafiee / Shahsavari, Shadab / Dorkoosh, Farid Abedin

    Journal of pharmaceutical sciences

    2024  

    Abstract: Purpose: In the present study, biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) containing insulin were loaded in sodium alginate/jeffamine (ALG/jeff) hydrogel for prolonged delivery of insulin. The main aim of this ...

    Abstract Purpose: In the present study, biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) containing insulin were loaded in sodium alginate/jeffamine (ALG/jeff) hydrogel for prolonged delivery of insulin. The main aim of this work was to fabricate an efficient insulin delivery system to improve patient adherence by decreasing the repetition of injections.
    Methods: Swelling and morphological properties and crosslinking efficiency of ALG/jeff hydrogel were assessed. The composite hydrogel was prepared by adding PHBV NPs to ALG/jeff hydrogel concurrently with crosslinking process. The morphology and loading capacity of composite hydrogel were analyzed.
    Results: Circular dichroism measurement demonstrated that insulin remains stable following fabrication process. The release profile exhibited 54.6% insulin release from composite hydrogel within 31 days with minor initial burst release equated to nanoparticles and hydrogels. MTT cell viability analysis was performed by applying L-929 cell line and no cytotoxic effect was observed.
    Conclusions: Favorable results clearly introduced fabricated composite hydrogel as an excellent candidate for drug delivery systems and also paves the route for prolonged delivery systems of other proteins.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acupuncture or cupping plus standard care versus standard care in moderate to severe COVID-19 patients: An assessor-blinded, randomized, controlled trial.

    Alipour, Reihane / Jamalimoghadamsiahkali, Saeidreza / Karimi, Mehrdad / Asadi, Asma / Ghaem, Haleh / Adel-Mehraban, Mohammad Sadegh / Kazemi, Amir Hooman

    Integrative medicine research

    2022  Volume 11, Issue 4, Page(s) 100898

    Abstract: Background: Non-pharmacological strategies that have been proposed by complementary medical systems, can be effective in management of COVID-19.: Methods: This study was designed as a three-arm, assessor-blinded, randomized controlled trial. A total ... ...

    Abstract Background: Non-pharmacological strategies that have been proposed by complementary medical systems, can be effective in management of COVID-19.
    Methods: This study was designed as a three-arm, assessor-blinded, randomized controlled trial. A total of 139 hospitalized COVID-19 patients were randomly assigned into three groups: (1) acupuncture (ACUG), (2) cupping (CUPG), and (3) control (CTRG). All participants received conventional treatment. The primary study endpoint included changes in respiratory signs including oxygen saturation (SpO
    Results: Forty-two patients in ACUG, 44 patients in CUPG, and 42 patients in CTRG completed the trial. After 3 days, SpO
    Conclusion: Cupping and acupuncture are promising safe and effective therapies in management of COVID-19. Trial registration: This study was registered at Iranian Registry of Clinical Trials: IRCT20201127049504N1 (https://en.irct.ir/trial/52621).
    Language English
    Publishing date 2022-10-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2696588-4
    ISSN 2213-4220
    ISSN 2213-4220
    DOI 10.1016/j.imr.2022.100898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acupuncture or cupping plus standard care versus standard care in moderate to severe COVID-19 patients

    Reihane Alipour / Saeidreza Jamalimoghadamsiahkali / Mehrdad Karimi / Asma Asadi / Haleh Ghaem / Mohammad Sadegh Adel-Mehraban / Amir Hooman Kazemi

    Integrative Medicine Research, Vol 11, Iss 4, Pp 100898- (2022)

    An assessor-blinded, randomized, controlled trial

    2022  

    Abstract: Background: Non-pharmacological strategies that have been proposed by complementary medical systems, can be effective in management of COVID-19. Methods: This study was designed as a three-arm, assessor-blinded, randomized controlled trial. A total of ... ...

