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Article ; Online: The need for social group interventions to increase malaria rapid diagnostic test uptake in Nigeria.

Falade, Catherine O / Mokuolu, Olugbenga A

2021 Volume 9, Issue 3, Page(s) e231–e232

MeSH term(s)	Diagnostic Tests, Routine ; Health Personnel ; Humans ; Malaria/diagnosis ; Nigeria
Language	English
Publishing date	2021-02-16
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(21)00032-2
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Article: Changes in Inflammatory Cytokines After Chronic Hepatitis C Treatment Among People Living With HIV.

Karimi-Sari, Hamidreza / Piggott, Damani A / Scully, Eileen P / Ward, Kathleen / Sutcliffe, Catherine G / Sulkowski, Mark / Falade-Nwulia, Oluwaseun

Open forum infectious diseases

2024 Volume 11, Issue 1, Page(s) ofad623

Abstract: We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were ... ...

Abstract	We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were significantly lower at the 24-week time point in patients who achieved sustained virologic response as compared with those who did not.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad623
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Article ; Online: High genetic and haplotype diversity in vaccine candidate

Oboh, Mary Aigbiremo / Asmorom, Naemy / Falade, Catherine / Ojurongbe, Olusola / Thomas, Bolaji N

PeerJ

2023 Volume 11, Page(s) e16519

Abstract: Malaria remains a global public health challenge. The disease has a great impact in sub-Saharan Africa among children under five years of age and pregnant women. Malaria control programs targeting the parasite and mosquitoes vectors with combinational ... ...

Abstract	Malaria remains a global public health challenge. The disease has a great impact in sub-Saharan Africa among children under five years of age and pregnant women. Malaria control programs targeting the parasite and mosquitoes vectors with combinational therapy and insecticide-treated bednets are becoming obsolete due to the phenomenon of resistance, which is a challenge for reducing morbidity and mortality. Malaria vaccines would be effective alternative to the problem of parasite and insecticide resistance, but focal reports of polymorphisms in malaria candidate antigens have made it difficult to design an effective malaria vaccine. Therefore, studies geared towards elucidating the polymorphic pattern and how genes targeted for vaccine design evolve are imperative. We have carried out molecular and genetic analysis of two genes encoding vaccine candidates-the
MeSH term(s)	Pregnancy ; Child ; Animals ; Humans ; Female ; Child, Preschool ; Plasmodium falciparum/genetics ; Haplotypes ; Sporozoites ; Malaria Vaccines/genetics ; Nigeria ; Protozoan Proteins/genetics ; Malaria, Falciparum/prevention & control ; Malaria/prevention & control ; Antigens, Protozoan/genetics ; Nucleotides
Chemical Substances	Malaria Vaccines ; Protozoan Proteins ; Antigens, Protozoan ; Nucleotides
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16519
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Article ; Online: High genetic and haplotype diversity in vaccine candidate Pfceltos but not Pfrh5 among malaria-infected children in Ibadan, Nigeria

Mary Aigbiremo Oboh / Naemy Asmorom / Catherine Falade / Olusola Ojurongbe / Bolaji N. Thomas

PeerJ, Vol 11, p e

2023 Volume 16519

Abstract	Malaria remains a global public health challenge. The disease has a great impact in sub-Saharan Africa among children under five years of age and pregnant women. Malaria control programs targeting the parasite and mosquitoes vectors with combinational therapy and insecticide-treated bednets are becoming obsolete due to the phenomenon of resistance, which is a challenge for reducing morbidity and mortality. Malaria vaccines would be effective alternative to the problem of parasite and insecticide resistance, but focal reports of polymorphisms in malaria candidate antigens have made it difficult to design an effective malaria vaccine. Therefore, studies geared towards elucidating the polymorphic pattern and how genes targeted for vaccine design evolve are imperative. We have carried out molecular and genetic analysis of two genes encoding vaccine candidates—the Plasmodium falciparum cell traversal ookinetes and sporozoites (Pfceltos) and P. falciparum reticulocyte binding protein 5 (Pfrh5) in parasite isolates from malaria-infected children in Ibadan, Nigeria to evaluate their genetic diversity, relatedness and pattern of molecular evolution. Pfceltos and Pfrh5 genes were amplified from P. falciparum positive samples. Amplified fragments were purified and sequenced using the chain termination method. Post-sequence edit of fragments and application of various population genetic analyses was done. We observed a higher number of segregating sites and haplotypes in the Pfceltos than in Pfrh5 gene, the former also presenting higher haplotype (0.942) and nucleotide diversity (θ = 0.01219 and π = 0.01148). In contrast, a lower haplotype (0.426) and nucleotide diversity (θ = 0.00125; π = 0.00095) was observed in the Pfrh5 gene. Neutrality tests do not show deviation from neutral expectations for Pfceltos, with the circulation of multiple low frequency haplotypes (Tajima’s D = −0.21637; Fu and Li’s D = −0.08164; Fu and Li’s F = −0.14051). Strong linkage disequilibrium was observed between variable sites, in each of the ...
Keywords	Plasmodium falciparum ; Genetic diversity ; Polymorphism ; Phylogenetic relatedness ; Sub-sahara Africa ; Pfceltos ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article ; Online: Malaria and COVID-19: commonalities, intersections and implications for sustaining malaria control.

