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Article: Review on Disasters and Lower Limb Venous Disease.

Gianesini, Sergio / Menegatti, Erica / Bottini, Oscar / Chi, Yung-Wei

2022 Volume 14, Issue 4, Page(s) 315–322

Abstract: As per the World Health Organization, ... ...

Abstract	As per the World Health Organization, a
Language	English
Publishing date	2022-01-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.ra.21-00026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sulodexide Inhibits Arterial Contraction via the Endothelium-Dependent Nitric Oxide Pathway.

Ors Yildirim, Nadide / Yildirim, Alperen Kutay / Demeli Ertus, Meric / Dastan, Ahmet Onur / Pehlivanoglu, Bilge / Chi, Yung-Wei / Gianesini, Sergio / Doganci, Suat / Yildirim, Vedat

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: Background/ ... ...

Abstract	Background/Objectives
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082332
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Article ; Online: Leukemia cutis in a medical center in southern Taiwan

Yung-Wei Chang / Chih-Hung Lee / Han-Chi Tseng

Journal of the Formosan Medical Association, Vol 120, Iss 1, Pp 226-

A retrospective study of 42 patients

2021 Volume 233

Abstract: Background/Purpose: Leukemia cutis (LC), by definition, is the infiltration of neoplastic leukocytes in the skin. The overall incidence of LC is rare. We aimed to investigate the association between clinical characteristics, classifications and prognosis ...

Abstract	Background/Purpose: Leukemia cutis (LC), by definition, is the infiltration of neoplastic leukocytes in the skin. The overall incidence of LC is rare. We aimed to investigate the association between clinical characteristics, classifications and prognosis among different types of LC in Taiwan. Methods: We performed a retrospective analysis of forty-two patients with histopathology proven LC based on skin biopsies in a medical center in Southern Taiwan from 1997 to 2018. The study involved medical records of the patients, clinical manifestations, and outcomes according to different types of leukemia. Results: This series consisted of 27 males and 15 females, and the mean age was 55.7 years old. The most common cutaneous features were papules (38%) and nodules (29%), followed by plaques (16%) and ulcers (10%). The most commonly affected sites were the trunk (33%) and extremities (31.5%), although generalized distribution (14%) was not rare. The prognosis of LC was very poor, 76.2% of patients (32/42) died during the follow-up, and the median survival time was 7.2 months (95% CI, 4.53–9.87 months). No statistical significance was found (P = 0.068 for survival curves) among different types of LC. Conclusion: This study was the first large-scale research in regarding to LC of Han Chinese. The commonest clinical presentations were papules and nodules, and the predilection sites were trunk and extremities. Besides, there was the high frequency of LC from AML and MDS in Taiwan. Clinicians should pay more attention to the leukemia patients with extramedullary manifestations due to poor survival outcomes.
Keywords	Clinical characteristics ; Leukemia cutis ; Prognosis ; Taiwan ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Randomized controlled trial on occupational graduated compression clinical and cost-effectiveness.

Gianesini, Sergio / Vagnoni, Emidia / Cavicchi, Caterina / Chi, Yung-Wei / Pagani, Anselmo / Tessari, Mirko / Zamboni, Paolo / Menegatti, Erica

International angiology : a journal of the International Union of Angiology

2023 Volume 42, Issue 4, Page(s) 344–351

Abstract: Background: Subjects exposed to occupational standing are at risk of developing chronic venous disease. Graduated compression stockings (GCS) counteract venous hypertension. Aim of the present investigation was to assess GCS clinical and cost ... ...

