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  1. Article ; Online: Clinical Applications of High-Sensitivity Troponin Testing: From Diagnosis to Prognosis.

    Wiens, Evan J / Deviaene, Meagan / Shah, Ashish H

    The Canadian journal of cardiology

    2022  Volume 38, Issue 10, Page(s) 1521–1524

    MeSH term(s) Biomarkers ; Humans ; Prognosis ; Sensitivity and Specificity ; Troponin ; Troponin T
    Chemical Substances Biomarkers ; Troponin ; Troponin T
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Delayed HIV treatment, barriers in access to care and mortality in tuberculosis/HIV co-infected patients in Cali, Colombia.

    González-Duran, Jorge A / Plaza, Regina V / Luna, Lucy / Arbeláez, Maria Patricia / Deviaene, Meagan / Keynan, Yoav / Rueda, Zulma Vanessa / Marin, Diana

    Colombia medica (Cali, Colombia)

    2021  Volume 52, Issue 4, Page(s) e2024875

    Abstract: Objective: To determine factors associated with mortality in tuberculosis/HIV co-infected patients in Cali, Colombia.: Methods: This retrospective cohort design included tuberculosis/HIV co-infected persons. Kaplan-Meier and Cox regression were used ... ...

    Abstract Objective: To determine factors associated with mortality in tuberculosis/HIV co-infected patients in Cali, Colombia.
    Methods: This retrospective cohort design included tuberculosis/HIV co-infected persons. Kaplan-Meier and Cox regression were used to estimate survival and risk factors associated with mortality.
    Results: Of the 279 tuberculosis/HIV co-infected participants, 27.2% died during the study. Participants mainly were adults and males. CD4 count information was available for 41.6% (the median count was 83 cells/mm
    Conclusions: Delays in treatment initiation and factors associated with limited health care access or utilization were associated with mortality. As HIV and tuberculosis are both reportable conditions in Colombia, strategies should be focused on optimizing treatment outcomes within both tuberculosis and HIV programs, particularly improving early HIV diagnosis, early antiretroviral therapy treatment initiation, and adherence to tuberculosis treatment.
    MeSH term(s) Adult ; Coinfection ; Colombia/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Health Services Accessibility ; Humans ; Male ; Retrospective Studies ; Tuberculosis/complications ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
    Language English
    Publishing date 2021-12-08
    Publishing country Colombia
    Document type Journal Article
    ZDB-ID 2059694-7
    ISSN 1657-9534 ; 0120-8322
    ISSN (online) 1657-9534
    ISSN 0120-8322
    DOI 10.25100/cm.v52i3.4875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sample adequacy controls for infectious disease diagnosis by oral swabbing.

    Deviaene, Meagan / Weigel, Kris M / Wood, Rachel C / Luabeya, Angelique K K / Jones-Engel, Lisa / Hatherill, Mark / Cangelosi, Gerard A

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0241542

    Abstract: Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of ...

    Abstract Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of samples collected within the oral cavity. This study evaluated two candidate SACs for this purpose. One detected representative oral microbiota (Streptococcus species DNA) and the other, human cells (human mitochondrial DNA, mtDNA). Quantitative PCR (qPCR) assays for the two target cell types were applied to buccal swabs (representing samples collected within the oral cavity) and hand swabs (representing improperly collected samples) obtained from 51 healthy U.S. volunteers. Quantification cycle (Cq) cutoffs that maximized Youden's index were established for each assay. The streptococcal target at a Cq cutoff of ≤34.9 had 99.0% sensitivity and specificity for oral swab samples, whereas human mtDNA perfectly distinguished between hand and mouth swabs with a Cq cutoff of 31.3. The human mtDNA test was then applied to buccal, tongue, and gum swabs that had previously been collected from TB patients and controls in South Africa, along with "air swabs" collected as negative controls (total N = 292 swabs from 71 subjects). Of these swabs, 287/292 (98%) exhibited the expected Cq values. In a paired analysis the three oral sites yielded indistinguishable amounts of human mtDNA, however PurFlockTM swabs collected slightly more human mtDNA than did OmniSwabsTM (p = 0.012). The results indicate that quantification of human mtDNA cannot distinguish swabs collected from different sites within the mouth. However, it can reliably distinguish oral swabs from swabs that were not used orally, which makes it a useful SAC for oral swab-based diagnosis.
    MeSH term(s) Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; COVID-19 Testing/methods ; DNA, Mitochondrial/analysis ; DNA, Mitochondrial/genetics ; DNA, Viral/analysis ; DNA, Viral/genetics ; Diagnostic Tests, Routine/methods ; Female ; Humans ; Male ; Mouth/virology ; Real-Time Polymerase Chain Reaction ; Reference Standards ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; South Africa/epidemiology ; Specimen Handling/methods ; Washington/epidemiology
    Chemical Substances DNA, Mitochondrial ; DNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0241542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sample adequacy controls for infectious disease diagnosis by oral swabbing.

