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Book ; Online: Advances in Infectious Diseases and Clinical Microbiology during the COVID-19 Pandemic

Khan, Yusra Habib / Mallhi, Tauqeer Hussain / Khan, Tahir Mehmood / Salman, Muhammad

2023

Keywords	Humanities ; Social interaction ; n/a ; COVID-19 ; antibiotic therapy ; mortality ; female gender ; neoplasm history ; heart failure ; diabetes mellitus ; aspirin ; elderly population ; low molecular weight heparin ; pulmonary thromboembolism ; hospital stay ; parental knowledge ; HPV infection ; HPV vaccine ; children ; adolescents ; NSAID ; duration ; side effects ; safety ; vaccine hesitancy ; comorbidities ; hypertension ; hyperlipidemia ; pharmacovigilance ; SARS-CoV-2 ; sequencing ; Nanopore ; MinION ; Ion Torrent ; mediterranean diet ; inflammatory factors ; stress oxidative ; appetite ; antiviral ; clinical outcome ; coronavirus ; disease severity ; Saudi Arabia ; vaccine ; knowledge ; attitude ; perception ; survey ; questionnaire ; breakthrough infections ; neutralizing antibodies (NAbs) ; Omicron ; vaccines ; variants ; latent tuberculosis infection ; hemodialysis ; QuantiFERON-TB Gold Plus assay ; Lebanon ; dexamethasone ; tocilizumab ; epidural abscess ; bacteremia ; inflammatory markers ; therapeutic plasma exchange ; plasmapheresis ; monkeypox outbreak ; public health ; emergency ; Peru ; coinfections ; antimicrobials ; Colombia ; epidemiology ; superinfections ; telemedicine ; primary practice ; ophthalmological diseases ; HIV infection ; CMV retinitis ; tuberculosis verrucosa cutis (TBVC) ; multifocal ; infectious diseases ; tuberculosis
Language	English
Size	1 electronic resource (250 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645713
ISBN	9783036594699 ; 3036594698
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Optimisation of food grade mixed surfactant-based l-ascorbic acid nanoemulsions using response surface methodology.

Mehmood, Tahir

IET nanobiotechnology

2021 Volume 15, Issue 3, Page(s) 309–317

Abstract: Co-surfactant free l-ascorbic acid (LAA) nanoemulsions were prepared using mixed surfactants (Soya lecithin and Tween 80). Response surface methodology (RSM) was used to optimise the emulsifying conditions for LAA nanoemulsions. The effects of water ... ...

Abstract	Co-surfactant free l-ascorbic acid (LAA) nanoemulsions were prepared using mixed surfactants (Soya lecithin and Tween 80). Response surface methodology (RSM) was used to optimise the emulsifying conditions for LAA nanoemulsions. The effects of water proportion (6%-14% w/w), homogenisation pressure (80-160 MPa), surfactant concentrations (4%-12% w/w) and LAA concentration (0.5-1.3 w/w) on responses (size of droplets and nanoemulsion stability) were investigated. RSM results showed that the values of responses can be successfully predicted through second-order polynomial model. The coefficients of determinations for droplet size and nanoemulsion stability were 0.9375 and 0.9027, respectively. The optimum preparation conditions for l-LAA nanoemulsion were 9.04% water proportion, 114.48 MPa homogenisation pressure, 7.36% surfactant concentration and 1.09% LAA concentration. At the end of one month storage study, the retention of LAA in optimised nanoemulsions stored at 4°C and 25°C were 74.4% and 66.7%, respectively. These results may provide valuable contributions for food and pharmaceutical industry to develop delivery system for food additives and nutraceutical components.
MeSH term(s)	Ascorbic Acid ; Emulsions ; Lecithins ; Particle Size ; Surface-Active Agents
Chemical Substances	Emulsions ; Lecithins ; Surface-Active Agents ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2264529-9
ISSN	1751-875X ; 1751-8741
ISSN (online)	1751-875X
ISSN	1751-8741
DOI	10.1049/nbt2.12014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence and Risk Factors of Anemia in Inflammatory Bowel Diseases: A Case-Control Study.

Aslam, Tahir / Mehmood, Asim

Cureus

2023 Volume 15, Issue 7, Page(s) e41990

Abstract: Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis may induce anemia, ranging from 25% to 75% depending on the study population and diagnostic criteria. It might negatively impact their health and quality of ... ...

