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  1. Article: Diagnostic Validation and Feasibility of a Non-invasive Haemoglobin Screening Device (EzeCheck) for 'Anaemia Mukt Bharat' in India.

    Sahoo, Krushna Chandra / Sinha, Abhinav / Sahoo, Rakesh Kumar / Suman, S Shradha / Bhattacharya, Debdutta / Pati, Sanghamitra

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52877

    Abstract: Anaemia remains a major public health issue in India despite several efforts. It is crucial to introduce technology-based innovations for the mass screening and early diagnosis of anaemia. Traditional anaemia screening requires drawing blood and ... ...

    Abstract Anaemia remains a major public health issue in India despite several efforts. It is crucial to introduce technology-based innovations for the mass screening and early diagnosis of anaemia. Traditional anaemia screening requires drawing blood and laboratory analysis and can be logistically expensive in resource-constrained settings. A non-invasive haemoglobin test for mass screening in such settings is vital which can quickly and efficiently screen large populations. This study validated the haemoglobin estimation between the invasive haematology analyzer and the non-invasive EzeCheck (EzeRx Health Tech Pvt. Ltd., Bhubaneswar, Odisha, India) in the community setting. We conducted a cross-sectional study among 416 urban slum members in Bhubaneswar, India. We used inter-rater reliability (kappa statistic) of haemoglobin estimation between the haematology analyzer and EzeCheck devices. The finding showed a moderate agreement between both devices (kappa=0.4221). Between both devices, 91.59% of the results were with +/-1.5 difference; 43.51%, no difference; 33.65%, less than one difference; and 14.42%, +/-1 to +/-1.5 difference of haemoglobin estimation. There was no significant difference in overall anaemia status estimates between the devices. Mass screening in schools and communities with non-invasive haemoglobin tests can help identify anaemic people for early diagnosis and bring patients for timely treatment, which can be used in remote areas to support 'Anaemia Mukt Bharat'.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-communicable disease multimorbidity among tribal older adults in India: evidence from Study on Global AGEing and adult health, 2015.

    Sinha, Abhinav / Kanungo, Srikanta / Bhattacharya, Debdutta / Kaur, Harpreet / Pati, Sanghamitra

    Frontiers in public health

    2023  Volume 11, Page(s) 1217753

    Abstract: Introduction: Multimorbidity defined as the simultaneous presence of two or more chronic conditions in an individual is on the rise in low- and middle-income countries such as India. With India aiming to achieve universal health coverage, it is ... ...

    Abstract Introduction: Multimorbidity defined as the simultaneous presence of two or more chronic conditions in an individual is on the rise in low- and middle-income countries such as India. With India aiming to achieve universal health coverage, it is imperative to address the inequalities in accessing healthcare, especially among vulnerable groups such as tribal. Moreover, changing lifestyle has led to the emergence of multimorbidity among tribals in India. We aimed to estimate the prevalence and assess the correlates of multimorbidity among tribal older adults in India.
    Methods: We employed nationally representative data from the World Health Organization's Study on Global AGEing and Adult Health conducted in 2015. We included 522 participants aged ≥50 years who reported their caste to be 'Scheduled Tribe' in the survey. A multivariable regression model assessed the association between multimorbidity and various attributes.
    Results: Arthritis, cataract, and hypertension were the most common chronic conditions. The overall prevalence of multimorbidity was ~22.61%. We observed a higher likelihood of having multimorbidity among respondents aged ≥80 years [AOR: 4.08 (1.17-14.18)] than the younger age groups, and among the most affluent group [AOR: 2.64 (1.06-6.56)] than the most deprived class.
    Conclusion: The prevalence of multimorbidity among tribal older adults is emerging which cannot be overlooked. Health and wellness centers may be a window of opportunity to provide egalitarian and quality preventive and curative services to achieve universal health coverage. Future studies should explore the outcomes of multimorbidity in terms of healthcare utilization, expenditure, and quality of life in this group.
    MeSH term(s) Humans ; Aged ; Multimorbidity ; Noncommunicable Diseases ; Quality of Life ; Aging ; India/epidemiology
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1217753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Outbreaks and sporadic cases of japanese encephalitis in the state of Odisha, India: Outcome of 7 years of laboratory surveillance.

    Sabat, Jyotsnamayee / Bhattacharya, Debdutta / Subhadra, Subhra / Gurav, Yogesh K / Pati, Satya Sundar / Dwibedi, Bhagirathi

    Indian journal of public health

    2023  Volume 67, Issue 2, Page(s) 324–327

    Abstract: Acute encephalitis syndrome (AES) is a major public health challenge in India. We report here the epidemiology of sporadics and outbreaks of Japanese Encephalitis (JE) in Odisha state during 2012-2018. A total of 4235 AES cases (sporadics - 3394, ... ...