    Abstract Background: Non-pharmacological strategies that have been proposed by complementary medical systems, can be effective in management of COVID-19. Methods: This study was designed as a three-arm, assessor-blinded, randomized controlled trial. A total of 139 hospitalized COVID-19 patients were randomly assigned into three groups: (1) acupuncture (ACUG), (2) cupping (CUPG), and (3) control (CTRG). All participants received conventional treatment. The primary study endpoint included changes in respiratory signs including oxygen saturation (SpO2) and respiratory rate (RR). The secondary endpoints were COVID-19-related hospitalization duration and serious adverse events such as intensive care unit (ICU) admission, intubation or death, all up to day 30. Also, improvements in cough, dyspnea, chest tightness, oxygen demand, anorexia, headache, weakness, sore throat, and myalgia were evaluated. Results: Forty-two patients in ACUG, 44 patients in CUPG, and 42 patients in CTRG completed the trial. After 3 days, SpO2 and RR improved significantly in CUPG and ACUG compared with CTRG (effect size: 8.49 (6.4 to 10.57) and 8.51 (6.67 to 10.34), respectively: p<0.001). Compared with CTRG, patients in CUPG and ACUG recovered faster (mean difference: 6.58 (4.8 to 8.35) and 9.16 (7.16 to 11.15), respectively) and except for two patients in ACUG who were admitted to ICU, none of patients in ACUG or CUPG needed ICU or intubation (p<0.001 in comparison to CTRG). Amelioration of clinical COVID-19 related symptoms reached a high level of statistical significance in CUPG and ACUG in comparison with CTRG (p<0.01). Conclusion: Cupping and acupuncture are promising safe and effective therapies in management of COVID-19. Trial registration: This study was registered at Iranian Registry of Clinical Trials: IRCT20201127049504N1 (https://en.irct.ir/trial/52621).
    Keywords COVID-19 ; Persian medicine ; Traditional Chinese Medicine ; Cupping therapy ; Acupuncture ; Miscellaneous systems and treatments ; RZ409.7-999
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial.

    Honarkar Shafie, Elaheh / Taheri, Fateme / Alijani, Neda / Okhovvat, Ahmad Reza / Goudarzi, Razieh / Borumandnia, Nasrin / Aghaghazvini, Leila / Rezayat, Seyed Mahdi / Jamalimoghadamsiahkali, Saeidreza / Hosseinzadeh-Attar, Mohammad Javad

    Phytotherapy research : PTR

    2022  Volume 36, Issue 2, Page(s) 1013–1022

    Abstract: It has been more than a year since the outbreak of COVID-19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to ... ...

    Abstract It has been more than a year since the outbreak of COVID-19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to determine the effects of nanocurcumin on the severity of symptoms and length of hospital stay (LOS) in COVID-19 patients. Forty-eight COVID-19 patients were randomly assigned into nanocurcumin (n = 24) and placebo (n = 24) groups receiving 160 mg/day nanocurcumin or placebo capsules for 6 days. Mean differences of O
    MeSH term(s) COVID-19 ; Dietary Supplements ; Double-Blind Method ; Humans ; Length of Stay ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID‐19: A randomized double‐blind placebo‐controlled trial

    Honarkar Shafie, Elaheh / Taheri, Fateme / Alijani, Neda / Okhovvat, Ahmad Reza / Goudarzi, Razieh / Borumandnia, Nasrin / Aghaghazvini, Leila / Rezayat, Seyed Mahdi / Jamalimoghadamsiahkali, Saeidreza / Hosseinzadeh‐Attar, Mohammad Javad

    Phytotherapy research. 2022 Feb., v. 36, no. 2

    2022  

    Abstract: It has been more than a year since the outbreak of COVID‐19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to ... ...