Abstract	Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis may induce anemia, ranging from 25% to 75% depending on the study population and diagnostic criteria. It might negatively impact their health and quality of life. Objectives The aim of this work is to study the effectiveness and safety of treatments for anemia in patients with IBD. Methodology This case-control study compared patients with IBD who have anemia (cases; n=60) with patients who have IBD but do not have anemia (controls; n=60) from June 2019 to August 2021 in Hayatabad Medical Complex, Peshawar, Pakistan. Data were collected through interviews, from patients` medical records, and from lab test reports. Statistical analysis was performed using SPSS, Version 23.0 (IBM Corp., Armonk, NY). Results Cases had a greater mean age (45.2 years) than controls (42.8 years). Cases included 60% females and controls 45%. Also, cases earned less (p = 0.019). Anemic patients (group 1) had lower mean hemoglobin (10.2 g/dL) and iron than non-anemic controls (group 2) (p = 0.042 and 0.009, respectively). Anemia increased Crohn's Disease Activity Index and Mayo Score. Group 1 has iron deficiency anemia, whereas group 2 has chronic disease. Group 1 reacts rapidly, but gastrointestinal side effects, allergies, and iron overload are more prevalent. Conclusion IBD patients exhibited low hemoglobin and iron, suggesting anemia. Anemia increased disease activity, but not statistically. IBD patients need iron and anemia treatment. Comparing groups demonstrates differences in anemia types, iron replacement history, treatment response, and bad effects, proposing targeted iron supplementation for deficiency anemia and managing chronic illness factors for chronic disease anemia. IBD anemia treatment involves individualization.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.41990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Complete Kawasaki disease after COVID-19 infection in an infant.

Tahir, Maliha / Mehmood, Ramlah / Ahmad, Mirza Sultan

Pakistan journal of medical sciences

2023 Volume 39, Issue 2, Page(s) 616–618

Abstract: Kawasaki disease is a generalized systemic vasculitis that affects blood vessels throughout the body. The aetiology of Kawasaki disease is still unknown but is thought to be related to the combined effects of the immune response, genetic susceptibility, ... ...

Abstract	Kawasaki disease is a generalized systemic vasculitis that affects blood vessels throughout the body. The aetiology of Kawasaki disease is still unknown but is thought to be related to the combined effects of the immune response, genetic susceptibility, and infections including COVID-19. In this case report, we present a seven months old male infant who presented to us with fever, swollen lips, ulcers in the mouth, enlarged tonsils, strawberry tongue, conjunctivitis and generalised non-blanchable maculopapular rash. The detailed workup fulfilled the criteria of Kawasaki disease. The COVID-19 IgM antibodies were positive. The patient was treated with IV Immunoglobulins, IV methylprednisolone and Aspirin. The repeat echocardiography on six weeks follow-up turned out normal. In conclusion, there should be a high index of suspicion of Kawasaki disease while evaluating pediatric patients with COVID-19 infection so that timely intervention can be made to prevent complications. Prospective studies are needed to evaluate the relationship between Kawasaki Disease and COVID-19 infection.
Language	English
Publishing date	2023-01-20
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.2.6359
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Zs.A 3948: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Quantitative Profiling of Alpha-Subunit of IL-3 Receptor on Single Acute Myeloid Leukemia Cells by Super-Resolution Imaging.

Mehmood, Tahir / Zhang, Xian-En

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 1, Page(s) 185–194

Abstract: Background: Quantitative profiling of specific cell surface markers is a new approach in characterization of tumor heterogeneity and single cell biology. The current tools have dearth in detection and quantification of receptor proteins on single cells.! ...

