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  1. Article ; Online: Epidemiologic Feature and Diagnostic Outcome of Traumatic PediatricPatients Referred to Emergency Department of Imam-Reza Hospital,Tabriz, Iran in 2016-2017

    Farzad Rahmani / Zahra Parsian / Haniyeh Ebrahimi Bakhtavar / Shiva Salmasi / Tahereh Hashemi

    Journal of Research in Clinical Medicine, Vol 8, Iss 1, Pp 10-

    2020  Volume 10

    Abstract: ... conducted at emergency department,Imam-Reza hospital of Tabriz University of Medical Sciences in 2016-2017 ...

    Abstract Introduction: Trauma has been recognized as the leading cause of mortality and morbidityamong children in developed countries. Therefore, it is highly desirable to have a controlprogram in this area. The aim of this study was determining epidemiologic feature and diagnosticoutcome of traumatic pediatric patients referred to emergency department in 2016-2017. Methods: This descriptive cross-sectional study was conducted at emergency department,Imam-Reza hospital of Tabriz University of Medical Sciences in 2016-2017 on a total of 518traumatic children. Variables of interest were age, gender, location of trauma, mechanism oftrauma, type of transfer to emergency department, time of trauma, and outcome of the incident. Results: Among 518 traumatic children involved in the study, the most common age for traumawas 3-6 years, and 66.4% and 33.6% of the studied population were boys and girls, respectively.Falling (42.5%) was the most common mechanism of trauma, and the most of traumas occurredduring evening (56.9%) and spring (38.8%) time. In additions, 75.5% of traumatic children weretransferred to the emergency department by their family, and among them, only for two casessafety instructions had been considered. Conclusion: In general, the results of this study demonstrated that boys with the age of 3-6 yearsare the most vulnerable group against trauma. Falling and traffic accidents are the main causesof trauma in children, whereas safety devices were not used in the majority of accident cases.Thus, it is highly recommended to use safety equipment for children inside vehicles.
    Keywords epidemiology ; multiple trauma ; pediatrics ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The obeticholic acid can positively regulate the cancerous behavior of MCF7 breast cancer cell line.

    Rahmani, Reza / Eivazi, Neda / Emamgholipour, Solaleh / Aminian, Mahdi / Jalilian, Ali / Paknejad, Maliheh

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 250

    Abstract: Background: The diagnosis and treatment processes of cancer are among the main challenges of medical science in recent decades. The use of different therapeutic agents is one of the most common methods frequently utilized for cancer treatment. ... ...

    Abstract Background: The diagnosis and treatment processes of cancer are among the main challenges of medical science in recent decades. The use of different therapeutic agents is one of the most common methods frequently utilized for cancer treatment. Accumulating evidence points to a potential effect of Obeticholic acid (OCA), a specific ligand for farnesoid X receptor, on the regulation of cancer-associated pathways. In spite of tremendous efforts to introduce OCA into the clinical setting, there is a great deal of uncertainty about its impact on breast cancer treatment. This study was performed to evaluate the effects of OCA on breast cancer.
    Methods and results: In this experiment, the MCF-7 (Michigan Cancer Foundation-7) cell line was treated with 0.1 µM OCA, and cancerous characteristics of the MCF-7 cell line was evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H-tetrazolium bromide) assay, gelatin zymography, western blot, Real-time PCR, flow cytometry, and ELISA techniques. The results indicated that OCA increased the rate of apoptosis and the expression levels of PPARα (Peroxisome proliferator-activated receptor alpha) and TIMP-1 (tissue inhibitor of metalloproteinase-1) genes in this cell line, while it reduced the mRNA levels of MMP7 (matrix metalloproteinase 7) and Bcl-2 (B-cell lymphoma 2) genes, as well as the protein levels of the active form of AKT (protein kinase B), Erk1/2 (extracellular signal-regulated kinase 1/2) and STAT3 (Signal transducers and activators of transcription-3). Also, OCA decreased the activity of MMP9, while it increased the secretion of VEGF-A (vascular endothelial growth factor-A).
    Conclusions: It seems that OCA can exert anti-cancer effects on the MCF-7 cells by reducing growth, proliferation, migration, invasion, and regulation of the expression of genes involved in cancer-associated pathways. However, it should be noted that further studies are warranted to establish this concept, especially the increase of VEGF-A can be considered a challenge for the results of this study.
    MeSH term(s) Humans ; Female ; Vascular Endothelial Growth Factor A/genetics ; MCF-7 Cells ; Tissue Inhibitor of Metalloproteinase-1 ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Chenodeoxycholic Acid/analogs & derivatives
    Chemical Substances Vascular Endothelial Growth Factor A ; Tissue Inhibitor of Metalloproteinase-1 ; obeticholic acid (0462Z4S4OZ) ; Chenodeoxycholic Acid (0GEI24LG0J)
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09106-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effect of different concentrations of substrate in microbial fuel cells toward bioenergy recovery and simultaneous wastewater treatment