Ajayi, IkeOluwapo Oyeneye / Ajumobi, Olufemi Olamide / Falade, Catherine

The Pan African medical journal

2020 Volume 37, Issue Suppl 1, Page(s) 1

Abstract: The devastating impact of infectious disease outbreaks and pandemics on health systems could be overwhelming especially when there is an overlap in clinical presentations with other disease conditions. A case in point is the disruptive effect of the ... ...

Abstract	The devastating impact of infectious disease outbreaks and pandemics on health systems could be overwhelming especially when there is an overlap in clinical presentations with other disease conditions. A case in point is the disruptive effect of the Ebola Virus Disease outbreak on health service delivery and its consequences for malaria management in the affected West and Central African countries between 2014 and 2016. This could be the case with the current infectious disease pandemic (COVID-19) the world is experiencing as malaria illness shares many symptoms with COVID-19 illness. Caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is reported to have originated from Wuhan city, China in December 2019. COVID-19 was declared a Public Health Emergency of International Concern on 30 January 2020 and declared a pandemic on March 11, 2020 by the World Health Organization (WHO). Practically, all community infrastructure has been activated in affected countries in response to COVID-19. However, the deployment of huge resources in combating COVID-19 pandemic should not be a missed opportunity for the advancement of infectious diseases control including malaria. This calls for conscious and heightened effort to sustain the gains in malaria control. The WHO has emphasized that the response to the COVID-19 pandemic must utilize and strengthen existing infrastructure for addressing malaria and other infectious diseases globally. Leveraging these to maintain malaria control activities in endemic countries could boost and help to sustain the gains in malaria control in accordance with the 2016-2030 Global technical strategy for malaria (GTS) milestones. In addition, it will help to keep the "High burden to high impact" (HBHI) and other initiatives on track. This article highlights the commonalities of the two diseases, discusses implications and recommendations to support decision making strategies to keep malaria control on track in the COVID-19 pandemic era.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/prevention & control ; Global Health ; Humans ; Malaria/diagnosis ; Malaria/drug therapy ; Malaria/epidemiology ; Malaria/prevention & control ; Practice Guidelines as Topic
Language	English
Publishing date	2020-09-01
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.supp.2020.37.1.25738
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Article ; Online: Surveillance of Pretreatment Drug Resistance Among HIV-Infected Children in Ibadan, Nigeria.

Olusola, Fiyinfoluwa I / Olusola, Babatunde A / Oladokun, Regina / Falade, Catherine O

AIDS research and human retroviruses

2021 Volume 37, Issue 12, Page(s) 922–929

Abstract: There are about 2.1 million children infected with HIV globally and about 120,000 deaths annually. Nigeria has one of the highest rates of pediatric HIV infection globally. Pretreatment HIV drug resistance data inform the choice of first- and second-line ...