Abstract	Background: Quantitative profiling of specific cell surface markers is a new approach in characterization of tumor heterogeneity and single cell biology. The current tools have dearth in detection and quantification of receptor proteins on single cells. Methods: we focused on our newly developed protocol to determine the distribution pattern and density of cell surface markers on single acute myeloid leukemia cells. Cell surface proteins were labeled with quantum dots (Qdots) followed by super resolution Structured Illumination Microscopy (SIM) imaging to imprisonment the optical signals emitted by Qdots which were further analyzed by software imaris to do three dimensional (3D) structure reconstruction and digital simulation. Furthermore, MTT assays and flow cytometry was performed to establish association between expression of cell surface markers and drug response. Results: In the present study, we found that the Molm13 and cytarabine-enriched Molm13 cells exhibit different densities of CD123, an alpha-subunit of interleukin-3 receptor, i.e. 0.92 and 1.73 per μm2 of cell surface respectively. Sub-populations of Molm13 cells expressing higher densities of CD123 on cells membranes showed resistance against cytarabine. Further study revealed that romidepsin sensitized and augmented the cytotoxicity of cytarabine in Molm13 and cytarabine-enriched Molm13 cells. Romidepsin increased the percentage of cell death-induced by cytarabine from 21.6 % to 28.6 % and 37.1 % to 57.2 % in Molm13 and cytarabine-enriched Molm13 cells respectively. Conclusion: Altogether, the study suggests that Molm13 cells have sub-populations with differential expression of CD123+ phenotype. Romidepsin sensitizes and augments the effect of cytarabine in Molm13 and cytarabine-enriched Molm13 cells.
MeSH term(s)	Humans ; Receptors, Interleukin-3 ; Interleukin-3 Receptor alpha Subunit ; Leukemia, Myeloid, Acute/pathology ; Cytarabine/pharmacology ; Flow Cytometry ; Cell Line, Tumor
Chemical Substances	Receptors, Interleukin-3 ; Interleukin-3 Receptor alpha Subunit ; Cytarabine (04079A1RDZ)
Language	English
Publishing date	2023-01-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.1.185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action.

Mehmood, Tahir / Muanprasat, Chatchai

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 7

Abstract: Cancer is a leading cause of morbidity and mortality worldwide. The development of cancer involves aberrations in multiple pathways, representing promising targets for anti-cancer drug discovery. Natural products are regarded as a rich source for ... ...

Abstract	Cancer is a leading cause of morbidity and mortality worldwide. The development of cancer involves aberrations in multiple pathways, representing promising targets for anti-cancer drug discovery. Natural products are regarded as a rich source for developing anti-cancer therapies due to their unique structures and favorable pharmacology and toxicology profiles. Deoxyelephantopin and isodeoxyelephantopin, sesquiterpene lactone compounds, are major components of
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Asteraceae/chemistry ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Humans ; Lactones/chemistry ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology ; Sesquiterpenes/therapeutic use
Chemical Substances	Antineoplastic Agents ; Biological Products ; Lactones ; Sesquiterpenes ; deoxyelephantopin ; isodeoxyelephantopin
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27072086
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Article ; Online: Use of social media and WhatsApp to conduct teaching activities during the COVID-19 lockdown in Pakistan.

Khan, Tahir Mehmood

The International journal of pharmacy practice

2020 Volume 29, Issue 1, Page(s) 90

MeSH term(s)	COVID-19 ; Humans ; Mobile Applications ; Pakistan ; Pandemics ; Quarantine ; Social Media ; Teaching ; Universities
Keywords	covid19
Language	English
Publishing date	2020-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1087040-4
ISSN	2042-7174 ; 0961-7671
ISSN (online)	2042-7174
ISSN	0961-7671
DOI	10.1111/ijpp.12659
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3320: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Healthcare professionals' understanding and perception of drug-related issues linked to off-label pharmacological medications used for COVID-19.

Munir, Muhammad Zeeshan / Khan, Amer Hayat / Khan, Tahir Mehmood

Expert review of anti-infective therapy

2024 , Page(s) 1–7

Abstract: Background: To evaluate the opinions of healthcare workers regarding drug therapy problems linked to anti-infective medicines used for the treatment of COVID-19 infection in Pakistan.: Research methodology: This cross-sectional study was conducted ... ...

