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Article ; Online: Alternate fluency in Parkinson’s disease

Roberta Ferrucci / Francesca Mameli / Fabiana Ruggiero / Mariella Reitano / Mario Miccoli / Angelo Gemignani / Ciro Conversano / Michelangelo Dini / Stefano Zago / Silvie Piacentini / Barbara Poletti / Alberto Priori / Graziella Orrù

PLoS ONE, Vol 17, Iss

A machine learning analysis

2022 Volume 3

Abstract: Objective The aim of the present study was to investigate whether patients with Parkinson’s ...

Abstract	Objective The aim of the present study was to investigate whether patients with Parkinson’s Disease (PD) had changes in their level of performance in extra-dimensional shifting by implementing a novel analysis method, utilizing the new alternate phonemic/semantic fluency test. Method We used machine learning (ML) in order to develop high accuracy classification between PD patients with high and low scores in the alternate fluency test. Results The models developed resulted to be accurate in such classification in a range between 80% and 90%. The predictor which demonstrated maximum efficiency in classifying the participants as low or high performers was the semantic fluency test. The optimal cut-off of a decision rule based on this test yielded an accuracy of 86.96%. Following the removal of the semantic fluency test from the system, the parameter which best contributed to the classification was the phonemic fluency test. The best cut-offs were identified and the decision rule yielded an overall accuracy of 80.43%. Lastly, in order to evaluate the classification accuracy based on the shifting index, the best cut-offs based on an optimal single rule yielded an overall accuracy of 83.69%. Conclusion We found that ML analysis of semantic and phonemic verbal fluency may be used to identify simple rules with high accuracy and good out of sample generalization, allowing the detection of executive deficits in patients with PD.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Floral nectaries in Sapindaceae s.s.: morphological and structural diversity, and their systematic implications.

Solís, Stella M / Zini, Lucía M / González, Valeria V / Ferrucci, María S

Protoplasma

2017 Volume 254, Issue 6, Page(s) 2169–2188

Abstract: We investigated the morphology and structure of the floral nectary in 11 Neotropical genera belonging to the subfamilies Dodonaeoideae and Paullinioideae (Sapindaceae) from southern South America representing three tribes (Dodonaeaeae, Paullinieae, and ... ...

Abstract	We investigated the morphology and structure of the floral nectary in 11 Neotropical genera belonging to the subfamilies Dodonaeoideae and Paullinioideae (Sapindaceae) from southern South America representing three tribes (Dodonaeaeae, Paullinieae, and Melicocceae), in relation to other floral traits in species with contrasting morphological flower characteristics. Nectary organization was analyzed under light, stereoscopic, and scanning electron microscopes; Diplokeleba floribunda N.E. Br. was also observed using transmission electron microscopy. Our comparative data may contribute to the understanding of floral nectary evolution and systematic value in this family. The nectaries were studied in both staminate and pistillate flowers. All the floral nectaries are typical of Sapindaceae: extrastaminal, receptacular, structured, and persistent. The anatomical analysis revealed a differentiated secretory parenchyma and an inner non-secretory parenchyma; the nectary is supplied by phloem traces and, less frequently, by phloem and xylem traces. Nectar is secreted through nectarostomata of anomocytic type. The anatomical analysis showed the absence of nectary in the three morphs of Dodonaea viscosa flowers. Nectary ultrastructure is described in D. floribunda. In this species, the change in nectary color is related to progressive accumulation of anthocyanins during the functional phase. We found relatively small variation in the nectary structural characteristics compared with large variation in nectary morphology. The latter aspect agreed with the main infrafamilial groupings revealed by recent phylogenetic studies, so it is of current valuable systematic importance for Sapindaceae. In representatives of Paullinieae, the reduction of the floral nectary to 4-2 posterior lobes should be interpreted as a derived character state.
MeSH term(s)	Flowers/metabolism ; Flowers/ultrastructure ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Plant Epidermis/ultrastructure ; Plant Nectar/biosynthesis ; Plant Vascular Bundle/ultrastructure ; Sapindaceae/metabolism ; Sapindaceae/ultrastructure
Chemical Substances	Plant Nectar
Language	English
Publishing date	2017-11
Publishing country	Austria
Document type	Journal Article
ZDB-ID	123809-7
ISSN	1615-6102 ; 0033-183X
ISSN (online)	1615-6102
ISSN	0033-183X
DOI	10.1007/s00709-017-1108-x
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Article ; Online: Pushing the Limits of Clingo’s Incremental Grounding and Solving Capabilities in Practical Applications

Marcello Balduccini / Michael Barborak / David Ferrucci

Algorithms, Vol 16, Iss 169, p

2023 Volume 169

Abstract: ... challenges and ultimately increase the adoption of clingo’s incremental capabilities for complex practical ...