    Rahmani, Ali Reza / Navidjouy, Nahid / Rahimnejad, Mostafa / Alizadeh, Saber / Samarghandi, Mohammad Reza / Nematollahi, Davood

    Environmental technology. 2022 Jan. 02, v. 43, no. 1

    2022  

    Abstract: Microbial fuel cells (MFCS) is a promising and expanding technology able to eliminate various pollutants of wastewater while converting its chemical energy into power energy using biocatalysts. The potential application of double-chamber microbial fuel ... ...

    Abstract Microbial fuel cells (MFCS) is a promising and expanding technology able to eliminate various pollutants of wastewater while converting its chemical energy into power energy using biocatalysts. The potential application of double-chamber microbial fuel cell (DC-MFC) for chemical oxygen demand (COD) removal and generated power from wastewater in the different conditions is investigated. DC-MFC is operated with anaerobic sludge as an active biocatalyst in an anode section, an aerobic cathode section and a Nafion117 membrane as a separator. The performance of the bioreactor is determined with different concentrations of chemical oxygen demand (COD) loadings in the MFC process, in terms of COD removal, power generation and columbic efficiencies. The results illustrated that COD removal efficiency increased at the high concentrations of organic matter. So that at COD concentration of 2000.0 mg/L the highest COD removal efficiency (84%) was obtained. But with increasing substrate initial concentration to 10000.0 mg/L the efficiency decreased to 79%. The important outputs of the system like the highest voltage, maximum generated power, current density, and energy efficiency with the 100,000 mg/L COD are 447 mV, 50.7 mW/m², 570.0 mA/m², and 18.6%, respectively. The optical density levels increased due to bacterial growth while pH severely decreased in the anode chamber when using high-concentration substrates in the MFC.
    Keywords absorbance ; anodes ; bacterial growth ; biocatalysts ; cathodes ; chemical oxygen demand ; electric potential difference ; energy efficiency ; environmental technology ; microbial fuel cells ; organic matter ; pH ; power generation ; sludge ; wastewater ; wastewater treatment
    Language English
    Dates of publication 2022-0102
    Size p. 1-9.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 1479-487X
    DOI 10.1080/09593330.2020.1772374
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose-response meta-analysis of cohort studies including 105,380 participants.

    Nikparast, Ali / Rahmani, Jamal / Bagheri, Reza / Mohammadpour, Saba / Shadnoosh, Mehdi / Wong, Alexei / Ghanavati, Matin

    Journal of diabetes investigation

    2023  Volume 14, Issue 8, Page(s) 973–984

    Abstract: Aims/introduction: Although the association between uric acid levels and adverse pregnancy outcomes has been investigated, the effects of higher uric acid levels on the risk of gestational diabetes mellitus (GDM) have yet to be established. Therefore, ... ...

    Abstract Aims/introduction: Although the association between uric acid levels and adverse pregnancy outcomes has been investigated, the effects of higher uric acid levels on the risk of gestational diabetes mellitus (GDM) have yet to be established. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between uric acid levels during pregnancy and the risk of GDM.
    Materials and methods: PubMed/Medline, Scopus and Web of Science databases were searched up to April 2022 for relevant observational studies. A random effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (95% CI). To assess the heterogeneity of included studies, the I
    Results: Among the initial 262 studies that were recognized from the databases search, 23 studies including 105,380 participants were eligible. Pooled analysis showed that higher uric acid levels significantly affected the risk of GDM (OR 2.58, 95% CI 1.89-3.52, I
    Conclusions: This study showed a positive association between uric acid levels and the risk of GDM. Also, our results indicate that measuring uric acid levels before 20 weeks of gestation can potentially predict GDM, especially in younger women.
    MeSH term(s) Pregnancy ; Female ; Humans ; Diabetes, Gestational/epidemiology ; Uric Acid ; Pregnancy Outcome ; Cohort Studies ; Odds Ratio
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-05-03
    Publishing country Japan
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The effect of glatiramer acetate, IFNβ-1a, fingolimod, and dimethyl fumarate on the expression of T-bet, IFN-γ, and MEG3 in PBMC of RRMS patients.