Abstract	There are about 2.1 million children infected with HIV globally and about 120,000 deaths annually. Nigeria has one of the highest rates of pediatric HIV infection globally. Pretreatment HIV drug resistance data inform the choice of first- and second-line antiretroviral therapy (ART) regimens. This study investigated the prevalence of HIV drug-resistant strains among ART-naive children in Ibadan, Nigeria. A total of 20 children aged <15 years were enrolled. Demographic, clinical, and laboratory data were documented. Total nucleic acid was extracted from blood samples after which amplification of HIV-1 pol gene was done using polymerase chain reaction. Amplified gene was sequenced using big dye sequencing method. The sequenced HIV-1 pol gene was typed and analyzed for identification of mutations indicative of drug resistance across the different classes of ART. HIV-1 RNA pol gene was successfully amplified in 12/20 (60%) children. All were identified as HIV-1 and the subtypes were G and CRF 02AG, recombinant of 02_AG/G and recombinant of 02_AG/A1. Drug-resistant mutations (DRMs) were identified in 4/12 (33%). Three out of the four mutations were identified as non-nucleoside reverse transcriptase inhibitors DRM (K103N), whereas the fourth had nucleoside reverse transcriptase inhibitors DRM (M184V). Results from this preliminary study show that drug resistance among ART-naive children is a problem in Ibadan. Pretreatment drug resistance testing is desirable in children before initiation of ART to guide effective treatment.
MeSH term(s)	Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Child ; Drug Resistance, Viral/genetics ; Genotype ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1/genetics ; Humans ; Mutation ; Nigeria
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2021-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2020.0272
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Article ; Online: High prevalence of persistent residual parasitemia on days 3 and 14 after artemether-lumefantrine or pyronaridine-artesunate treatment of uncomplicated Plasmodium falciparum malaria in Nigeria.

Funwei, Roland I / Uyaiabasi, Gabriel N / Hammed, Wasiu A / Ojurongbe, Olusola / Walker, Oladapo / Falade, Catherine O

Parasitology research

2022 Volume 122, Issue 2, Page(s) 519–526

Abstract: Background: Microscopic evaluation of parasite clearance is the gold standard in antimalarial drug efficacy trials. However, the presence of sub-microscopic residual parasitemia after artemisinin-based combination therapy (ACT) needs to be investigated.! ...

Abstract	Background: Microscopic evaluation of parasite clearance is the gold standard in antimalarial drug efficacy trials. However, the presence of sub-microscopic residual parasitemia after artemisinin-based combination therapy (ACT) needs to be investigated. Methods: One hundred and twenty (AL: n = 60, PA: n = 60) days 3 and 14 dried blood spots, negative by microscopy were analysed for residual parasitemia using nested PCR. Isolates with residual parasitemia on days 3 and 14 were further genotyped with their corresponding day-0 isolates using merozoite surface proteins msp-1, msp-2, and glurp genes for allelic similarity. Results: Persistent PCR-determined sub-microscopic residual parasitemia at day 3 post ACT treatment was 83.3 (AL) and 88.3% (PA), respectively (ρ = 0.600), while 63.6 and 36.4% (ρ = 0.066) isolates were parasitemic at day 14 for AL and PA, respectively. Microscopy-confirmed gametocytemia persisted from days 0 to 7 and from days 0 to 21 for AL and PA. When the alleles of day 3 versus day 0 were compared according to base pair sizes, 59% of parasites shared identical alleles for glurp, 36% each for 3D7 and FC27, while K1 was 77%, RO33 64%, and MAD20 23%, respectively. Similarly, day 14 versus day 0 was 36% (glurp), 64% (3D7), and 32% (FC27), while 73% (K1), 77% (RO33), and 41% (MAD20), respectively. Conclusion: The occurrence of residual parasitemia on days 3 and 14 following AL or PA treatment may be attributable to the presence of either viable asexual, gametocytes, or dead parasite DNAs, which requires further investigation.
MeSH term(s)	Humans ; Antimalarials/therapeutic use ; Plasmodium falciparum ; Parasitemia/drug therapy ; Parasitemia/epidemiology ; Parasitemia/parasitology ; Prevalence ; Nigeria/epidemiology ; Artemether/therapeutic use ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/parasitology ; Merozoite Surface Protein 1/genetics
Chemical Substances	pyronaridine tetraphosphate, artesunate drug combination ; Antimalarials ; Artemether (C7D6T3H22J) ; Artemether, Lumefantrine Drug Combination ; Merozoite Surface Protein 1
Language	English
Publishing date	2022-12-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-022-07753-8
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Article: Malaria parasite density and plasma apolipoprotein A1 in symptomatic and asymptomatic infections in Nigerian children.

Orimadegun, Bose E / Odaibo, Georgina O / Orimadegun, Adebola E / Agbedana, Emmanuel O / Falade, Catherine O

Journal of vector borne diseases

2022 Volume 58, Issue 4, Page(s) 311–316

Abstract: Background & objectives: Alterations in plasma apolipoproteins in individuals with malaria infection and their potential roles in the pathogenesis are known but the link between the malaria parasite density and apolipoprotein A1 (apo-A1) level is ... ...