Abstract	Incremental techniques aim at making it possible to improve the performance of the grounding and solving processes by reusing the results of previous executions. Clingo supports both incremental grounding and incremental solving computations. In order to leverage incremental computations in clingo, the incremental fragments of ASP programs must satisfy certain safety-related conditions. In a number of problem domains and reasoning tasks, these conditions can be satisfied in a fairly straightforward way. However, we have observed that in certain practical applications, satisfying the conditions becomes more challenging, to the point that it is sometimes unclear how or even if it is possible to leverage incremental computations. In this paper, we report our findings, and ultimate success, with the use of incremental grounding and solving techniques in one of these challenging cases. We describe the domain, which is linked to a large practical application, discuss the challenges we faced in attempting to leverage incremental computations, and then describe the techniques that we developed, in particular at the level of methods for encoding the domain knowledge and of algorithms supporting the intended interleaving of grounding and solving. We believe that our findings may provide valuable information to practitioners facing similar challenges and ultimately increase the adoption of clingo’s incremental capabilities for complex practical applications.
Keywords	answer set programming ; multi-shot solving ; durative actions ; durative fluents ; reasoning about actions and change ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington’s disease

Andrew McGarry / Krystal Hunter / John Gaughan / Peggy Auinger / Thomas N. Ferraro / Basant Pradhan / Luigi Ferrucci / Josephine M. Egan / Ruin Moaddel

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 13

Abstract: Abstract Huntington’s disease (HD) is increasingly recognized for diverse pathology outside ...

Abstract	Abstract Huntington’s disease (HD) is increasingly recognized for diverse pathology outside of the nervous system. To describe the biology of HD in relation to functional progression, we previously analyzed the plasma and CSF metabolome in a cross-sectional study of participants who had various degrees of functional impairment. Here, we carried out an exploratory study in plasma from HD individuals over a 3-year time frame to assess whether differences exist between those with fast or absent clinical progression. There were more differences in circulating metabolite levels for fast progressors compared to absent progressors (111 vs 20, nominal p < 0.05). All metabolite changes in faster progressors were decreases, whereas some metabolite concentrations increased in absent progressors. Many of the metabolite levels that decreased in the fast progressors were higher at Screening compared to absent progressors but ended up lower by Year 3. Changes in faster progression suggest greater oxidative stress and inflammation (kynurenine, diacylglycerides, cysteine), disturbances in nitric oxide and urea metabolism (arginine, citrulline, ornithine, GABR), lower polyamines (putrescine and spermine), elevated glucose, and deficient AMPK signaling. Metabolomic differences between fast and absent progressors suggest the possibility of predicting functional decline in HD, and possibly delaying it with interventions to augment arginine, polyamines, and glucose regulation.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Liu, Zuyun / Chen, Brian H / Assimes, Themistocles L / Ferrucci, Luigi / Horvath, Steve / Levine, Morgan E

Psychoneuroendocrinology

2019 Volume 104, Page(s) 18–24

Abstract: ... for mortality disparities by race/ethnicity and education in a sample of U.S. postmenopausal women.: Methods ...

