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  1. Article ; Online: Central venous catheter-related bloodstream infections: Epidemiology and risk factors for hematogenous complications.

    Ngo Bell, Elisabeth Carolle / Chapon, Virginie / Bessede, Emilie / Meriglier, Etienne / Issa, Nahema / Domblides, Charlotte / Bonnet, Fabrice / Vandenhende, Marie-Anne

    Infectious diseases now

    2024  Volume 54, Issue 3, Page(s) 104859

    Abstract: Background: Central catheter-related bloodstream infections (CRBIs) can lead to severe complications, including suppurative thrombophlebitis, endocarditis, and metastatic infections. While complications due to CRBIs caused by Staphylococcus aureus (SA) ... ...

    Abstract Background: Central catheter-related bloodstream infections (CRBIs) can lead to severe complications, including suppurative thrombophlebitis, endocarditis, and metastatic infections. While complications due to CRBIs caused by Staphylococcus aureus (SA) are well-known, there are limited data regarding CRBIs caused by other bacteria.
    Methods: This 2-year retrospective single-center study of patients with CRBIs from a tertiary care hospital examined the hematogenous complications associated with CRBIs according to patient characteristics, central venous catheter (CVC) types, and causative bacteria.
    Results: All in all, 254 patients with confirmed CRBIs were included; 285 bacteria types were isolated, mainly Enterobacteriaceae (n = 94), coagulase-negative Staphylococci (CNS, n = 82), SA (n = 45), and non-fermenting Gram-negative bacteria (NGB, n = 45). Among the patients, 35 developed at least one hematogenous complication (14 %), including suppurative thrombophlebitis (n = 15), endocarditis (n = 7) and metastatic infections (n = 16). In multivariate analysis, hemodialysis, persistent bacteremia for at least 3 days, and CRBIs caused by SA were associated with increased risk for hematogenous complications, while previous curative anticoagulant treatment was associated with reduced risk. Diabetes, CVC maintenance, and hematogenous complications were associated with increased 3-month mortality.
    Conclusion: A thorough investigation of hematogenous complications should be envisioned in patients with persistent bacteremia, particularly those with SA infections and those on hemodialysis.
    MeSH term(s) Humans ; Central Venous Catheters/adverse effects ; Retrospective Studies ; Staphylococcal Infections ; Staphylococcus aureus ; Risk Factors ; Thrombophlebitis/etiology ; Thrombophlebitis/complications ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Endocarditis/complications
    Language English
    Publishing date 2024-02-01
    Publishing country France
    Document type Journal Article
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2024.104859
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  2. Article ; Online: Giant calcinosis revealing systemic sclerosis.

    Meriglier, Etienne / Lafourcade, François / Gombert, Bruno / Landron, Cedric

    International journal of rheumatic diseases

    2019  Volume 22, Issue 9, Page(s) 1787–1788

    Abstract: Calcinosis is a complication of systemic sclerosis, most often occurring more than several years after diagnosis. We report the case of a man who developed severe calcinosis in shoulders and hips occurring before other systemic sclerosis' symptoms. ...

    Abstract Calcinosis is a complication of systemic sclerosis, most often occurring more than several years after diagnosis. We report the case of a man who developed severe calcinosis in shoulders and hips occurring before other systemic sclerosis' symptoms.
    MeSH term(s) Aged ; Biomechanical Phenomena ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Calcinosis/physiopathology ; Hip Joint/diagnostic imaging ; Hip Joint/physiopathology ; Humans ; Male ; Predictive Value of Tests ; Prognosis ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Severity of Illness Index ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/physiopathology ; Time Factors
    Language English
    Publishing date 2019-07-02
    Publishing country England
    Document type Case Reports
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13648
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  3. Article ; Online: Surdité dans l’artérite à cellules géantes : à propos d’une observation.

    De Fontcuberta, Pedro / Vandenhende, Marie-Anne / Laux, Miranda / Tourbier, Benjamin / Paz, Rafael / Bonnet, Fabrice / Meriglier, Etienne

    La Revue de medecine interne

    2022  

    Abstract: Introduction: Hearing loss is a rare manifestation in giant cell arteritis. The different types of deafness are possible with a predominance of sensorineural deafness.: Case report: We report a 75-year-old woman who presented with typical ... ...