Abstract	Background: Subjects exposed to occupational standing are at risk of developing chronic venous disease. Graduated compression stockings (GCS) counteract venous hypertension. Aim of the present investigation was to assess GCS clinical and cost effectiveness in prolonged standing up workers. Methods: Randomized controlled trial involving 75 healthy healthcare professionals working in 6 hours standing up shifts without or with GCS (group A and B, respectively). Outcome measures were performed before and after the shift, at baseline (T0), at 1 (T1), 6 (T6) and 12 (T12) months and included lower limb volume, air plethysmography (APG), quality of life, and dedicated cost-effectiveness questionnaires. Results: Seventy-two subjects completed the data collection. Leg volume increased in group A and decreased in B at all assessment points (T0, 1, 6, 12) (P<0.0001). Venous filling index did not change within the 12 months, but, after every shift, its value was lower in B compared to A (P<0.0001). At 12 months, VVSymQ worsened in A and improved in B (P<0.0001) and CIVIQ significantly worsened in A (P<0.0001), while in B it significantly improved (P<0.0001). Perceived disability was higher in A at 12 months (P<0.001) and the cost calculation revealed a saving of 1510 euro per year in B. Conclusions: GCS counteracted occupational oedema and positively influenced venous filling index, while improving vein specific quality of life measurements in addition to cost savings.
Language	English
Publishing date	2023-07-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.23.05030-7
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Article: Leukemia cutis in a medical center in southern Taiwan: A retrospective study of 42 patients.

Chang, Yung-Wei / Lee, Chih-Hung / Tseng, Han-Chi

Journal of the Formosan Medical Association = Taiwan yi zhi

2020 Volume 120, Issue 1 Pt 1, Page(s) 226–233

Abstract: Background/purpose: Leukemia cutis (LC), by definition, is the infiltration of neoplastic leukocytes in the skin. The overall incidence of LC is rare. We aimed to investigate the association between clinical characteristics, classifications and ... ...

Abstract	Background/purpose: Leukemia cutis (LC), by definition, is the infiltration of neoplastic leukocytes in the skin. The overall incidence of LC is rare. We aimed to investigate the association between clinical characteristics, classifications and prognosis among different types of LC in Taiwan. Methods: We performed a retrospective analysis of forty-two patients with histopathology proven LC based on skin biopsies in a medical center in Southern Taiwan from 1997 to 2018. The study involved medical records of the patients, clinical manifestations, and outcomes according to different types of leukemia. Results: This series consisted of 27 males and 15 females, and the mean age was 55.7 years old. The most common cutaneous features were papules (38%) and nodules (29%), followed by plaques (16%) and ulcers (10%). The most commonly affected sites were the trunk (33%) and extremities (31.5%), although generalized distribution (14%) was not rare. The prognosis of LC was very poor, 76.2% of patients (32/42) died during the follow-up, and the median survival time was 7.2 months (95% CI, 4.53-9.87 months). No statistical significance was found (P = 0.068 for survival curves) among different types of LC. Conclusion: This study was the first large-scale research in regarding to LC of Han Chinese. The commonest clinical presentations were papules and nodules, and the predilection sites were trunk and extremities. Besides, there was the high frequency of LC from AML and MDS in Taiwan. Clinicians should pay more attention to the leukemia patients with extramedullary manifestations due to poor survival outcomes.
MeSH term(s)	Female ; Humans ; Leukemia/epidemiology ; Leukemic Infiltration ; Male ; Middle Aged ; Retrospective Studies ; Skin ; Skin Neoplasms ; Taiwan/epidemiology
Language	English
Publishing date	2020-05-18
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2020.04.025
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Article ; Online: Endovenous laser ablation vs phlebectomy of foot varicose veins.

Albernaz, Luiz Fernando / Reis E Silva, Alexandre / Schlindwein Albernaz, Daiane Taís / Zignani, Fernanda Rita / Santiago, Fabricio / Chi, Yung-Wei

Journal of vascular surgery. Venous and lymphatic disorders

2023 Volume 12, Issue 2, Page(s) 101703

Abstract: Objective: The aim of this study was to compare the outcomes and complications of selected patients treated with endovenous laser ablation (EVLA) or ambulatory phlebectomy for foot varicose veins.: Methods: From October 2016 to February 2022, ... ...

