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  1. Article ; Online: SARS-CoV-2 variants of concern and vaccine escape, from Alpha to Omicron and beyond.

    Ong, Sean Wei Xiang / Chia, Travis / Young, Barnaby Edward

    Expert review of respiratory medicine

    2022  Volume 16, Issue 5, Page(s) 499–502

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2057299
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  2. Article ; Online: Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes.

    Ong, Sean Wei Xiang / Young, Barnaby Edward / Lye, David Chien

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 9, Page(s) 1195–1197

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00201-2
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    Zs.A 5743: Show issues Location:
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  3. Article ; Online: Haemophagocytic lymphohistiocytosis in dengue fever.

    Ren, Dongdong / Ong, Sean Wei Xiang / Batac, Jireh Ann Landingin / Fan, Bingwen Eugene / Vasoo, Shawn

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 3, Page(s) 437

    MeSH term(s) Adult ; Bone Marrow Examination ; Dengue/complications ; Dengue/diagnosis ; Dengue/drug therapy ; Dexamethasone/administration & dosage ; Erythema/etiology ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/virology ; Male ; Treatment Outcome
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30788-X
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    Zs.A 5743: Show issues Location:
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  4. Article ; Online: Compliance with face mask use during the COVID-19 pandemic: a community observational study in Singapore.

    Xiang Ong, Sean Wei / Tang, Ying Wei / Linn, Kyaw Zaw / Huan, Xiao Wei / Lim, Allie / Poon, Chu Ying / Ru Tan, Danielle Hui / Binte Hamed, Nur Hafizah / Syed Husen, Sharifah Farhanah Binte / Hui Ong, Clara Chong / Chan, Monica / Vasoo, Shawn / Leo, Yee-Sin / Ng, Oon-Tek / Marimuthu, Kalisvar

    Singapore medical journal

    2023  

    Abstract: Introduction: Widespread mask use is an important intervention for control of the coronavirus disease 2019 pandemic. However, data on the factors affecting mask use are lacking. In this observational study, we evaluated the proportion of and factors ... ...

    Abstract Introduction: Widespread mask use is an important intervention for control of the coronavirus disease 2019 pandemic. However, data on the factors affecting mask use are lacking. In this observational study, we evaluated the proportion of and factors influencing face mask use and related hygiene practices.
    Methods: We observed randomly selected members from the public in 367 venues across Singapore, and recorded the proportion of individuals with full compliance with mask use and mask hygiene (hand hygiene before and after touching the mask or face). Logistic regression analyses were used to determine variables associated with mask and hand hygiene compliance.
    Results: We made 3,821 observations - 2,149 (56.2%) females, 3,569 (93.4%) adults (≥21 years), 212 (5.5%) children (6-20 years) and 40 (1.0%) children (2-5 years). The overall full compliance rate (correct mask use), poor compliance rate (incorrect mask use) and absent mask use were 84.5%, 12.9% and 2.6%, respectively. The factors - male gender, fabric mask usage and crowded indoor venues - were associated with lower mask compliance. Face or mask touching behaviour was observed in 10.7% and 13.7% of individuals observed, respectively. Only one individual performed hand hygiene before and after touching the mask.
    Conclusion: The rate of mask compliance was high, probably due to legislation mandating mask usage. However, specific factors and crowded indoor venues associated with lower mask compliance were identified. We also noted an issue with the absence of hand hygiene before and after face or mask touching. These issues may benefit from targeted public health messaging.
    Language English
    Publishing date 2023-04-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2021-010
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  5. Article ; Online: Validation of ISARIC 4C Mortality and Deterioration Scores in a Mixed Vaccination Status Cohort of Hospitalized Coronavirus Disease 2019 (COVID-19) Patients in Singapore.

    Ong, Sean Wei Xiang / Sutjipto, Stephanie / Lee, Pei Hua / Dugan, Christopher / Khoo, Bo Yan / Ren, Dongdong / Young, Barnaby Edward / Lye, David Chien

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 1, Page(s) e874–e877

    Abstract: In this cross-sectional study, we studied performance of the International Severe Acute Respiratory and Emerging Infections Consortium mortality and deterioration scores in a cohort of 410 hospitalized patients (51.2% fully vaccinated). area under the ... ...

    Abstract In this cross-sectional study, we studied performance of the International Severe Acute Respiratory and Emerging Infections Consortium mortality and deterioration scores in a cohort of 410 hospitalized patients (51.2% fully vaccinated). area under the receiver operating characteristic curves were 0.778 and 0.764, respectively, comparable to originally published validation cohorts. Subgroup analysis showed equally good performance in vaccinated and partially or unvaccinated patients.
    MeSH term(s) COVID-19/prevention & control ; Cross-Sectional Studies ; Humans ; SARS-CoV-2 ; Singapore/epidemiology ; Vaccination
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac087
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  6. Article ; Online: Association of Higher Body Mass Index With Severe Coronavirus Disease 2019 (COVID-19) in Younger Patients.

    Ong, Sean Wei Xiang / Young, Barnaby Edward / Leo, Yee-Sin / Lye, David Chien

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 16, Page(s) 2300–2302

    MeSH term(s) Betacoronavirus ; Body Mass Index ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Obesity ; Pandemics ; Pneumonia, Viral/epidemiology ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa548
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  7. Article ; Online: Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

    Ward, Helen / Flower, Barnaby / Garcia, Patricia J / Ong, Sean Wei Xiang / Altmann, Daniel M / Delaney, Brendan / Smith, Nikki / Elliott, Paul / Cooke, Graham

    Lancet (London, England)

    2021  Volume 398, Issue 10316, Page(s) 2057–2059

    MeSH term(s) COVID-19/complications ; Chronic Disease ; Cognitive Dysfunction/etiology ; Disease Management ; Fatigue/etiology ; Humans ; Population Surveillance ; Research ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02444-2
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  8. Article ; Online: Severe dengue and liver involvement: an overview and review of the literature.

