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  1. Article ; Online: Rebuttal from Sergei N. Orlov, Michael M. Model and Ryszard Grygorczyk.

    Orlov, Sergei N / Model, Michael A / Grygorczyk, Ryszard

    The Journal of physiology

    2013  Volume 591, Issue 24, Page(s) 6129

    MeSH term(s) Animals ; Apoptosis ; Cell Size ; Humans ; Ion Transport
    Language English
    Publishing date 2013-11-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2013.265264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Membrane transporters in the pathogenesis of cardiovascular and lung disorders

    Orlov, Sergei N.

    (Current topics in membranes ; 83)

    2019  

    Author's details edited by Sergei N. Orlov
    Series title Current topics in membranes ; 83
    Collection
    Language English
    Size 1 Online-Ressource (887 Seiten), Illustrationen
    Edition First edition
    Publisher Academic Press, an imprint of Elsevier
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020108726
    ISBN 978-0-12-817765-5 ; 9780128177648 ; 0-12-817765-9 ; 0128177640
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Preface.

    Orlov, Sergei N

    Current topics in membranes

    2019  Volume 83, Page(s) xv–xvii

    MeSH term(s) Genome, Human/genetics ; Humans ; Ion Transport ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/S1063-5823(19)30024-9
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  4. Article: Effects of Hypoxia on Erythrocyte Membrane Properties-Implications for Intravascular Hemolysis and Purinergic Control of Blood Flow.

    Grygorczyk, Ryszard / Orlov, Sergei N

    Frontiers in physiology

    2017  Volume 8, Page(s) 1110

    Abstract: Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated ...

    Abstract Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated release of adenosine triphosphate (ATP) may be an important mechanism for
    Language English
    Publishing date 2017-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2017.01110
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  5. Article ; Online: A global phase II randomized trial comparing oral taxane ModraDoc006/r to intravenous docetaxel in metastatic castration resistant prostate cancer.

    Vaishampayan, Ulka N / Keessen, Marianne / Dreicer, Robert / Heath, Elisabeth I / Buchler, Tomas / Árkosy, Péter F / Csöszi, Tibor / Wiechno, Pawel / Kopyltsov, Evgeny / Orlov, Sergey V / Plekhanov, Alexey / Smagina, Maria / Varlamov, Sergei / Shore, Neal D

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 202, Page(s) 114007

    Abstract: Study aim: ModraDoc006, an oral formulation of docetaxel, is co-administered with the cytochrome P450-3A4 and P-glycoprotein inhibitor, ritonavir (r): ModraDoc006/r. The preliminary efficacy and safety of oral ModraDoc006/r was evaluated in a global ... ...

    Abstract Study aim: ModraDoc006, an oral formulation of docetaxel, is co-administered with the cytochrome P450-3A4 and P-glycoprotein inhibitor, ritonavir (r): ModraDoc006/r. The preliminary efficacy and safety of oral ModraDoc006/r was evaluated in a global randomized phase II trial and compared to the current standard chemotherapy regimen of intravenous (i.v.) docetaxel and prednisone.
    Methods: 103 mCRPC patients, chemotherapy-naïve with/without abiraterone and/or enzalutamide pretreated, with adequate organ function and evaluable disease per RECIST v1.1 and PCWG3 guidelines were randomized 1:1 into two cohorts. In Cohort 1, 49 patients received docetaxel 75 mg/m
    Results: There was no significant difference in rPFS between the 2 arms (p = 0.1465). Median rPFS was 9.5 months and 11.1 months (95% CI) for ModraDoc006/r and i.v. docetaxel, respectively. Partial response was noted in 44.1% and 38.7% measurable disease patients, and 50% decline of PSA was seen in 23 (50%) and 26 (56.5%) evaluable cases treated with ModraDoc006/r and i.v. docetaxel, respectively. The safety profile of ModraDoc006/r 20-20/200-100 mg dose was significantly better than i.v. docetaxel, with mild (mostly Grade 1) gastrointestinal toxicities, no hematologic adverse events, and neuropathy and alopecia incidence of 11.5% and 25%, respectively.
    Conclusions: ModraDoc006/r potentially represents a widely applicable, convenient, effective, and better tolerated oral taxane therapy option for mCRPC. Further investigation of ModraDoc006/r in a large randomized trial is warranted.
    MeSH term(s) Male ; Humans ; Docetaxel/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prednisone ; Ritonavir/adverse effects ; Treatment Outcome ; Taxoids/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Prostate-Specific Antigen ; Bridged-Ring Compounds
    Chemical Substances Docetaxel (15H5577CQD) ; Prednisone (VB0R961HZT) ; Ritonavir (O3J8G9O825) ; taxane (1605-68-1) ; Taxoids ; Prostate-Specific Antigen (EC 3.4.21.77) ; Bridged-Ring Compounds
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  6. Article: Control of lung myofibroblast transformation by monovalent ion transporters.

