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Article ; Online: Hepatoprotective and antioxidant effects of Wu-Zi-Yuan-Chung-Wan against CCl-induced oxidative damage in rats

Hao-Yuan Cheng / Jung Chao / Chuan-Sung Chiu / I-Chien Hsieh / Hui-Chi Huang / Lung-Yuan Wu / Wen-Huang Peng

European Journal of Inflammation, Vol

2021 Volume 19

Abstract: This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan ...

Abstract	This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan (WZYCW) using an animal model of carbon tetrachloride (CCl 4 ) induced liver injury. CCl 4 induced chronic liver hepatotoxicity in adult Sprague-Dawley rats. Excluding the control group, all of the rats with chronic liver fibrosis received 0.4% CCl 4 (1.5 mL/kg of body weight, ip) twice per week for 8 weeks. WZYCW (20, 100, and 500 mg/kg) and silymarin (200 mg/kg) were administered five times per week for 8 weeks. After 8 weeks, the rats were sacrificed, blood samples were obtained, and liver histological examinations were performed for subsequent assays. These results suggest that WZYCW considerably reduced Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT), Triglyceride (TG); and cholesterol activity; and the levels of malonaldehyde (MDA), nitric oxide (NO), and transforming growth factor-β 1 (TGF-β 1 ) in the liver. WZYCW also increased the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in liver tissue. WZYCW produced hepatoprotective and antifibrotic effects. This is the first study to demonstrate that WZYCW expressed hepatoprotective activity against CCl 4 induced acute hepatotoxicity in rat. In addition, the primary compound of WZCYW was analyzed using HPLC. The major peaks of WZCYW, including schizandrin. The results indicate that WZYCW not only enhances hepatic antioxidant enzyme activities and inhibits lipid peroxidation but also suppresses inflammatory responses in CCl 4 induced liver damage. Our findings provide evidence that WZYCW possesses a hepatoprotective activity to ameliorate chronic liver injury.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Spatial and Temporal Distribution of Bacterioplankton Molecular Ecological Networks in the Yuan River under Different Human Activity Intensity.

Wu, Bobo / Wang, Peng / Devlin, Adam T / Chen, Lu / Xia, Yang / Zhang, Hua / Nie, Minghua / Ding, Mingjun

Microorganisms

2021 Volume 9, Issue 7

Abstract: Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes ...

Abstract	Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes in microbial networks could have implications for their functionality and vulnerability to future disturbances. Here, we compare the spatiotemporal and biogeographical patterns of bacterioplankton molecular ecological networks using high-throughput sequencing of Illumina HiSeq and multivariate statistical analyses from a subtropical river during wet and dry seasons. Results demonstrated that the lower reaches (high human activity intensity) network had less of an average degree (10.568/18.363), especially during the dry season, when compared with the upper reaches (low human activity intensity) network (10.685/37.552) during the wet and dry seasons, respectively. The latter formed more complexity networks with more modularity (0.622/0.556) than the lower reaches (high human activity intensity) network (0.505/0.41) during the wet and dry seasons, respectively. Bacterioplankton molecular ecological network under high human activity intensity became significantly less robust, which is mainly caused by altering of the environmental conditions and keystone species. Human activity altered the composition of modules but preserved their ecological roles in the network and environmental factors (dissolved organic carbon, temperature, arsenic, oxidation-reduction potential and Chao1 index) were the best parameters for explaining the variations in bacterioplankton molecular ecological network structure and modules.
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9071532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Scale effects of multi-medium heavy metals in response to landscape indices in the Yuan River, China

Chen, Liwen / Yang, Yutao / Ding, Mingjun / Zhang, Hua / Zou, Fu / Wang, Peng / Nie, Minghua / Huang, Gaoxiang / Yan, Caixia

Journal of cleaner production. 2022 Aug. 20,

2022

Abstract: ... indices in the riparian zone of the Yuan River. Results show that the most sensitive spatial scales ...

Abstract	Heavy metals in river basins can affect the entire ecosystem through water recycling. Different heavy metals are significantly affected by riparian landscape patterns due to the difference of source and migration processes, while the intensity of impact is directly influenced by the spatial scale of landscape patterns. Here, we employ correlation analyses (CA) and redundancy analyses (RDA) to determine spatial scales for which multi-medium heavy metals (Cr, Mn, Cu, Zn, As, Cd and Pb) are most sensitive landscape indices in the riparian zone of the Yuan River. Results show that the most sensitive spatial scales for dissolved heavy metals were the 300 m line buffer in the wet season and catchments in the dry season. The most sensitive spatial scales for suspended particulate heavy metals were catchments in the wet season, and the 300 m and 500 m line buffers in the dry season. However, correlations between heavy metals in sediment and landscape indices were unclear at all spatial scales. The spatial scales of the 100 m point buffer and catchments showed the highest explained variances for all media. The most important landscape indices for dissolved heavy metals were ENN_MN (Mean Euclidean Nearest Neighbor Distance) and LPI (Largest Patch Index), and SHDI (Shannon's Diversity Index) and ED (Edge Density) for particulate heavy metals. More accurate spatial scale effects of landscape indicators can provide data and reference for similar watershed studies.
Keywords	dry season ; ecosystems ; landscapes ; riparian areas ; rivers ; sediments ; watersheds ; wet season ; China
Language	English
Dates of publication	2022-0820
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.133784
Database	NAL-Catalogue (AGRICOLA)

