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  1. Article: Facilitators and barriers for nurses when educating people with chronic wounds - A qualitative interview study.

    Pađen, Ljubiša / Gschwind, Géraldine / Vettorazzi, Renata / Probst, Sebastian

    Journal of tissue viability

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1282604-2
    ISSN 0965-206X
    ISSN 0965-206X
    DOI 10.1016/j.jtv.2024.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4357: Show issues Location:
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  2. Article ; Online: First report of Spirometra (Eucestoda; Diphyllobothriidae) naturally occurring in a fish host.

    Vettorazzi, Renzo / Norbis, Walter / Martorelli, Sergio R / Garcia, Graciela / Rios, Nestor

    Folia parasitologica

    2023  Volume 70

    Abstract: Spirometra Faust, Campbell et Kellogg, 1929 is a genus of cestodes belonging to the family Diphyllobothriidae. To date, amphibians, reptiles, and mammals are known second intermediate hosts of these parasites; humans can also be infected (the zoonotic ... ...

    Abstract Spirometra Faust, Campbell et Kellogg, 1929 is a genus of cestodes belonging to the family Diphyllobothriidae. To date, amphibians, reptiles, and mammals are known second intermediate hosts of these parasites; humans can also be infected (the zoonotic disease is known as sparganosis or spirometrosis). Although the number of phylogenetic studies on Spirometra spp. has increased worldwide in recent years, there are few in South America. Specifically in Uruguay, molecular studies have shown that tapeworms of S. decipiens (Diesing, 1850) complexes 1 and 2 are present in this country. In this study, we characterised the larvae of Spirometra present in the annual fish Austrolebias charrua Costa et Cheffe. Phylogenetic analysis of the cytochrome c oxidase subunit I (COI) sequences of these larvae showed that they belong to S. decipiens complex 1. This is the first report of teleost fishes serving as a second intermediate host for tapeworms of the genus Spirometra in nature.
    MeSH term(s) Animals ; Humans ; Spirometra/genetics ; Phylogeny ; Cestoda ; Cestode Infections/veterinary ; Cestode Infections/parasitology ; Fishes ; Mammals
    Language English
    Publishing date 2023-04-04
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 162048-4
    ISSN 1803-6465 ; 0015-5683
    ISSN (online) 1803-6465
    ISSN 0015-5683
    DOI 10.14411/fp.2023.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 212: Show issues Location:
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  3. Article ; Online: Acute corneal allograft rejection following SARS-CoV-2 vaccination-A systematic review.

    Moura-Coelho, Nuno / Cunha, João Paulo / Papa-Vettorazzi, Renato / Gris, Óscar / Güell, José Luis

    Acta ophthalmologica

    2022  Volume 101, Issue 1, Page(s) e1–e13

    Abstract: ... to-vaccination time (G-Vt), vaccination-to-immune reaction onset time (V-Rt), management, best-corrected ... had history of immune reactions; 52.9% of cases occurred after the first dose. Median (P25-P75) G-Vt ...

    Abstract All documented cases of acute corneal allograft rejection following SARS-CoV-2 vaccination were examined, to characterize possible risk factors and graft outcomes. Comprehensive search (4 electronic databases: PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar, plus manual search in articles' reference lists) until March 1st 2022 to identify studies reporting acute corneal allograft rejection following SARS-CoV-2 vaccination; study protocol was developed in line with PRISMA statement. We analysed demographics, allograft type, rejection prophylaxis regime at the time of vaccination, transplantation-to-vaccination time (G-Vt), vaccination-to-immune reaction onset time (V-Rt), management, best-corrected visual acuity before and after rejection, and graft survival. Of 169 titles/abstracts screened, 16 studies (n  = 36 eyes) met the inclusion criteria. Fourteen eyes (38.9%) had received >1 graft, and 11.1% of cases had history of immune reactions; 52.9% of cases occurred after the first dose. Median (P25-P75) G-Vt was 48 (10-78) months; median V-Rt was 9 (7-14) days. In eyes with resolved rejection, median time-to-resolution was 3 (1-4) weeks. Four eyes (11.1%) had partial resolution of corneal decompensation, and 5 grafts (13.9%) failed. Acute corneal allograft rejection after SARS-CoV-2 vaccination is a rare event, but may occur any time post-keratoplasty. Early recognition and prompt, aggressive treatment is warranted to optimize vision and graft survival. Well-known risk factors for rejection may be confounding factors, including the high proportion of cases with a history of previous grafts and the rejection prophylaxis regimes at the time of vaccination. Increasing immunosuppressants in the peri-vaccination period may decrease the risk of immune reactions, especially in high-risk cases.
    MeSH term(s) Humans ; Corneal Diseases/surgery ; Corneal Transplantation/methods ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Graft Rejection/prevention & control ; Graft Rejection/etiology ; Graft Survival ; Keratoplasty, Penetrating/adverse effects ; SARS-CoV-2 ; Vaccination ; Vision Disorders/etiology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-07-04
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15211
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    Ul I Zs.90: Show issues Location:
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  4. Book: Handbook of international food regulatory toxicology / 2