    Dabbaghi, Rozhin / Safaralizadeh, Reza / Rahmani, Shima / Barpour, Nesa / Hosseinpourfeizi, Mohammadali / Rajabi, Ali / Baradaran, Behzad

    BMC research notes

    2023  Volume 16, Issue 1, Page(s) 273

    Abstract: Objective: Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon- ...

    Abstract Objective: Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon-gamma (IFN-γ), and long non-coding RNA MEG3 in peripheral blood mononuclear cells (PBMCs) from treatment-naïve Relapsing-Remitting Multiple Sclerosis patients (RRMS), healthy controls, and RRMS patients on different Disease Modifying Therapies (DMTs). The aim is to understand the role of T-bet, IFN-γ, and MEG3 in MS pathogenesis and their potential as diagnostic and therapeutic targets.
    Results: Elevated T-bet expression is observed in treatment-naïve RRMS patients compared to healthy individuals. RRMS patients treated with Interferon beta-1alpha (IFNβ-1a) and fingolimod exhibit downregulated T-bet and MEG3 expression levels, respectively, with more pronounced effects in females. Healthy individuals show a moderate positive correlation between T-bet and MEG3 and between IFN-γ and T-bet. In RRMS patients treated with Glatiramer Acetate (GA), a strong positive correlation is observed between MEG3 and IFN-γ. Remarkably, RRMS patients treated with Dimethyl Fumarate (DMF) exhibit a significant positive correlation between T-bet and MEG3. These findings underscore the diagnostic potential of T-bet in RRMS, warranting further exploration of MEG3, T-bet, and IFN-γ interplay in RRMS patients.
    MeSH term(s) Female ; Humans ; Glatiramer Acetate/therapeutic use ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/genetics ; Fingolimod Hydrochloride/therapeutic use ; Dimethyl Fumarate ; Leukocytes, Mononuclear ; Interferon-gamma/genetics ; Neurodegenerative Diseases ; Multiple Sclerosis/drug therapy
    Chemical Substances Glatiramer Acetate (5M691HL4BO) ; Fingolimod Hydrochloride (G926EC510T) ; Dimethyl Fumarate (FO2303MNI2) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-023-06556-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening

    Mina Niusha / Seyed Ali Rahmani / Leila Kohan / Ladan Sadeghi / Mohammad Nouri / Hamid Reza Nejabati

    Asian Pacific Journal of Reproduction, Vol 12, Iss 1, Pp 16-

    2023  Volume 22

    Abstract: Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 ... ...

    Abstract Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to the embryo scope until transfer. Embryo integrity and blastocyst formation were assessed on day 5. Results: Totally, 282 embryos from 62 couples were evaluated. The chromosomes were normal in 199 (70.57%) embryos and abnormal in 83 (29.43%) embryos. There was no significant association between the quality of embryos and numerical chromosomal abnormality (P=0.67). Conclusions: Embryo quality is not significantly correlated with its genetic status. Hence, the quality of embryos determined by morphological parameters is not an appropriate method for choosing embryos without these abnormalities.
    Keywords assisted reproductive technology ; preimplantation genetic screening ; aneuploidy ; fluorescence insitu hybridization ; chromosomal abnormalities ; embryo quality ; blastomere ; blastocyst ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The long-term effects of the Covid-19 infection on cardiac symptoms.

