Article ; Online: Sarcomatoid renal cell carcinoma with rhabdoid features.
2013 Volume 33, Issue 5, Page(s) 495–499
Abstract: Sarcomatoid renal cell carcinoma (SRCC) with rhabdoid features is a rare tumor with aggressive behavior and poor prognosis. We report a case of a 71-year-old man with a large left-sided renal mass. Nephrectomy specimen revealed clear cell carcinoma with ... ...
| Abstract | Sarcomatoid renal cell carcinoma (SRCC) with rhabdoid features is a rare tumor with aggressive behavior and poor prognosis. We report a case of a 71-year-old man with a large left-sided renal mass. Nephrectomy specimen revealed clear cell carcinoma with sarcomatoid and rhabdoid tumor cells. The rhabdoid cells were immunoreactive for mesenchymal markers such as vimentin, epithelial markers such as cytokeratin, and epithelial membrane antigen. These cells were also positive for p53 and had a high proliferation index. The rhabdoid component also demonstrated the loss of immunostaining for integrase interactor 1 (INI1), which stained the other components of the tumor. Only a few cases are available in the published reports documenting rhabdoid cells in SRCC. None of these cases were studied by INI1 immunostain. |
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| MeSH term(s) | Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy ; Rhabdoid Tumor/diagnosis ; Rhabdoid Tumor/pathology ; Rhabdoid Tumor/surgery ; SMARCB1 Protein ; Sarcoma/diagnosis ; Sarcoma/pathology ; Sarcoma/surgery ; Transcription Factors/metabolism |
| Chemical Substances | Biomarkers, Tumor ; Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; SMARCB1 Protein ; SMARCB1 protein, human ; Transcription Factors |
| Language | English |
| Publishing date | 2013-11-02 |
| Publishing country | Saudi Arabia |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 639014-6 |
| ISSN | 0975-4466 ; 0256-4947 |
| ISSN (online) | 0975-4466 |
| ISSN | 0256-4947 |
| DOI | 10.5144/0256-4947.2013.495 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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