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Article ; Conference proceedings: Optimization of the cultivation of different ecotypes of Sarcocornia perennis L

Castañeda-Loaiza, V / João Rodrigues, M / Fernandes, L / Custódio, L

2022 Volume 88, Issue 15

Event/congress	GA - 70th Annual Meeting 2022, Thessaloniki, Greece, 2022-08-28
Language	English
Publishing date	2022-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0042-1759070
Database	Thieme publisher's database

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Article ; Online: First of report of occurrence and damage of Synoeca cyanea (Hymenoptera: Vespidae) on Mangifera indica L. in Brazil.

Rocha, E A A / Silva, L F / Fernandes, M E S / Macedo, A F / Soares, C S / Pereira, R C / Fernandes, F L

Brazilian journal of biology = Revista brasleira de biologia

2023 Volume 83, Page(s) e275126

MeSH term(s)	Animals ; Hymenoptera ; Mangifera ; Brazil ; Wasps ; Plant Extracts
Chemical Substances	Plant Extracts
Language	English
Publishing date	2023-10-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.275126
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Article ; Online: Effects of different probiotic strains B. lactis, L. rhamnosus and L. reuteri on brain-intestinal axis immunomodulation in an endotoxin-induced inflammation.

Michels, Monique / Jesus, Gabriel Fernandes Alves / Abatti, Mariane Rocha / Córneo, Emily / Cucker, Luana / de Medeiros Borges, Heloisa / da Silva Matos, Natan / Rocha, Luana Bezerra / Dias, Rodrigo / Simon, Carla Sasso / Voytena, Ana Paula Lorenzen / Rossetto, Marina / Ramlov, Fernanda / Dal-Pizzol, Felipe

Molecular neurobiology

2022 Volume 59, Issue 8, Page(s) 5168–5178

Abstract: ... distributed into five groups: control; lipopolysaccharide (LPS); LPS + B. lactis (LACT GB™); LPS + L ... rhamnosus (RHAM GB™); and LPS + L. reuteri (REUT GB™). The animals were supplemented with their respective ...

Abstract	The study evaluated the effects of supplementation with three different probiotic strains Bifidobacterium lactis (LACT GB™), Lactobacillus rhamnosus (RHAM GB™) and Lactobacillus reuteri (REUT GB™) on brain-intestinal immunomodulation in an animal model of LPS-induced inflammation. Fifty mice Balb/C were distributed into five groups: control; lipopolysaccharide (LPS); LPS + B. lactis (LACT GB™); LPS + L. rhamnosus (RHAM GB™); and LPS + L. reuteri (REUT GB™). The animals were supplemented with their respective probiotic microorganisms daily, for 30 days, at a concentration of 1 × 10
MeSH term(s)	Animals ; Brain ; Endotoxins ; Immunomodulation ; Inflammation ; Lactobacillus reuteri ; Lipopolysaccharides/pharmacology ; Mice ; Probiotics/pharmacology ; Probiotics/therapeutic use
Chemical Substances	Endotoxins ; Lipopolysaccharides
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-022-02906-3
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Article ; Conference proceedings: In vitro propagation of the aromatic edible halophyte Inula crithmoides L.

Rodrigues, Maria / Castañeda-Loaiza, Viana / Fernandes, Eliana / Custódio, Luísa

Planta Medica

2023 Volume 89, Issue 14

Event/congress	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
Language	English
Publishing date	2023-11-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0043-1774099
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Article ; Conference proceedings: Unravelling the ecotype influence on metabolomics and toxicity of Corema album L.

Fernandes, Eliana / Trentin, Riccardo Trentin / Rodrigues, Maria João / Custódio, Luís

Planta Medica

2023 Volume 89, Issue 14

Event/congress	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
Language	English
Publishing date	2023-11-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0043-1773963
Database	Thieme publisher's database

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Article ; Online: Bothrops snake venom L-amino acid oxidases impair biofilm formation of clinically relevant bacteria.

Alves de Melo Fernandes, Thales / Rafaella Costa, Tássia / de Paula Menezes, Ralciane / Arantes de Souza, Meliza / Gomes Martins, Carlos Henrique / Junior, Nilson Nicolau / Gobbi Amorim, Fernanda / Quinton, Loïc / Polloni, Lorena / Teixeira, Samuel Cota / Amália Vieira Ferro, Eloisa / Soares, Andreimar Martins / de Melo Rodrigues Ávila, Veridiana

Toxicon : official journal of the International Society on Toxinology

2023 Volume 238, Page(s) 107569

Abstract: The present work addressed the abilities of two L-amino acid oxidases isolated from Bothrops ...