Abstract	Background: To evaluate the opinions of healthcare workers regarding drug therapy problems linked to anti-infective medicines used for the treatment of COVID-19 infection in Pakistan. Research methodology: This cross-sectional study was conducted from January to October 2022 using a self-administered questionnaire developed by the authors, having three sections: demographics, knowledge, and perception. The study was validated by research experts and pilot-tested on 30 subjects. The study included medical doctors, nurses, pharmacists from Punjab's government and private medical institutes. Results: In this study, 382 of 400 participants replied. The mean knowledge score was 9.52 (SD 2.97), showing that participants had adequate knowledge of COVID-19 pharmacological interventions. The knowledge scores were significantly higher of those who treated COVID-19 patients and were from Lahore. Many doctors considered that elderly patients and those with blood disorders were at greater risk of experiencing drug-related problems. Most pharmacists support electronic prescription systems. Many doctors thought the lack of unified treatment guidelines, multiple prescribers, and self-medication were key obstacles in managing COVID-19 patients. Conclusion: Most respondents had adequate knowledge. Older patients with comorbidities are at risk of adverse effects. Self-medication, polypharmacy, and multiple prescriptions can lead to misdiagnosis and complications. Electric prescriptions, team effort, and training programs can decrease these issues.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2024.2310004
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Zs.A 6106: Show issues

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Article ; Online: Impact of Limosilactobacillus fermentum probiotic treatment on gut microbiota composition in sahiwal calves with rotavirus diarrhea: A 16S metagenomic analysis study".

Murtaza, Nadeem / Nawaz, Muhammad / Yaqub, Tahir / Mehmood, Asim Khalid

BMC microbiology

2024 Volume 24, Issue 1, Page(s) 114

Abstract: Background: Diarrhea poses a major threat to bovine calves leading to mortality and economic losses. Among the causes of calf diarrhea, bovine rotavirus is a major etiological agent and may result in dysbiosis of gut microbiota. The current study was ... ...

Abstract	Background: Diarrhea poses a major threat to bovine calves leading to mortality and economic losses. Among the causes of calf diarrhea, bovine rotavirus is a major etiological agent and may result in dysbiosis of gut microbiota. The current study was designed to investigate the effect of probiotic Limosilactobacillus fermentum (Accession No.OR504458) on the microbial composition of rotavirus-infected calves using 16S metagenomic analysis technique. Screening of rotavirus infection in calves below one month of age was done through clinical signs and Reverse Transcriptase PCR. The healthy calves (n = 10) were taken as control while the infected calves (n = 10) before treatment was designated as diarrheal group were treated with Probiotic for 5 days. All the calves were screened for the presence of rotavirus infection on each day and fecal scoring was done to assess the fecal consistency. Infected calves after treatment were designated as recovered group. Fecal samples from healthy, recovered and diarrheal (infected calves before sampling) were processed for DNA extraction while four samples from each group were processed for 16S metagenomic analysis using Illumina sequencing technique and analyzed via QIIME 2. Results: The results show that Firmicutes were more abundant in the healthy and recovered group than in the diarrheal group. At the same time Proteobacteria was higher in abundance in the diarrheal group. Order Oscillospirales dominated healthy and recovered calves and Enterobacterials dominated the diarrheal group. Alpha diversity indices show that diversity indices based on richness were higher in the healthy group and lower in the diarrheal group while a mixed pattern of clustering between diarrheal and recovered groups samples in PCA plots based on beta diversity indices was observed. Conclusion: It is concluded that probiotic Limosilactobacillus Fermentum N-30 ameliorate the dysbiosis caused by rotavirus diarrhea and may be used to prevent diarrhea in pre-weaned calves after further exploration.
MeSH term(s)	Animals ; Cattle ; Rotavirus/genetics ; Rotavirus Infections/drug therapy ; Rotavirus Infections/veterinary ; Gastrointestinal Microbiome/genetics ; Limosilactobacillus fermentum ; Dysbiosis ; Diarrhea/drug therapy ; Diarrhea/veterinary ; Feces/microbiology ; Probiotics/therapeutic use ; Cattle Diseases/drug therapy ; Cattle Diseases/microbiology
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-024-03254-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 4-Adamantyl-(2-(arylidene)hydrazinyl)thiazoles as potential antidiabetic agents: experimental and docking studies.

Iqbal, Yasir / Akhtar, Tashfeen / Haroon, Muhammad / Mehmood, Hasnain / Nizami, Tauqir / Tahir, Ehsaan / Ehsan, Muhammad

Future medicinal chemistry

2023 Volume 15, Issue 7, Page(s) 599–613

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Molecular Docking Simulation ; Thiazoles/pharmacology ; Thiazoles/chemistry ; Hypoglycemic Agents/pharmacology ; alpha-Amylases ; Structure-Activity Relationship
Chemical Substances	Antioxidants ; Thiazoles ; Hypoglycemic Agents ; alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2023-0010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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