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Article ; Online: Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma.

Zhu, Zhenzhen / Wang, Weiqing / Zha, Yang / Wang, Xiaowei / Aodeng, Surita / Wang, Lei / Liu, Yuzhuo / Lv, Wei

2024 Volume 24, Issue 1, Page(s) 184

Abstract: Background: Sinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify prognostic factors and establish a nomogram model to predict the overall survival (OS) of patients with SNMM.!# ...

Abstract	Background: Sinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify prognostic factors and establish a nomogram model to predict the overall survival (OS) of patients with SNMM. Methods: A total of 459 patients with SNMM were selected from the Surveillance, Epidemiology, and End Results (SEER) database as the training cohort. Univariate and multivariate Cox regression analyses were used to screen for independent factors associated with patient prognosis and develop the nomogram model. In addition, external validation was performed to evaluate the effectiveness of the nomogram with a cohort of 34 patients with SNMM from Peking Union Medical College Hospital. Results: The median OS in the cohort from the SEER database was 28 months. The 1-year, 3-year and 5-year OS rates were 69.8%, 40.4%, and 30.0%, respectively. Multivariate Cox regression analysis indicated that age, T stage, N stage, surgery and radiotherapy were independent variables associated with OS. The areas under the receiver operating characteristic curves (AUCs) of the nomograms for predicting 1-, 3- and 5-year OS were 0.78, 0.71 and 0.71, respectively, in the training cohort. In the validation cohort, the area under the curve (AUC) of the nomogram for predicting 1-, 3- and 5-year OS were 0.90, 0.75 and 0.78, respectively. Patients were classified into low- and high-risk groups based on the total score of the nomogram. Patients in the low-risk group had a significantly better survival prognosis than patients in the high-risk group in both the training cohort (P < 0.0001) and the validation cohort (P = 0.0016). Conclusion: We established and validated a novel nomogram model to predict the OS of SNMM patients stratified by age, T stage, N stage, surgery and radiotherapy. This predictive tool is of potential importance in the realms of patient counselling and clinical decision-making.
MeSH term(s)	Humans ; Nomograms ; Melanoma/therapy ; Paranasal Sinus Neoplasms/therapy ; Area Under Curve ; Clinical Decision-Making ; Prognosis ; SEER Program
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11888-5
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Article: Sinonasal NUT carcinoma: A retrospective case series from a single institution.

Wang, Lei / Zhu, Zhenzhen / Wang, Weiqing / Zha, Yang / Wang, Xiaowei / Surita, Aodeng / Liu, Yuzhuo / Lv, Wei

Frontiers in surgery

2023 Volume 10, Page(s) 1098704

Abstract: Purpose: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive tumor defined by the presence of : Methods: We retrospectively investigated NUT expression with clinicopathologic features in 145 cases with sinonasal malignancies diagnosed ... ...

Abstract	Purpose: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive tumor defined by the presence of Methods: We retrospectively investigated NUT expression with clinicopathologic features in 145 cases with sinonasal malignancies diagnosed from January 2017 to December 2021 and reviewed the reported cases. Results: Three (3/145, 2.07%) cases showed strong nuclear expression for NUT immunohistochemical, including one male and two females with ages from 37 to 57 years (mean, 45.33 years). All three cases involved the nasal cavity and sinuses; one of them involved the orbit and intracranial area. Histologically, all subjects showed poorly differentiated, small round cell morphology with distinct nuclei. All patients received surgery and chemoradiotherapy. One patient died of the disease 13 months after diagnosis, and two survived 12 and 15 months, respectively, without evidence of tumor recurrence. 51 cases of sinonasal NUT carcinoma (mean age 40.96 years) have been described to date. Among them, 28 are male, and 23 are female. Most cases expressed p63, AE1/AE3, as well as p40. Conclusion: NUT carcinoma is a rare and aggressive disease with a poor prognosis. It is crucial to perform
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1098704
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Article ; Online: Otorhinolaryngology publication from Chinese authors: a 11-year survey of the literature.

Aodeng, Surita / Gao, Zhiqiang

Acta oto-laryngologica

2018 Volume 138, Issue 1, Page(s) 90–94

Abstract: Objective: Scientific publication is the reflection of the capability of not only an individual scholar, but also a group, even a country. Over the past few decades, Chinese researchers have made great progress in medical scientific field. However, the ... ...