    Meagan Deviaene / Kris M Weigel / Rachel C Wood / Angelique K K Luabeya / Lisa Jones-Engel / Mark Hatherill / Gerard A Cangelosi

    PLoS ONE, Vol 15, Iss 10, p e

    2020  Volume 0241542

    Abstract: Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of ...

    Abstract Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of samples collected within the oral cavity. This study evaluated two candidate SACs for this purpose. One detected representative oral microbiota (Streptococcus species DNA) and the other, human cells (human mitochondrial DNA, mtDNA). Quantitative PCR (qPCR) assays for the two target cell types were applied to buccal swabs (representing samples collected within the oral cavity) and hand swabs (representing improperly collected samples) obtained from 51 healthy U.S. volunteers. Quantification cycle (Cq) cutoffs that maximized Youden's index were established for each assay. The streptococcal target at a Cq cutoff of ≤34.9 had 99.0% sensitivity and specificity for oral swab samples, whereas human mtDNA perfectly distinguished between hand and mouth swabs with a Cq cutoff of 31.3. The human mtDNA test was then applied to buccal, tongue, and gum swabs that had previously been collected from TB patients and controls in South Africa, along with "air swabs" collected as negative controls (total N = 292 swabs from 71 subjects). Of these swabs, 287/292 (98%) exhibited the expected Cq values. In a paired analysis the three oral sites yielded indistinguishable amounts of human mtDNA, however PurFlockTM swabs collected slightly more human mtDNA than did OmniSwabsTM (p = 0.012). The results indicate that quantification of human mtDNA cannot distinguish swabs collected from different sites within the mouth. However, it can reliably distinguish oral swabs from swabs that were not used orally, which makes it a useful SAC for oral swab-based diagnosis.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Sample adequacy controls for infectious disease diagnosis by oral swabbing

    Deviaene, Meagan / Weigel, Kris M / Wood, Rachel C / Luabeya, Angelique K K / Jones-Engel, Lisa / Hatherill, Mark / Cangelosi, Gerard A

    PLoS One

    Abstract: Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of ...

    Abstract Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19. To assure proper sample collection, sample adequacy controls (SACs) are needed that detect substances indicative of samples collected within the oral cavity. This study evaluated two candidate SACs for this purpose. One detected representative oral microbiota (Streptococcus species DNA) and the other, human cells (human mitochondrial DNA, mtDNA). Quantitative PCR (qPCR) assays for the two target cell types were applied to buccal swabs (representing samples collected within the oral cavity) and hand swabs (representing improperly collected samples) obtained from 51 healthy U.S. volunteers. Quantification cycle (Cq) cutoffs that maximized Youden's index were established for each assay. The streptococcal target at a Cq cutoff of ≤34.9 had 99.0% sensitivity and specificity for oral swab samples, whereas human mtDNA perfectly distinguished between hand and mouth swabs with a Cq cutoff of 31.3. The human mtDNA test was then applied to buccal, tongue, and gum swabs that had previously been collected from TB patients and controls in South Africa, along with "air swabs" collected as negative controls (total N = 292 swabs from 71 subjects). Of these swabs, 287/292 (98%) exhibited the expected Cq values. In a paired analysis the three oral sites yielded indistinguishable amounts of human mtDNA, however PurFlockTM swabs collected slightly more human mtDNA than did OmniSwabsTM (p = 0.012). The results indicate that quantification of human mtDNA cannot distinguish swabs collected from different sites within the mouth. However, it can reliably distinguish oral swabs from swabs that were not used orally, which makes it a useful SAC for oral swab-based diagnosis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #895083
    Database COVID19

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