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Article: Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng

Peng, Mengyuan / Chen, Yanlin / Wang, Wenjuan / He, Zhihua / Dai, Wangqiang / Lin, Zhiyun / Yang, Zemin / Gong, Mengjuan / Yin, Yongqin / Han, Bin / Zeng, Yu / Wang, Yingfang

Journal of plant biochemistry and biotechnology. 2021 Sept., v. 30, no. 3

2021

Abstract: ... traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng, are widely used ... of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain ... challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study ...

Abstract	Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng, are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng, it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng. Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng.
Keywords	Oriental traditional medicine ; Panax ginseng ; biotechnology ; biotic stress ; energy metabolism ; gene expression regulation ; immunity ; microRNA ; pharmacodynamics ; plant biochemistry ; transcriptome ; unigenes
Language	English
Dates of publication	2021-09
Size	p. 429-439.
Publishing place	Springer India
Document type	Article
ZDB-ID	2206337-7
ISSN	0974-1275 ; 0971-7811
ISSN (online)	0974-1275
ISSN	0971-7811
DOI	10.1007/s13562-020-00613-5
Database	NAL-Catalogue (AGRICOLA)

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Article: Evaluation of landslide susceptibility based on the occurrence mechanism of landslide: a case study in Yuan' an county, China

Ma, Chuanming / Yan, Zhiwei / Huang, Peng / Gao, Lin

Environmental earth sciences. 2021 Feb., v. 80, no. 3

2021

Abstract: ... The geological conditions in Yuan’ an County are complex, and the landslide is extremely serious. This paper ... of landslides. Combined with the geological environment conditions of Yuan' an County, 5 inherent factors ... of GIS, the landslide susceptibility in Yuan' an county was evaluated and zoned. And in the chapter ...

Abstract	Landslide is one of the most serious and widespread disasters in natural disasters, which seriously endangers the lives and property of residents. Based on the occurrence mechanism of landslide, this paper uses the analytic hierarchy process-comprehensive index (AHP-CI) model and takes Yuan'an County in China as an example to study and evaluate the susceptibility characteristics of landslides in this area. The geological conditions in Yuan’ an County are complex, and the landslide is extremely serious. This paper will discuss separately from the inherent factors and the inducing factors that lead to the occurrence of landslides. Combined with the geological environment conditions of Yuan' an County, 5 inherent factors, including the slope, slope structure, rock and soil characteristics, geological structure, and the lithology were selected as evaluation indexes in this evaluation. Based on the spatial superposition function of GIS, the landslide susceptibility in Yuan' an county was evaluated and zoned. And in the chapter of analysis and discussion, the influence mechanism of two induced factors of rainfall and human activities on the occurrence of landslide was discussed. Since the inherent factors could not be easily changed, but the induced factors could be controlled artificially, so according to the evaluation results, scientific prevention and control measures could be put forward for different grades of landslide prone areas in the study area. This paper studied the evaluation of landslide susceptibility based on the occurrence mechanism of landslide, which has good practicability and can provide important reference for the evaluation and prevention of landslide susceptibility in other areas.
Keywords	case studies ; humans ; landslides ; lithology ; models ; rain ; China
Language	English
Dates of publication	2021-02
Size	p. 94.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-021-09381-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Spatial and Temporal Distribution of Bacterioplankton Molecular Ecological Networks in the Yuan River under Different Human Activity Intensity

Bobo Wu / Peng Wang / Adam T. Devlin / Lu Chen / Yang Xia / Hua Zhang / Minghua Nie / Mingjun Ding

