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  1. Article ; Online: Hyperbaric oxygen should not be used routinely for carbon monoxide poisoning.

    Juurlink, David N

    British journal of clinical pharmacology

    2022  Volume 89, Issue 3, Page(s) 942–945

    MeSH term(s) Humans ; Carbon Monoxide Poisoning/diagnosis ; Carbon Monoxide Poisoning/therapy ; Hyperbaric Oxygenation ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15603
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    Zs.A 1118: Show issues Location:
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  2. Article ; Online: Antiemetics, stroke, and the limits of observational epidemiology.

    Juurlink, David N

    BMJ (Clinical research ed.)

    2022  Volume 377, Page(s) o924

    MeSH term(s) Antiemetics/therapeutic use ; Humans ; Nausea/drug therapy ; Stroke/epidemiology ; Stroke/prevention & control ; Vomiting/drug therapy
    Chemical Substances Antiemetics
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [No title information]

    Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 41, Page(s) E1242–E1246

    Title translation Considérations pour la prise en charge sécuritaire d’une infection au SRAS-CoV-2 au moyen de chloroquine, d’hydroxychloroquine et d’azithromycine.
    Keywords covid19
    Language French
    Publishing date 2020-10-13
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200528-f
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  4. Article ; Online: Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection.

    Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 17, Page(s) E450–E453

    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; Azithromycin/adverse effects ; Azithromycin/therapeutic use ; Betacoronavirus ; COVID-19 ; Chloroquine/adverse effects ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Monitoring, Physiologic ; Pandemics ; Patient Selection ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200528
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  5. Article: First-line therapy in drug reaction with eosinophilia and systemic symptoms (DReSS): Thinking beyond corticosteroids.

    Verstegen, Ruud H J / Phillips, Elizabeth J / Juurlink, David N

    Frontiers in medicine

    2023  Volume 10, Page(s) 1138464

    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1138464
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  6. Article ; Online: [No title information]

    De Halleux, Cyrille / Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 42, Page(s) E1449–E1456

    Title translation Diagnostic et prise en charge des effets toxiques du protoxyde d’azote utilisé à des fins récréatives.
    Language French
    Publishing date 2023-10-31
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230196-f
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  7. Article ; Online: Rethinking "doing well" on chronic opioid therapy.

    Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2019  Volume 189, Issue 39, Page(s) E1222–E1223

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Humans ; Opioid-Related Disorders/prevention & control ; Pain Management/methods
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-07-09
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.170628
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  8. Article ; Online: Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.

    Wu, Peter E / Juurlink, David N

    The Canadian journal of cardiology

    2022  Volume 38, Issue 9, Page(s) 1378–1383

    Abstract: Loperamide is a nonprescription medication commonly used to treat diarrhea. Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses. In recent years, however, loperamide has been ingested in ... ...

    Abstract Loperamide is a nonprescription medication commonly used to treat diarrhea. Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses. In recent years, however, loperamide has been ingested in very large quantities, sometimes with concomitant medications intended to enhance absorption and/or passage across the blood-brain barrier. Most people who misuse loperamide do so for its euphoric effects or to treat symptoms of opioid withdrawal. In addition to the risks of central opioid toxicity, this practice can result in potentially fatal cardiac dysrhythmias, because very high concentrations of loperamide alter the cardiac action potential. Patients will often present with recurrent, unexplained syncope accompanied with marked electrocardiographic abnormalities including QT-interval prolongation, widening of the QRS complex, and dysrhythmias such as torsades de pointes. Treatment involves early identification and discontinuation of loperamide, reversal of central opioid effects if present, and interventions aimed at addressing any cardiac conduction abnormalities. In addition, if there is an underlying opioid use disorder, efforts should be made to refer to specialised addictions care and initiate opioid agonist therapy when appropriate. We review the pharmacology of loperamide and the clinical presentation, pathophysiology, and suggested management of loperamide cardiac toxicity.
    MeSH term(s) Analgesics, Opioid ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/therapy ; Humans ; Long QT Syndrome/chemically induced ; Loperamide/adverse effects ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/drug therapy
    Chemical Substances Analgesics, Opioid ; Loperamide (6X9OC3H4II)
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.04.005
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  9. Article ; Online: Diagnosis and management of toxicity associated with the recreational use of nitrous oxide.

    De Halleux, Cyrille / Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 32, Page(s) E1075–E1081

    MeSH term(s) Humans ; Nitrous Oxide/adverse effects
    Chemical Substances Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2023-08-21
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230196
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  10. Article ; Online: [No title information]

    Rodrigues, David M / Hsieh, Eugene / Bernstein, Michael / Juurlink, David N

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 3, Page(s) E132–E135

    Title translation Colite lymphocytaire associée à l’entacapone.
    MeSH term(s) Humans ; Colitis, Lymphocytic ; Catechols ; Nitriles
    Chemical Substances entacapone (4975G9NM6T) ; Catechols ; Nitriles
    Language French
    Publishing date 2023-01-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.220680-f
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