Abstract	Background & objectives: Alterations in plasma apolipoproteins in individuals with malaria infection and their potential roles in the pathogenesis are known but the link between the malaria parasite density and apolipoprotein A1 (apo-A1) level is insufficiently understood. This study was conducted to determine whether the plasma apo-A1 level is influenced by the degree of parasitaemia in malaria infections. Methods: In a case-control study, a convenient sample of children aged 2-10 years with uncomplicated malaria cases (UMC), asymptomatic parasitaemia cases (APC) and healthy children without parasitaemia (HCP) was recruited. The cases consisted of 61 UMC and 21 APC, while the controls consisted of 24 HCP. Levels of apo-A1 was determined using immunoturbidimetric assay and compared among the different degrees of parasite density. Results: Of the 82 participants with parasitaemia, density was ≤1000/μL in 12, 1001-10000/μL in 21 and >10000/μL in 49 children. There was significant difference among the mean values of apolipoprotein A1 of the three groups, viz: UMC [91.4 (95% CI: 81.3, 101.5) mg/dL], APC [67.0 (95% CI: 48.9, 84.9) mg/dL] and HCP [99.0 (95% CI: 76.6, 121.3) mg/dL], p=0.029. Post-hoc analysis revealed that the mean plasma level of apo-A1 in HCP was significantly higher than APC by 32.0±12.4 mg/dL and UMC by 7.5±4.2 mg/dL. However, there were no differences in the mean apolipoprotein A1 levels among the three groups of parasite density. Interpretation & conclusion: The presence of parasitaemia causes a remarkable reduction in apolipoprotein A1 level that was not influenced by the degree of parasitaemia.
MeSH term(s)	Apolipoprotein A-I/blood ; Asymptomatic Infections ; Case-Control Studies ; Child ; Child, Preschool ; Humans ; Malaria/parasitology ; Nigeria ; Parasitemia
Chemical Substances	Apolipoprotein A-I
Language	English
Publishing date	2022-04-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2161218-3
ISSN	0972-9062
ISSN	0972-9062
DOI	10.4103/0972-9062.318309
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Article ; Online: Hepatitis C Treatment in People With HIV: Potential to Eliminate Disease and Disparity.

Falade-Nwulia, Oluwaseun / Lesko, Catherine R / Fojo, Anthony T / Keruly, Jeanne C / Moore, Richard D / Sutcliffe, Catherine G / Mehta, Shruti H / Chander, Geetanjali / Thomas, David L / Sulkowski, Mark

The Journal of infectious diseases

2023 Volume 229, Issue 3, Page(s) 775–779

Abstract: Access to direct acting antivirals (DAAs) may be associated with reductions in hepatitis C virus (HCV) viremia prevalence among people with human immunodeficiency virus (PWH). Among 3755 PWH, estimated HCV viremia prevalence decreased by 94.0% from 36% ( ... ...

Abstract	Access to direct acting antivirals (DAAs) may be associated with reductions in hepatitis C virus (HCV) viremia prevalence among people with human immunodeficiency virus (PWH). Among 3755 PWH, estimated HCV viremia prevalence decreased by 94.0% from 36% (95% confidence interval [CI], 27%-46%) in 2009 (pre-DAA era) to 2% (95% CI, 0%-4%) in 2021 (DAA era). Male sex, black race, and older age were associated with HCV viremia in 2009 but not in 2021. Injection drug use remained associated with HCV viremia in 2009 and 2021. Targeted interventions are needed to meet the HCV care needs of PWH who use drugs.
MeSH term(s)	Humans ; Male ; HIV ; Antiviral Agents/therapeutic use ; Viremia/drug therapy ; Viremia/epidemiology ; Hepatitis C, Chronic/drug therapy ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepacivirus ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad433
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Book: Fighting a moving target

Falade, Catherine Olufunke

malaria the pains and the gains : an inaugural lecture delivered at the University of Ibadan on Thursday, 27 November, 2014

(Inaugural lecture ; 2013/2014)

2014

Institution	University of Ibadan,
Author's details	by Catherine Olufunke Falade
Series title	Inaugural lecture ; 2013/2014
MeSH term(s)	Malaria/drug therapy ; Malaria/therapy ; Antimalarials/therapeutic use
Keywords	Nigeria
Language	English
Size	73 pages :, illustrations.
Document type	Book
ISBN	9789788456650 ; 9788456650
Database	Catalogue of the US National Library of Medicine (NLM)

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