Microorganisms, Vol 9, Iss 1532, p

2021 Volume 1532

Abstract	Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes in microbial networks could have implications for their functionality and vulnerability to future disturbances. Here, we compare the spatiotemporal and biogeographical patterns of bacterioplankton molecular ecological networks using high-throughput sequencing of Illumina HiSeq and multivariate statistical analyses from a subtropical river during wet and dry seasons. Results demonstrated that the lower reaches (high human activity intensity) network had less of an average degree (10.568/18.363), especially during the dry season, when compared with the upper reaches (low human activity intensity) network (10.685/37.552) during the wet and dry seasons, respectively. The latter formed more complexity networks with more modularity (0.622/0.556) than the lower reaches (high human activity intensity) network (0.505/0.41) during the wet and dry seasons, respectively. Bacterioplankton molecular ecological network under high human activity intensity became significantly less robust, which is mainly caused by altering of the environmental conditions and keystone species. Human activity altered the composition of modules but preserved their ecological roles in the network and environmental factors (dissolved organic carbon, temperature, arsenic, oxidation–reduction potential and Chao1 index) were the best parameters for explaining the variations in bacterioplankton molecular ecological network structure and modules. Proteobacteria , Actinobacteria and Bacteroidetes were the keystone phylum in shaping the structure and niche differentiations in the network. In addition, the lower reaches (high human activity intensity) reduce the bacterioplankton diversity and ecological niche differentiation, which deterministic processes become more important with increased farmland and ...
Keywords	human activity intensity ; bacterioplankton ; molecular ecological networks ; freshwater ecosystem functioning ; Biology (General) ; QH301-705.5
Subject code	333
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Spatial and Temporal Distribution of Bacterioplankton Molecular Ecological Networks in the Yuan River under Different Human Activity Intensity

Wu, Bobo / Wang, Peng / Devlin, Adam T. / Chen, Lu / Xia, Yang / Zhang, Hua / Nie, Minghua / Ding, Mingjun

Microorganisms. 2021 July 19, v. 9, no. 7

2021

Abstract	Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes in microbial networks could have implications for their functionality and vulnerability to future disturbances. Here, we compare the spatiotemporal and biogeographical patterns of bacterioplankton molecular ecological networks using high-throughput sequencing of Illumina HiSeq and multivariate statistical analyses from a subtropical river during wet and dry seasons. Results demonstrated that the lower reaches (high human activity intensity) network had less of an average degree (10.568/18.363), especially during the dry season, when compared with the upper reaches (low human activity intensity) network (10.685/37.552) during the wet and dry seasons, respectively. The latter formed more complexity networks with more modularity (0.622/0.556) than the lower reaches (high human activity intensity) network (0.505/0.41) during the wet and dry seasons, respectively. Bacterioplankton molecular ecological network under high human activity intensity became significantly less robust, which is mainly caused by altering of the environmental conditions and keystone species. Human activity altered the composition of modules but preserved their ecological roles in the network and environmental factors (dissolved organic carbon, temperature, arsenic, oxidation–reduction potential and Chao1 index) were the best parameters for explaining the variations in bacterioplankton molecular ecological network structure and modules. Proteobacteria, Actinobacteria and Bacteroidetes were the keystone phylum in shaping the structure and niche differentiations in the network. In addition, the lower reaches (high human activity intensity) reduce the bacterioplankton diversity and ecological niche differentiation, which deterministic processes become more important with increased farmland and constructed land area (especially farmland) with only 35% and 40% of the community variation explained by the neutral community model during the wet season and dry season, respectively. Keystone species in high human activity intensity stress habitats yield intense functional potentials and Bacterioplankton communities harbor keystone taxa in different human activity intensity stress habitats, which may exert their influence on microbiome network composition regardless of abundance. Therefore, human activity plays a crucial role in shaping the structure and function of bacterioplankton molecular ecological networks in subtropical rivers and understanding the mechanisms of this process can provide important information about human–water interaction processes, sustainable uses of freshwater as well as watershed management and conservation.
Keywords	Actinobacteria ; Bacteroidetes ; Proteobacteria ; agricultural land ; arsenic ; bacterioplankton ; dry season ; ecological differentiation ; freshwater ; freshwater ecosystems ; geographical distribution ; humans ; keystone species ; microbiome ; models ; redox potential ; rivers ; temperature ; watershed management ; wet season
Language	English
Dates of publication	2021-0719
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9071532
Database	NAL-Catalogue (AGRICOLA)

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Book: Zhongguo ren de qi yuan

Fang, Peng

ji yin jie du san huang wu di

2010

Title variant	Ji yin jie du san huang wu di
Author's details	Fang Peng zhu
MeSH term(s)	Anthropology, Physical ; Genetics, Medical
Keywords	China
Language	Chinese
Size	[1], 160 p. :, ill. (some col.), maps ;, 24 cm.
Edition	Di 1 ban.
Publisher	Jiangxi ren min chu ban she
Publishing place	Nanchang Shi
Document type	Book
ISBN	9787210041689 ; 7210041680
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Online: Table S1 A study of Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. Yuan et al

PENG, L (via Mendeley Data)

2020

Abstract: Oligo sequences used in this ... ...

Abstract	Oligo sequences used in this study
Keywords	Interdisciplinary sciences ; covid19
Publishing date	2020-10-16T22:41:28.534Z
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Table S2 A study of Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. Yuan et al

PENG, L (via Mendeley Data)

2020

Abstract: Source data and summary statistics of cellular viability effect by introduction of SARS-CoV-2 viral proteins and ... ...

Abstract	Source data and summary statistics of cellular viability effect by introduction of SARS-CoV-2 viral proteins and mutants
Keywords	Interdisciplinary sciences ; covid19
Publishing date	2020-10-16T22:41:21.379Z
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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