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Article: Morbus Waldenström. im Interview M. Hensel

Spitzwieser, M. / Hensel, M.

2022 Volume -, Issue 5, Sonderheft "Seltene Erkrankungen", Page(s) 29

Language	German
Document type	Article
ZDB-ID	2475266-6
ISSN	1607-8861
Database	Current Contents Medicine

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Article ; Online: Retrospective Survey of Amphibian Pathology Cases at Texas A&M University System (2016-2020).

Balamayooran, Gayathriy / Snook, Eric / Tocidlowski, Maryanne / Flanagan, Joe / Sims, Will / Helman, Gayman / Hensel, Martha / Hodo, Carolyn L / Templeton, Alexis A / Anguiano, Maritza / Edwards, Erin E / Hoffman, Jay / Porter, Brian F / Groch, Kátia R / Gomez, Gabriel / Díaz-Delgado, Josue

Journal of comparative pathology

2021 Volume 185, Page(s) 87–95

Abstract: ... affecting these species. To delineate the health issues of amphibians submitted to Texas A&M University ...

Abstract	Dramatic declines in amphibians worldwide highlight the need for a better understanding of diseases affecting these species. To delineate the health issues of amphibians submitted to Texas A&M University System (2016-2020), the databases were queried on the basis of defined selection criteria. A total of 502 anurans (157 frogs [44 species] and 345 toads [10 species]) and 30 caudatans (23 salamanders [6 species] and 7 newts [4 species]) were reviewed. A most likely cause of death or major pathological finding (CD-MPF) leading to euthanasia was identified in 295 (55%) Anura cases and 15 (50%) Caudata cases. Of the 532 records reviewed, anurans included 492 captive, seven free-ranging and three undetermined specimens. All caudatans were captive. The most common CD-MPF in anurans was infectious/inflammatory (228/295; 77%), involving mycobacteriosis (73/228; 32%), chlamydiosis (44/228; 19%) and mycosis (32/228; 14%). Neoplasia was less common (28/295; 9%). Infectious/inflammatory lesions (14/15; 93%) were the main CD-MPFs in caudatans. Infectious diseases are a significant threat to captive amphibians in Texas and these results may aid personnel involved in amphibian conservation programmes, veterinarians and diagnosticians.
MeSH term(s)	Amphibians ; Animal Diseases/epidemiology ; Animals ; Anura ; Retrospective Studies ; Urodela
Language	English
Publishing date	2021-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2021.04.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Verlagerung der A. cerebri media bei der adulten M. Pompe-Erkrankung

Peetz, A / Hensel, O / Posch, S / Zierz, S / Schneider, I

Nervenheilkunde

2019 Volume 38, Issue 05

Event/congress	24. Kongress des Medizinisch-Wissenschaftlichen Beirates der Deutschen Gesellschaft für Muskelkranke (DGM) e.V., Göttingen, 2019-05-09
Language	German
Publishing date	2019-05-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2223503-6
ISSN	2567-5788 ; 0722-1541
ISSN (online)	2567-5788
ISSN	0722-1541
DOI	10.1055/s-0039-1685062
Database	Thieme publisher's database

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Article ; Online: Intraobserver and interobserver reproducibility of M-mode and B-mode acquired mitral annular plane systolic excursion (MAPSE) and its dependency on echocardiographic image quality in children.

Hensel, Kai O / Roskopf, Markus / Wilke, Lucia / Heusch, Andreas

PloS one

2018 Volume 13, Issue 5, Page(s) e0196614

Abstract: ... without structural heart disease (mean age 12.6±3.1 years, 50.4% female). B-mode and M-mode derived MAPSE ... bias. Both inter- and intraobserver reliability were significantly better for M-mode derived MAPSE (p<0 ... 001). Echocardiographic image quality did not significantly influence M-mode MAPSE reproducibility (p ...

Abstract	Background: Mitral annular plane systolic excursion (MAPSE) is an increasingly used echocardiography technique to assess left ventricular (LV) function. However, reproducibility and dependence on echocardiographic image quality for MAPSE in pediatric patients have not been studied to date. Methods: We analyzed 284 transthoracic echocardiograms performed on consecutive normotensive children without structural heart disease (mean age 12.6±3.1 years, 50.4% female). B-mode and M-mode derived MAPSE measurements were performed and analyzed regarding inter- and intraobserver reliability and the influence of echocardiographic image quality. Results: Overall, MAPSE measurements were highly reproducible with only minor bias. Both inter- and intraobserver reliability were significantly better for M-mode derived MAPSE (p<0.001). Echocardiographic image quality did not significantly influence M-mode MAPSE reproducibility (p>0.235). In contrast, B-mode lateral MAPSE was significantly better reproducible in optimal image quality (-0.07±1.04) when compared to suboptimal echocardiographic images (0.42±1.59, p<0.001). Moreover, poor quality images yielded significantly lower M-mode MAPSE values (14.3±2 mm) than near-optimal (15.2±1.9 mm, p<0.001) or optimal images (15.1±2.2 mm, p = 0.006). Conclusion: Echocardiographic image quality essentially has a negligible effect on MAPSE reproducibility and measurements. Consequently, MAPSE is a robust echocardiographic parameter with convincing reproducibility for the assessment of LV function in children-even in patients with substandard imaging conditions.
MeSH term(s)	Adolescent ; Child ; Echocardiography/methods ; Female ; Humans ; Male ; Mitral Valve/physiology ; Reproducibility of Results ; Systole/physiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0196614
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Article: Retrospective Survey of Amphibian Pathology Cases at Texas A&M University System (2016–2020)