    Golchin Vafa, Reza / Heydarzadeh, Reza / Rahmani, Mohammadhossein / Tavan, Ali / Khoshnoud Mansorkhani, Soroush / Zamiri, Bardia / Amiri, Farhang / Azadian, Alireza / Khademolhosseini, Amin / Montaseri, Mohammad / Hosseini, Nazanin / Hosseini, Seyed Ali / Kojuri, Javad

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 286

    Abstract: Background: Besides the lungs, coronavirus disease 2019 (COVID-19) can affect the cardiovascular, digestive, urinary, hepatic, and central nervous systems. Other than its short-term effects, COVID-19 may also cause long-term complications. In this study, ...

    Abstract Background: Besides the lungs, coronavirus disease 2019 (COVID-19) can affect the cardiovascular, digestive, urinary, hepatic, and central nervous systems. Other than its short-term effects, COVID-19 may also cause long-term complications. In this study, we assessed long-term COVID-19 cardiovascular symptoms among patients in a cardiovascular clinic.
    Method: A retrospective cohort was conducted between October 2020 to May 2021 on patients at an outpatient cardiovascular clinic in Shiraz, Iran. Patients with a history of COVID-19 at least one year before their referral were included. Baseline information was extracted from the clinic's database. Data were collected regarding symptoms like dyspnea, chest pain, fatigue, and palpitations after a year of COVID-19. We also noted any major adverse cardiac events (MACE).
    Results: Most common symptoms after a year of COVID-19 were exertional dyspnea (51.2%), dyspnea at rest (41.6%), fatigue (39%), and chest pain (27.1%). The symptoms were more prevalent in hospitalized patients than in non-hospitalized patients. The prevalence of MACE was about 6.1% during the 12-month follow-up, with this rate being higher in those with a history of hospitalization or comorbid diseases.
    Conclusion: The prevalence of cardiovascular symptoms was fairly high in patients at our clinic a year after COVID-19, and the most common symptom was dyspnea. Hospitalized patients had more MACE. (Clinicaltrial.gov number: NCT05715879)(04/02/2023).
    MeSH term(s) Humans ; Chest Pain/diagnosis ; Chest Pain/epidemiology ; Chest Pain/etiology ; COVID-19/complications ; COVID-19/diagnosis ; Dyspnea/diagnosis ; Dyspnea/epidemiology ; Fatigue/diagnosis ; Fatigue/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Clinical Study ; Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03322-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hydrocortisone Long-term Treatment Effect on Immunomodulatory Properties of Human Adipose-Derived Mesenchymal Stromal/Stem Cells.

    Salimiyan, Samira / Mohammadi, Mobin / Aliakbari, Sara / Kazemi, Romina / Amini, Abbas Ali / Rahmani, Mohammad Reza

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2022  Volume 42, Issue 2, Page(s) 72–81

    Abstract: Cortisol is secreted in prolonged stress and has therapeutic effects in inflammatory diseases. Considering the immunomodulatory effects of mesenchymal stem cells, here we investigated the effect of hydrocortisone (HC) long-term treatment on ... ...

    Abstract Cortisol is secreted in prolonged stress and has therapeutic effects in inflammatory diseases. Considering the immunomodulatory effects of mesenchymal stem cells, here we investigated the effect of hydrocortisone (HC) long-term treatment on immunomodulatory properties of human adipose-derived mesenchymal stromal/stem cells (ASCs). Isolated ASCs from healthy subjects were treated with different HC concentrations for 14 days. The effect of HC-treated ASCs on the proliferative response of peripheral blood mononuclear cells (PBMCs) was evaluated in ASCs/2-way mixed leukocyte reaction coculture using 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT)-assay. HC-treated ASCs were further divided into interferon gamma (IFN-γ) stimulated and unstimulated groups. Transforming growth factor beta 1 (TGF-β1) and interleukin (IL)-6 levels were measured in culture supernatants by enzyme-linked immunosorbent assay. Relative expression of
    MeSH term(s) Adipose Tissue/metabolism ; Cells, Cultured ; Coculture Techniques ; Cyclooxygenase 2 ; Humans ; Hydrocortisone/metabolism ; Hydrocortisone/pharmacology ; Immunity ; Interferon-gamma ; Interleukin-6/metabolism ; Leukocytes, Mononuclear ; Mesenchymal Stem Cells/metabolism ; Transforming Growth Factor beta1/pharmacology
    Chemical Substances Interleukin-6 ; Transforming Growth Factor beta1 ; Interferon-gamma (82115-62-6) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2021.0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Combined effects of pioglitazone and doxorubicin on migration and invasion of MDA-MB-231 breast cancer cells.

