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  1. Article: Innovative Standards in Oncoplastic Breast Conserving Surgery: From Radical Mastectomy to Extreme Oncoplasty.

    Karadeniz Cakmak, Guldeniz

    Breast care (Basel, Switzerland)

    2021  Volume 16, Issue 6, Page(s) 559–573

    Abstract: Background: Oncoplastic breast conserving surgery (OBCS), which is the current procedure of choice for eligible BC patients, describes a philosophy that prioritizes oncologic and cosmetic outcomes. However, knowledge gaps regarding training, acceptance, ...

    Abstract Background: Oncoplastic breast conserving surgery (OBCS), which is the current procedure of choice for eligible BC patients, describes a philosophy that prioritizes oncologic and cosmetic outcomes. However, knowledge gaps regarding training, acceptance, and practice preclude standardization and make it difficult to design algorithmic guidelines to optimize individualized management in the era of precision medicine.
    Summary: The harmony between patient expectations and oncologic goals creates the state of the art of OBCS. Nevertheless, to achieve these goals, multidisciplinary approach is a must. Surgical decisions require a comprehensive evaluation including patient factors, tumor biology, genetics, technical considerations, and adjunct therapies. Moreover, the quality-of-life (QOL) issues should be considered as the highest level of priority with a shared decision making instituted on realistic discussions with the patient.
    Key messages: The standardization in OBCS should be initiated via defining a breast surgeon who should gain theorical and practical competence on techniques via national or international educational programs. The algorithmic patient assessment with appropriate documentation before and after surgery should be established. A simple and safe global lexicon should be designed regarding techniques to be proposed and quality metrics to be considered. Additionally, international multicenter prospective trials should be instituted to overcome knowledge gaps. It is evident that OBCS is the perfect union of science with art. Nevertheless, at the very end, the question is not the nature of the surgeon/artist who would be the extremist, the innovator, or the conservative, but the patient's satisfaction, prognosis, and QOL that conclude the cascade of state of the art of OBCS.
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000518992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Utilizing Surgeon-Performed Intraoperative Translaryngeal Ultrasound for Verifying Vocal Fold Function: A Troubleshooting Approach for Intraoperative Neuromonitoring in Neck Surgery.

    Balbaloglu, Hakan / Karadeniz, Emre / Erkek, Ahmet / Yilmaz, Cem / Ugurlu, Mustafa Umit / Cakmak, Guldeniz Karadeniz

    Journal of voice : official journal of the Voice Foundation

    2024  

    Abstract: Introduction: We investigated transcutaneous laryngeal ultrasonography (TLUS) for assessing vocal fold (VF) mobility during thyroid and parathyroid surgeries, emphasizing its precision and utility in signal loss scenarios.: Methods: Between October ... ...

    Abstract Introduction: We investigated transcutaneous laryngeal ultrasonography (TLUS) for assessing vocal fold (VF) mobility during thyroid and parathyroid surgeries, emphasizing its precision and utility in signal loss scenarios.
    Methods: Between October 2020 and January 2023, we performed TLUS, Doppler sonography, laryngeal twitch response (LTR) palpation, and electromyography (EMG) to monitor recurrent laryngeal nerve function during neck surgeries. Postoperatively, the VF activity was verified using fiberoptic video laryngoscopy (FL). Concordance with FL was categorized based on VF activity.
    Results: Of the 443 VF evaluations, no instances of permanent bilateral paralysis were noted. Temporary unilateral palsy was found in 3.38% and permanent in 0.45%. TLUS displayed 97.8% agreement with EMG and was diagnostically superior (99.7% vs 98.2%) and more affordable ($68 vs $300) compared to analogous operative durations.
    Conclusion: TLUS rivals EMG in terms of intraoperative neuromonitoring accuracy and outperforms LTR. Being cost-effective, TLUS can effectively address signal loss situations, thereby averting additional surgeries.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2024.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can inflammatory indices predict sentinel lymph node status in patients with early-stage breast cancer?

    Balbaloglu, Hakan / Tasdoven, Ilhan / Karadeniz Cakmak, Guldeniz

    Medicine

    2023  Volume 102, Issue 33, Page(s) e34808

    Abstract: Breast cancer research has focused on the early detection and treatment of breast cancer. Axillary lymph node status is essential for primary breast cancer staging, recurrence, and survival. The current quest for precision medicine is to identify ... ...

    Abstract Breast cancer research has focused on the early detection and treatment of breast cancer. Axillary lymph node status is essential for primary breast cancer staging, recurrence, and survival. The current quest for precision medicine is to identify predictive markers that offer the advantage of individualized treatment options. This study aimed to investigate the value of inflammatory indices in predicting positive sentinel nodes in breast cancer. We studied 602 patients with early-stage breast cancer who underwent sentinel lymph node biopsies (SLNB) at the Bülent Ecevit University General Surgery Clinic. We obtained data, including the clinical and demographic characteristics of the patients, such as age, histological type, and sentinel lymph nodes. Neutrophil, lymphocyte, platelet, and monocyte counts were obtained from preoperative complete blood count test data from the patient registry. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammatory index (SII), and sentinel lymph node biopsy were analyzed. Sentinel LAP was negative in 391 (65%) patients and positive in 211 (35%). In the receiver operating characteristic curve analysis, no significant difference was found between SLNB positivity and negativity in terms of NLR, PLR, LMR, or SII. In contrast to previous research, NLR, PLR, LMR, or SII did not affect SLNB positivity prediction in our study.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node ; Breast Neoplasms ; Sentinel Lymph Node Biopsy ; Lymphadenopathy ; Lymph Nodes
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000034808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parathyroid fine needle aspiration with PTH washout: Can it lead to parathyroid cell seeding in primary hyperparathyroidism?