    Abstract Acute encephalitis syndrome (AES) is a major public health challenge in India. We report here the epidemiology of sporadics and outbreaks of Japanese Encephalitis (JE) in Odisha state during 2012-2018. A total of 4235 AES cases (sporadics - 3394, outbreak cases - 841) recorded including 42 outbreaks; majority (n = 18) of which were during 2016. Overall JE virus (JEV) positivity was 11.78% (outbreak cases - 24.5%, sporadic cases - 8.6%). Age ≤15 years were largely affected during outbreaks, while 16-60 years population was dominant among sporadics. The major outbreak (2016) involved 336 patients from a tribal dominated district, spread over 173 villages. JEV seropositivity was high (43.45%) with 28.57% mortality. Epidemiological linkage with pig rearing was documented through JEV neutralizing antibodies in 50% of pig serum samples. Although the postvaccination period (2017-18) showed increase in AES case reporting but low JE proportion. Ongoing surveillance and preparedness of the health system would be of importance, especially in tribal-dominated districts.
    MeSH term(s) Animals ; Swine ; Encephalitis, Japanese/epidemiology ; India/epidemiology ; Encephalitis Virus, Japanese ; Disease Outbreaks
    Language English
    Publishing date 2023-07-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.ijph_1294_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identification of potential inhibitor against CTX-M-3 and CTX-M-15 proteins: an

    Kar, Bipasa / Kundu, Chanakya Nath / Singh, Mahender Kumar / Dehury, Budheswar / Pati, Sanghamitra / Bhattacharya, Debdutta

    Journal of biomolecular structure & dynamics

    2023  Volume 42, Issue 1, Page(s) 177–193

    Abstract: Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is a serious global threat. ESBLs target 3rd generation cephalosporin antibiotics, the most commonly prescribed medicine for gram-negative bacterial infections. As bacteria ... ...

    Abstract Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is a serious global threat. ESBLs target 3rd generation cephalosporin antibiotics, the most commonly prescribed medicine for gram-negative bacterial infections. As bacteria are prone to develop resistance against market-available ESBL inhibitors, finding a novel and effective inhibitor has become mandatory. Among ESBL, the worldwide reported two enzymes, CTX-M-15 and CTX-M-3, are selected for the present study. CTX-M-3 protein was modeled, and two thousand phyto-compounds were virtually screened against both proteins. After filtering through docking and pharmacokinetic properties, four phyto-compounds (catechin gallate, silibinin, luteolin, uvaol) were further selected for intermolecular contact analysis and molecular dynamics (MD) simulation. MD trajectory analysis results were compared, revealing that both catechin gallate and silibinin had a stabilizing effect against both proteins. Silibinin having the lowest docking score, also displayed the lowest MIC (128 µg/mL) against the bacterial strains. Silibinin was also reported to have synergistic activity with cefotaxime and proved to have bactericidal effect. Nitrocefin assay confirmed that silibinin could inhibit beta-lactamase enzyme only in living cells, unlike clavulanic acid. Thus the present study validated the CTX-M inhibitory activity of silibinin both
    MeSH term(s) Silybin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Enterobacteriaceae/metabolism ; Cefotaxime/pharmacology ; beta-Lactamases/metabolism ; Microbial Sensitivity Tests
    Chemical Substances Silybin (4RKY41TBTF) ; Anti-Bacterial Agents ; Cefotaxime (N2GI8B1GK7) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2192811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Re: "Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2" by Krsak

    Mishra, Bijaya Kumar / Bhattacharya, Debdutta / Kshatri, Jaya Singh / Pati, Sanghamitra

    Viral immunology

    2021  Volume 34, Issue 9, Page(s) 658

    MeSH term(s) Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/prevention & control ; Humans ; Immunity, Humoral ; SARS-CoV-2/immunology ; Seroepidemiologic Studies ; Time Factors ; Vaccination
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639075-4
    ISSN 1557-8976 ; 0882-8245
    ISSN (online) 1557-8976
    ISSN 0882-8245
    DOI 10.1089/vim.2021.0131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of Natural Product in Modulation of Drug Transporters and New Delhi Metallo-β Lactamases.

    Chandar, Brinda / Bhattacharya, Debdutta

    Current topics in medicinal chemistry

    2019  Volume 19, Issue 10, Page(s) 874–885

    Abstract: A rapid growth in drug resistance has brought options for treating antimicrobial resistance to a halt. Bacteria have evolved to accumulate a multitude of genes that encode resistance for a single drug within a single cell. Alternations of drug ... ...