    Abstract It has been more than a year since the outbreak of COVID‐19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to determine the effects of nanocurcumin on the severity of symptoms and length of hospital stay (LOS) in COVID‐19 patients. Forty‐eight COVID‐19 patients were randomly assigned into nanocurcumin (n = 24) and placebo (n = 24) groups receiving 160 mg/day nanocurcumin or placebo capsules for 6 days. Mean differences of O₂ saturation were significantly higher in patients who received nanocurcumin supplements (p = 0.02). Also, nanocurcumin treatment significantly reduced the scores of domains 3 and 4 and the total score of Wisconsin Upper Respiratory System Survey (WURSS‐24), indicating milder symptoms in the treatment group (p = 0.01, 0.03, and 0.01 respectively). Besides, the LOS in curcumin groups was lower than in the placebo group, although the difference was not statistically significant (6.31 ± 5.26 vs. 8.87 ± 8.12 days; p = 0.416). CBC/differentiate, hs‐CRP level and the pulmonary involvement in CT scan were not different between the two groups. As nanocurcumin can be effective in increasing O₂ saturation and reducing the severity of symptoms in COVID‐19 patients, it could probably be used as a complementary agent to accelerate the recovery of patients.
    Keywords COVID-19 infection ; computed tomography ; curcumin ; health services ; hospitals ; mortality ; phytotherapy ; placebos ; research ; respiratory system ; surveys ; Wisconsin
    Language English
    Dates of publication 2022-02
    Size p. 1013-1022.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7374
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Treatment With 25-Hydroxyvitamin D

    Maghbooli, Zhila / Sahraian, Mohammad Ali / Jamalimoghadamsiahkali, Saeidreza / Asadi, Asma / Zarei, Azadeh / Zendehdel, Abolfazl / Varzandi, Tarlan / Mohammadnabi, Sara / Alijani, Neda / Karimi, Mehrdad / Shirvani, Arash / Holick, Michael F

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2021  Volume 27, Issue 12, Page(s) 1242–1251

    Abstract: Objective: The goal of this randomized, double-blinded, placebo-controlled clinical trial was to investigate the therapeutic efficacy of oral 25-hydroxyvitamin D: Methods: This is a multicenter, randomized, double-blinded, placebo-controlled clinical ...

    Abstract Objective: The goal of this randomized, double-blinded, placebo-controlled clinical trial was to investigate the therapeutic efficacy of oral 25-hydroxyvitamin D
    Methods: This is a multicenter, randomized, double-blinded, placebo-controlled clinical trial. Participants were recruited from 3 hospitals that are affiliated to [Institution Blinded for Review] and [Institution Blinded for Review].
    Results: A total 106 hospitalized patients who had a circulating 25(OH)D
    Conclusion: Our analysis indicated that oral 25(OH)D
    MeSH term(s) COVID-19 ; Calcifediol ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Double-Blind Method ; Humans ; Neutrophils ; SARS-CoV-2 ; Severity of Illness Index ; Vitamin D/analogs & derivatives ; Vitamin D Deficiency/drug therapy
    Chemical Substances Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2021.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial.

    JamaliMoghadamSiahkali, Saeidreza / Zarezade, Besharat / Koolaji, Sogol / SeyedAlinaghi, SeyedAhmad / Zendehdel, Abolfazl / Tabarestani, Mohammad / Sekhavati Moghadam, Ehsan / Abbasian, Ladan / Dehghan Manshadi, Seyed Ali / Salehi, Mohamadreza / Hasannezhad, Malihe / Ghaderkhani, Sara / Meidani, Mohsen / Salahshour, Faeze / Jafari, Fatemeh / Manafi, Navid / Ghiasvand, Fereshteh

    European journal of medical research

    2021  Volume 26, Issue 1, Page(s) 20

    Abstract: Background: Vitamin C is an essential water-soluble nutrient that functions as a key antioxidant and has been proven to be effective for boosting immunity. In this study, we aimed to assess the efficacy of adding high-dose intravenous vitamin C (HDIVC) ... ...

