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Article ; Online: Change in patellar height in medial and lateral unicompartmental knee arthroplasty: a clinical trial.

D'Ambrosi, Riccardo / Rubino, Francesco / Ursino, Chiara / Mariani, Ilaria / Ursino, Nicola / Formica, Matteo / Prinz, Julia / Migliorini, Filippo

Archives of orthopaedic and trauma surgery

2023 Volume 144, Issue 3, Page(s) 1345–1352

Abstract: Introduction: Evidence on patellar height changes following unicompartmental knee arthroplasty (UKA) is lacking. Therefore, this study compared the patella height in patients who underwent medial versus lateral UKA. Moreover, a subgroup analysis was ... ...

Abstract	Introduction: Evidence on patellar height changes following unicompartmental knee arthroplasty (UKA) is lacking. Therefore, this study compared the patella height in patients who underwent medial versus lateral UKA. Moreover, a subgroup analysis was conducted to investigate whether sex, age, and BMI of the patients exert an influence on the postoperative patellar height. Methods: Radiographs and hospital records of patients undergoing UKA were prospectively collected. Surgeries were performed by one author with long experience in UKA in a highly standardised fashion. The implants were fixed-bearing medial PPK (Zimmer Biomet, Warsaw, Indiana, USA) and fixed-bearing lateral ZUK (Lima Corporate, Udine, Italy). The patellar height was measured using the Insall-Salvati and Caton-Deschamps indices. Results: A total of 203 patients were included: 119 patients were included in the medial and 84 in the lateral UKA. The mean age of the patients was 68.9 ± 6.7 years, and the mean BMI was 28.1 ± 4.1 kg/m Conclusion: No difference was found in patella height in patients who have undergone medial compared to lateral UKA. Furthermore, there was no evidence of an association between patient characteristics (sex, age, BMI) and patella height between medial and lateral UKA.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Middle Aged ; Arthroplasty, Replacement, Knee ; Knee Joint/surgery ; Knee Prosthesis ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/diagnostic imaging ; Patella/diagnostic imaging ; Patella/surgery ; Postoperative Period ; Radiography
Language	English
Publishing date	2023-12-18
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-05139-8
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Article ; Online: Respiratory Protection against Pandemic and Epidemic Diseases.

Rubino, Ilaria / Choi, Hyo-Jick

Trends in biotechnology

2017 Volume 35, Issue 10, Page(s) 907–910

Abstract: Respiratory protection against airborne pathogens is crucial for pandemic/epidemic preparedness in the context of personal protection, healthcare systems, and governance. We expect that the development of technologies that overcome the existing ... ...

Abstract	Respiratory protection against airborne pathogens is crucial for pandemic/epidemic preparedness in the context of personal protection, healthcare systems, and governance. We expect that the development of technologies that overcome the existing challenges in current respiratory protective devices will lead to a timely and effective response to the next outbreak.
MeSH term(s)	Animals ; Communicable Disease Control ; Communicable Diseases/epidemiology ; Humans ; Pandemics/prevention & control ; Respiratory Protective Devices
Keywords	covid19
Language	English
Publishing date	2017-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2017.06.005
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Zs.A 2750: Show issues

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Article ; Online: Papa Pio XII nella storia della Radiologia: San Michele Arcangelo protettore dei radiologi.

Martini, Mariano / Barberis, Ilaria / Bragazzi, Nicola Luigi / Rubino, Lugi / Cardinale, Elio Adelfio

Acta medico-historica adriatica : AMHA

2020 Volume 17, Issue 2, Page(s) 337–346

Abstract: In 1933 the Professors of Genoa School of Medicine V. Maragliano, GB. Cardinale, and A. Vallebona proposed to designate Saint Michael the Archangel as Patron Saint and Protector of Radiologists. The proposal of Italian radiology scientists was ... ...