    Vettorazzi, Gaston

    1981  

    Author's details Gaston Vettorazzi
    Collection Handbook of international food regulatory toxicology
    Language English
    Publisher MTP Press
    Publishing place Lancaster
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT001512104
    ISBN 0-85200-552-0 ; 978-0-85200-552-1
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  5. Book: Handbook of international food regulatory toxicology / 2

    Vettorazzi, Gaston

    1981  

    Author's details Gaston Vettorazzi
    Collection Handbook of international food regulatory toxicology
    Language English
    Publisher MTP Press
    Publishing place Lancaster
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT001512104
    ISBN 0-85200-552-0 ; 978-0-85200-552-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1981 A 3189 -2- order for loan Magazin

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  6. Book: Handbook of international food regulatory toxicology / 1

    Vettorazzi, Gaston

    1980  

    Author's details Gaston Vettorazzi
    Collection Handbook of international food regulatory toxicology
    Language English
    Publisher MTP Press
    Publishing place Lancaster
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT001512103
    ISBN 0-85200-517-2 ; 978-0-85200-517-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    828/95 (1) order for loan Geschlossenes Magazin (U2)

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  7. Book: Handbook of international food regulatory toxicology / 1

    Vettorazzi, Gaston

    1980  

    Author's details Gaston Vettorazzi
    Collection Handbook of international food regulatory toxicology
    Language English
    Publisher MTP Press
    Publishing place Lancaster
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT001512103
    ISBN 0-85200-517-2 ; 978-0-85200-517-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1981 A 3189 -1- order for loan Magazin

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  8. Article: European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds

    Vettorazzi, Ariane / López de Cerain, Adela / Sanz-Serrano, Julen / Gil, Ana G / Azqueta, Amaya

    Nutrients. 2020 Feb. 26, v. 12, no. 3

    2020  

    Abstract: A great variety of functional foods, nutraceuticals, or foods with bioactive compounds are provided nowadays to consumers. Aware of the importance of the safety aspects, the food industry has to comply with different legal requirements around the world. ... ...

    Abstract A great variety of functional foods, nutraceuticals, or foods with bioactive compounds are provided nowadays to consumers. Aware of the importance of the safety aspects, the food industry has to comply with different legal requirements around the world. In this review, the European regulatory framework for food-related bioactive compounds is summarized. The term ‘bioactive compound’ is not defined in the European regulations, however, since they can be part of food supplements, fortified foods, or novel food, they are included within the legal requirements of those corresponding types of foods or supplements. Lists of authorized compounds/foods appear in the correspondent regulations, however, when a new compound/food is going to be launched into the market, its safety assessment is essential. Although the responsibility for the safety of these compounds/foods lies with the food business operator placing the product on the market, the European Food Safety Authority (EFSA) carries out scientific evaluations to assess the risks for human health. To facilitate this procedure, different guidelines exist at the European level to explain the tier toxicity testing approach to be considered. This approach divides the evaluation into four areas: (a) toxicokinetics; (b) genotoxicity; (c) subchronic and chronic toxicity and carcinogenicity; and (d) reproductive and developmental toxicity.
    Keywords bioactive compounds ; carcinogenicity ; chronic toxicity ; developmental toxicity ; dietary supplements ; food industry ; food safety ; functional foods ; genotoxicity ; guidelines ; human health ; markets ; novel foods ; nutrients ; pharmacokinetics ; risk assessment ; safety assessment ; toxicity testing
    Language English
    Dates of publication 2020-0226
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12030613
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: TUDCA receptors and their role on pancreatic beta cells.

