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  1. Article ; Online: Secukinumab is effective in a patient on haemodialysis for end-stage renal disease and severe hidradenitis suppurativa.

    Abu Rached, Nessr / Ocker, Lennart / Stockfleth, Eggert / Bechara, Falk G

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  

    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  2. Article ; Online: Clinical characteristics and complete blood count data of 506 patients with erysipelas: Predictors for length of hospitalization and recurrence.

    Gambichler, Thilo / Schubert, Luzie / Abu Rached, Nessr / Susok, Laura

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 9, Page(s) e1161–e1163

    MeSH term(s) Humans ; Erysipelas/diagnosis ; Erysipelas/drug therapy ; Hospitalization ; Anti-Bacterial Agents/therapeutic use ; Blood Cell Count ; Recurrence
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  3. Article ; Online: Interleukin-17RA blockade by brodalumab decreases inflammatory pathways in hidradenitis suppurativa skin and serum.

    Scheel, Christina H / Rached, Nessr Abu / Gambichler, Thilo

    The British journal of dermatology

    2022  Volume 187, Issue 2, Page(s) 138–139

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Hidradenitis Suppurativa ; Humans ; Interleukins ; Skin/metabolism
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interleukins ; brodalumab (6ZA31Y954Z)
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21591
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  4. Article ; Online: Serum neuron-specific enolase independently predicts outcomes of patients with Merkel cell carcinoma.

    Gambichler, Thilo / Abu Rached, Nessr / Susok, Laura / Becker, Jürgen C

    The British journal of dermatology

    2022  Volume 187, Issue 5, Page(s) 806–808

    MeSH term(s) Humans ; Carcinoma, Merkel Cell/pathology ; Phosphopyruvate Hydratase ; Skin Neoplasms/pathology
    Chemical Substances Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2022-07-17
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.23: Show issues Location:
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  5. Article: Model for End-Stage Liver Disease Correlates with Disease Relapse and Death of Patients with Merkel Cell Carcinoma.

    Gambichler, Thilo / Becker, Jürgen C / Susok, Laura / Käpynen, Riina / Abu Rached, Nessr

    Cancers

    2023  Volume 15, Issue 12

    Abstract: Merkel cell carcinoma (MCC) is a highly malignant skin tumor that occurs mainly in elderly and/or immunosuppressed patients. MCC prognosis has been significantly improved by the introduction of immune checkpoint inhibitor treatment. Recently, blood-based ...

    Abstract Merkel cell carcinoma (MCC) is a highly malignant skin tumor that occurs mainly in elderly and/or immunosuppressed patients. MCC prognosis has been significantly improved by the introduction of immune checkpoint inhibitor treatment. Recently, blood-based biomarkers have been investigated that can potentially predict the outcome of MCC patients. In this context, parameters of liver scores have not yet been investigated. We retrospectively recruited 47 MCC patients with available relevant laboratory data at primary diagnosis. At this time, we investigated blood-based scores as follows: model for end-stage liver disease (MELD), aspartate aminotransferase/platelet count ratio index (APRI), and the alanine transaminase/aspartate aminotransferase ratio (De Ritis ratio). MCC relapse was negatively correlated with the De Ritis score (r = -0.3,
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15123195
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  6. Article ; Online: Comparison of clinical and laboratory data of adult patients with cutaneous IgA-vasculitis and non-IgA vasculitis.

    Gambichler, Thilo / Bui, Duyên / Domin, Belanna / Ardabili, Larisa / Devrim, Yusa / Abu Rached, Nessr / Susok, Laura

    Clinical and experimental dermatology

    2024  

    Abstract: Background: Immune complex vasculitides may be subdivided into adult IgA small vessel vasculitis (aIgA-SVV, adult Henoch-Schönlein purpura) and non-IgA-SVV (hypersensitivity vasculitis, etc.).: Objectives: We aimed to evaluate clinical and laboratory ...

