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Article ; Online: Correction: Temperature Dependence of Thermal Properties of Ex Vivo Porcine Heart and Lung in Hyperthermia and Ablative Temperature Ranges.

Bianchi, Leonardo / Bontempi, Martina / De Simone, Sabrina / Franceschet, Martina / Saccomandi, Paola

2023 Volume 51, Issue 5, Page(s) 1119

Language	English
Publishing date	2023-03-25
Publishing country	United States
Document type	Published Erratum
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-023-03161-w
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Article ; Online: Temperature Dependence of Thermal Properties of Ex Vivo Porcine Heart and Lung in Hyperthermia and Ablative Temperature Ranges.

Bianchi, Leonardo / Bontempi, Martina / De Simone, Sabrina / Franceschet, Martina / Saccomandi, Paola

Annals of biomedical engineering

2023 Volume 51, Issue 6, Page(s) 1181–1198

Abstract: This work proposes the characterization of the temperature dependence of the thermal properties of heart and lung tissues from room temperature up to > 90 °C. The thermal diffusivity (α), thermal conductivity (k), and volumetric heat capacity ( ... ...

Abstract	This work proposes the characterization of the temperature dependence of the thermal properties of heart and lung tissues from room temperature up to > 90 °C. The thermal diffusivity (α), thermal conductivity (k), and volumetric heat capacity (C
MeSH term(s)	Animals ; Swine ; Temperature ; Hot Temperature ; Hyperthermia, Induced/methods ; Computer Simulation ; Lung
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-022-03122-9
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Article ; Online: Allergic Contact Dermatitis to Petrolatum: A Timeless Problem.

Corazza, Monica / Catani, Martina / Franchina, Flavio Antonio / Cavazzini, Alberto / Bianchi, Anna / Borghi, Alessandro / Pacetti, Lucrezia / Schettini, Natale

Dermatitis : contact, atopic, occupational, drug

2024

Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
DOI	10.1089/derm.2024.0009
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Article ; Online: Differentiation States of Phenotypic Transition of Melanoma Cells Are Revealed by 3D Cell Cultures.

Fontana, Fabrizio / Sommariva, Michele / Anselmi, Martina / Bianchi, Francesca / Limonta, Patrizia / Gagliano, Nicoletta

Cells

2024 Volume 13, Issue 2

Abstract: Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and ... ...

Abstract	Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and BLM melanoma cell lines cultured in 2D monolayers and 3D spheroids using morphological and molecular methods. The expression of EMT markers was strongly affected by 3D arrangement and revealed a hybrid phenotype for the two cell lines. Indeed, although E-cadherin was almost undetectable in both A375 and BLM cells, cortical actin was detected in A375 2D monolayers and 3D spheroids and was strongly expressed in BLM 3D spheroids. The mesenchymal marker N-cadherin was significantly up-regulated in A375 3D spheroids while undetectable in BLM cells, but vimentin was similarly expressed in both cell lines at the gene and protein levels. This pattern suggests that A375 cells exhibit a more undifferentiated/mesenchymal phenotype, while BLM cells have more melanocytic/differentiated characteristics. Accordingly, the Zeb1 and 2, Slug, Snail and Twist gene expression analyses showed that they were differentially expressed in 2D monolayers compared to 3D spheroids, supporting this view. Furthermore, A375 cells are characterized by a greater invasive potential, strongly influenced by 3D arrangement, compared to the BLM cell line, as evaluated by SDS-zymography and TIMPs gene expression analysis. Finally, TGF-β1, a master controller of EMT, and lysyl oxidase (LOX), involved in melanoma progression, were strongly up-regulated by 3D arrangement in the metastatic BLM cells alone, likely playing a role in the metastatic phases of melanoma progression. Overall, these findings suggest that A375 and BLM cells possess a hybrid/intermediate phenotype in relation to the expression of EMT markers. The former is characterized by a more mesenchymal/undifferentiated phenotype, while the latter shows a more melanocytic/differentiated phenotype. Our results contribute to the characterization of the role of EMT in melanoma cells and confirm that a 3D cell culture model could provide deeper insight into our understanding of the biology of melanoma.
MeSH term(s)	Humans ; Melanoma/genetics ; Cell Differentiation ; Epithelial-Mesenchymal Transition/genetics ; Cell Culture Techniques, Three Dimensional ; Phenotype
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13020181
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Article: Mepolizumab induced palmoplantar psoriasis: A case report.

Artosi, Fabio / Diluvio, Laura / Vultaggio, Martina / Campione, Elena / Bianchi, Luca

World journal of clinical cases

2023 Volume 11, Issue 26, Page(s) 6154–6158

Abstract: Background: Atopic dermatitis and asthma are two diseases whose pathogenesis is largely attributable to the activation, at least in the initial stages, of T helper (Th)-2 Lymphocytes, the related cytokine axis, and B lymphocytes with antibody production. ...