    Title translation Hearing loss in giant cell arteritis: A case report.
    Abstract Introduction: Hearing loss is a rare manifestation in giant cell arteritis. The different types of deafness are possible with a predominance of sensorineural deafness.
    Case report: We report a 75-year-old woman who presented with typical manifestations of giant cell arteritis associated concomitantly with the occurrence of bilateral mixed hearing loss confirmed on the audiogram. Corticosteroids allowed a rapidly favorable clinical and biological outcome. The follow-up audiogram at 3 months was markedly improved and showed a decrease in sensorineural hearing loss and disappearance of conductive hearing loss.
    Conclusion: Any rapid onset deafness in an inflammatory context in the elderly should lead to a search for giant cell arteritis. The diagnosis can be difficult in the absence of other typical manifestations, especially since the biopsy of the temporal artery most often comes back negative. Corticosteroids are usually effective.
    Language French
    Publishing date 2022-06-22
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2022.05.008
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  4. Article ; Online: Amylose cervicale à bêta-2-microglobuline chez un patient hémodialysé.

    Meriglier, Etienne / Fritz, Olivier

    Presse medicale (Paris, France : 1983)

    2015  Volume 44, Issue 9, Page(s) 966–968

    Title translation Cervical spine mass due to beta-2-microglobulin amyloidosis in a long-term hemodialysed patient.
    MeSH term(s) Amyloidosis/complications ; Cervical Vertebrae/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Renal Dialysis/adverse effects ; beta 2-Microglobulin/metabolism
    Chemical Substances beta 2-Microglobulin
    Language French
    Publishing date 2015-09
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2015.04.031
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  5. Article ; Online: Neglecting Plasma Protein Binding in COVID-19 Patients Leads to a Wrong Interpretation of Lopinavir Overexposure.

    Stanke-Labesque, Francoise / Concordet, Didier / Djerada, Zoubir / Bouchet, Stéphane / Solas, Caroline / Mériglier, Etienne / Bonnet, Fabrice / Mourvillier, Bruno / Ruiz, Stéphanie / Martin-Blondel, Guillaume / Epaulard, Olivier / Schwebel, Carole / Gautier-Veyret, Elodie / Gandia, Peggy

    Clinical pharmacology and therapeutics

    2021  Volume 109, Issue 4, Page(s) 1030–1033

    Abstract: Boffito et al. recalled the critical importance to correctly interpret protein binding. Changes of lopinavir pharmacokinetics in coronavirus disease 2019 (COVID-19) are a perfect illustration. Indeed, several studies described that total lopinavir plasma ...

    Abstract Boffito et al. recalled the critical importance to correctly interpret protein binding. Changes of lopinavir pharmacokinetics in coronavirus disease 2019 (COVID-19) are a perfect illustration. Indeed, several studies described that total lopinavir plasma concentrations were considerably higher in patients with severe COVID-19 than those reported in patients with HIV. These findings have led to a reduction of the dose of lopinavir in some patients, hypothesizing an inhibitory effect of inflammation on lopinavir metabolism. Unfortunately, changes in plasma protein binding were never investigated. We performed a retrospective cohort study. Data were collected from the medical records of patients hospitalized for COVID-19 treated with lopinavir/ritonavir in intensive care units or infectious disease departments of Toulouse University Hospital (France). Total and unbound concentrations of lopinavir, C reactive protein, albumin, and alpha-1-acid glycoprotein (AAG) levels were measured during routine care on the same samples. In patients with COVID-19, increased total lopinavir concentration is the result of an increased AAG-bound lopinavir concentration, whereas the unbound concentration remains constant, and insufficient to reduce the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral load. Although international guidelines have recently recommended against using lopinavir/ritonavir to treat severe COVID-19, the description of lopinavir pharmacokinetics changes in COVID-19 is a textbook case of the high risk of misinterpretation of a total drug exposure when changes in protein binding are not taken into consideration.
    MeSH term(s) Aged ; Albumins/metabolism ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; C-Reactive Protein/metabolism ; COVID-19/drug therapy ; Female ; Glycoproteins/metabolism ; Humans ; Lopinavir/pharmacokinetics ; Lopinavir/therapeutic use ; Male ; Middle Aged ; Plasma/physiology ; Protein Binding/physiology ; Retrospective Studies ; SARS-CoV-2 ; Viral Load
    Chemical Substances Albumins ; Antiviral Agents ; Glycoproteins ; Lopinavir (2494G1JF75) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2196
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  6. Article ; Online: Nodules cutanés révélant une fusariose chez un patient atteint d'une aplasie médullaire idiopathique.

    Meriglier, Etienne / Puyade, Mathieu / Cateau, Estelle / Maillard, Natacha

    Presse medicale (Paris, France : 1983)

    2015  Volume 44, Issue 5, Page(s) 574–576

    Title translation Nodular skin lesions revealing fusariosis in a severe aplastic anemia patient.
    MeSH term(s) Anemia, Aplastic/complications ; Anemia, Aplastic/pathology ; Diagnosis, Differential ; Fusariosis/complications ; Fusariosis/pathology ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Severity of Illness Index
    Language French
    Publishing date 2015-05
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2014.08.013
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  7. Article ; Online: Covichem: A biochemical severity risk score of COVID-19 upon hospital admission.