    Rosa, Lucas Rodolfo de Oliveira / Vettorazzi, Jean Franciesco / Zangerolamo, Lucas / Carneiro, Everardo Magalhães / Barbosa, Helena Cristina de Lima

    Progress in biophysics and molecular biology

    2021  Volume 167, Page(s) 26–31

    Abstract: ... in the endocrine pancreas. We review the studies that focused on G protein-coupled bile acid receptor (TGR5), Sphingosine-1 ...

    Abstract Bile acids have received increasing attention over the past years as their multiple alternative roles became clearer. Tauroursodeoxycholic Acid (TUDCA) in specific has generated special interest due to its ability to promote pancreatic survival and function, as well as reduce endoplasmic reticulum stress. However, there are few studies explaining the molecular mechanisms behind TUDCA's beneficial actions on pancreatic beta cells. In this review, we decided to review the literature in order to craft a primer for researchers on what is known about TUDCA's receptors and the molecular pathways involved in this bile acid's function in the endocrine pancreas. We review the studies that focused on G protein-coupled bile acid receptor (TGR5), Sphingosine-1-phosphate receptor 2 (S1PR2) and α5β1 Integrin function in pancreatic cells. Our hope is to provide a basis for future studies to expand upon, especially considering the current lack of studies focusing on the importance of these receptors, either through TUDCA signaling or other signaling molecules.
    MeSH term(s) Insulin-Secreting Cells ; Receptors, G-Protein-Coupled ; Signal Transduction ; Taurochenodeoxycholic Acid
    Chemical Substances Receptors, G-Protein-Coupled ; Taurochenodeoxycholic Acid (516-35-8) ; ursodoxicoltaurine (60EUX8MN5X)
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2021.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.281: Show issues Location:
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  10. Article ; Online: Evaluation of postural stability in patients screened for osteoporosis: A retrospective study of 1086 cases.

    Simon, Alexander / Rupp, Tobias / Hoenig, Tim / Vettorazzi, Eik / Amling, Michael / Rolvien, Tim

    Gait & posture

    2021  Volume 88, Page(s) 304–310

    Abstract: ... g., bone mineral density (BMD). Accordingly, the role of balance parameters in the setting ...

    Abstract Background: Although the interactions between balance, falls and fracture risk have been demonstrated in various aspects, the clinical focus of fracture risk evaluation has been on bone properties, e.g., bone mineral density (BMD). Accordingly, the role of balance parameters in the setting of osteoporosis assessment remained to be further explored.
    Research question: Is postural stability assessed by Romberg quiet stance posturography influenced by BMD or prior fragility fractures in a cohort of more than 1000 patients screened for osteoporosis?
    Methods: Patients who completed both Romberg test and dual energy X-ray absorptiometry (DXA) were included retrospectively from a large database. Quantification of the Romberg test was performed by using posturography. Center of pressure (CoP) movements were tracked and the corresponding path length for ten seconds as well as an ellipse area including 90 % of all CoP were calculated. To determine potential predictors of posturography, simple and multiple linear regression analyses were performed including DXA results, grip strength, age, sex and BMI. As a secondary outcome, the influence of a previous fragility fracture on postural stability was evaluated.
    Results: Overall, 1086 patients (801 women, 285 men) met the inclusion criteria. Lower femoral BMD T-score (p < 0.05), higher age (p < 0.001) and male sex (p < 0.001) were associated with higher Romberg path length (both eyes open and eyes closed). Both women and men with any previous fragility fracture showed significantly increased values in the path length with eyes open (p < 0.05) and eyes closed (women p < 0.001, men p < 0.05) compared to those without a history of a fragility fracture.
    Significance: Our study indicates that postural stability is affected by femoral BMD, age and sex. As a history of prior fragility fracture was associated with postural instability, assessment and management of impaired balance in everyday clinical practice is advisable for optimal fracture prevention.
    MeSH term(s) Absorptiometry, Photon ; Bone Density ; Female ; Fractures, Bone ; Humans ; Male ; Osteoporosis/diagnosis ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1162323-8
    ISSN 1879-2219 ; 0966-6362
    ISSN (online) 1879-2219
    ISSN 0966-6362
    DOI 10.1016/j.gaitpost.2021.06.013
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    Zs.A 3804: Show issues Location:
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