    Balbaloglu, Hakan / Deniz, Oguzhan / Ozaydin, R Yigit / Tasdoven, Ilhan / Karadeniz Cakmak, Guldeniz

    Medicine

    2024  Volume 103, Issue 15, Page(s) e37754

    Abstract: Although parathyroid fine-needle aspiration (P-FNA) with parathyroid hormone (PTH) washout is effective in detecting preoperative parathyroid lesions, it also presents risks such as fibrosis, hematoma, and, in rare cases, tumor seeding. This study aimed ... ...

    Abstract Although parathyroid fine-needle aspiration (P-FNA) with parathyroid hormone (PTH) washout is effective in detecting preoperative parathyroid lesions, it also presents risks such as fibrosis, hematoma, and, in rare cases, tumor seeding. This study aimed to investigate whether P-FNA with PTH washout leads to the seeding of parathyroid cells along the path of the needle. A retrospective analysis was conducted on patients undergoing minimally invasive parathyroidectomy guided by preoperative PTH washout. Permanent pathology reports, imaging data, and postoperative serum parathyroid hormone and calcium levels were assessed to determine the effectiveness and safety of the procedure. Complications following P-FNA with PTH washout were also reviewed using data from the patient registration system of Bulent Ecevit University. The procedure accurately localized parathyroid adenomas in 87 patients who underwent ultrasound-guided parathyroidectomy following preoperative P-FNA and PTH washout. Postoperatively, 75 patients showed normal parathyroid hormone and calcium levels. Two patients required secondary surgery for contralateral adenomas. Critically, there was no evidence of P-FNA with PTH washout-induced parathyromatosis or seeding during the follow-up. Effective adenoma localization is crucial for successful minimally invasive surgery of hyperparathyroidism. Our study indicates that combining preoperative P-FNAB with PTH washout and imaging enhances adenoma detection, especially when intraoperative PTH measurements are not available, thus improving surgical outcomes. Notably, we found no evidence of cell implantation after P-FNA, suggesting the safety and efficacy of this method for preventing parathyroid cell seeding.
    MeSH term(s) Humans ; Adenoma/surgery ; Biopsy, Fine-Needle/adverse effects ; Biopsy, Fine-Needle/methods ; Calcium ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/surgery ; Parathyroid Hormone ; Retrospective Studies
    Chemical Substances Calcium (SY7Q814VUP) ; Parathyroid Hormone
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Breast cancer surgery under the shadow of COVID-19: Quest for optimal axillary management after neo-adjuvant chemotherapy.

    Tasdoven, Ilhan / Karadeniz Cakmak, Guldeniz

    The breast journal

    2020  Volume 26, Issue 8, Page(s) 1606–1608

    MeSH term(s) Adult ; Axilla ; Betacoronavirus ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; COVID-19 ; Chemotherapy, Adjuvant ; Coronavirus Infections/epidemiology ; Female ; Humans ; Lymph Node Excision ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sentinel Lymph Node Biopsy
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.13892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Predicting coexisting thyroid cancer with primary hyperparathyroidism in an endemic region of multinodular goiter: evaluating the effectiveness of preoperative inflammatory markers.

    Balbaloglu, Hakan / Tasdoven, Ilhan / Buyukuysal, Mustafa Cagatay / Karadeniz, Emre / Comert, Mustafa / Cakmak, Guldeniz Karadeniz

    Annals of surgical treatment and research

    2023  Volume 105, Issue 5, Page(s) 290–296

    Abstract: Purpose: The aim is to examine the efficacy of inflammatory indicators to predict thyroid cancer in patients with primary hyperparathyroidism (PHPT) in an endemic region of nodular goiter.: Methods: The prospective database was reviewed to identify ... ...