    Chia, Po Ying / Thein, Tun-Linn / Ong, Sean Wei Xiang / Lye, David Chien / Leo, Yee Sin

    Expert review of anti-infective therapy

    2020  Volume 18, Issue 3, Page(s) 181–189

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Aged ; Animals ; Chemical and Drug Induced Liver Injury/etiology ; Hepatitis, Viral, Human/epidemiology ; Humans ; Liver Diseases/epidemiology ; Liver Diseases/etiology ; Liver Function Tests ; Severe Dengue/complications ; Severe Dengue/epidemiology ; Severe Dengue/mortality
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2020.1720652
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  9. Article ; Online: Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma.

    Teo, Andrew / Chan, Louisa L Y / Cheung, Christine / Chia, Po Ying / Ong, Sean Wei Xiang / Fong, Siew Wai / Ng, Lisa F P / Renia, Laurent / Lye, David Chien / Young, Barnaby Edward / Yeo, Tsin Wen

    Communications medicine

    2023  Volume 3, Issue 1, Page(s) 62

    Abstract: Background: SARS-CoV-2, the causative agent of COVID-19, is a threat to public health. Evidence suggests increased neutrophil activation and endothelial glycocalyx (EG) damage are independently associated with severe COVID-19. Here, we hypothesised that ...

    Abstract Background: SARS-CoV-2, the causative agent of COVID-19, is a threat to public health. Evidence suggests increased neutrophil activation and endothelial glycocalyx (EG) damage are independently associated with severe COVID-19. Here, we hypothesised that an increased level of blood neutrophil myeloperoxidase (MPO) is associated with soluble EG breakdown, and inhibiting MPO activity may reduce EG damage.
    Methods: Analysing a subset of acute and convalescent COVID-19 plasma, 10 from severe and 15 from non-severe COVID-19 cases, and 9 from pre-COVID-19 controls, we determined MPO levels, MPO activity and soluble EG proteins (syndecan-1 and glypican-1) levels by enzyme-linked immunosorbent assay. In vitro primary human aortic endothelial cells were cultured with plasma untreated or treated with specific MPO inhibitors (MPO-IN-28, AZD5904) to determine EG shedding. We then investigated whether inhibiting MPO activity decreased EG degradation.
    Results: In COVID-19 plasma, MPO levels, MPO activity and levels of soluble EG proteins are significantly raised compared to controls, and concentrations increase in proportion to disease severity. Despite clinical recovery, protein concentrations remain significantly elevated. Interestingly, there is a trend of increasing MPO activity in convalescent plasma in both severe and non-severe groups. MPO levels and MPO activity correlate significantly with soluble EG levels and inhibiting MPO activity leads to reduced syndecan-1 shedding, in vitro.
    Conclusions: Neutrophil MPO may increase EG shedding in COVID-19, and inhibiting MPO activity may protect against EG degradation. Further research is needed to evaluate the utility of MPO inhibitors as potential therapeutics against severe COVID-19.
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-023-00293-x
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  10. Article ; Online: Genomic surveillance uncovers ongoing transmission of carbapenem-resistant

    Ong, Sean Wei Xiang / Rao, Pooja / Khong, Wei Xin / Ong, Victor Yi Fa / Sridatta, Prakki Sai Rama / Thevasagayam, Natascha May / Ho, Benjamin Choon Heng / Ang, Brenda Sze Peng / De, Partha Pratim / Ng, Oon Tek / Marimuthu, Kalisvar

    Infection control and hospital epidemiology

    2022  Volume 44, Issue 3, Page(s) 460–466

    Abstract: Objective: In our center, previous infection prevention and control (IPC) resources were concentrated on multidrug-resistant organisms other than CRAB because the rate of CRAB was stable with no evidence of outbreaks. Triggered by an increase in the ... ...

    Abstract Objective: In our center, previous infection prevention and control (IPC) resources were concentrated on multidrug-resistant organisms other than CRAB because the rate of CRAB was stable with no evidence of outbreaks. Triggered by an increase in the baseline rate of CRAB isolated in clinical cultures, we investigated horizontal transmission of CRAB to guide targeted IPC actions.
    Methods: We prospectively collected clinical data of patients with positive CRAB cultures. We identified genetic relatedness of CRAB isolates using whole-genome sequencing. Findings were regularly presented to the IPC committee, and follow-up actions were documented.
    Results: During the study period, 66 CRAB isolates were available for WGS. Including 12 clinical isolates and 10 environmental isolates from a previous study, a total of 88 samples were subjected to WGS, of which 83 were successfully sequenced and included in the phylogenetic analysis. We identified 5 clusters involving 44 patients. Genomic transmissions were explained by spatiotemporal overlap in 12 patients and by spatial overlap only in 12 patients. The focus of transmission was deduced to be the intensive care units. One cluster was related to a retrospective environmental isolate, suggesting the environment as a possible route of transmission. Discussion of these findings at multidisciplinary IPC meetings led to implementation of measures focusing on environmental hygiene, including hydrogen peroxide vapor disinfection in addition to terminal cleaning for rooms occupied by CRAB patients.
    Conclusions: We showed that WGS could be utilized as a "tool of persuasion" by demonstrating the presence of ongoing transmission of CRAB in an endemic setting, and by identifying actionable routes of transmission for directed IPC interventions.
    MeSH term(s) Humans ; Acinetobacter baumannii/genetics ; Retrospective Studies ; Phylogeny ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Acinetobacter Infections/epidemiology ; Microbial Sensitivity Tests ; Carbapenems/pharmacology ; Genomics
    Chemical Substances Carbapenems
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2022.115
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