    Dulin, Nickolai O / Smolyaninova, Larisa V / Orlov, Sergei N

    Current topics in membranes

    2019  Volume 83, Page(s) 15–43

    Abstract: Myofibroblast differentiation is a critical process in the pathogenesis of tissue fibrosis. We focus our mini-review on recent data showing an implication of monovalent ion transporters in fibroblast to myofibroblast transformation of human lung ... ...

    Abstract Myofibroblast differentiation is a critical process in the pathogenesis of tissue fibrosis. We focus our mini-review on recent data showing an implication of monovalent ion transporters in fibroblast to myofibroblast transformation of human lung fibroblasts (HLF). In cultured HLF, cardiotonic steroids (CTS) known as potent inhibitors of Na
    MeSH term(s) Animals ; Cell Differentiation/drug effects ; Humans ; Ion Transport/drug effects ; Lung/cytology ; Membrane Transport Proteins/metabolism ; Myofibroblasts/cytology ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Signal Transduction/drug effects
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2019-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/bs.ctm.2019.01.002
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  7. Article ; Online: NKCC1 as an epigenetically regulated transporter involved in blood pressure elevation with age.

    Orlov, Sergei N

    American journal of hypertension

    2011  Volume 24, Issue 12, Page(s) 1264

    MeSH term(s) Animals ; Epigenomics ; Gene Expression Regulation/genetics ; Hypertension/genetics ; Male ; Sodium-Potassium-Chloride Symporters/biosynthesis ; Solute Carrier Family 12, Member 2
    Chemical Substances Sodium-Potassium-Chloride Symporters ; Solute Carrier Family 12, Member 2
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1038/ajh.2011.150
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    Zs.A 2329: Show issues Location:
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  8. Article ; Online: Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways.

    Orlov, Sergei N / Hamet, Pavel

    Pflugers Archiv : European journal of physiology

    2015  Volume 467, Issue 3, Page(s) 489–498

    Abstract: Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]i/[K+]i). Side-by-side with sensing of osmolality ... ...

    Abstract Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]i/[K+]i). Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]i/[K+]i-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption. This novel mechanism includes the sensing of heightened Na+ concentration in the plasma, interstitial, and cerebrospinal fluids via augmented Na+ influx in the endothelium, immune system cells, and the subfornical organ, respectively. In these cells, [Na+]i/[K+]i ratio elevation, triggered by augmented Na+ influx, is further potentiated by increased production of endogenous Na+,K+-ATPase inhibitors documented in salt-sensitive hypertension.
    MeSH term(s) Animals ; Humans ; Immune System/metabolism ; Potassium/metabolism ; Signal Transduction ; Sodium/metabolism ; Sodium Channels/genetics ; Sodium Channels/metabolism ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism ; Subfornical Organ/metabolism ; Transcriptional Activation
    Chemical Substances Sodium Channels ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2015-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-014-1650-8
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  9. Article: On the history of ecto-ATPases: The role of W. A. Engelhardt.

    Orlov, Sergei N

    Purinergic signalling

    2007  Volume 3, Issue 3, Page(s) 231–232

    Language English
    Publishing date 2007-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-007-9055-1
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  10. Article: Ion transport in the pathogenesis of cardiovascular diseases: An update.

    Orlov, Sergei N

    Pathophysiology : the official journal of the International Society for Pathophysiology

    2007  Volume 14, Issue 3-4, Page(s) 133–134

    Language English
    Publishing date 2007-10-17
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1212740-1
    ISSN 0928-4680
    ISSN 0928-4680
    DOI 10.1016/j.pathophys.2007.09.001
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