Abstract	The present work addressed the abilities of two L-amino acid oxidases isolated from Bothrops moojeni (BmooLAAO-I) and Bothrops jararacussu (BjussuLAAO-II) snake venoms to control the growth and prevent the biofilm formation of clinically relevant bacterial pathogens. Upon S. aureus (ATCC BAA44) and S. aureus (clinical isolates), BmooLAAO-I (MIC = 0.12 and 0.24 μg/mL, respectively) and BjussuLAAO-II (MIC = 0.15 μg/mL) showed a potent bacteriostatic effect. Against E. coli (ATCC BAA198) and E. coli (clinical isolates), BmooLAAO-I (MIC = 15.6 and 62.5 μg/mL, respectively) and BjussuLAAO-II (MIC = 4.88 and 9.76 μg/mL, respectively) presented a lower extent effect. Also, BmooLAAO-I (MICB
MeSH term(s)	Animals ; Crotalid Venoms/toxicity ; L-Amino Acid Oxidase/pharmacology ; L-Amino Acid Oxidase/chemistry ; Staphylococcus aureus ; Escherichia coli ; Bothrops ; Snake Venoms/chemistry ; Bacteria ; Biofilms ; Venomous Snakes
Chemical Substances	Crotalid Venoms ; L-Amino Acid Oxidase (EC 1.4.3.2) ; Snake Venoms
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107569
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Article ; Online: The leaf of Agapanthus africanus (L.) Hoffm.: A physical-chemical perspective of terrestrialization in the cuticle

Nunes, P. / Nunes, S.C. / Pereira, R.F.P. / Cruz, R. / Rocha, J. / Ravishankar, A.P. / Fernandes, L. / Bacelar, E. / Casal, S. / Anand, S. / Crespí, A.L. / Fernandes, M. / de Zea Bermudez, V.

Environmental and Experimental Botany. 2023 Apr., v. 208 p.105240-

2023

Abstract: Although Agapanthus africanus (L.) Hoffm. is one of the most popular ornamental species ...

Abstract	Although Agapanthus africanus (L.) Hoffm. is one of the most popular ornamental species in both hemispheres, it has an extremely restricted wild occurrence (Cape province, South Africa). This contradiction between generalized ornamental application and natural distribution was the basis for the analytical approach adopted in the present work. We hypothesized that characteristic features of the cuticular waxes were adopted by this species to help it cope with severe dehydration associated with marine salinity on account of the short distance of the wild populations to the sea. A comprehensive morpho-anatomical, histological and physical-chemical analysis was performed on the epicuticular and intracuticular layers of the adaxial and abaxial surfaces of leaves of specimens of A. africanus. The adaxial epicuticular surface is hydrophilic and the abaxial epicuticular surface exhibits globally hydrophobic behavior. The main chemical compounds detected in the wax layers of both surfaces of the leaf are the short-chain monocaprylin monoglyceride (C8), and very long-chain 1-hexacosanol (C26) and 1-octacosanol (C28) alcohols. While monocaprylin is particularly abundant in the intracuticular layers, the epicuticular adaxial surface revealed the highest concentration of both alcohols. We demonstrate that the smart combination of these two classes of molecules with opposite water affinity endows the A. africanus leaf cuticle with a unique water management system combining the efficient entrapment of water in the disordered α-gel phase formed by monocaprylin and the high resistance to water transport provided by ordered domains composed of tightly packed, all-trans alkyl chains of the above pair of alcohols. The remarkable structural similarity existing between the monocaprylin α-gel and the mucilage of algae is an evidence of the terrestrialization process.
Keywords	Agapanthus africanus ; analytical methods ; geographical distribution ; histology ; hydrophilicity ; hydrophobicity ; leaves ; management systems ; monoacylglycerols ; mucilages ; salinity ; water management ; South Africa ; Leaf ; Cuticle ; Wax ; Monocaprylin α-gel ; 1-Hexacosanol ; 1-Octacosanol ; Sclerophyllization
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	195968-2
ISSN	0098-8472
ISSN	0098-8472
DOI	10.1016/j.envexpbot.2023.105240
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-

C de S L Oliveira, Ana Luiza / Araújo Júnior, Raimundo Fernandes de / Gomes de Carvalho, Thaís / B Chan, Alan / Schomann, Timo / Tamburini, Filippo / de Geus-Oei, Lioe-Fee / J Cruz, Luis

Pharmaceutics

2020 Volume 12, Issue 2

Abstract: ... cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide- ...

Abstract	Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-
Language	English
Publishing date	2020-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics12020193
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Article ; Online: L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor.

Lima, Kaio Ramon de Aguiar / Lopes, Maria Luiza Diniz de Sousa / Souza, Sara Raquel Garcia de / Fracaro, Luciane / Purificação, Natan Reyges Castro da / Lima, Marília Fabiana de Oliveira / Lins, Lucas Alexandre Araújo / Lacchini, Silvia / Araújo, Aurigena Antunes de / Araújo Júnior, Raimundo Fernandes de / Perles, Juliana Vanessa Colombo Martins / Zanoni, Jacqueline Nelisis / Clebis, Naianne Kelly

Acta cirurgica brasileira

2023 Volume 38, Page(s) e383923

Abstract: Purpose: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine ... distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with Walker ... 256 tumor (WT); and rats with Walker-256 tumor treated with 2% L-glutamine (WTG). Renal histological ...