Title translation	Pope Pius XII in the History of Radiology: St. Michael the Archangel Protector of Radiologists.
Abstract	In 1933 the Professors of Genoa School of Medicine V. Maragliano, GB. Cardinale, and A. Vallebona proposed to designate Saint Michael the Archangel as Patron Saint and Protector of Radiologists. The proposal of Italian radiology scientists was immediately accepted by colleagues with great enthusiasm. A petition was then sent to Pope Pius XII to obtain official recognition by the Catholic Church. The choice of the Holy Archangel Michael was argued by the Professors because he is the Saint who, in religious iconography, is the one who wears armor, is the guardian of paradise, and leads souls to God. Moreover, the Saint represents the triumph of the Light of Good against the darkness of evil. On January 15, 1941, the Sacred Congregation of Rites issued the decree that constituted: "Sanctus Michael, Archangelus pro radiologis et radiumtherapeuticis patronus et protector declaratus".
MeSH term(s)	Catholicism/history ; History, 20th Century ; Humans ; Radiologists/history ; Religion and Medicine ; Saints/history
Language	Italian
Publishing date	2020-05-26
Publishing country	Croatia
Document type	Historical Article ; Journal Article
ZDB-ID	2195042-8
ISSN	1334-6253 ; 1334-4366
ISSN (online)	1334-6253
ISSN	1334-4366
DOI	10.31952/amha.17.2.10
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Article: Effects of Dietary Supplementation of

Colombino, Elena / Biasato, Ilaria / Michetti, Alberta / Rubino, Maria Gabriella / Franciosa, Irene / Giribaldi, Marzia / Antoniazzi, Sara / Bergagna, Stefania / Paliasso, Giulia / Ferrocino, Ilario / Cavallarin, Laura / Gasco, Laura / Capucchio, Maria Teresa

Animals : an open access journal from MDPI

2022 Volume 12, Issue 24

Abstract: This study aimed to evaluate the effects of Lactobacillus acidophilus D2/CSL (L-1 × 109 cfu/kg feed/day) on biochemical parameters, faecal score (FS), cecal pH, gut morphometry, microbiota and cecal short-chain fatty acid (SCFAs) in rabbits. Three ... ...

Abstract	This study aimed to evaluate the effects of Lactobacillus acidophilus D2/CSL (L-1 × 109 cfu/kg feed/day) on biochemical parameters, faecal score (FS), cecal pH, gut morphometry, microbiota and cecal short-chain fatty acid (SCFAs) in rabbits. Three zootechnical trials were performed and in each trial 30 rabbits were allotted to two groups; a probiotic group (L) and a control group (C). At slaughter (day 45), samples of blood, duodenum, jejunum, ileum, liver and spleen were collected and submitted to histomorphometric analyses. Blood biochemical analyses, cecal microbiota and SCFAs determination were also performed. In trial 1 and 3, L. acidophilus D2/CSL did not affect productive parameters (p > 0.05). However, L group of trial 1 showed a lower morbidity and mortality compared to the control. In trial 2, C group showed a higher daily feed intake (p = 0.018) and a positive statistical tendency for live weight and average daily gain (p = 0.068). On the contrary, albumin was higher and ALFA-1 globulin was lower in the C group compared to L (p < 0.05). In all the trials, FS, cecal pH, histomorphometry, microbiota and SCFAs were unaffected. In conclusion, L. acidophilus D2/CSL did not impair growth performances, gut and rabbit’s health, reducing morbidity and mortality.
Language	English
Publishing date	2022-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12243543
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Article ; Online: Comparative Prognostic Value of Parameters of Pulsatile Right Ventricular Afterload in Patients With Advanced Heart Failure Awaiting Heart Transplantation.

Rubino, Francesca / Scarsini, Roberto / Piccoli, Anna / San Biagio, Livio / Tropea, Ilaria / Pighi, Michele / Prati, Daniele / Tavella, Domenico / Pesarini, Gabriele / Benfari, Giovanni / Onorati, Francesco / Gottin, Leonardo / Faggian, Giuseppe / Ribichini, Flavio Luciano

The American journal of cardiology

2022 Volume 183, Page(s) 55–61

Abstract: Right ventricular pulsatile afterload (RVPA) demonstrated a strong impact on survival of patients with advanced heart failure (HF) with reduced ejection fraction. The best prognostic parameter of RVPA is unknown. The aim of this work was to examine the ... ...

