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Book ; Online: Social Development in the World Bank : Essays in Honor of Michael M. Cernea

Koch-Weser, Maritta / Guggenheim, Scott

2021

Keywords	Society & social sciences ; Development studies ; Central government policies ; Sociology ; Social Sciences, general ; Development Studies ; Environmental Policy ; Sociology, general ; Sociological Methods ; Environmental Social Sciences ; Social Development ; World Bank ; International Development Aid ; Development Anthropology ; Sustainable Development ; Open Access ; Society & Social Sciences ; Central / national / federal government policies
Size	1 electronic resource (368 pages)
Publisher	Springer Nature
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047352
ISBN	9783030574260 ; 3030574261
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Reinvestigating the clinical relevance of the m

Koch, Jonas / Neuberger, Manuel / Schmidt-Dengler, Martina / Xu, Jinyun / Carneiro, Vitor Coutinho / Ellinger, Jörg / Kriegmair, Maximilian C / Nuhn, Philipp / Erben, Philipp / Michel, Maurice Stephan / Helm, Mark / Rodríguez-Paredes, Manuel / Nientiedt, Malin / Lyko, Frank

iScience

2023 Volume 26, Issue 8, Page(s) 107300

Abstract: METTL3 is the major writer of N6-Methyladenosine (m ...

Abstract	METTL3 is the major writer of N6-Methyladenosine (m
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107300
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Article ; Online: Downregulation of the FTO m

Jeschke, Jana / Collignon, Evelyne / Al Wardi, Clémence / Krayem, Mohammad / Bizet, Martin / Jia, Yan / Garaud, Soizic / Wimana, Zéna / Calonne, Emilie / Hassabi, Bouchra / Morandini, Renato / Deplus, Rachel / Putmans, Pascale / Dube, Gaurav / Singh, Nitesh Kumar / Koch, Alexander / Shostak, Kateryna / Rizzotto, Lara / Ross, Robert L /

Desmedt, Christine / Bareche, Yacine / Rothé, Françoise / Lehmann-Che, Jacqueline / Duterque-Coquillaud, Martine / Leroy, Xavier / Menschaert, Gerben / Teixeira, Luis / Guo, Mingzhou / Limbach, Patrick A / Close, Pierre / Chariot, Alain / Leucci, Eleonora / Ghanem, Ghanem / Yuan, Bi-Feng / Willard-Gallo, Karen / Sotiriou, Christos / Marine, Jean-Christophe / Fuks, François

Nature cancer

2021 Volume 2, Issue 6, Page(s) 611–628

Abstract: Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene expression. The demethylase fat mass- and obesity-associated protein (FTO), an eraser of ... ...

Abstract	Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene expression. The demethylase fat mass- and obesity-associated protein (FTO), an eraser of N
MeSH term(s)	Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Animals ; Down-Regulation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Humans ; Mice ; Neoplasms, Glandular and Epithelial ; RNA
Chemical Substances	RNA (63231-63-0) ; FTO protein, mouse (EC 1.14.11.-) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-021-00223-7
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Article ; Online: Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant.

Blickhäuser, Beryll / Stenton, Sarah L / Neuhofer, Christiane M / Floride, Elisa / Nesbitt, Victoria / Fratter, Carl / Koch, Johannes / Kauffmann, Birgit / Catarino, Claudia / Schlieben, Lea Dewi / Kopajtich, Robert / Carelli, Valerio / Sadun, Alfredo A / McFarland, Robert / Fang, Fang / La Morgia, Chiara / Paquay, Stéphanie / Nassogne, Marie Cécile / Ghezzi, Daniele /

Lamperti, Costanza / Wortmann, Saskia / Poulton, Jo / Klopstock, Thomas / Prokisch, Holger

Brain : a journal of neurology

2024

Abstract: ... Leber hereditary optic neuropathy (LHON) variants of the mtDNA, coding for CI subunits (m.3460G>A in MT-ND1, m.11778G>A in MT-ND4 ... and m.14484T>C in MT-ND6). The underlying mechanism by which these variants manifest as LSS, a severe ... co-occurrence of the m.11778G>A variant with damaging heterozygous variants in nuclear disease genes ...