Abstract	Background: Higher mortality experienced by socially disadvantaged groups and/or racial/ethnic minorities is hypothesized to be, at least in part, due to an acceleration of the aging process. Using a new epigenetic aging measure, Levine DNAmAge, this study aimed to investigate whether epigenetic aging accounts for mortality disparities by race/ethnicity and education in a sample of U.S. postmenopausal women. Methods: 1834 participants from an ancillary study (BA23) in the Women's Health Initiative, a national study that recruited postmenopausal women (50-79 years) were included. Over the 22 years of follow-up, 551 women died, and 31,946 person-years were observed. Levine DNAmAge (unit in years) was calculated based on an equation that we previously developed in an independent sample, which incorporates methylation levels at 513 CpG sites. Results: As previously reported, non-Hispanic blacks and Hispanics were epigenetically older than non-Hispanic whites of the same chronological age. Similarly, those with less education had older epigenetic ages than expected in the full sample, as well as among non-Hispanic whites and Hispanics, but not among non-Hispanic blacks. Non-Hispanic blacks and those with low education exhibited the greatest risk of mortality. However, this association was partially attenuated when accounting for differences in DNAmAge. Furthermore, formal mediation analysis suggested that DNAmAge partially mediated the mortality increase among non-Hispanic blacks, compared to non-Hispanic whites (proportion mediated, 15.8%, P = 0.002), as well as the mortality increase for those with less than high school education, compared to college educated (proportion mediated, 11.6%, P < 2E-16). Conclusions: Among a group of postmenopausal women, non-Hispanic blacks and those with less education exhibit higher epigenetic aging, which partially accounts for their shorter life expectancies.
MeSH term(s)	African Americans ; Aged ; Aged, 80 and over ; Aging/genetics ; Continental Population Groups/education ; Continental Population Groups/genetics ; Epigenesis, Genetic/genetics ; Ethnic Groups/education ; Ethnic Groups/genetics ; European Continental Ancestry Group ; Female ; Health Status Disparities ; Hispanic Americans ; Humans ; Life Expectancy/ethnology ; Middle Aged ; Minority Groups/education ; Mortality/ethnology ; United States
Language	English
Publishing date	2019-02-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2019.01.028
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Article ; Online: The Impact of Telemedicine on Parkinson’s Care during the COVID-19 Pandemic

Fabiana Ruggiero / Linda Lombi / Maria Takeko Molisso / Giorgio Fiore / Eleonora Zirone / Roberta Ferrucci / Elena Pirola / Marco Locatelli / Sergio Barbieri / Francesca Mameli

Healthcare, Vol 10, Iss 1065, p

An Italian Online Survey

2022 Volume 1065

Abstract: Traditionally, medical care and research in Parkinson’s disease (PD) have been conducted ...

Abstract	Traditionally, medical care and research in Parkinson’s disease (PD) have been conducted through in-person visit. The recent Coronavirus Disease 2019 (COVID-19) pandemic has profoundly impacted the delivery of in-person clinical care. We conducted an online survey to investigate the impact of COVID-19 on access to telehealth care, interviewing both PD patients and neurologists. Survey responses were collected from 1 March to 31 May 2021 through an anonymous, self-reported questionnaire, on the ‘Qualtrics’ platform. In total, 197 patients and 42 neurologists completed the survey. In our sample, 37.56% of PD patients and 88.10% of neurologists reported having used alternatives to in-person visits, while 13.70% of PD patients and 40.48% of neurologists used telemedicine. Data showed that respondents were generally satisfied with the use of telemedicine during the COVID-19 pandemic. The relational dimension between patient and neurologist seems to be the factor that most positively affected the telemedicine experience, contributing greatly to a more patient-centred care. Current findings suggest the need to improve the access to telehealth services for patients with PD. The technology has the potential to improve the care of frail patients, especially when availability of face-to-face visits is limited.
Keywords	survey ; Parkinson’s disease ; COVID-19 ; telehealth ; telemedicine ; E-health ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Floral nectaries in Sapindaceae s.s.: morphological and structural diversity, and their systematic implications

Solís, Stella M / Lucía M. Zini / María S. Ferrucci / Valeria V. González

Protoplasma. 2017 Nov., v. 254, no. 6

2017

Abstract	We investigated the morphology and structure of the floral nectary in 11 Neotropical genera belonging to the subfamilies Dodonaeoideae and Paullinioideae (Sapindaceae) from southern South America representing three tribes (Dodonaeaeae, Paullinieae, and Melicocceae), in relation to other floral traits in species with contrasting morphological flower characteristics. Nectary organization was analyzed under light, stereoscopic, and scanning electron microscopes; Diplokeleba floribunda N.E. Br. was also observed using transmission electron microscopy. Our comparative data may contribute to the understanding of floral nectary evolution and systematic value in this family. The nectaries were studied in both staminate and pistillate flowers. All the floral nectaries are typical of Sapindaceae: extrastaminal, receptacular, structured, and persistent. The anatomical analysis revealed a differentiated secretory parenchyma and an inner non-secretory parenchyma; the nectary is supplied by phloem traces and, less frequently, by phloem and xylem traces. Nectar is secreted through nectarostomata of anomocytic type. The anatomical analysis showed the absence of nectary in the three morphs of Dodonaea viscosa flowers. Nectary ultrastructure is described in D. floribunda. In this species, the change in nectary color is related to progressive accumulation of anthocyanins during the functional phase. We found relatively small variation in the nectary structural characteristics compared with large variation in nectary morphology. The latter aspect agreed with the main infrafamilial groupings revealed by recent phylogenetic studies, so it is of current valuable systematic importance for Sapindaceae. In representatives of Paullinieae, the reduction of the floral nectary to 4–2 posterior lobes should be interpreted as a derived character state.
Keywords	anthocyanins ; bromine ; color ; Dodonaea viscosa ; morphs ; nectar ; nectaries ; phloem ; phylogeny ; scanning electron microscopes ; transmission electron microscopy ; ultrastructure ; xylem ; South America
Language	English
Dates of publication	2017-11
Size	p. 2169-2188.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	123809-7
ISSN	1615-6102 ; 0033-183X
ISSN (online)	1615-6102
ISSN	0033-183X
DOI	10.1007/s00709-017-1108-x
Database	NAL-Catalogue (AGRICOLA)