    Abstract A rapid growth in drug resistance has brought options for treating antimicrobial resistance to a halt. Bacteria have evolved to accumulate a multitude of genes that encode resistance for a single drug within a single cell. Alternations of drug transporters are one of the causes for the development of resistance in drug interactions. Conversely, the production of enzymes also inactivates most antibiotics. The discovery of newer classes of antibiotics and drugs from natural products is urgently needed. Alternative medicines play an integral role in countries across the globe but many require validation for treatment strategies. It is essential to explore this chemical diversity in order to find novel drugs with specific activities which can be used as alternative drug targets. This review describes the interaction of drugs with resistant pathogens with a special focus on natural product-derived efflux pump and carbapenemase inhibitors.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/enzymology ; Biological Products/chemistry ; Biological Products/pharmacology ; Microbial Sensitivity Tests ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Biological Products ; beta-Lactamase Inhibitors ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase NDM-1 (EC 3.5.2.6)
    Language English
    Publishing date 2019-04-16
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1871529X19666190415110724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: One Health intervention for elimination of anthrax in an endemic district of Odisha: A baseline and endline study.

    Pattnaik, Matrujyoti / Choudhary, Hari Ram / Parai, Debaprasad / Shandilya, Jyoti / Padhi, Arun Kumar / Sahoo, Niranjana / Ghosal, Shishirendu / Sathpathy, Sarangdhar / Panigrahi, Santosh Kumar / Sahu, Susanta Kumar / Samantaray, Aurobindo / Pati, Sanghamitra / Bhattacharya, Debdutta

    One health (Amsterdam, Netherlands)

    2024  Volume 18, Page(s) 100729

    Abstract: Background: This study was to compare a baseline and endline survey which were conducted to assess the changes in knowledge, attitude and practices about anthrax disease among the communities after One Health intervention for the elimination of human ... ...

    Abstract Background: This study was to compare a baseline and endline survey which were conducted to assess the changes in knowledge, attitude and practices about anthrax disease among the communities after One Health intervention for the elimination of human anthrax in an endemic district of Odisha.
    Methods: A total of 2670 respondents were interviewed during the baseline and 2511 for the endline survey using a structured questionnaire by multi-stage sampling method. Descriptive statistics were used and logistic regression was performed to estimate the relationship between the variables and knowledge of anthrax.
    Results: Out of the total participants in the study, males were about 76.25% in baseline and 72.08% in endline and about half of the total respondents were illiterate. Majority of the respondents had reported agriculture as their main occupation during both surveys. More than 50% of the respondents had livestock in their houses and farming was the main purpose for keeping them in both surveys. Around 20.26% of respondents knew about anthrax in baseline which raised to 53.64% after One Health intervention. Almost 21.29% of livestock owners had vaccinated their animals against anthrax disease throughout baseline, which increased to 66.5% during the endline survey.
    Conclusion: This study highlights a significant surge in both knowledge and practices related to anthrax within the community after the implementation of intervention packages based on the One Health approach. The outcome of our study signified the importance of One Health interventions to address the health challenges related to zoonotic diseases in tribal communities. The data could be useful for local Governments to incorporate such an approach in their health policy to eliminate human anthrax.
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2024.100729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Antibacterial and genotoxic activity of Bixa orellana, a folk medicine and food supplement against multidrug resistant clinical isolates

    Kar, Bipasa / Chandar, Brinda / Rachana, Suman Smruti / Bhattacharya, Haimanti / Bhattacharya, Debdutta

    Journal of herbal medicine. 2022 Mar., v. 32

    2022  

    Abstract: Worldwide rapid spread of multi drug resistance among the community as well as healthcare associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. The current study aimed to find the ... ...

    Abstract Worldwide rapid spread of multi drug resistance among the community as well as healthcare associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. The current study aimed to find the antibacterial activity of hydro-ethanolic extract of Bixa orellana, the seed of which is frequently used as a food supplement. Multidrug resistant strains isolated from various outbreaks and sporadic cases of infectious diseases in various parts of the country like A&N Islands, Karnataka, Assam and Odisha were included in the study. The plant extract was tested for minimum inhibitory concentration (MIC) assay, synergistic activity, DNA damage, chemical constituent profiling using Gas Chromatography-Mass spectrometry (GC–MS). The zone of inhibition of the extract ranged from 13 to 25 mm and the MIC ranged from 512 to 2048 μg/mL against these pathogens. All the strains were initially resistant to ampicillin, however in combination with the plant extract, the MIC was reduced to 2–10 folds. DNA damage assay exhibited the cell damage capability against all these pathogens. The genotoxic effect of the plant extract was also established for the first time in the current study in B. orellana. GC–MS analysis of hydro-ethanolic extract from leaves of B. orellana showed the presence of 40 compounds which had not been previously reported from this plant. The present study demonstrates the antibacterial activity of a hydro-ethanolic extract from the leaves of B. orellana against multi-drug resistant pathogens alone and in combination with an antibiotic.
    Keywords Bixa orellana ; DNA damage ; ampicillin ; antibacterial properties ; dietary supplements ; drug therapy ; gas chromatography-mass spectrometry ; genotoxicity ; health services ; herbal medicines ; minimum inhibitory concentration ; multiple drug resistance ; synergism ; traditional medicine ; India
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier GmbH
    Document type Article
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2021.100502
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Use of Portable Automated Auditory Brainstem Responses in Universal Neonatal Hearing Screening: A Mixed-Method Study in Odisha, India.