Abstract	Right ventricular pulsatile afterload (RVPA) demonstrated a strong impact on survival of patients with advanced heart failure (HF) with reduced ejection fraction. The best prognostic parameter of RVPA is unknown. The aim of this work was to examine the prognostic relevance of pulmonary artery compliance (PAC), pulmonary artery elastance (PAE), and pulmonary artery pulsatile index (PAPi) in a consecutive cohort of patients with advanced HF evaluated for heart transplantation (HT). A total of 149 patients with end-stage HF underwent right-sided cardiac catheterization and were clinically followed up until death or any censoring events, including HT, left ventricular assist device, and hospitalization for acute HF. The primary endpoint occurred in 29 patients (19.5%) during a median follow-up time of 12 (interquartile range 3 to 34) months. This cohort presented a worse hemodynamic profile than event-free survivors. PAC <1.9 mL/mm Hg (hazard ratio 3, 95% confidence interval 1.3 to 6.0, p= 0.007) and PAE >0.9 mmHg/mL (hazard ratio 2.5, 95% confidence interval 1.1 to 5.2, p= 0.02) were associated with the adverse outcome. On the contrary, PAPi was not associated with the outcome. PAC demonstrated a superior predictive value for the composite adverse outcome compared with pulmonary vascular resistance (area under the curve comparison p= 0.019) and PAPi (p= 0.03) but similar compared with PAE (p= 0.19) and mean pulmonary arterial pressure (p= 0.51). PAC, but not PAE, showed incremental prognostic value compared with cardiac index (p= 0.02). In conclusion, hemodynamic indexes of RVPA are associated with worse survival in patients with end-stage HF. PAC and PAE demonstrated superior prognostic value compared with PAPi and pulmonary vascular resistance. Moreover, PAC showed incremental prognostic value compared with cardiac index in patients awaiting HT.
MeSH term(s)	Heart Failure ; Heart Transplantation ; Heart Ventricles/diagnostic imaging ; Heart-Assist Devices/adverse effects ; Humans ; Prognosis ; Pulmonary Artery ; Stroke Volume ; Ventricular Function, Right
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.08.010
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Ui IV Zs.73: Show issues

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Article ; Online: Recurrent Bilateral Salpingitis in a Sexually Inactive Adolescent: Don't Forget about the Appendix.

Rubino, Chiara / Barbati, Federica / Regoli, Marta / Bencini, Erica / Mattei, Alberto / Fierro, Francesca / Brizzi, Ilaria / Indolfi, Giuseppe

Journal of pediatric and adolescent gynecology

2020 Volume 34, Issue 2, Page(s) 217–219

Abstract: Background: Salpingitis is an acute inflammation of the fallopian tubes and is extremely uncommon in patients who are sexually inactive or premenarchal.: Case: We describe a 15-year-old sexually inactive patient with recurrent bilateral salpingitis. ... ...

Abstract	Background: Salpingitis is an acute inflammation of the fallopian tubes and is extremely uncommon in patients who are sexually inactive or premenarchal. Case: We describe a 15-year-old sexually inactive patient with recurrent bilateral salpingitis. After the second episode, she underwent an exploratory laparoscopy and was diagnosed with chronic appendicitis. Summary and conclusion: Appendicular involvement should be kept in mind in recurrent salpingitis episodes, especially if previous imaging studies do not show signs of appendicitis. Imaging studies should be repeated in experienced centers in case of recurrent episodes. Laparoscopy is the gold standard for the diagnosis of salpingitis and can confirm appendicular or other abdominal involvement. Early diagnosis can help to prevent recurrent episodes of salpingitis and thus reduce the risk of sequelae.
MeSH term(s)	Adolescent ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/pathology ; Appendix/pathology ; Chronic Disease ; Diagnosis, Differential ; Fallopian Tubes/pathology ; Female ; Humans ; Laparoscopy ; Medical Illustration ; Recurrence ; Salpingitis/diagnosis ; Salpingitis/etiology ; Salpingitis/pathology ; Sexual Abstinence
Language	English
Publishing date	2020-12-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	1325079-6
ISSN	1873-4332 ; 1083-3188
ISSN (online)	1873-4332
ISSN	1083-3188
DOI	10.1016/j.jpag.2020.12.014
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Article ; Online: Effect of Migalastat on cArdiac InvOlvement in FabRry DiseAse: MAIORA study.