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Article: Two New Species of Serjania (Sapindaceae) from Michoacán, Mexico, with Notes on S. biternata

Ferrucci, María Silvia / Steinmann, Victor Werner

Systematic botany. 2019 Aug. 6, v. 44, no. 3

2019

Abstract: ... investigated. A treatment of the endemic S. biternata from Guerrero is also included because it is a little ... known taxon similar to S. rosalindae whose fruits were previously unknown. All of these taxa share ...

Abstract	Serjania rosalindae and Serjania crucensis (Sapindaceae-Paullinieae), new species from the municipality of La Huacana, Michoacán, Mexico, are described, illustrated, and compared with closely related species. In addition, micromorphological features of the leaves, flowers, and pollen grains are investigated. A treatment of the endemic S. biternata from Guerrero is also included because it is a little-known taxon similar to S. rosalindae whose fruits were previously unknown. All of these taxa share capsules that are chartaceous to almost woody and septifragal, a fruit type otherwise uncommon within Serjania. The distinctive fruit morphology of these species is discussed in relation to other species of Serjania.
Keywords	flowers ; fruit morphology ; fruits ; leaves ; new species ; plant taxonomy ; pollen ; Sapindaceae ; scientific illustration ; taxon descriptions ; Mexico
Language	English
Dates of publication	2019-0806
Size	p. 670-680.
Publishing place	American Society of Plant Toxonomists
Document type	Article
ZDB-ID	2052625-8
ISSN	1548-2324 ; 0363-6445
ISSN (online)	1548-2324
ISSN	0363-6445
DOI	10.1600/036364419X15620113920725
Database	NAL-Catalogue (AGRICOLA)

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Article: A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead.

Chia, Chee W / Ferrucci, Luigi

Annals of translational medicine

2014 Volume 2, Issue 12, Page(s) 121

Language	English
Publishing date	2014-12-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.3978/j.issn.2305-5839.2014.10.05
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Article ; Online: Coding of Self and Other’s Future Choices in Dorsal Premotor Cortex during Social Interaction

Rossella Cirillo / Lorenzo Ferrucci / Encarni Marcos / Stefano Ferraina / Aldo Genovesio

Cell Reports, Vol 24, Iss 7, Pp 1679-

2018 Volume 1686

Abstract: ... to monitor the other’s action in order to select the correct target in that agent’s own turn. We report ...

Abstract	Summary: Representing others’ intentions is central to primate social life. We explored the role of dorsal premotor cortex (PMd) in discriminating between self and others’ behavior while two male rhesus monkeys performed a non-match-to-goal task in a monkey-human paradigm. During each trial, two of four potential targets were randomly presented on the right and left parts of a screen, and the monkey or the human was required to choose the one that did not match the previously chosen target. Each agent had to monitor the other’s action in order to select the correct target in that agent’s own turn. We report neurons that selectively encoded the future choice of the monkey, the human agent, or both. Our findings suggest that PMd activity shows a high degree of self-other differentiation during face-to-face interactions, leading to an independent representation of what others will do instead of entailing self-centered mental rehearsal or mirror-like activities. : Understanding others’ intentions is essential to successful primate social life. Cirillo et al. explore the role of dorsal premotor cortex (PMd) in discriminating between self and others’ behavior while macaques interacted with humans. They show that the majority of neurons encoding the future choice did so selectively for the monkey or the human agent. PMd thus differentiates self from others’ behavior, leading to independent representations of future actions. Keywords: social interaction, prediction, primate cognition, premotor cortex, mirror neurons, non-human primate
Keywords	Biology (General) ; QH301-705.5
Subject code	120
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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