Journal of comparative pathology. 2021 May, v. 185

2021

Abstract: ... affecting these species. To delineate the health issues of amphibians submitted to Texas A&M University ...

Abstract	Dramatic declines in amphibians worldwide highlight the need for a better understanding of diseases affecting these species. To delineate the health issues of amphibians submitted to Texas A&M University System (2016–2020), the databases were queried on the basis of defined selection criteria. A total of 502 anurans (157 frogs [44 species] and 345 toads [10 species]) and 30 caudatans (23 salamanders [6 species] and 7 newts [4 species]) were reviewed. A most likely cause of death or major pathological finding (CD-MPF) leading to euthanasia was identified in 295 (55%) Anura cases and 15 (50%) Caudata cases. Of the 532 records reviewed, anurans included 492 captive, seven free-ranging and three undetermined specimens. All caudatans were captive. The most common CD-MPF in anurans was infectious/inflammatory (228/295; 77%), involving mycobacteriosis (73/228; 32%), chlamydiosis (44/228; 19%) and mycosis (32/228; 14%). Neoplasia was less common (28/295; 9%). Infectious/inflammatory lesions (14/15; 93%) were the main CD-MPFs in caudatans. Infectious diseases are a significant threat to captive amphibians in Texas and these results may aid personnel involved in amphibian conservation programmes, veterinarians and diagnosticians.
Keywords	Anura ; Caudata ; chlamydiosis ; death ; euthanasia ; human resources ; mycobacterial diseases ; mycoses ; neoplasms ; surveys ; Texas
Language	English
Dates of publication	2021-05
Size	p. 87-95.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2021.04.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: GRP78-directed immunotherapy in relapsed or refractory multiple myeloma - results from a phase 1 trial with the monoclonal immunoglobulin M antibody PAT-SM6.

Rasche, Leo / Duell, Johannes / Castro, Inês C / Dubljevic, Valentina / Chatterjee, Manik / Knop, Stefan / Hensel, Frank / Rosenwald, Andreas / Einsele, Hermann / Topp, Max S / Brändlein, Stephanie

Haematologica

2015 Volume 100, Issue 3, Page(s) 377–384

Abstract: ... tolerability of the anti-glucose regulated protein 78 monoclonal immunoglobulin M antibody PAT-SM6 in subjects ...

Abstract	Unlabelled: The primary objective of this phase 1 study was to evaluate the safety and tolerability of the anti-glucose regulated protein 78 monoclonal immunoglobulin M antibody PAT-SM6 in subjects with relapsed or refractory multiple myeloma. Twelve heavily pretreated patients received four intravenous infusions of PAT-SM6 at doses of 0.3, 1, 3, and 6 mg/kg within 2 weeks. Efficacy, pharmacokinetics and immunogenicity were followed up until the end of the trial (day 36). In addition, immune cell patterns in peripheral blood were assessed by flow cytometry and glucose regulated protein 78 expression status was evaluated in bone marrow specimens by immunohistochemistry and flow cytometry at screening. All doses administered were found to be safe and well tolerated; the maximum tolerated dose was not reached. The most common treatment emergent adverse event was leukopenia (grades 1 and 2) in eight out of the 12 multiple myeloma patients. Pharmacokinetic analysis demonstrated dose-proportional increases in drug serum concentration. The terminal half-life ranged from 5.86 to 8.41 h, the apparent volume of distribution ranged from 101 to 150 mL/kg, and clearance ranged from 8.11 to 16.1 mL/h/kg. All patients showed glucose regulated protein 78 surface expression on multiple myeloma cells. Four out of the 12 patients (33.3 %) had stable disease, according to the International Myeloma Working Group criteria, after PAT-SM6 treatment across the doses 1, 3 and 6 mg/kg. In summary, single-agent PAT-SM6 was well tolerated with modest clinical activity in relapsed or refractory multiple myeloma. Further trials exploring the combination of PAT-SM6 with existing myeloma therapies are planned. Trial registration: clinicaltrials.gov identifier: NCT01727778.
MeSH term(s)	Aged ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/pharmacokinetics ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Dose-Response Relationship, Immunologic ; Female ; Gene Expression ; Half-Life ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/immunology ; Humans ; Immunization, Passive/methods ; Immunoglobulin M/administration & dosage ; Immunoglobulin M/adverse effects ; Immunoglobulin M/metabolism ; Infusions, Intravenous ; Leukopenia/etiology ; Leukopenia/pathology ; Male ; Multiple Myeloma/genetics ; Multiple Myeloma/immunology ; Multiple Myeloma/pathology ; Multiple Myeloma/therapy ; Recurrence
Chemical Substances	Antibodies, Monoclonal ; Heat-Shock Proteins ; Immunoglobulin M ; molecular chaperone GRP78
Language	English
Publishing date	2015-03
Publishing country	Italy
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2014.117945
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Article ; Conference proceedings: Dilatation der hirnversorgenden Arterien bei Patienten mit adultem M. Pompe