Abstract	Purpose: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine supplementation, an antioxidant, on the glomerular morphology of rats. Methods: Twenty Wistar rats were distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with Walker-256 tumor (WT); and rats with Walker-256 tumor treated with 2% L-glutamine (WTG). Renal histological samples were submitted to periodic acid-Schiff and Masson's Trichrome staining to analyze glomerular density, morphometry of glomerular components and glomerulosclerosis; and to immunohistochemistry for fibroblast growth factor-2 (FGF-2). Results: WT showed 50% reduction in body mass gain and cachexia index > 10%, while WTG demonstrated reduction in cachexia (p < 0.05). WT revealed reduction of glomerular density, increase in the glomerular tuft area, mesangial area, matrix in the glomerular tuft, decrease in the urinary space and synechia, and consequently higher glomerulosclerosis (p < 0.05). L-glutamine supplementation in the WTG improved glomerular density, and reduced glomerular tuft area, urinary space, mesangial area, and glomerulosclerosis compared to WT(p < 0.05). WT showed higher collagen area and FGF-2 expression compared to C (p < 0.05). WTG presented lower collagen fibers and FGF-2 expression compared to WT (p < 0.05). Conclusions: L-glutamine supplementation reduced cachexia and was beneficial for glomerular morphology of the rats, as well as it reduced kidney damage and improved the remaining glomeruli morphology.
MeSH term(s)	Rats ; Animals ; Rats, Wistar ; Glutamine/pharmacology ; Cachexia/metabolism ; Cachexia/pathology ; Fibroblast Growth Factor 2 ; Neoplasms ; Dietary Supplements ; Collagen
Chemical Substances	Glutamine (0RH81L854J) ; Fibroblast Growth Factor 2 (103107-01-3) ; Collagen (9007-34-5)
Language	English
Publishing date	2023-10-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 1678-2674
ISSN (online)	1678-2674
ISSN	1678-2674
DOI	10.1590/acb383923
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Article ; Online: Mechanical writing of electrical polarization in poly (L-lactic) acid.

Barroca, Nathalie / Collins, Liam / Rodriguez, Brian J / Fernandes, M Helena V / Vilarinho, Paula M

Acta biomaterialia

2021 Volume 139, Page(s) 249–258

Abstract: ... to biomolecular sensors. Here, we report the production of poly (L-lactic acid) (PLLA) thin films that exhibit ... the fabrication of poly(L-lactic) acid platforms that exhibit a mechanical stress responsive behaviour ...

Abstract	Stimuli responsive materials are found in a broad range of applications, from energy harvesters to biomolecular sensors. Here, we report the production of poly (L-lactic acid) (PLLA) thin films that exhibit a mechanical stress responsive behaviour. By simply applying a mechanical stress through an AFM tip, a local electrical polarization was generated and measured by Kelvin Probe Force Microscopy. We showed that the magnitude of the stress generated electrical polarization can be manipulated by varying the thickness or crystallization state of the PLLA thin films. Besides exhibiting a mechanical stress-response behaviour with potential for energy harvesting and sensor applications, we show by AFM that these platforms react to mechanical forces with physiological relevance: interaction forces as low as a cell sheet migrating over a substrate or larger ones as the fluid induced stresses in bone tissue. In living tissues, as most mechanical stimuli are transduced as strain gradients for the anatomical structures, these mechanically responsive substrates can be used as ex vivo platforms to study the protein and cells response over a large range of electrical stimuli amplitude. As a proof of concept, selective adsorption of a human fibronectin was demonstrated by local patterning of the stimuli responsive PLLA films. STATEMENT OF SIGNIFICANCE: Bioelectricity is inherent to the formation and repair of living tissues and electrical stimulation has been recognized for promoting regeneration. Given the proven beneficial effects of electric fields and the absence of a suitable method of stimulation, there is a clinical need for smart substrates, which can generate a polarization (charges) to promote tissue regeneration without the need of external devices. In this work, we report the fabrication of poly(L-lactic) acid platforms that exhibit a mechanical stress responsive behaviour when subjected to physiologically relevant forces. This behaviour can be tailored by varying the thickness or crystallization state of the PLLA films. We further demonstrate the biofunctionality of such platforms by exploiting the mechanically-induced charge for adhesion protein adsorption.
MeSH term(s)	Electricity ; Humans ; Mechanical Phenomena ; Microscopy, Atomic Force ; Polyesters/chemistry ; Polymers/chemistry ; Writing
Chemical Substances	Polyesters ; Polymers
Language	English
Publishing date	2021-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2021.05.057
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