    Abstract Background: Vitamin C is an essential water-soluble nutrient that functions as a key antioxidant and has been proven to be effective for boosting immunity. In this study, we aimed to assess the efficacy of adding high-dose intravenous vitamin C (HDIVC) to the regimens for patients with severe COVID-19 disease.
    Methods: An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received HDIVC (6 g daily) added to the same regimen.
    Results: There were no statistically significant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. The mean body temperature was significantly lower in the case group on the 3rd day of hospitalization (p = 0.001). Peripheral capillary oxygen saturations (SpO
    Conclusions: We did not find significantly better outcomes in the group who were treated with HDIVC in addition to the main treatment regimen at discharge. Trial registration irct.ir (IRCT20200411047025N1), April 14, 2020.
    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Ascorbic Acid/administration & dosage ; Ascorbic Acid/therapeutic use ; Body Temperature ; COVID-19/drug therapy ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Intensive Care Units ; Length of Stay ; Lopinavir/therapeutic use ; Male ; Middle Aged ; Oxygen/blood ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/virology ; Ritonavir/therapeutic use ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Ritonavir (O3J8G9O825) ; Ascorbic Acid (PQ6CK8PD0R) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-021-00490-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern.

    Salehi, Mohammadreza / Ahmadikia, Kazem / Mahmoudi, Shahram / Kalantari, Saeed / Jamalimoghadamsiahkali, Saeidreza / Izadi, Alireza / Kord, Mohammad / Dehghan Manshadi, Seyed Ali / Seifi, Arash / Ghiasvand, Fereshteh / Khajavirad, Nasim / Ebrahimi, Saeedeh / Koohfar, Amirhossein / Boekhout, Teun / Khodavaisy, Sadegh

    Mycoses

    2020  Volume 63, Issue 8, Page(s) 771–778

    Abstract: Background: Emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. Apparently, the novel coronavirus (SARS-CoV-2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal ... ...

    Abstract Background: Emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. Apparently, the novel coronavirus (SARS-CoV-2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID-19 patients with a list of attributable risk factors for oral infections has not yet been investigated.
    Objectives: We here aim to investigate the prevalence, causative agents and antifungal susceptibility pattern of OPC in Iranian COVID-19 patients.
    Patients and methods: A total of 53 hospitalised COVID-19 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21-plex PCR and sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method.
    Results: In 53 COVID-19 patients with OPC, cardiovascular diseases (52.83%) and diabetes (37.7%) were the principal underlying conditions. The most common risk factor was lymphopaenia (71%). In total, 65 Candida isolates causing OPC were recovered. C albicans (70.7%) was the most common, followed by C glabrata (10.7%), C dubliniensis (9.2%), C parapsilosis sensu stricto (4.6%), C tropicalis (3%) and Pichia kudriavzevii (=C krusei, 1.5%). Majority of the Candida isolates were susceptible to all three classes of antifungal drugs.
    Conclusion: Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID-19 patients. Further studies should be conducted to design an appropriate prophylaxis programme and improve management of OPC in critically ill COVID-19 patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antifungal Agents/pharmacology ; COVID-19 ; Candida/classification ; Candida/drug effects ; Candida/genetics ; Candidiasis, Oral/complications ; Candidiasis, Oral/microbiology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Humans ; Iran ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Pandemics ; Phenotype ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Time Factors
    Chemical Substances Antifungal Agents
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Oropharyngeal candidiasis in hospitalised COVID‐19 patients from Iran

    Salehi, Mohammadreza / Ahmadikia, Kazem / Mahmoudi, Shahram / Kalantari, Saeed / Jamalimoghadamsiahkali, Saeidreza / Izadi, Alireza / Kord, Mohammad / Dehghan Manshadi, Seyed Ali / Seifi, Arash / Ghiasvand, Fereshteh / Khajavirad, Nasim / Ebrahimi, Saeedeh / Koohfar, Amirhossein / Boekhout, Teun / Khodavaisy, Sadegh

    Mycoses

    Species identification and antifungal susceptibility pattern

    2020  Volume 63, Issue 8, Page(s) 771–778

    Keywords Infectious Diseases ; Dermatology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13137
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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