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Article ; Online: Recognizing the importance of physical activity on sarcopenia in chronic kidney disease.

Wilkinson, Thomas J / Ribeiro, Heitor S

Osteoporosis and sarcopenia

2022 Volume 8, Issue 1, Page(s) 30–31

Language	English
Publishing date	2022-04-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-5263
ISSN (online)	2405-5263
DOI	10.1016/j.afos.2022.02.002
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Article ; Online: Physical activity and living well with kidney disease.

Wilkinson, Thomas J / Smith, Alice C

Nature reviews. Nephrology

2021 Volume 17, Issue 3, Page(s) 145–146

MeSH term(s)	Disease Management ; Exercise/physiology ; Humans ; Kidney Diseases/physiopathology
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-021-00398-3
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Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 107: Show issues

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Article ; Online: Reply: Ad Hoc Measurements of the Anterior Thigh Muscle (Mass and Function) in Sarcopenia.

Wilkinson, Thomas J / Smith, Alice C

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2021 Volume 41, Issue 1, Page(s) 261–262

MeSH term(s)	Humans ; Muscle Strength ; Muscle, Skeletal/diagnostic imaging ; Sarcopenia/diagnostic imaging ; Thigh/diagnostic imaging
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.15697
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 495: Show issues

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Article ; Online: Structure and ligand binding in the putative anti-microbial peptide transporter protein, YejA.

Ackroyd, Bryony K / Dodson, Eleanor J / Mehboob, Javeria / Dowle, Adam A / Thomas, Gavin H / Wilkinson, Anthony J

Microbiology (Reading, England)

2024 Volume 170, Issue 2

Abstract: YejABEF is an ATP-binding cassette transporter that is implicated in the sensitivity ... ...

Abstract	YejABEF is an ATP-binding cassette transporter that is implicated in the sensitivity of
MeSH term(s)	Ligands ; Peptides/metabolism ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Oligopeptides ; Escherichia coli/metabolism ; Protein Binding ; Membrane Transport Proteins
Chemical Substances	peptide permease (97599-47-8) ; Ligands ; Peptides ; ATP-Binding Cassette Transporters ; Oligopeptides ; Membrane Transport Proteins
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/mic.0.001430
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Ud II Zs.140: Show issues

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Article ; Online: Corrigendum to 'Clinical outcomes associated with the emergency treatment of hyperkalaemia with intravenous insulin-dextrose' [European Journal of Internal Medicine 95C (2021) 87-92].

Humphrey, Toby J L / James, Glen / Wilkinson, Ian B / Hiemstra, Thomas F

European journal of internal medicine

2023 Volume 116, Page(s) 170

Language	English
Publishing date	2023-08-26
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2023.08.008
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Zs.A 2608: Show issues

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Article ; Online: Improving self-management behaviour through a digital lifestyle intervention: An internal pilot study.

Lightfoot, Courtney J / Wilkinson, Thomas J / Vadaszy, Noemi / Graham-Brown, Matthew P M / Davies, Melanie J / Yates, Thomas / Smith, Alice C

Journal of renal care

2024

Abstract: Background: Self-management is a key component of successful chronic kidney disease (CKD) management. Here, we present the findings from the internal pilot of a multicentre randomised controlled trial (RCT) aimed to test the effect of a digital self- ... ...

Abstract	Background: Self-management is a key component of successful chronic kidney disease (CKD) management. Here, we present the findings from the internal pilot of a multicentre randomised controlled trial (RCT) aimed to test the effect of a digital self-management programme ('My Kidneys & Me' (MK&M)). Methods: Participants (aged ≥18 years and CKD stages 3-4) were recruited from hospital kidney services across England. Study processes were completed virtually. Participants were randomised 2:1 to either intervention (MK&M) or control group. The first 60 participants recruited were included in a 10-week internal pilot which assessed study feasibility and acceptability against pre-specified progression criteria: 1) eligibility and recruitment, acceptability of 2) randomisation and 3) outcomes, 4) MK&M activation, and 5) retention and attrition rates. Semi-structured interviews further explored views on trial participation. Results: Of the 60 participants recruited, 41 were randomised to MK&M and 19 to control. All participants completed baseline measures and 62% (n=37) completed post-intervention outcome measures. All progression criteria met the minimum thresholds to proceed. Nine participants were interviewed. The themes identified were satisfaction with study recruitment processes (openness to participate, reading and agreeing to "terms and conditions"), acceptability of study design (remote study participation, acceptability of randomisation, completion of online assessment(s)), and methods to improve recruitment and retention (personalised approach, follow-up communication). Conclusion: This internal pilot demonstrated the feasibility and acceptability of a virtually run RCT. Progression criteria thresholds to proceed to the definitive RCT were met. Areas for improvement were identified and protocol amendments were made to improve trial delivery.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375362-6
ISSN	1755-6686 ; 1755-6678 ; 1019-083X
ISSN (online)	1755-6686
ISSN	1755-6678 ; 1019-083X
DOI	10.1111/jorc.12488
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Zs.A 6308: Show issues