Journal of medical genetics

2023 Volume 60, Issue 9, Page(s) 850–858

Abstract: Background: A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported in Fabry disease (FD). This study aimed to assess the effect of migalastat on FD cardiac involvement, combining LV ... ...

Abstract	Background: A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported in Fabry disease (FD). This study aimed to assess the effect of migalastat on FD cardiac involvement, combining LV morphology and tissue characterisation by cardiac magnetic resonance (CMR) with cardiopulmonary exercise testing (CPET). Methods: Sixteen treatment-naïve patients with FD (4 women, 46.4±16.2 years) with cardiac involvement (reduced T1 values on CMR and/or LV hypertrophy) underwent ECG, echocardiogram, troponin T and NT-proBNP (N-Terminal prohormone of Brain Natriuretic Peptide) assay, CMR with T1 mapping, and CPET before and after 18 months of migalastat. Results: No change in LV mass was detected at 18 months compared to baseline (95.2 g/m Conclusion: In treatment-naïve FD patients with cardiac involvement, 18-month treatment with migalastat stabilised LV mass and was associated with a trend towards an improvement in exercise tolerance. A tendency to T1 increase was detected by CMR. The subset of patients who had significant benefits from the treatment showed an earlier cardiac disease compared to the others. Trial registration number: NCT03838237.
MeSH term(s)	Humans ; Female ; Adult ; Fabry Disease ; Heart Diseases ; Magnetic Resonance Imaging ; 1-Deoxynojirimycin ; Predictive Value of Tests
Chemical Substances	migalastat (C4XNY919FW) ; 1-Deoxynojirimycin (19130-96-2)
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmg-2022-108768
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Article: Fingerprinting of anti-alpha enolase antibodies in systemic sclerosis.

Perconti, Giovanni / Pratesi, Federico / Angelotti, Francesca / Manca, Laura / Puxeddu, Ilaria / Rubino, Patrizia / Maranto, Cristina / Giallongo, Agata / Migliorini, Paola

Clinical and experimental rheumatology

2019 Volume 38 Suppl 125, Issue 3, Page(s) 115–119

Abstract: Objectives: Anti-alpha enolase antibodies have been detected in systemic sclerosis (SSc), but little is known on their fine specificity and their predictive value on single disease manifestations. The aim of this work is to perform an epitope mapping of ...

Abstract	Objectives: Anti-alpha enolase antibodies have been detected in systemic sclerosis (SSc), but little is known on their fine specificity and their predictive value on single disease manifestations. The aim of this work is to perform an epitope mapping of alpha enolase by means of truncated recombinant proteins and to analyse the clinico-serological correlations of anti-alpha enolase antibodies in SSc patients. Methods: Thirty-eight SSc patients were recruited and fully clinically and serologically characterised. Plasmids encoding full length and truncated polypeptides of alpha enolase were generated; the polypeptides were purified under native conditions and used in dot blot to test sera from SSc patients and controls. The densitometric values obtained on all the polypeptides with anti-IgG subclass specific antibodies were analysed by cluster analysis and partial least square regression. Results: Anti-alpha enolase antibodies (mostly IgG1 and IgG2) are detected in 47% of SSc patients. IgG1 target the amino terminal region of alpha enolase, while IgG2 are more restricted to the central portion of the molecule. Anti-alpha enolase antibodies are not associated with disease-specific antibodies or with interstitial lung disease and do not identify patients affected by the limited vs. diffuse form. Conclusions: Anti-alpha enolase antibodies are very frequent in SSc but are not associated with clinical or serological features of the disease. Further studies on larger cohorts of patients are necessary to define their possible contribution in defining specific subsets of the disease.
MeSH term(s)	Autoantibodies ; Epitope Mapping ; Humans ; Immunoglobulin G ; Phosphopyruvate Hydratase ; Scleroderma, Systemic
Chemical Substances	Autoantibodies ; Immunoglobulin G ; Phosphopyruvate Hydratase (EC 4.2.1.11)
Language	English
Publishing date	2019-12-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: Universal and reusable virus deactivation system for respiratory protection.