Abstract	Objective: Scientific publication is the reflection of the capability of not only an individual scholar, but also a group, even a country. Over the past few decades, Chinese researchers have made great progress in medical scientific field. However, the status about the quantity and quality of the publications in otorhinolaryngology have not been reported. The aim of this study was to compare the output by Chinese authors from three regions of China: Mainland China (MC), Taiwan (TW) and Hong Kong (HK). Methods: Literature was retrieved from the 43 otorhinolaryngology journals based on the subject category 'otorhinolaryngology' of the Science Citation Index Expanded (2015) from Web of Science Core Collection. The first authors of these articles were limited in three regions of China: MC, TW and HK from 2006 to 2016 by using the data mining software Thomson Data Analyzer (TDA). Evaluation criteria are based on total number of articles, impact factors (IFs), citations, articles published in high-impact journals and funding support. Result: A total of 59,832 articles were published worldwide in 43 otorhinolaryngology related journals from 2006 to 2016. Publications from MC was rapidly increasing and the total number contributed the most articles of the China (1931/3362, 57.44%), followed by TW (1220/3362, 36.29%) and HK (211/3362, 6.28%). The quantity of annual publications from MC has exceeded that of TW since 2010. MC was in the first place for cumulative IFs, but the last place for average IF. For total and average citations, MC was in the same situation of IF. Acta Otolaryngol was the most popular journal to choose in MC, and for TW and HK was Head & Neck. Conclusions: The total number of otorhinolaryngology articles in China increased markedly from 2006 to 2016, especially for MC. Despite the rapid growth in the number of articles from MC, the quality was not that satisfactory.
MeSH term(s)	Bibliometrics ; China ; Hong Kong ; Otolaryngology/statistics & numerical data ; Otolaryngology/trends ; Periodicals as Topic/statistics & numerical data ; Taiwan
Language	English
Publishing date	2018-01
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2017.1373853
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Ul II Zs 105: Show issues

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Article: Adverse Events for Monoclonal Antibodies in Patients with Allergic Rhinitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Lin, Yuxi / Wang, Weiqing / Zhu, Zhenzhen / Aodeng, Surita / Wang, Lei / Liu, Yuzhuo / Li, Jingjing / Zha, Yang / Wang, Xiaowei / Lv, Wei

Journal of clinical medicine

2023 Volume 12, Issue 8

Abstract: 1) Background: Allergic rhinitis (AR) is a common disease in otolaryngology and novel biological therapies are required for clinical needs. To assess the tolerability of monoclonal antibodies, justifying their clinical applications, we presented a ... ...

Abstract	(1) Background: Allergic rhinitis (AR) is a common disease in otolaryngology and novel biological therapies are required for clinical needs. To assess the tolerability of monoclonal antibodies, justifying their clinical applications, we presented a comprehensive safety profile of biologics in AR; (2) Methods: A systematic literature search was conducted following PRISMA guidelines for randomized clinical trials comparing monoclonal antibodies and placebo in AR. PubMed, Web of Science, Medline, and Cochrane were searched up until 9 January 2023. Among 3590 records in total, 12 studies with more than 2600 patients were included. Quality was assessed for all studies using Cochrane risk-of-bias tool for randomized trials, and subgrouped meta-analysis was performed; (3) Results: We accomplished an up-to-date literature overview and analysis on adverse events of monoclonal antibodies in AR. Total, common, severe, discontinuation-causing, and serious adverse events failed to reach statistical significance. Country was an essential factor for heterogeneity, and urticaria was the adverse event at highest risk (RR 2.81, 95% CI 0.79-9.95); (4) Conclusions: Monoclonal antibodies are considered well tolerated and relatively safe in patients with AR. The regions of patients and hypersensitive adverse reactions such as urticaria require a special caution in biological treatments in AR.
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12082848
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Article: [Spontaneous cerebrospinal fluid otorrhea in children:report of two cases].

Wang, X / Feng, G D / Tian, X / Zhao, Y / Aodeng, Surita / Sun, H Y / Gao, Z Q

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2022 Volume 57, Issue 8, Page(s) 991–994

MeSH term(s)	Cerebrospinal Fluid Otorrhea/surgery ; Child ; Humans ; Temporal Bone
Language	Chinese
Publishing date	2022-09-04
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20211221-00812
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Zs.A 3733: Show issues

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Article ; Online: Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis.

Wang, Weiqing / Xu, Yi / Wang, Lun / Zhu, Zhenzhen / Aodeng, Surita / Chen, Hui / Cai, Menghua / Huang, Zhihao / Han, Jinbo / Wang, Lei / Lin, Yuxi / Hu, Yu / Zhou, Liangrui / Wang, Xiaowei / Zha, Yang / Jiang, Weihong / Gao, Zhiqiang / He, Wei / Lv, Wei /

Zhang, Jianmin

Nature immunology

2022 Volume 23, Issue 10, Page(s) 1484–1494

Abstract: The heterogeneous cellular microenvironment of human airway chronic inflammatory diseases, including chronic rhinosinusitis (CRS) and asthma, is still poorly understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on the nasal mucosa of ... ...