Abstract	Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterised by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA (mtDNA) genes and more than 100 nuclear genes, most often related to mitochondrial complex I (CI) dysfunction. Rarely, LSS has been reported in association with primary Leber hereditary optic neuropathy (LHON) variants of the mtDNA, coding for CI subunits (m.3460G>A in MT-ND1, m.11778G>A in MT-ND4, and m.14484T>C in MT-ND6). The underlying mechanism by which these variants manifest as LSS, a severe neurodegenerative disease, as opposed to the LHON phenotype of isolated optic neuropathy, remains an open question. Here, we analyse the exome sequencing of six probands with LSS carrying primary LHON variants, and report digenic co-occurrence of the m.11778G>A variant with damaging heterozygous variants in nuclear disease genes encoding CI subunits as a plausible explanation. Our findings suggest a digenic mechanism of disease for m.11778G>A-associated LSS, consistent with recent reports of digenic disease in individuals manifesting with LSS due to biallelic variants in the recessive LHON-associated disease gene DNAJC30 in combination with heterozygous variants in CI subunits.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awae057
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Article ; Online: In Memoriam: Robert M. Stern.

Koch, Kenneth L / Ray, William J / Gianaros, Peter J / Levine, Max E / Muth, Eric R

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2020 Volume 32, Issue 9, Page(s) e13970

Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Editorial
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.13970
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Article ; Online: GW190521: A Binary Black Hole Merger with a Total Mass of 150 M_{⊙}.

Abbott, R / Abbott, T D / Abraham, S / Acernese, F / Ackley, K / Adams, C / Adhikari, R X / Adya, V B / Affeldt, C / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aich, A / Aiello, L / Ain, A / Ajith, P / Akcay, S / Allen, G /