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Article ; Online: Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus.

Belfield, Archie E / Wilkinson, Thomas J / Henson, Joseph / Sargeant, Jack A / Breen, Leigh / Hall, Andrew P / Davies, Melanie J / Yates, Thomas

Age and ageing

2024 Volume 53, Issue 5

Abstract: Background: The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, ... ...

Abstract	Background: The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, adiposity may differentially influence these strength criteria and produce discrepant sarcopenia prevalence. Objective: To determine the prevalence of sarcopenia using HGS or the CST, and to investigate the associations between these strength criteria and adiposity in adults with type 2 diabetes mellitus. Methods: The EWGSOP2 definition was used to assess the prevalence of probable (low muscle strength), confirmed (plus low muscle mass) and severe (plus poor physical performance) sarcopenia. Linear regression models were used to study the association between different measures of muscle strength and adiposity. Results: We used data from 732 adults with type 2 diabetes mellitus (35.7% female, aged 64 ± 8 years, body mass index 30.7 ± 5.0 kg/m2). Using the CST compared with HGS produced a higher prevalence of probable (31.7% vs. 7.1%), confirmed (5.6% vs. 1.6%) and severe (1.0% vs. 0.3%) sarcopenia, with poor agreement between strength criteria to identify probable sarcopenia. CST performance, but not HGS, was significantly associated with all measures of adiposity in unadjusted and adjusted models. Conclusions: Higher levels of adiposity may impact CST performance, but not HGS, resulting in a higher prevalence of sarcopenia in adults with type 2 diabetes mellitus. Consideration should be paid to the most appropriate measure of muscle function in this population.
MeSH term(s)	Humans ; Sarcopenia/epidemiology ; Sarcopenia/physiopathology ; Sarcopenia/diagnosis ; Hand Strength ; Female ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/complications ; Male ; Aged ; Prevalence ; Middle Aged ; Adiposity ; Cross-Sectional Studies ; Geriatric Assessment/methods ; Predictive Value of Tests ; Age Factors ; Linear Models
Language	English
Publishing date	2024-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comparative Study
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afae090
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incidence, Prevalence, and Outcomes of Hand Manifestations in Patients With Diabetes Mellitus: A Comprehensive Literature Review.

Knoedler, Thomas G / Gaertner, Aidan P / Wilkinson, Paul J / Neil Salvapongse, A

Hand (New York, N.Y.)

2024 , Page(s) 15589447231219522

Abstract: Diabetes mellitus is a metabolic disease that results in long-term hyperglycemia. Among the many long-term complications associated with diabetes, manifestations in the hand include Dupuytren's contracture, trigger finger, compressive neuropathies, and ... ...