Abstract	The heterogeneous cellular microenvironment of human airway chronic inflammatory diseases, including chronic rhinosinusitis (CRS) and asthma, is still poorly understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on the nasal mucosa of healthy individuals and patients with three subtypes of CRS and identified disease-specific cell subsets and molecules that specifically contribute to the pathogenesis of CRS subtypes. As such, ALOX15
MeSH term(s)	Animals ; Chronic Disease ; Eosinophils ; Humans ; Mice ; Nasal Mucosa ; Nasal Polyps ; Rhinitis ; Sinusitis
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-022-01312-0
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: Tympanum reconstruction using a sternocleidomastoid flap in patients with lateral skull base lesions: surgical technique and clinical report.

Feng, Guodong / Wei, Xingmei / Sun, Huiying / Zhang, Zhuhua / Tian, Xu / Zhao, Yang / Aodeng, Surita / Zhou, Yalin / Gao, Zhiqiang

Head & neck

2020 Volume 42, Issue 10, Page(s) 2821–2829

Abstract: Background: During surgical treatment of lesions involving the skull base, conductive hearing is often sacrificed due to tympanum destruction. This study aimed to develop a method for tympanum reconstruction using a sternocleidomastoid (SCM) flap to ... ...

Abstract	Background: During surgical treatment of lesions involving the skull base, conductive hearing is often sacrificed due to tympanum destruction. This study aimed to develop a method for tympanum reconstruction using a sternocleidomastoid (SCM) flap to preserve conductive hearing during lateral skull base surgery. Methods: This study included five patients with lateral skull base lesions who underwent surgery including tympanum reconstruction with an SCM flap between July 2015 and November 2017. Results: Three patients seen with facial nerve schwannoma, and two had paraganglioma of the head and neck. All patients' inferior and posterior tympanic walls were resected; the tympanum and ossicular chain were reconstructed with an SCM flap and prosthesis. The mean postoperative air-bone gap was 14 dB. No lesion recurrences were observed until the last follow-up. Conclusion: The SCM flap is effective in preserving conductive hearing through reconstruction of the inferior and posterior tympanic walls in lateral skull base surgery.
MeSH term(s)	Ear, Middle ; Humans ; Neoplasm Recurrence, Local ; Reconstructive Surgical Procedures ; Retrospective Studies ; Skull Base/surgery
Language	English
Publishing date	2020-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26323
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Zs.A 1493: Show issues

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Article ; Online: Prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion in acute facial paralysis patients.

Zhao, Yang / Feng, Guodong / Wu, Haiyan / Aodeng, Surita / Tian, Xu / Volk, Gerd Fabian / Guntinas-Lichius, Orlando / Gao, Zhiqiang

Head & face medicine

2020 Volume 16, Issue 1, Page(s) 15

Abstract: Background: To investigate the prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion (3D ASFM) in acute facial palsy patients and compare it with subjective grading methods and electroneurography.: ... ...

Abstract	Background: To investigate the prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion (3D ASFM) in acute facial palsy patients and compare it with subjective grading methods and electroneurography. Methods: We continuously recruited 37 patients with acute (< 1 month) Bell's palsy. An integrated evaluation of facial palsy was performed for each patient. The integrated evaluation included the House-Brackmann grading system (H-BGS), Sunnybrook Facial Grading System (SFGS), electroneurography and three-dimensional objective measurements. Then, the entire set of evaluations were repeated for each patient 1 month later. The patients were followed up monthly until recovery or for up to more than 6 months. We adopted the SFGS and H-BGS as the representative subjective grading system and final criteria for recovery. Poor recovery was defined as an SFGS score less than 70 or H-BGS score higher than II. Results: Multiple regression analysis was performed to find the best prognostic indicators. In less than 1 month from onset, ENoG had the highest prognostic value. However, in the second month from onset, the results of SFGS and 3D ASFM were identified as the best prognostic parameters, and a prediction formula with a determination coefficient of 0.673 was established. The receiver operating characteristic curves revealed that a gross score of the 3D ASFM less than 31 in the first evaluation and 49 in the second evaluation had higher sensitivity and specificity to predict poor recovery. Conclusions: In different phases of Bell's palsy, the best predictor of prognosis is different. ENOG is the most effective predictor of the prognosis in the first month after onset. In the second month after onset, the combination of SFGS and 3D ADSM is considered to be the best prognostic predictor.
MeSH term(s)	Bell Palsy ; Face ; Facial Paralysis/diagnosis ; Humans ; Male ; Motion ; Prognosis ; ROC Curve
Language	English
Publishing date	2020-07-18
Publishing country	England
Document type	Journal Article
ISSN	1746-160X
ISSN (online)	1746-160X
DOI	10.1186/s13005-020-00230-6
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Article ; Online: Prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion in acute facial paralysis patients

Yang Zhao / Guodong Feng / Haiyan Wu / Surita Aodeng / Xu Tian / Gerd Fabian Volk / Orlando Guntinas-Lichius / Zhiqiang Gao

Head & Face Medicine, Vol 16, Iss 1, Pp 1-

2020 Volume 10

Abstract: Abstract Background To investigate the prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion (3D ASFM) in acute facial palsy patients and compare it with subjective grading methods and electroneurography. ... ...