Abstract	Objective: The aim of this study was to compare the outcomes and complications of selected patients treated with endovenous laser ablation (EVLA) or ambulatory phlebectomy for foot varicose veins. Methods: From October 2016 to February 2022, selected patients undergoing EVLA (using 1470-nm with radial-slim or bare-tip fibers) or phlebectomy of foot varicose veins for cosmetic indications were analyzed, and the outcomes were compared. Patients were classified according to the Clinical, Etiologic, Anatomical, and Pathophysiological (CEAP) classification. Anatomic criteria provided the basis for the decision to perform EVLA or phlebectomy. Clinical and ultrasound assessments were performed on postoperative days 7, 30, and 90 for visualization of the sapheno-femoral and sapheno-popliteal junctions and the deep venous system. Disease severity was graded with the Venous Clinical Severity Score (VCSS), and quality of life was measured with the Aberdeen Varicose Vein Questionnaire (AVVQ) before and after treatment. Treatment outcomes were evaluated based on changes in VCSS and AVVQ scores. The groups were also compared for procedure-related complications. Data were statistically analyzed in SPSS v. 20.0 using the χ Results: The study included 270 feet of 171 patients. Mean patient age was 52.3 (standard deviation, 13.1) years, ranging from 21 to 84 years; 133 (77.8%) were women. Of 270 feet, 113 (41.9%) were treated with EVLA and 157 (58.1%) with phlebectomy. The median preoperative CEAP class was 2 (interquartile range, 2-3) in the phlebectomy and EVLA groups, with no statistically significant difference between the groups (P = .507). Dysesthesia was the most common complication in both groups. Only transient induration was significantly different between EVLA (7.1%) and phlebectomy (0.0%) (P = .001). The two approaches had an equal impact on quality of life and disease severity. Conclusions: Treatment complications were similar in phlebectomy and EVLA and to those previously described in the literature.
MeSH term(s)	Humans ; Female ; Adolescent ; Male ; Quality of Life ; Saphenous Vein/diagnostic imaging ; Saphenous Vein/surgery ; Varicose Veins/diagnostic imaging ; Varicose Veins/surgery ; Varicose Veins/etiology ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Treatment Outcome ; Surveys and Questionnaires ; Venous Insufficiency/diagnostic imaging ; Venous Insufficiency/surgery ; Venous Insufficiency/etiology
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2023.101703
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Article ; Online: Empty vein ablation innovative technique for chronic venous disease treatment: proof of concept and ex-vivo analysis.

Salerno, Mario / Bissacco, Daniele / Chi, Yung-Wei / Narayanan, Sriram / Addis, Alessandro / Dellavia, Claudia / Canciani, Elena / Gard, Marco / Gianesini, Sergio

International angiology : a journal of the International Union of Angiology

2023 Volume 42, Issue 5, Page(s) 420–426

Abstract: Background: Sclerotherapy is among the mainstays of chronic venous disease treatment, yet its occlusion rate remains suboptimal compared to thermal tumescent techniques. An innovative three-balloons catheter has been developed to allow sclerotherapy in ... ...