Hensel, O / Hanisch, F / Müller, T

Klinische Neurophysiologie

2014

Abstract: ... Zusammenfassung: Bei Patienten mit adultem M. Pompe sind die Durchmesser der intrakraniellen hirnversorgenden ...

Event/congress	58. Jahrestagung der Deutschen Gesellschaft für Klinische Neurophysiologie und Funktionelle Bildgebung (DGKN), Berlin, 2014
Abstract	Einleitung: Die Glykogenose Typ II (Morbus Pompe) ist eine lysosomale Speicherkrankheit verursacht durch eine Mutation im GAA Gen, dass das Enzym Alpha-Glukosidase kodiert. Charakteristisch ist die intrazelluläre Glykogenspeicherung insbesondere in der quergestreiften Muskulatur, aber auch in der glatten Gefäßmuskulatur (Winkel et al. 2003). Fallberichte über fusiforme Aneurysmen an den Hirnbasisgefäßen und intrakranielle Blutungen legen nahe, dass die zu Grunde liegende Gefäßpathologie Folge der Glykogenablagerungen in der Gefäßmuskulatur ist (Laforêt et al. 2008, Sacconi et al. 2010, Lilleker et al. 2013). Wir konnten bisher zeigen, dass die Durchmesser der Hirnbasisgefäße von Patienten mit adulter Pompe-Erkrankung ohne zerebrovaskuläre Vorerkrankungen dilatiert sind (submitted). Die Dilatation der thorakalen Aorta wurde ebenfalls beschrieben (El-Gharbawy 2011). Wir untersuchten jetzt, ob weitere extrakranielle Arterien wie die A. carotis communis dilatiert sind. Methoden: 10 Patienten mit genetisch nachgewiesener adulter Pompe-Erkrankung (Alter 46 ± 12 Jahre, 5 Frauen) ohne zerebrovaskuläre Vorerkrankungen wurden eingeschlossen. Der Durchmesser der A. carotis communis wurde duplexsonographisch mindestens 1 cm vor dem Bulbus caroticus im B-Bild bestimmt. Die maximalen Durchmesser der Aa. vertebrales, A. basilaris, Aa. cerebri mediae, anteriores und posteriores, der Aa. carotides internae sowie der Durchmesser des distalen M1-Segmentes der Aa. cerebri mediae wurden in einer Voruntersuchung gd-MR-angiographisch bestimmt. Zum Vergleich wurden 24 MR-Angiografien und 50 Duplexsonografien von Patienten ohne zerebrovaskuläre Vorerkrankungen verwendet. Ergebnisse: Der Durchmesser der A. carotis communis betrug bei Patienten mit adulter Pompe-Erkrankung 6,2 ± 0,7 mm (Kontrollen 6,5 ± 0,8 mm, n.s.). Die Durchmesser der intrakraniellen Aa. carotides internae, des M1-Segmentes der Aa. cerebri mediae, der Aa. cerebri anteriores und der A. basilaris waren erweitert. Zusammenfassung: Bei Patienten mit adultem M. Pompe sind die Durchmesser der intrakraniellen hirnversorgenden Gefäße vergrößert. Der Durchmesser der A. carotis communis ist dagegen normal.
Language	German
Publishing date	2014-03-12
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80107-0
ISSN	1439-4081 ; 1434-0275 ; 0012-7590
ISSN (online)	1439-4081
ISSN	1434-0275 ; 0012-7590
DOI	10.1055/s-0034-1371265
Database	Thieme publisher's database

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Article ; Online: Structure of the corrinoid:coenzyme M methyltransferase MtaA from Methanosarcina mazei.

