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  1. Article ; Online: Phytic Acid Demonstrates Rapid Antibiofilm Activity and Inhibits Biofilm Formation When Used as a Surface Conditioning Agent.

    Nassar, Rania / Nassar, Mohannad / Senok, Abiola / Williams, David

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0026723

    Abstract: Root canal infections are associated with biofilms and are treated with chemical irrigants with a high success rate. However, treatment failure does arise, which is attributed primarily to resistance exhibited by biofilms. Currently used irrigants in ... ...

    Abstract Root canal infections are associated with biofilms and are treated with chemical irrigants with a high success rate. However, treatment failure does arise, which is attributed primarily to resistance exhibited by biofilms. Currently used irrigants in root canal treatment have disadvantages, and there is therefore a need for more biocompatible alternatives with antibiofilm properties to reduce root canal treatment failure and complications. The aim of this study was to evaluate the
    MeSH term(s) Phytic Acid/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Candida albicans ; Biofilms
    Chemical Substances Phytic Acid (7IGF0S7R8I) ; Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00267-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 Transcriptomic Atlas: A Comprehensive Analysis of COVID-19 Related Transcriptomics Datasets.

    Alqutami, Fatma / Senok, Abiola / Hachim, Mahmood

    Frontiers in genetics

    2021  Volume 12, Page(s) 755222

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.755222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epidemiology and antimicrobial resistance trends of

    Thomsen, Jens / Abdulrazzaq, Najiba M / AlRand, Hussain / Everett, Dean B / Senok, Abiola / Menezes, Godfred A / Ayoub Moubareck, Carole

    Frontiers in public health

    2024  Volume 11, Page(s) 1245131

    Abstract: Introduction: Acinetobacter: Methods: A retrospective 12-year analysis of 17,564 non-duplicate diagnostic : Results: Species belonging to the : Conclusion: Carbapenem- ... ...

    Abstract Introduction: Acinetobacter
    Methods: A retrospective 12-year analysis of 17,564 non-duplicate diagnostic
    Results: Species belonging to the
    Conclusion: Carbapenem-resistant
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; United Arab Emirates/epidemiology ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter baumannii ; Drug Resistance, Bacterial ; Carbapenems
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1245131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polycystic Ovary Syndrome and Endometrial Cancer: A Scoping Review of the Literature on Gut Microbiota.

    Prakash, Amog / Nourianpour, Milad / Senok, Abiola / Atiomo, William

    Cells

    2022  Volume 11, Issue 19

    Abstract: Gut dysbiosis has been associated with polycystic ovary syndrome (PCOS) and endometrial cancer (EC) but no studies have investigated whether gut dysbiosis may explain the increased endometrial cancer risk in polycystic ovary syndrome. The aim of this ... ...

    Abstract Gut dysbiosis has been associated with polycystic ovary syndrome (PCOS) and endometrial cancer (EC) but no studies have investigated whether gut dysbiosis may explain the increased endometrial cancer risk in polycystic ovary syndrome. The aim of this scoping review is to evaluate the extent and nature of published studies on the gut microbiota in polycystic ovary syndrome and endometrial cancer and attempt to find any similarities between the composition of the microbiota. We searched for publications ranging from the years 2016 to 2022, due to the completion date of the 'Human Microbiome Project' in 2016. We obtained 200 articles by inputting keywords such as 'gut microbiome', 'gut microbiota', 'gut dysbiosis', 'PCOS', and 'endometrial cancer' into search engines such as PubMed and Scopus. Of the 200 identified in our initial search, we included 25 articles in our final review after applying the exclusion and inclusion criteria. Although the literature is growing in this field, we did not identify enough published studies to investigate whether gut dysbiosis may explain the increased EC risk in PCOS. Within the studies identified, we were unable to identify any consistent patterns of the microbiome similarly present in studies on women with PCOS compared with women with EC. Although we found that the phylum Firmicutes was similarly decreased in women with PCOS and studies on women with EC, there was however significant variability within the studies identified making it highly likely that this may have arisen by chance. Further research pertaining to molecular and microbiological mechanisms in relation to the gut microbiome is needed to elucidate a greater understanding of its contribution to the pathophysiology of endometrial cancer in patients with polycystic ovarian syndrome.
    MeSH term(s) Dysbiosis/complications ; Dysbiosis/microbiology ; Endometrial Neoplasms ; Female ; Gastrointestinal Microbiome/physiology ; Humans ; Microbiota ; Polycystic Ovary Syndrome
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11193038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evolving trends among