Abstract	Background: Sclerotherapy is among the mainstays of chronic venous disease treatment, yet its occlusion rate remains suboptimal compared to thermal tumescent techniques. An innovative three-balloons catheter has been developed to allow sclerotherapy in empty vein conditions (empty vein ablation technique, EVA). Aim of this investigation was to describe the EVA technical aspects and related ex-vivo effects on vein wall. Methods: Two samples from jugular veins of an adult sheep were treated by EVA or foam sclerotherapy (FS, Tessari method). Primary outcome was the percentage of circumferential intima treated by EVA or FS; secondary outcomes were intima and media thickness modifications after treatment. Results: Intact circumferential residual intima were 6.07±2.94% and 16.55±0.70% after EVA and FS, respectively (P=0.020). Despite the average intima and media thickness did not differ between treatments, EVA demonstrated a homogenous damage throughout the vein segment, while FS effect was less destructive distally to the injection site, because moving away from the injection site and floating, it has a less contact with internal surface of the vein. Conclusions: EVA seems to overcome chemical ablation limits as flushing effect and the increases vein wall/sclerosant agent contact effect compared to FS. Ex-vivo encouraging results need in-vivo validation to evaluate other points like deactivation of sclerosing agent by blood protein and the contact time control between SA and the vein wall. If we have further confirmations in vivo we might think we have a potential higher occlusion rate compared to FS, paving the way for future clinical trials.
MeSH term(s)	Humans ; Animals ; Sheep ; Varicose Veins/surgery ; Veins ; Sclerosing Solutions ; Sclerotherapy/adverse effects ; Sclerotherapy/methods ; Ablation Techniques ; Saphenous Vein/diagnostic imaging ; Saphenous Vein/surgery ; Treatment Outcome ; Venous Insufficiency/surgery
Chemical Substances	Sclerosing Solutions
Language	English
Publishing date	2023-06-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.23.05055-1
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Article ; Online: Empty vein ablation (EVA) technique: an in-vivo animal model to assess the effects of sclerosing agent concentration and wall contact time on intima and media tunicae structure.

Salerno, Mario / Bissacco, Daniele / Chi, Yung-Wei / Narayanan, Sryram / Addis, Alessandro / Dellavia, Claudia / Canciani, Elena / Righini, Paolo C / Nano, Giovanni / Gianesini, Sergio

International angiology : a journal of the International Union of Angiology

2024

Abstract: Background: Sclerotherapy is a cornerstone of the treatment of chronic venous disease, despite some technical aspects (e.g., sclerosant liquid agent concentration [SLAC] and contact time between sclerosant agent and vein wall [ctSA/VW]) to maximize ... ...

Abstract	Background: Sclerotherapy is a cornerstone of the treatment of chronic venous disease, despite some technical aspects (e.g., sclerosant liquid agent concentration [SLAC] and contact time between sclerosant agent and vein wall [ctSA/VW]) to maximize outcomes remain an unsolved problem and a source of debate. An innovative three-balloon catheter has been developed to allow sclerotherapy in empty vein conditions (Empty Vein Ablation technique, EVA), revolutionizing the definition of SLAC and ctSA/VW. Aim of this experimental study is to analyze EVA effects on intima and media vessel tunicae using different SLAC and ctSA/VW in an in-vivo animal model. Methods: Two adult sheep were treated by EVA using jugular and common iliac vein axes (eight vein segments). Different SLAC (polidocanol 0.5% or 1%) and different ctSA/VW (3 or 5 minutes) were combined for testing residual circumferential intima percentage and media thickness after EVA. Results: Intact circumferential residual intima after the treatment was 21.3±4.9%, 18.2±7.4%, 15.7±2.4% and 8.9±2.0% using 0.5% (3 min), 0.5% (5 min), 1% (3 min) and 1% (5 min), respectively (R Conclusions: EVA proved to be effective in venous wall destruction even with a very low SLAC and ctSA/VW (0.5% in 3 minutes), in quite large caliber veins. Direct comparisons with foam/liquid sclerotherapy should be done to confirm therapeutic effectiveness of these results, despite EVA has provided a maximized and controlled SA/VW contact time and ratio.
Language	English
Publishing date	2024-03-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.24.05147-2
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Article ; Online: iWRAP: A Theranostic Wearable Device With Real-Time Vital Monitoring and Auto-Adjustable Compression Level for Venous Thromboembolism.