Hoeppner, Astrid / Thomas, Frank / Rueppel, Alma / Hensel, Reinhard / Blankenfeldt, Wulf / Bayer, Peter / Faust, Annette

Acta crystallographica. Section D, Biological crystallography

2012 Volume 68, Issue Pt 11, Page(s) 1549–1557

Abstract: The zinc-containing corrinoid:coenzyme M methyltransferase MtaA is part of the methanol-coenzyme M ... from methyl-cob(III)alamin (bound to MtaC) to coenzyme M (bound to MtaA). The crystal structure of the MtaB ... MtaC complex from M. barkeri has previously been determined. Here, the crystal structures of MtaA ...

Abstract	The zinc-containing corrinoid:coenzyme M methyltransferase MtaA is part of the methanol-coenzyme M-methyltransferase complex of Methanosarcina mazei. The whole complex consists of three subunits: MtaA, MtaB and MtaC. The MtaB-MtaC complex catalyses the cleavage of methanol (bound to MtaB) and the transfer of the methyl group onto the cobalt of cob(I)alamin (bound to MtaC). The MtaA-MtaC complex catalyses methyl transfer from methyl-cob(III)alamin (bound to MtaC) to coenzyme M (bound to MtaA). The crystal structure of the MtaB-MtaC complex from M. barkeri has previously been determined. Here, the crystal structures of MtaA from M. mazei in a substrate-free but Zn(2+)-bound state and in complex with Zn(2+) and coenzyme M (HS-CoM) are reported at resolutions of 1.8 and 2.1 Å, respectively. A search for homologous proteins revealed that MtaA exhibits 23% sequence identity to human uroporphyrinogen III decarboxylase, which has also the highest structural similarity (r.m.s.d. of 2.03 Å for 306 aligned amino acids). The main structural feature of MtaA is a TIM-barrel-like fold, which is also found in all other zinc enzymes that catalyse thiol-group alkylation. The active site of MtaA is situated at the narrow bottom of a funnel such that the thiolate group of HS-CoM points towards the Zn(2+) ion. The Zn(2+) ion in the active site of MtaA is coordinated tetrahedrally via His240, Cys242 and Cys319. In the substrate-free form the fourth ligand is Glu263. Binding of HS-CoM leads to exchange of the O-ligand of Glu263 for the S-ligand of HS-CoM with inversion of the zinc geometry. The interface between MtaA and MtaC for transfer of the methyl group from MtaC-bound methylcobalamin is most likely to be formed by the core complex of MtaB-MtaC and the N-terminal segment (a long loop containing three α-helices and a β-hairpin) of MtaA, which is not part of the TIM-barrel core structure of MtaA.
MeSH term(s)	Amino Acid Sequence ; Catalytic Domain ; Corrinoids/chemistry ; Corrinoids/metabolism ; Humans ; Mesna/chemistry ; Mesna/metabolism ; Methanosarcina/chemistry ; Methanosarcina/enzymology ; Methanosarcina/metabolism ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Sequence Alignment ; Substrate Specificity ; Zinc/chemistry ; Zinc/metabolism
Chemical Substances	Corrinoids ; Methyltransferases (EC 2.1.1.-) ; Zinc (J41CSQ7QDS) ; Mesna (NR7O1405Q9)
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020492-9
ISSN	1399-0047 ; 2059-7983 ; 0907-4449
ISSN (online)	1399-0047 ; 2059-7983
ISSN	0907-4449
DOI	10.1107/S090744491203853X
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Book ; Thesis: Prädiktoren für die Behandlungsdauer schizophrener Patienten im psychiatrischen Maßregelvollzug (§ 63 StGB)

Hensel, Maik

2016

Institution	Universität Duisburg-Essen
Author's details	vorgelegt von Maik Hensel
Language	German
Size	88 Blätter, Diagramme
Publishing place	Duisburg ; Essen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität Duisburg-Essen, 2017
HBZ-ID	HT019569406
Database	Catalogue ZB MED Medicine, Health

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Book ; Thesis: Der Einfluss perzeptueller kognitiver Distraktoren auf die olfaktorische Wahrnehmung und die Hautleitfähigkeit bei der Verwendung einer atmungsgetriggerten olfaktorischen Stimulationsmethodik (RETROS) beim Menschen

Hoffmann-Hensel, Sonja Maria

2018

Author's details	vorgelegt von Sonja Maria Hoffmann-Hensel, M.Sc. geb. Hensel
Language	English
Size	Seite 567-578, Seite 723-736, Illustrationen, Diagramme
Publishing place	Aachen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2018
Note	Die Dissertation besteht aus 2 Aufsätzen
HBZ-ID	HT019572672
Database	Catalogue ZB MED Medicine, Health

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