    Thomsen, Jens / Menezes, Godfred A / Abdulrazzaq, Najiba M / Moubareck, Carole Ayoub / Senok, Abiola / Everett, Dean B

    Frontiers in public health

    2023  Volume 11, Page(s) 1243973

    Abstract: Introduction: Pseudomonas: Methods: A retrospective 12-year analysis of 56,618 non-duplicate diagnostic : Results: Among the total isolates (: Conclusion: The resistance trends ... ...

    Abstract Introduction: Pseudomonas
    Methods: A retrospective 12-year analysis of 56,618 non-duplicate diagnostic
    Results: Among the total isolates (
    Conclusion: The resistance trends in
    MeSH term(s) Humans ; Pseudomonas aeruginosa ; Retrospective Studies ; United Arab Emirates/epidemiology ; Drug Resistance, Multiple, Bacterial ; Pseudomonas Infections/epidemiology ; Pseudomonas Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1243973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Antimicrobial resistance in

    Senok, Abiola / Thomsen, Jens / Abdulrazzaq, Najiba M / Menezes, Godfred Antony / Ayoub Moubareck, Carole / Everett, Dean

    Frontiers in public health

    2023  Volume 11, Page(s) 1244357

    Abstract: Introduction: Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of : Methods: Retrospective analysis of : Results: From 2010 to 2021, 11,242 non-duplicate : Conclusion: The increasing trend of ... ...

    Abstract Introduction: Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of
    Methods: Retrospective analysis of
    Results: From 2010 to 2021, 11,242 non-duplicate
    Conclusion: The increasing trend of pneumococcal disease and AMR with emergence of isolates with MDR phenotype despite is of concern. In the absence of
    MeSH term(s) Child ; Humans ; Streptococcus pneumoniae ; Anti-Bacterial Agents/pharmacology ; Retrospective Studies ; United Arab Emirates/epidemiology ; Drug Resistance, Bacterial ; Pneumococcal Vaccines ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology
    Chemical Substances Anti-Bacterial Agents ; Pneumococcal Vaccines
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1244357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia.

    Alsuwaidi, Laila / Hachim, Mahmood / Senok, Abiola

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 706129

    Abstract: Background: The extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, we have carried out : Methods: ... ...

    Abstract Background: The extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, we have carried out
    Methods: To explore novel genes that show promising clinical and molecular signatures, we examined the cBioPortal online tool for publicly available datasets on lymphoid cancers. Three studies on lymphoblastic and lymphoid leukemia with 1706 patients and 2144 samples of which were identified. Only B-Lymphoblastic Leukemia/Lymphoma samples (
    Results: ADAM6 gene homozygous deletions (HOM:DEL) were present in 59.60% of the profiled patients and were associated with poor ten years of overall patients' survival. Moreover, patients with ADAM6 HOM:DEL showed a distinguished clinical and molecular profile with higher Central Nervous System (CNS) sites of relapse. In addition, ADAM6 HOM:DEL was significantly associated with unique microRNAs gene expression patterns.
    Conclusion: ADAM6 has the potential to be a novel biomarker for the development and progress of BCP- ALL.
    Language English
    Publishing date 2021-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.706129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Emergence of highly resistant

    Thomsen, Jens / Abdulrazzaq, Najiba M / Oulhaj, Abderrahim / Nyasulu, Peter S / Alatoom, Adnan / Denning, David W / Al Dhaheri, Fatima / Menezes, Godfred Antony / Moubareck, Carole Ayoub / Senok, Abiola / Everett, Dean B

    Frontiers in public health

    2024  Volume 11, Page(s) 1244358

    Abstract: Introduction: The Centers for Disease Prevention and Control lists : Methods: The United Arab Emirates has carried out a 12 years of antimicrobial resistance surveillance (2010-2021) across the country, spanning all seven Emirates. A retrospective ... ...