Zhang, Zhichao / Zhang, Ruoyu / Chang, Chi-Wei / Guo, Yaojun / Chi, Yung-Wei / Pan, Tingrui

IEEE transactions on bio-medical engineering

2021 Volume 68, Issue 9, Page(s) 2776–2786

Abstract: Objective: Venous Thromboembolism (VTE) is a commonly underdiagnosed disease with severe consequences and an exceedingly high mortality rate. Conventional compression wraps are devised for therapeutic purpose but lack diagnostic capacity. Recent ... ...

Abstract	Objective: Venous Thromboembolism (VTE) is a commonly underdiagnosed disease with severe consequences and an exceedingly high mortality rate. Conventional compression wraps are devised for therapeutic purpose but lack diagnostic capacity. Recent advances in flexible electronics and wearable technologies offer many possibilities for chronic disease management. In particular, vital signs have been studied to show a strong correlation with the risk of VTE patients. In this study, we aim to develop an intelligent theranostic compression device, referred to as iWRAP, with the built-in capacity of real-time vital sign monitoring together with auto-adjustable compression level. Methods: An instantaneous pneumatic feedback control with a high-resolution pressure sensor is integrated to provide a highly stabilized compression level at the prescribed interface pressure for an improved therapeutic outcome. Meanwhile, arterial pulse waveforms extracted from the pressure readings from the smart compression device can be utilized to derive the body vital signs, including heart rate (HR), respiratory rate (RR) and blood pressure (BP). Results: A reliable delivery of the targeted compression level within ±5% accuracy in the range of 20-60 mmHg has been achieved through the feedback of the interface pressure. Both HR and RR have been measured within clinical-grade accuracies. Moreover, BP estimated using an ALA model has been achieved at low compression levels, which is also within a clinical-acceptable accuracy. The acquired vital information has been instantaneously fit into the clinically acceptable criteria for life-threatening PE risk with timely assessments. Conclusion: The iWRAP has shown the potential to become the first theranostic wearable device with both continuous delivery of accurate and effective compression therapy and real-time monitoring of life-threatening conditions for VTE patients.
MeSH term(s)	Humans ; Precision Medicine ; Pressure ; Venous Thromboembolism/diagnosis ; Vital Signs ; Wearable Electronic Devices
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2021.3054335
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Article ; Online: State of the art on cryo-laser cryo-sclerotherapy in lower limb venous aesthetic treatment.

Miyake, Roberto Kasuo / Chi, Yung-Wei / Franklin, Ian J / Gianesini, Sergio

Journal of vascular surgery. Venous and lymphatic disorders

2020 Volume 8, Issue 5, Page(s) 893–895

Abstract: Here we describe a combination of neodymium:yttrium-aluminium-garnet 1064-nm laser emission and injection of 75% dextrose solution to treat lower limb reticular veins. The strategy is known as cryo-laser cryo-sclerotherapy. Preliminary outcomes are ... ...

Abstract	Here we describe a combination of neodymium:yttrium-aluminium-garnet 1064-nm laser emission and injection of 75% dextrose solution to treat lower limb reticular veins. The strategy is known as cryo-laser cryo-sclerotherapy. Preliminary outcomes are reported, showing ecchymosis in up to 30% of cases and intravenous thrombus in 14%. A satisfactory vessel elimination is found in 86% of cases. No improvement or worsening was reported in 14% of patients. The paper provides technical details with the aim of promoting homogeneity in future data collection, so fostering publication of long-term effectiveness and related comparative evaluation with sclerotherapy and laser treatment alone.
MeSH term(s)	Cryosurgery/adverse effects ; Cryosurgery/instrumentation ; Esthetics ; Humans ; Laser Therapy/adverse effects ; Laser Therapy/instrumentation ; Lasers, Solid-State/therapeutic use ; Lower Extremity/blood supply ; Patient Satisfaction ; Sclerotherapy/adverse effects ; Telangiectasis/diagnosis ; Telangiectasis/surgery ; Treatment Outcome ; Veins/surgery
Language	English
Publishing date	2020-03-14
Publishing country	United States
Document type	Journal Article
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2020.01.003
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