    Sahoo, Krushna Chandra / Athe, Ramesh / Bhattacharya, Debdutta / Dwivedi, Rinshu / Sahoo, Rakesh Kumar / Aimol, Lanu Wanboy / Jain, Shalu / Rajsekhar, Kavitha / Pati, Sanghamitra

    Indian journal of pediatrics

    2023  Volume 90, Issue 3, Page(s) 298–300

    Abstract: Hearing loss in children affects cognitive development, so early detection is crucial. It is because of the lack of portable technology that the majority of hearing problems go undetected. The authors conducted a mixed-method study in India to examine ... ...

    Abstract Hearing loss in children affects cognitive development, so early detection is crucial. It is because of the lack of portable technology that the majority of hearing problems go undetected. The authors conducted a mixed-method study in India to examine the concurrent validity and operational feasibility of portable automated brainstem response (P-AABR) and otoacoustic emissions (OAE) in universal neonatal hearing screening. They screened 198 children's ears using ABR and OAE devices. Additionally, 60 observations were recorded during the 'portable automated ABR' screening process. The hearing screening could be performed with P-AABR by any health care staff with basic skill-based training. However, the interpretation of the graphical wave required an audiologist. If the baby was quiet, the test could be performed in 20 min, including electrode implantation, impediment setting, earphone installation, and swipe counts. The P-AABR device can be used in the universal health coverage of hearing screening among infants in outreach areas due to its portability and minimal infrastructural requirements.
    MeSH term(s) Infant, Newborn ; Infant ; Child ; Humans ; Evoked Potentials, Auditory, Brain Stem/physiology ; Neonatal Screening/methods ; Hearing Loss ; Deafness ; Otoacoustic Emissions, Spontaneous ; India
    Language English
    Publishing date 2023-01-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-022-04435-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of phytocompounds as newer antiviral drugs against COVID-19 through molecular docking and simulation based study.

    Kar, Bipasa / Dehury, Budheswar / Singh, Mahender Kumar / Pati, Sanghamitra / Bhattacharya, Debdutta

    Journal of molecular graphics & modelling

    2022  Volume 114, Page(s) 108192

    Abstract: COVID-19 pandemic has emerged as a global threat with its highly contagious and mutating nature. Several existing antiviral drugs has been worked on, without proper results and meanwhile the virus is mutating rapidly to create more infectious variant. In ...

    Abstract COVID-19 pandemic has emerged as a global threat with its highly contagious and mutating nature. Several existing antiviral drugs has been worked on, without proper results and meanwhile the virus is mutating rapidly to create more infectious variant. In order to find some alternatives, phytocompounds can be opted as good one. In this study, three hundred phytocompounds were screened virtually against two viral proteins namely main protease and spike protein. Molecular docking and dynamic simulation study was used to find binding affinity, structural stability and flexibility of the complex. Pharmacokinetic properties were studied through ADMET analysis. To understand energy variation of the complex structure free energy landscape analysis was performed. Among three hundred phytocompounds virtual screening, three phytocompounds were selected for detailed molecular interaction analysis. Oleanderolide, Proceragenin A and Balsaminone A, showed strong binding affinity against both the target proteins and reflected conformational stability throughout the MD run. Oleanderolide, proceragenin A and balsaminone A has docking score -9.4 kcal/mol, -8.6 kcal/mol, and -8.1 kcal/mol respectively against main protease and same -8.3 kcal/mol docking score against spike protein. These three phytocompounds has high gastrointestinal absorption capacity. They were unexplored till now for their antiviral activity. Their promising in silico results suggests that they can be promoted in the long run for development of new antiviral drugs.
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Peptide Hydrolases ; Spike Glycoprotein, Coronavirus/chemistry
    Chemical Substances Antiviral Agents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2022.108192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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