Allocca, A / Altin, P A / Amato, A / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Ansoldi, S / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ascenzi, S / Ashton, G / Aston, S M / Astone, P / Aubin, F / Aufmuth, P / AultONeal, K / Austin, C / Avendano, V / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baer, A M / Baird, J / Baldaccini, F / Ballardin, G / Ballmer, S W / Bals, A / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Bankar, R S / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barkett, K / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Benjamin, M G / Bentley, J D / Bergamin, F / Berger, B K / Bergmann, G / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bhandari, A V / Bidler, J / Biggs, E / Bilenko, I A / Billingsley, G / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Bissenbayeva, G / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, S / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brighenti, F / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callaghan, J D / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Cannon, K C / Cao, H / Cao, J / Carapella, G / Carbognani, F / Caride, S / Carney, M F / Carullo, G / Casanueva Diaz, J / Casentini, C / Castañeda, J / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, O / Chakravarti, K / Chan, C / Chan, M / Chandra, K / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, D / Chaturvedi, M / Chatziioannou, K / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Cheong, C K / Chia, H Y / Chiadini, F / Chierici, R / Chincarini, A / Chiummo, A / Cho, G / Cho, H S / Cho, M / Christensen, N / Chu, Q / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciecielag, P / Cieślar, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Cohadon, P-F / Cohen, D / Colleoni, M / Collette, C G / Collins, C / Colpi, M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Croquette, M / Crowder, S G / Cudell, J-R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curylo, M / Canton, T Dal / Dálya, G / Dana, A / Daneshgaran-Bajastani, L M / D'Angelo, B / Danilishin, S L / D'Antonio, S / Danzmann, K / Darsow-Fromm, C / Dasgupta, A / Datrier, L E H / Dattilo, V / Dave, I / Davier, M / Davies, G S / Davis, D / Daw, E J / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Delfavero, M / De Lillo, N / Del Pozzo, W / DeMarchi, L M / D'Emilio, V / Demos, N / Dent, T / De Pietri, R / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Diaz-Ortiz, M / Dietrich, T / Di Fiore, L / Di Fronzo, C / Di Giorgio, C / Di Giovanni, F / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Divakarla, A K / Dmitriev, A / Doctor, Z / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Downes, T P / Drago, M / Driggers, J C / Du, Z / Ducoin, J-G / Dupej, P / Durante, O / D'Urso, D / Dwyer, S E / Easter, P J / Eddolls, G / Edelman, B / Edo, T B / Edy, O / Effler, A / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Ejlli, A / Errico, L / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Ewing, B E / Fafone, V / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fazio, M / Feicht, J / Fejer, M M / Feng, F / Fenyvesi, E / Ferguson, D L / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferreira, T A / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fittipaldi, R / Fitz-Axen, M / Fiumara, V / Flaminio, R / Floden, E / Flynn, E / Fong, H / Font, J A / Forsyth, P W F / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fronzè, G / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Galaudage, S / Ganapathy, D / Ganguly, A / Gaonkar, S G / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Gibson, D R / Gier, C / Gill, K / Glanzer, J / Gniesmer, J / Godwin, P / Goetz, E / Goetz, R / Gohlke, N / Goncharov, B / González, G / Gopakumar, A / Gossan, S E / Gosselin, M / Gouaty, R / Grace, B / Grado, A / Granata, M / Grant, A / Gras, S / Grassia, P / Gray, C / Gray, R / Greco, G / Green, A C / Green, R / Gretarsson, E M / Griggs, H L / Grignani, G / Grimaldi, A / Grimm, S J / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Guimaraes, A R / Guixé, G / Gulati, H K / Guo, Y / Gupta, A / Gupta, Anchal / Gupta, P / Gustafson, E K / Gustafson, R / Haegel, L / Halim, O / Hall, E D / Hamilton, E Z / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hansen, T J / Hanson, J / Harder, T / Hardwick, T / Haris, K / Harms, J / Harry, G M / Harry, I W / Hasskew, R K / Haster, C-J / Haughian, K / Hayes, F J / Healy, J / Heidmann, A / Heintze, M C / Heinze, J / Heitmann, H / Hellman, F / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennes, E / Hennig, J / Heurs, M / Hild, S / Hinderer, T / Hoback, S Y / Hochheim, S / Hofgard, E / Hofman, D / Holgado, A M / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Howell, E J / Hoy, C G / Huang, Y / Hübner, M T / Huerta, E A / Huet, D / Hughey, B / Hui, V / Husa, S / Huttner, S H / Huxford, R / Huynh-Dinh, T / Idzkowski, B / Iess, A / Inchauspe, H / Ingram, C / Intini, G / Isac, J-M / Isi, M / Iyer, B R / Jacqmin, T / Jadhav, S J / Jadhav, S P / James, A L / Jani, K / Janthalur, N N / Jaranowski, P / Jariwala, D / Jaume, R / Jenkins, A C / Jiang, J / Johns, G R / Johnson-McDaniel, N K / Jones, A W / Jones, D I / Jones, J D / Jones, P / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Kashyap, R / Kasprzack, M / Kastaun, W / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Kéfélian, F / Keitel, D / Keivani, A / Kennedy, R / Key, J S / Khadka, S / Khalili, F Y / Khan, I / Khan, S / Khan, Z A / Khazanov, E A / Khetan, N / Khursheed, M / Kijbunchoo, N / Kim, Chunglee / Kim, G J / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / Kimball, C / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Knyazev, E / Koch, P / Koehlenbeck, S M / Koekoek, G / Koley, S / Kondrashov, V / Kontos, A / Koper, N / Korobko, M / Korth, W Z / Kovalam, M / Kozak, D B / Kringel, V / Krishnendu, N V / Królak, A / Krupinski, N / Kuehn, G / Kumar, A / Kumar, P / Kumar, Rahul / Kumar, Rakesh / Kumar, S / Kuo, L / Kutynia, A / Lackey, B D / Laghi, D / Lalande, E / Lam, T L / Lamberts, A / Landry, M / Lane, B B / Lang, R N / Lange, J / Lantz, B / Lanza, R K / La Rosa, I / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lecoeuche, Y K / Lee, C H / Lee, H M / Lee, H W / Lee, J / Lee, K / Lehmann, J / Leroy, N / Letendre, N / Levin, Y / Li, A K Y / Li, J / Li, K / Li, T G F / Li, X / Linde, F / Linker, S D / Linley, J N / Littenberg, T B / Liu, J / Liu, X / Llorens-Monteagudo, M / Lo, R K L / Lockwood, A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lousto, C O / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Ma, Y / Macas, R / Macfoy, S / MacInnis, M / Macleod, D M / MacMillan, I A O / Macquet, A / Magaña Hernandez, I / Magaña-Sandoval, F / Magee, R M / Majorana, E / Maksimovic, I / Malik, A / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Mapelli, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Marsat, S / Martelli, F / Martin, I W / Martin, R M / Martinez, V / Martynov, D V / Masalehdan, H / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Mavalvala, N / Maynard, E / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIsaac, C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Mehta, A K / Mejuto Villa, E / Melatos, A / Mendell, G / Mercer, R A / Mereni, L / Merfeld, K / Merilh, E L / Merritt, J D / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Meylahn, F / Mhaske, A / Miani, A / Miao, H / Michaloliakos, I / Michel, C / Middleton, H / Milano, L / Miller, A L / Millhouse, M / Mills, J C / Milotti, E / Milovich-Goff, M C / Minazzoli, O / Minenkov, Y / Mishkin, A / Mishra, C / Mistry, T / Mitra, S / Mitrofanov, V P / Mitselmakher, G / Mittleman, R / Mo, G / Mogushi, K / Mohapatra, S R P / Mohite, S R / Molina-Ruiz, M / Mondin, M / Montani, M / Moore, C J / Moraru, D / Morawski, F / Moreno, G / Morisaki, S / Mours, B / Mow-Lowry, C M / Mozzon, S / Muciaccia, F / Mukherjee, Arunava / Mukherjee, D / Mukherjee, S / Mukherjee, Subroto / Mukund, N / Mullavey, A / Munch, J / Muñiz, E A / Murray, P G / Nagar, A / Nardecchia, I / Naticchioni, L / Nayak, R K / Neil, B F / Neilson, J / Nelemans, G / Nelson, T J N / Nery, M / Neunzert, A / Ng, K Y / Ng, S / Nguyen, C / Nguyen, P / Nichols, D / Nichols, S A / Nissanke, S / Nitz, A / Nocera, F / Noh, M / North, C / Nothard, D / Nuttall, L K / Oberling, J / O'Brien, B D / Oganesyan, G / Ogin, G H / Oh, J J / Oh, S H / Ohme, F / Ohta, H / Okada, M A / Oliver, M / Olivetto, C / Oppermann, P / Oram, Richard J / O'Reilly, B / Ormiston, R G / Ortega, L F / O'Shaughnessy, R / Ossokine, S / Osthelder, C / Ottaway, D J / Overmier, H / Owen, B J / Pace, A E / Pagano, G / Page, M A / Pagliaroli, G / Pai, A / Pai, S A / Palamos, J R / Palashov, O / Palomba, C / Pan, H / Panda, P K / Pang, P T H / Pankow, C / Pannarale, F / Pant, B C / Paoletti, F / Paoli, A / Parida, A / Parker, W / Pascucci, D / Pasqualetti, A / Passaquieti, R / Passuello, D / Patricelli, B / Payne, E / Pearlstone, B L / Pechsiri, T C / Pedersen, A J / Pedraza, M / Pele, A / Penn, S / Perego, A / Perez, C J / Périgois, C / Perreca, A / Perriès, S / Petermann, J / Pfeiffer, H P / Phelps, M / Phukon, K S / Piccinni, O J / Pichot, M / Piendibene, M / Piergiovanni, F / Pierro, V / Pillant, G / Pinard, L / Pinto, I M / Piotrzkowski, K / Pirello, M / Pitkin, M / Plastino, W / Poggiani, R / Pong, D Y T / Ponrathnam, S / Popolizio, P / Porter, E K / Powell, J / Prajapati, A K / Prasai, K / Prasanna, R / Pratten, G / 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Physical review letters