Abstract	Diabetes mellitus is a metabolic disease that results in long-term hyperglycemia. Among the many long-term complications associated with diabetes, manifestations in the hand include Dupuytren's contracture, trigger finger, compressive neuropathies, and infections. These conditions can have a profound impact on a patient's quality of life, highlighting the importance of timely recognition and treatment of these manifestations. This review aims to provide updated information regarding the incidence and outcomes of these clinical manifestations in the diabetic versus nondiabetic population. A systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was performed. The literature search included the use of PubMed and Ovid databases to find relevant articles that were then selected based on an inclusion criterion that required level 4 evidence. Diabetes mellitus results in an increased incidence of Dupuytren's contracture, trigger finger, carpal tunnel syndrome, cubital tunnel syndrome, and hand infections. Dupuytren's, trigger finger, and carpal tunnel syndrome all had similar outcomes, while diabetic patients had worse outcomes related to infections. There was a lack of data regarding the effect of diabetes on cubital tunnel syndrome. Future studies should be performed to analyze the effects of diabetes mellitus on hand manifestations, particularly regarding the outcomes of diabetic patients with cubital tunnel syndrome.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2277325-3
ISSN	1558-9455 ; 1558-9447
ISSN (online)	1558-9455
ISSN	1558-9447
DOI	10.1177/15589447231219522
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Article ; Online: Modelling the impact of cabbage stem flea beetle larval feeding on oilseed rape lodging risk.

Wilkinson, Thomas Dj / Coston, Duncan J / Berry, Pete M / Pickering, Frances / White, Sacha / Kendall, Sarah L

Pest management science

2024

Abstract: Background: Cabbage stem flea beetle (CSFB, Psylliodes chrysocephala L.) is a major pest of oilseed rape (OSR, Brassica napus L.) in the UK and low availability of effective chemical control has increased the need for integrated pest management ... ...

Abstract	Background: Cabbage stem flea beetle (CSFB, Psylliodes chrysocephala L.) is a major pest of oilseed rape (OSR, Brassica napus L.) in the UK and low availability of effective chemical control has increased the need for integrated pest management approaches. The risk of OSR to lodging is strongly related to stem strength, however, the impact of CSFB larval tunnelling on stem strength and subsequent risk to stem lodging is unknown. The study investigated this by applying the Generalised Crop Lodging Model to conventionally grown OSR crops scored for varying levels of CSFB larval tunnelling. Lodging risk mitigation strategies including plant growth regulators (PGR) and varying nitrogen regimes were tested under high CSFB larval pressure. Results: Stems of OSR plants were categorised by the proportion of visual damage (< 5%; 5-25%; 26-50%; 51-75%; 75-100%). Stems of 26-50% damage had significantly lower breaking strengths and diameters compared to plants that scored < 5%, with the associated reduction in stem failure windspeed equivalent to an order of magnitude increase in the risk of a lodging event occurring in the UK. PGR use reduced plant height and subsequently lodging risk variably across the sites. Conclusion: Estimating the proportion of stem tunnelling alongside larval pressure may be a useful tool in considering the contribution of CSFB pressure to lodging risk. The research demonstrates that the use of canopy management principles to optimise canopy size through nitrogen management and PGR use may help offset increased lodging risk caused by CSFB tunnelling. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.8079
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Article ; Online: Exploring the Validity of GOLD 2023 Guidelines: Should GOLD C and D Be Combined?

Duckworth, Christopher / Boniface, Michael J / Kirk, Adam / Wilkinson, Thomas M A

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 2335–2339

Abstract: Introduction: The GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2023 guidelines proposed important changes to the stratification of disease severity using the "ABCD" assessment tool. The highest risk groups "C" and "D" were combined into ...

Abstract	Introduction: The GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2023 guidelines proposed important changes to the stratification of disease severity using the "ABCD" assessment tool. The highest risk groups "C" and "D" were combined into a single category "E" based on exacerbation history, no longer considering symptomology. Purpose: We quantify the differential disease progression of individuals initially stratified by the GOLD 2022 "ABCD" scheme to evaluate these proposed changes. Patients and methods: We utilise data collected from 1529 users of the myCOPD mobile app, a widely used and clinically validated app supporting people living with COPD in the UK. For patients in each GOLD group, we quantify symptoms using COPD Assessment Tests (CAT) and rate of exacerbation over a 12-month period post classification. Results: CAT scores for users initially classified into GOLD C and GOLD D remain significantly different after 12 months (Kolmogorov-Smirnov statistic = 0.59, P = 8.2 × 10 Conclusion: CAT scores remain important for stratifying disease progression both in-terms of symptomology and future exacerbation risk. Based on this evidence, the merger of GOLD C and GOLD D should be reconsidered.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Forced Expiratory Volume ; Severity of Illness Index ; Disease Progression ; Asthma
Language	English
Publishing date	2023-10-24
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S430344
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