    Malakouti, Parisa / Mohammadi, Mobin / Boshagh, Mohammad Amin / Amini, Abbasali / Rezaee, Mohammad Ali / Rahmani, Mohammad Reza

    Journal of the Egyptian National Cancer Institute

    2022  Volume 34, Issue 1, Page(s) 13

    Abstract: Background: Despite antitumor properties, chemotherapy medication can create conditions in tumor cells that work in favor of the tumor. Doxorubicin, commonly prescribed chemotherapy agents, can increase the risk of migration and invasion of tumor cells ... ...

    Abstract Background: Despite antitumor properties, chemotherapy medication can create conditions in tumor cells that work in favor of the tumor. Doxorubicin, commonly prescribed chemotherapy agents, can increase the risk of migration and invasion of tumor cells through overexpression of the CXCR4 gene by affecting downstream signaling pathways. The regulatory role of CXCR7 on CXCR4 function has been demonstrated. Therefore, it is hypothesized that combining doxorubicin with another anticancer drug could be a promising approach.
    Methods: In this research, we evaluated the anti-invasive property of pioglitazone along with antitumor effects of doxorubicin on MDA-MB-231 breast cancer cell lines.
    Results: There was no significant difference between two treatment groups in neither the expression nor changes in the expression of CXCR7 and CXCR4 genes (P < 0.05). Pioglitazone-doxorubicin combination reduced cell migration in tumor cells to a significantly higher extent compared to doxorubicin alone (P < 0.05).
    Conclusions: Co-administration of pioglitazone and doxorubicin might reduce cell migration in breast cancer tumor cells, and that cell migration function is independent of some specific proteins.
    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Female ; Humans ; Neoplasm Invasiveness/genetics ; Pioglitazone/pharmacology ; Pioglitazone/therapeutic use
    Chemical Substances Doxorubicin (80168379AG) ; Pioglitazone (X4OV71U42S)
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1176790-x
    ISSN 2589-0409 ; 1110-0362
    ISSN (online) 2589-0409
    ISSN 1110-0362
    DOI 10.1186/s43046-022-00110-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Proposing a novel deep network for detecting COVID-19 based on chest images.

    Dialameh, Maryam / Hamzeh, Ali / Rahmani, Hossein / Radmard, Amir Reza / Dialameh, Safoura

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3116

    Abstract: The rapid outbreak of coronavirus threatens humans' life all around the world. Due to the insufficient diagnostic infrastructures, developing an accurate, efficient, inexpensive, and quick diagnostic tool is of great importance. To date, researchers have ...

    Abstract The rapid outbreak of coronavirus threatens humans' life all around the world. Due to the insufficient diagnostic infrastructures, developing an accurate, efficient, inexpensive, and quick diagnostic tool is of great importance. To date, researchers have proposed several detection models based on chest imaging analysis, primarily based on deep neural networks; however, none of which could achieve a reliable and highly sensitive performance yet. Therefore, the nature of this study is primary epidemiological research that aims to overcome the limitations mentioned above by proposing a large-scale publicly available dataset of chest computed tomography scan (CT-scan) images consisting of more than 13k samples. Secondly, we propose a more sensitive deep neural networks model for CT-scan images of the lungs, providing a pixel-wise attention layer on top of the high-level features extracted from the network. Moreover, the proposed model is extended through a transfer learning approach for being applicable in the case of chest X-Ray (CXR) images. The proposed model and its extension have been trained and evaluated through several experiments. The inclusion criteria were patients with suspected PE and positive real-time reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. The exclusion criteria were negative or inconclusive RT-PCR and other chest CT indications. Our model achieves an AUC score of 0.886, significantly better than its closest competitor, whose AUC is 0.843. Moreover, the obtained results on another commonly-used benchmark show an AUC of 0.899, outperforming related models. Additionally, the sensitivity of our model is 0.858, while that of its closest competitor is 0.81, explaining the efficiency of pixel-wise attention strategy in detecting coronavirus. Our promising results and the efficiency of the models imply that the proposed models can be considered reliable tools for assisting doctors in detecting coronavirus.
    MeSH term(s) COVID-19
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06802-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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