Quan, Fu-Shi / Rubino, Ilaria / Lee, Su-Hwa / Koch, Brendan / Choi, Hyo-Jick

Scientific reports

2017 Volume 7, Page(s) 39956

Abstract: Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus ... ...

Abstract	Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases.
MeSH term(s)	Aerosols/adverse effects ; Animals ; Filtration/instrumentation ; Humans ; Mice ; Orthomyxoviridae/pathogenicity ; Orthomyxoviridae Infections/prevention & control ; Respiratory Protective Devices/virology ; Sodium Chloride/chemistry
Chemical Substances	Aerosols ; Sodium Chloride (451W47IQ8X)
Keywords	covid19
Language	English
Publishing date	2017-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep39956
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Article ; Online: MiRNA 126 as a New Predictor Biomarker in Venous Thromboembolism of Persistent Residual Vein Obstruction: A Review of the Literature Plus a Pilot Study.

Rossetti, Pietro / Goldoni, Matteo / Pengo, Vittorio / Vescovini, Rosanna / Mozzoni, Paola / Tassoni, Maria Ilaria / Lombardi, Maria / Rubino, Pasquale / Bernuzzi, Gino / Verzicco, Ignazio / Manotti, Cesare / Quintavalla, Roberto

Seminars in thrombosis and hemostasis

2021 Volume 47, Issue 8, Page(s) 982–991

Abstract: Venous thromboembolism (VTE) is the third most common cardiovascular disease. Interleukins (ILs) and micro-ribonucleic acids (miRNAs) have been proposed as molecules able to modulate endothelial inflammation and platelet hyperactivity. At present, no ... ...

Abstract	Venous thromboembolism (VTE) is the third most common cardiovascular disease. Interleukins (ILs) and micro-ribonucleic acids (miRNAs) have been proposed as molecules able to modulate endothelial inflammation and platelet hyperactivity. At present, no early biomarkers are available to predict the outcome of VTE. We investigated in a pilot study a selected number of miRNAs and ILs as prognostic VTE biomarkers and reviewed literature in this setting. Twenty-three patients (aged 18-65) with a new diagnosis of non-oncological VTE and free from chronic inflammatory diseases were enrolled. Twenty-three age- and sex-matched healthy blood donors were evaluated as control subjects. Serum miRNAs (MiRNA 126, 155, 17.92, 195), inflammatory cytokines (IL-6, tumor necrosis factor-α, IL-8), and lymphocyte subsets were evaluated in patients at enrolment (T0) and in controls. In VTE patients, clinical and instrumental follow-up were performed assessing residual vein obstruction, miRNA and ILs evaluation at 3 months' follow-up (T1). At T0, IL-8, activated T lymphocytes, Treg lymphocytes, and monocytes were higher in patients compared with healthy controls, as were miRNA 126 levels. Moreover, miRNA 126 and IL-6 were significantly increased at T0 compared with T1 evaluation in VTE patients. Higher levels of MiR126 at T0 correlated with a significant overall thrombotic residual at follow-up. In recent years an increasing number of studies (case-control studies, in vivo studies in animal models, in vitro studies) have suggested the potential role of miRNAs in modulating the cellular and biohumoral responses involved in VTE. In the frame of epidemiological evidence, this pilot study with a novel observational approach supports the notion that miRNA can be diagnostic biomarkers of VTE and first identifies miRNA 126 as a predictor of outcome, being associated with poor early recanalization.
MeSH term(s)	Animals ; Biomarkers ; Case-Control Studies ; Humans ; MicroRNAs/genetics ; Pilot Projects ; Venous Thromboembolism/genetics
Chemical Substances	Biomarkers ; MIRN126 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0041-1726341
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