    Abstract Purpose: The aim is to examine the efficacy of inflammatory indicators to predict thyroid cancer in patients with primary hyperparathyroidism (PHPT) in an endemic region of nodular goiter.
    Methods: The prospective database was reviewed to identify patients operated on with the diagnosis of PHPT and thyroid disease between April 2015 and June 2021. Permanent pathologic reports were used as the gold standard for diagnosis. Detailed imaging data with peripheral blood inflammation indices were analyzed to assess their predictive values for concomitant PHPT with thyroid cancer. Postoperative complications and the duration of hospitalization were also reviewed.
    Results: Thyroid malignancy accompanying PHPT was found in 13 patients (26.0%) out of 50 who had concurrent surgery. The analysis regarding inflammatory indexes revealed nothing significant between thyroid cancer and preoperative blood biochemistry (P > 0.05). In the concurrent surgery group, recurrent laryngeal nerve injury was observed in 1 patient (2.0%) and the mean hospital stay was longer.
    Conclusion: In endemic regions of nodular thyroid disease, thyroid cancer might accompany PHPT. The value of inflammatory indexes to predict thyroid malignancy in PHPT is controversial and should not be employed in the surgical decision-making process.
    Language English
    Publishing date 2023-10-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3012234-X
    ISSN 2288-6796 ; 2288-6575
    ISSN (online) 2288-6796
    ISSN 2288-6575
    DOI 10.4174/astr.2023.105.5.290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Diagnostic Accuracy of Axillary Ultrasound for Prediction of Axillary Pathologic Response after Neoadjuvant Treatment in Breast Cancer.

    Tasdoven, Ilhan / Erdemir, Rabiye Uslu / Cakmak, Guldeniz Karadeniz

    Chirurgia (Bucharest, Romania : 1990)

    2021  Volume 116, Issue 2 Suppl, Page(s) 45–58

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Axilla/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Humans ; Lymphatic Metastasis ; Neoadjuvant Therapy ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Sentinel Lymph Node Biopsy ; Treatment Outcome ; Ultrasonography
    Language English
    Publishing date 2021-05-08
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.116.2 Suppl.S45
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  8. Article ; Online: Breast cancer surgery under the shadow of COVID‐19

    Tasdoven, Ilhan / Karadeniz Cakmak, Guldeniz

    The Breast Journal

    Quest for optimal axillary management after neo‐adjuvant chemotherapy

    2020  Volume 26, Issue 8, Page(s) 1606–1608

    Keywords Internal Medicine ; Surgery ; Oncology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1289960-4
    ISSN 1075-122X
    ISSN 1075-122X
    DOI 10.1111/tbj.13892
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Triple mapping for axillary staging after neoadjuvant therapy: Axillary reverse mapping with indocyanine green and dual agent sentinel lymph node biopsy.

    Tasdoven, Ilhan / Balbaloglu, Hakan / Erdemir, Rabiye Uslu / Bahadir, Burak / Guldeniz Karadeniz, Cakmak

    Medicine

    2022  Volume 101, Issue 52, Page(s) e32545

    Abstract: Axillary staging is 1 of the major issues of current breast cancer management after neoadjuvant systemic therapy (NST). Sentinel lymph node biopsy (SLNB) is an option for clinically node negative patients. Axillary reverse mapping (ARM) was introduced to ...

    Abstract Axillary staging is 1 of the major issues of current breast cancer management after neoadjuvant systemic therapy (NST). Sentinel lymph node biopsy (SLNB) is an option for clinically node negative patients. Axillary reverse mapping (ARM) was introduced to identify and preserve the lymphatic drainage from the arm. The aim of the presented study is to employ triple mapping (radiocolloid, blue dye and indocyanine green [ICG]) to assess the crossover rate and metastatic involvement of ARM nodes after NST. Clinically node positive patients before NST who were converted to N0 and scheduled for targeted axillary dissection were included. sentinel lymph node (SLN) mapping was performed via dual agent mapping. ICG was used for ARM procedure. Blue, hot and fluorescent nodes and lymphatics were visualized in the axilla using infrared camera system and dual opto-nuclear probe (Euoroprobe3). Fifty-two patients underwent targeted axillary dissection and ARM procedures 12 out of whom had axillary node dissection. 45 of the 52 patients had at least 1 hot or blue SLN identified intraoperatively. Of these, 61.5% cases had hot SLNs, 42.3% had hot and blue, 15.4% had hot/blue/fluorescent, 7.7% had blue/fluorescent, 6 11.5% had hot/fluorescent and 7 13.5% had only clipped nodes. The overall identification rate of ARM-nodes by means of ICG technique was 86.5%. Overall crossover of ARM nodes with SLNs was determined in 36.5%. The ICG intensity was found to be higher in both hot and blue SLNS (8 out of 18 ICG positive cases, 44.4%). In 3 of 52 patients (5.7%) metastatic SLNs were hot or blue but fluorescent which predicts metastatic involvement of the ARM-nodes. More than 1-third of the patients revealed a crossover between arm and breast draining nodes. The higher observed rate of overlap might partially explain why more patients develop clinically significant lymphedema after NST even after sentinel lymph node biopsy alone. The triple mapping provides valuable data regarding the competency of lymphatic drainage and would have the potential to serve selecting patients for lymphovenous by-pass procedures at the index procedure. NST reduces the metastatic involvement of the ARM nodes. However, conservative axillary staging with sparing ARM nodes after NST necessitates further studies with larger sample size and longer follow-up.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy/methods ; Indocyanine Green ; Neoadjuvant Therapy ; Axilla/pathology ; Lymph Nodes/pathology ; Lymph Node Excision/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Coloring Agents
    Chemical Substances Indocyanine Green (IX6J1063HV) ; Coloring Agents
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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