    Abstract Background: Immune complex vasculitides may be subdivided into adult IgA small vessel vasculitis (aIgA-SVV, adult Henoch-Schönlein purpura) and non-IgA-SVV (hypersensitivity vasculitis, etc.).
    Objectives: We aimed to evaluate clinical and laboratory parameters of inpatients fulfilling the diagnostic criteria for aIgA-SVV and non-IgA-SVV.
    Methods: 29 adult patients (≥ 20years) with aIgA-SVV according to the EULAR/PRINTO/PRES criteria and 53 adult patients with non-IgA-SVV according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides were compared with respect to a variety of clinical and laboratory parameters using uni- and multivariable statistics.
    Results: Compared to aIgA-SVV patients, the platelet-to-lymphocyte ratio was significantly higher in non-IgA-SVV patients. Serum C3 levels and mean corpuscular haemoglobin concentration observed in non-IgA-SVV patients were significantly lower compared to aIgA-SVV patients. Laboratory-based evidence for proteinuria and haematuria was significantly more common in patients with aIgA SVV. Only in patients with aIgA-SVV, proteinuria and haematuria significantly correlated with systemic immune-inflammation biomarkers. In patients with aIgA-SVV, higher LDH and CRP were strong independent predictors for the presence of proteinuria and proteinuria. In patients with non-IgA-SVV, female sex was a protective factor for proteinuria, while skin lesions on the upper extremities proved to be a significant independent predictor of haematuria.
    Conclusions: We detected several clinical and laboratory differences between patients with aIgA-SVV and non-IgA-SVV. In both groups, distinct predictors for renal involvement could be observed indicating that aIgA-SVV and non-IgA-SVV are very similar conditions but do not appear to present the same entity.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae062
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; Thesis: Untersuchungen zur Expression von DNA-Mismatch-Reparaturproteinen im Merkelzellkarzinom

    Abu Rached, Nessr [Verfasser] / Gambichler, Thilo [Gutachter] / Hessam, Schapoor [Gutachter]

    2022  

    Author's details Nessr Abu Rached ; Gutachter: Thilo Gambichler, Schapoor Hessam ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: Cold Plasma Therapy in Chronic Wounds-A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results.

    Abu Rached, Nessr / Kley, Susanne / Storck, Martin / Meyer, Thomas / Stücker, Markus

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs. In ... ...

    Abstract Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs. In light of this, the POWER study was conducted as a multicenter, randomized clinical trial to investigate the effect of large-area plasma application compared with SWT in patients with chronic, non-healing arterial or venous wounds on the lower leg. To analyze the interim results, we employed a comprehensive range of statistical tests, including both parametric and non-parametric methods, as well as GLS model regression and an ordinal mixed model. Our findings clearly demonstrate that CPT therapy significantly accelerates wound closure compared with SWT. In fact, complete wound closure was exclusively observed in the CPT group during the intervention period. Additionally, the CPT group required significantly less antibiotic therapy (4%) compared with the SWT group (23%). Furthermore, CPT led to a significant reduction in wound pain and improved quality of life compared with SWT. In conclusion, the study highlights that the combination of CPT and SWT surpasses monotherapy with SWT alone.
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Upadacitinib treatment associated with varicella zoster infection complicated by haemophagocytic lymphohistiocytosis in a patient with severe hidradenitis suppurativa.

    Abu Rached, Nessr / Gambichler, Thilo / Ocker, Lennart / Schultheis, Beate / Susok, Laura / Schmidt, Wolfgang / Bechara, Falk G

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 2, Page(s) e139–e141

    MeSH term(s) Humans ; Hidradenitis Suppurativa/complications ; Hidradenitis Suppurativa/drug therapy ; Chickenpox ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Varicella Zoster Virus Infection/complications ; Herpes Zoster/complications ; Herpes Zoster/drug therapy ; Heterocyclic Compounds, 3-Ring
    Chemical Substances upadacitinib (4RA0KN46E0) ; Heterocyclic Compounds, 3-Ring
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  10. Article: Current Medical and Surgical Treatment of Hidradenitis Suppurativa-A Comprehensive Review.

    Ocker, Lennart / Abu Rached, Nessr / Seifert, Caroline / Scheel, Christina / Bechara, Falk G

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients' quality of life and is associated with a variety of comorbidities. ...

    Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients' quality of life and is associated with a variety of comorbidities. Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available. However, especially in moderate-to-severe HS, there is an urgent need for new treatment approaches. In recent years, increased research has led to the identification of new potential therapeutic targets. This review aims to give a comprehensive and practical overview of current treatment options for HS. Furthermore, the clinically most advanced novel treatment approaches will be discussed.
    Language English
    Publishing date 2022-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11237240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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