    Bats, Marie-Lise / Rucheton, Benoit / Fleur, Tara / Orieux, Arthur / Chemin, Clément / Rubin, Sébastien / Colombies, Brigitte / Desclaux, Arnaud / Rivoisy, Claire / Mériglier, Etienne / Rivière, Etienne / Boyer, Alexandre / Gruson, Didier / Pellegrin, Isabelle / Trimoulet, Pascale / Garrigue, Isabelle / Alkouri, Rana / Dupin, Charles / Moreau-Gaudry, François /
    Bedel, Aurélie / Dabernat, Sandrine

    PloS one

    2021  Volume 16, Issue 5, Page(s) e0250956

    Abstract: Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores. However, they all necessitate saturable equipment such as scanners, or procedures difficult to implement such as blood ... ...

    Abstract Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores. However, they all necessitate saturable equipment such as scanners, or procedures difficult to implement such as blood gas measures. To provide an easy and fast COVID-19 severity risk score upon hospital admission, and keeping in mind the above limits, we sought for a scoring system needing limited invasive data such as a simple blood test and co-morbidity assessment by anamnesis. A retrospective study of 303 patients (203 from Bordeaux University hospital and an external independent cohort of 100 patients from Paris Pitié-Salpêtrière hospital) collected clinical and biochemical parameters at admission. Using stepwise model selection by Akaike Information Criterion (AIC), we built the severity score Covichem. Among 26 tested variables, 7: obesity, cardiovascular conditions, plasma sodium, albumin, ferritin, LDH and CK were the independent predictors of severity used in Covichem (accuracy 0.87, AUROC 0.91). Accuracy was 0.92 in the external validation cohort (89% sensitivity and 95% specificity). Covichem score could be useful as a rapid, costless and easy to implement severity assessment tool during acute COVID-19 pandemic waves.
    MeSH term(s) Aged ; COVID-19/blood ; COVID-19/epidemiology ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Obesity/blood ; Obesity/epidemiology ; Paris/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0250956
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  8. Article ; Online: Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection.

    Meriglier, Etienne / Rivoisy, Claire / Hessamfar, Mojgan / Bernard, Noelle / Aureau, Ines / Lapoirie, Joelle / Contis, Anne / Sacher, Frédéric / Sacristan, Benjamin / Lahouati, Marin / Pedeboscq, Stéphane / Vandenhende, Marie-Anne / Bouchet, Stéphane / Bonnet, Fabrice

    The Journal of antimicrobial chemotherapy

    2020  Volume 76, Issue 2, Page(s) 482–486

    Abstract: Background: Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection.: Objectives: To examine the safety of ...

    Abstract Background: Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection.
    Objectives: To examine the safety of combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir.
    Methods: This was an observational cohort study of patients hospitalized for COVID-19 pneumonia treated with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir. Clinical evaluations, electrocardiograms and the pharmacokinetics of hydroxychloroquine, darunavir and lopinavir were examined according to clinical practice and guidelines.
    Results: Twenty-one patients received hydroxychloroquine with lopinavir/ritonavir (median age 68 years; 10 males) and 25 received hydroxychloroquine with darunavir/ritonavir (median age 71 years; 15 males). During treatment, eight patients (17.4%) developed ECG abnormalities. Ten patients discontinued treatment, including seven for ECG abnormalities a median of 5 (range 2-6) days after starting treatment. All ECG abnormalities reversed 1-2 days after interrupting treatment. Four patients died within 14 days. ECG abnormalities were significantly associated with age over 70 years, coexisting conditions (such as hypertension, chronic cardiovascular disease and kidney failure) and initial potential drug interactions, but not with the hydroxychloroquine concentration.
    Conclusions: Of the patients with COVID-19 who received hydroxychloroquine with lopinavir or darunavir, 17% had ECG abnormalities, mainly related to age or in those with a history of cardiovascular disease.
    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Antiviral Agents/blood ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Cohort Studies ; Darunavir/administration & dosage ; Darunavir/adverse effects ; Darunavir/blood ; Darunavir/therapeutic use ; Drug Therapy, Combination ; Electrocardiography ; France ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/blood ; Hydroxychloroquine/therapeutic use ; Long QT Syndrome/chemically induced ; Long QT Syndrome/epidemiology ; Lopinavir/administration & dosage ; Lopinavir/adverse effects ; Lopinavir/blood ; Lopinavir/therapeutic use ; SARS-CoV-2 ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Darunavir (YO603Y8113)
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa441
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