2021 Volume 125, Issue 10, Page(s) 101102

Abstract: ... with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer ... with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16 ... 28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance ...

Abstract	On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.101102
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Article ; Online: Non-invasive assessment of left ventricular relaxation property using color M-mode-derived intraventricular pressure gradients in cats.

Matsuura, K / Bach, M B T / Takahashi, K / Willesen, J L / Koch, J / Tanaka, R

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

2022 Volume 41, Page(s) 236–248

Abstract: ... intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode-derived IVPG ... cross-sectional study. Quantitative analysis of color Doppler M-mode images was used to estimate total and segmental ... in feline HCM are needed to evaluate the clinical applicability of color Doppler M-mode estimated IVPGs ...

Abstract	Introduction: Diastolic dysfunction is an early clinical feature of feline hypertrophic cardiomyopathy (HCM). The left ventricular filling in early diastole is facilitated by the diastolic intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode-derived IVPG calculation in cats as a non-invasive assessment of the left ventricular relaxation property to determine the normal ranges of peak IVPG in cats and investigate the influence of left ventricular function and heart rate (HR). Animals: One hundred and six client-owned apparently healthy cats. Methods: Prospective cross-sectional study. Quantitative analysis of color Doppler M-mode images was used to estimate total and segmental IVPGs non-invasively. Results: The total IVPG was 0.76 mmHg (95% reference interval (RI): 0.28-1.29 mmHg), the basal IVPG 0.34 mmHg (95% RI: 0.07-0.63 mmHg), and the mid-apical IVPG 0.42 mmHg (95% RI: 0.15-0.71 mmHg). Total and segmental IVPG increased with HR (P < 0.003), while segmental percent IVPG was HR independent. A short isovolumic relaxation time (IVRT) and a high mitral annular velocity in early diastole were associated with an increase in total IVPG (P = 0.008 and P = 0.009, respectively) adjusted for HR. An increase in IVPG was associated with an increase in mitral inflow velocity (P < 0.001). Conclusions: Feline IVPGs increase with HR and a short IVRT, which was believed to be a normal physiologic adrenergic response associated with an increased sympathetic tone. Future studies of segmental IVPG changes in feline HCM are needed to evaluate the clinical applicability of color Doppler M-mode estimated IVPGs in feline cardiology.
MeSH term(s)	Animals ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/veterinary ; Cat Diseases/diagnostic imaging ; Cats ; Cross-Sectional Studies ; Diastole/physiology ; Echocardiography, Doppler/veterinary ; Heart Rate ; Heart Ventricles/diagnostic imaging ; Prospective Studies ; Ventricular Function, Left/physiology ; Ventricular Pressure/physiology
Language	English
Publishing date	2022-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2198278-8
ISSN	1875-0834 ; 1760-2734
ISSN (online)	1875-0834
ISSN	1760-2734
DOI	10.1016/j.jvc.2022.03.006
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Article ; Online: Nicolas Guay, M.D., 1968 to 2020.

Taub, Peter J / Koch, R Michael

Plastic and reconstructive surgery

2021 Volume 149, Issue 2, Page(s) 529

Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000008802
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Article ; Online: “It feels like I’m coming to a friend’s house”

Sophia Dobischok / José R. Carvajal / Kyle Turner / Kaitlyn Jaffe / Eisha Lehal / Sarinn Blawatt / Casey Redquest / Rosalind Baltzer Turje / Patrick McDougall / Bryce Koch / Cheryl McDermid / Damon Hassan / Scott Harrison / Eugenia Oviedo-Joekes

Addiction Science & Clinical Practice, Vol 18, Iss 1, Pp 1-

an interpretive descriptive study of an integrated care site offering iOAT (Dr. Peter Centre)

2023 Volume 12

Abstract: Abstract Background Injectable opioid agonist treatment (iOAT) has proven to be a safe and effective treatment option for severe opioid use disorder (OUD). Yet, iOAT is often isolated from other health and social services. To align with a person-centered ...

Abstract	Abstract Background Injectable opioid agonist treatment (iOAT) has proven to be a safe and effective treatment option for severe opioid use disorder (OUD). Yet, iOAT is often isolated from other health and social services. To align with a person-centered care approach, iOAT can be embedded in sites that combine systems and services that have been historically fragmented and that address multiple comorbidities (integrated care sites). The present study investigates the addition of iOAT at an integrated care in Vancouver, British Columbia. We aimed to capture what it means for service users and service providers to incorporate iOAT in an integrated care site and describe the processes by which the site keeps people engaged. Methods We conducted 22 interviews with 15 service users and 14 interviews with 13 service providers across two rounds of individual semi-structured interviews (Fall 2021, Summer 2022). The second interview round was precipitated by a service interruption in medication dispensation. Interview audio was recorded, transcribed, and then analysed in NVivo 1.6 following an interpretive description approach. Results The emergent themes from the analysis are represented in two categories: (1) a holistic approach (client autonomy, de-medicalized care, supportive staff relationships, multiple opportunities for engagement, barriers to iOAT integration) and (2) a sense of place (physical location, social connection and community belonging, food). Conclusion Incorporating iOAT at an integrated care site revealed how iOAT delivery can be strengthened through its direct connection to a diverse, comprehensive network of health and social services that are provided in a community atmosphere with high quality therapeutic relationships.
Keywords	Medicine (General) ; R5-920 ; Social pathology. Social and public welfare. Criminology ; HV1-9960
Subject code	360
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pierre M. Montavon (1949-2018).

Koch, Daniel A / Vezzoni, Aldo / Damur, Daniel

Veterinary and comparative orthopaedics and traumatology : V.C.O.T

2018 Volume 31, Issue 6, Page(s) 495–496

MeSH term(s)	History, 20th Century ; History, 21st Century ; Orthopedics/history ; Orthopedics/veterinary ; Switzerland ; Veterinary Medicine/history
Language	English
Publishing date	2018-11-12
Publishing country	Germany
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	286750-3
ISSN	2567-6911 ; 0932-0814
ISSN (online)	2567-6911
ISSN	0932-0814
DOI	10.1055/s-0038-1675553
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