Abstract	Abstract Background To investigate the prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion (3D ASFM) in acute facial palsy patients and compare it with subjective grading methods and electroneurography. Methods We continuously recruited 37 patients with acute (< 1 month) Bell’s palsy. An integrated evaluation of facial palsy was performed for each patient. The integrated evaluation included the House-Brackmann grading system (H-BGS), Sunnybrook Facial Grading System (SFGS), electroneurography and three-dimensional objective measurements. Then, the entire set of evaluations were repeated for each patient 1 month later. The patients were followed up monthly until recovery or for up to more than 6 months. We adopted the SFGS and H-BGS as the representative subjective grading system and final criteria for recovery. Poor recovery was defined as an SFGS score less than 70 or H-BGS score higher than II. Results Multiple regression analysis was performed to find the best prognostic indicators. In less than 1 month from onset, ENoG had the highest prognostic value. However, in the second month from onset, the results of SFGS and 3D ASFM were identified as the best prognostic parameters, and a prediction formula with a determination coefficient of 0.673 was established. The receiver operating characteristic curves revealed that a gross score of the 3D ASFM less than 31 in the first evaluation and 49 in the second evaluation had higher sensitivity and specificity to predict poor recovery. Conclusions In different phases of Bell’s palsy, the best predictor of prognosis is different. ENOG is the most effective predictor of the prognosis in the first month after onset. In the second month after onset, the combination of SFGS and 3D ADSM is considered to be the best prognostic predictor.
Keywords	Bell’s palsy ; Facial palsy ; Three-dimensional ; Prognosis ; Objective ; Specialties of internal medicine ; RC581-951
Subject code	616
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19.

Zhang, Dong / Li, Liubing / Chen, Yu / Ma, Jie / Yang, Yanli / Aodeng, Surita / Cui, Qiuju / Wen, Kedi / Xiao, Meng / Xie, Jing / Xu, Yingchun / Li, Yongzhe

Molecular medicine (Cambridge, Mass.)

2021 Volume 27, Issue 1, Page(s) 151

Abstract: Background: We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.: Methods: The records of ...

Abstract	Background: We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality. Methods: The records of 49 COVID-19 patients who were admitted to an intensive care unit (ICU) in Wuhan, China between February and April 2020 were examined. Demographic, clinical, and laboratory data, and outcomes were compared between survivors and non-survivors COVID-19 patients, and between patients with high and low serum Syndecan-1 levels. The dynamics of serum Syndecan-1 levels were also analyzed. Results: The levels of Syndecan-1 were significantly higher in non-survivor group compared with survivor group (median 1031.4 versus 504.0 ng/mL, P = 0.002), and the levels of thrombomodulin were not significantly different between these two groups (median 4534.0 versus 3780.0 ng/mL, P = 0.070). Kaplan-Meier survival analysis showed that the group with high Syndecan-1 levels had worse overall survival (log-rank test: P = 0.023). Patients with high Syndecan-1 levels also had significantly higher levels of thrombomodulin, interleukin-6, and tumor necrosis factor-α. Data on the dynamics of Syndecan-1 levels indicated much greater variations in non-survivors than survivors. Conclusions: COVID-19 patients with high levels of Syndecan-1 develop more serious endothelial damage and inflammatory reactions, and have increased mortality. Syndecan-1 has potential for use as a marker for progression or severity of COVID-19. Protecting the glycocalyx from destruction is a potential treatment for COVID-19.
MeSH term(s)	Aged ; Biomarkers/blood ; Blood Coagulation ; COVID-19/blood ; COVID-19/mortality ; COVID-19/therapy ; China/epidemiology ; Cytokines/metabolism ; Endothelium/metabolism ; Endothelium, Vascular/pathology ; Female ; Glycocalyx/metabolism ; Humans ; Inflammation ; Intensive Care Units ; Interleukin-6/blood ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Oxygen ; ROC Curve ; SARS-CoV-2 ; Syndecan-1/blood ; Thrombomodulin/blood ; Treatment Outcome ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Biomarkers ; Cytokines ; IL6 protein, human ; Interleukin-6 ; SDC1 protein, human ; Syndecan-1 ; THBD protein, human ; TNF protein, human ; Thrombomodulin ; Tumor Necrosis Factor-alpha ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-12-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-021-00412-1
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