    Abstract Introduction: The Centers for Disease Prevention and Control lists
    Methods: The United Arab Emirates has carried out a 12 years of antimicrobial resistance surveillance (2010-2021) across the country, spanning all seven Emirates. A retrospective analysis of
    Results: Nine hundred eight non-duplicate
    Conclusion: The increasing trend of
    MeSH term(s) Humans ; Candida auris ; Retrospective Studies ; United Arab Emirates/epidemiology ; Microbial Sensitivity Tests ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida/genetics
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1244358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Novel Markers in Pediatric Acute Lymphoid Leukemia

    Laila Alsuwaidi / Mahmood Hachim / Abiola Senok

    Frontiers in Cell and Developmental Biology, Vol

    The Role of ADAM6 in B Cell Leukemia

    2021  Volume 9

    Abstract: BackgroundThe extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, we have carried out in silico analysis ...

    Abstract BackgroundThe extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, we have carried out in silico analysis of publicly available ALL datasets to identify genetic biomarkers for childhood BCP-ALL, which could be used either individually or in combination as markers for early detection, risk stratification, and prognosis.MethodsTo explore novel genes that show promising clinical and molecular signatures, we examined the cBioPortal online tool for publicly available datasets on lymphoid cancers. Three studies on lymphoblastic and lymphoid leukemia with 1706 patients and 2144 samples of which were identified. Only B-Lymphoblastic Leukemia/Lymphoma samples (n = 1978) were selected for further analysis. Chromosomal changes were assessed to determine novel genomic loci to analyze clinical and molecular profiles for the leukemia of lymphoid origin using cBioPortal tool.ResultsADAM6 gene homozygous deletions (HOM:DEL) were present in 59.60% of the profiled patients and were associated with poor ten years of overall patients’ survival. Moreover, patients with ADAM6 HOM:DEL showed a distinguished clinical and molecular profile with higher Central Nervous System (CNS) sites of relapse. In addition, ADAM6 HOM:DEL was significantly associated with unique microRNAs gene expression patterns.ConclusionADAM6 has the potential to be a novel biomarker for the development and progress of BCP- ALL.
    Keywords ADAM6 ; acute lymphoid leukemia ; bioinformactics analysis ; biomarkers ; pediatric leukemia ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Lung Epithelial Cells from Obese Patients Have Impaired Control of SARS-CoV-2 Infection.

    Gaudet, Mellissa / Kaufmann, Eva / Jalaleddine, Nour / Mogas, Andrea / Hachim, Mahmood / Senok, Abiola / Divangahi, Maziar / Hamid, Qutayba / Al Heialy, Saba

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Obesity is known to increase the complications of the COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the exact mechanisms of SARS-CoV-2 infection in obese patients have not been clearly ... ...

    Abstract Obesity is known to increase the complications of the COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the exact mechanisms of SARS-CoV-2 infection in obese patients have not been clearly elucidated. This study aims to better understand the effect of obesity on the course of SARS-CoV-2 infection and identify candidate molecular pathways involved in the progression of the disease, using an in vitro live infection model and RNA sequencing. Results from this study revealed the enhancement of viral load and replication in bronchial epithelial cells (NHBE) from obese subjects at 24 h of infection (MOI = 0.5) as compared to non-obese subjects. Transcriptomic profiling via RNA-Seq highlighted the enrichment of lipid metabolism-related pathways along with
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/metabolism ; SARS-CoV-2 ; Lung/metabolism ; Obesity/complications ; Obesity/metabolism ; Epithelial Cells/metabolism
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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