Abstract	Background: Atopic dermatitis and asthma are two diseases whose pathogenesis is largely attributable to the activation, at least in the initial stages, of T helper (Th)-2 Lymphocytes, the related cytokine axis, and B lymphocytes with antibody production. Psoriasis is conversely a pathology resulting from a recruitment of Th-17 and Th-1 lymphocytes, after an initial role of innate immunity. Mepolizumab is a humanized monoclonal antibody directed against interleukin (IL)-5, a central cytokine in the Th-2 axis, therefore involved in the pathogenesis of asthma. Several authors have described the appearance of psoriatic lesions in patients with asthma or atopic dermatitis following the therapy with dupilumab, a monoclonal antibody that blocks the interleukin (IL)-4, another Th-2 cytokine. Case summary: We present the case of a 59-year-old patient who developed psoriasiform lesions on the palms after mepolizumab therapy for asthma, for the activation of the parallel cytokine cascade after the blockade of IL-5. We successfully treated the patient with a topical calcipotriol and betamethasone ointment. Conclusion: We should investigate with further attention the possible impact on the human immunological ecosystem put in place by the inhibition of the activity of individual inflammatory mediators, so as to be able to recognize the initial adverse effects early.
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i26.6154
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Article ; Online: The

Taurino, Giuseppe / Chiu, Martina / Bianchi, Massimiliano G / Griffini, Erika / Bussolati, Ovidio

American journal of physiology. Cell physiology

2023 Volume 325, Issue 2, Page(s) C550–C562

Abstract: ... ...

Abstract	SLC38A5
MeSH term(s)	Pregnancy ; Female ; Humans ; Glutamine ; Amino Acid Transport Systems, Neutral/genetics ; Amino Acid Transport Systems, Neutral/metabolism ; Asparagine ; Tumor Microenvironment ; Amino Acid Transport Systems ; Amino Acids ; Serine ; Neoplasms/genetics
Chemical Substances	Glutamine (0RH81L854J) ; Amino Acid Transport Systems, Neutral ; Asparagine (7006-34-0) ; Amino Acid Transport Systems ; Amino Acids ; Serine (452VLY9402) ; SLC38A5 protein, human
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00169.2023
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Article ; Online: Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications.

Bianchi, Massimiliano G / Chiu, Martina / Taurino, Giuseppe / Bergamaschi, Enrico / Turroni, Francesca / Mancabelli, Leonardo / Longhi, Giulia / Ventura, Marco / Bussolati, Ovidio

Journal of nanobiotechnology

2024 Volume 22, Issue 1, Page(s) 45

Abstract: Amorphous silica nanoparticles (ASNP) are among the nanomaterials that are produced in large quantities. ASNP have been present for a long time in several fast-moving consumer products, several of which imply exposure of the gastrointestinal tract, such ... ...

Abstract	Amorphous silica nanoparticles (ASNP) are among the nanomaterials that are produced in large quantities. ASNP have been present for a long time in several fast-moving consumer products, several of which imply exposure of the gastrointestinal tract, such as toothpastes, food additives, drug excipients, and carriers. Consolidated use and experimental evidence have consistently pointed to the very low acute toxicity and limited absorption of ASNP. However, slow absorption implies prolonged exposure of the intestinal epithelium to ASNP, with documented effects on intestinal permeability and immune gut homeostasis. These effects could explain the hepatic toxicity observed after oral administration of ASNP in animals. More recently, the role of microbiota in these and other ASNP effects has attracted increasing interest in parallel with the recognition of the role of microbiota in a variety of conditions. Although evidence for nanomaterial effects on microbiota is particularly abundant for materials endowed with bactericidal activities, a growing body of recent experimental data indicates that ASNPs also modify microbiota. The implications of these effects are recounted in this contribution, along with a discussion of the more important open issues and recommendations for future research.
MeSH term(s)	Animals ; Humans ; Silicon Dioxide/toxicity ; Gastrointestinal Microbiome ; Nanoparticles/toxicity ; Intestinal Mucosa
Chemical Substances	Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-024-02305-x
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Article: Negative Outcomes of Blepharoplasty and Thyroid Disorders: Is Compensation Always Due? A Case Report with a Literature Review.

Defraia, Beatrice / Focardi, Martina / Grassi, Simone / Chiavacci, Giulia / Faccioli, Simone / Romano, Gianmaria Federico / Bianchi, Ilenia / Pinchi, Vilma / Innocenti, Alessandro

Diseases (Basel, Switzerland)

2024 Volume 12, Issue 4

Abstract: Background: Plastic surgery is one of the medical specialties with the highest risk of recurrent medical malpractice claims. The frequency of civil lawsuits represents an issue for the micro- and macro-economy of practitioners of these health treatments. ...

Abstract	Background: Plastic surgery is one of the medical specialties with the highest risk of recurrent medical malpractice claims. The frequency of civil lawsuits represents an issue for the micro- and macro-economy of practitioners of these health treatments. This paper aims to discuss the medico-legal aspects and claim path in a case of a cosmetic blepharoplasty complicated by lagophthalmos wrongly related to the procedure but due to missed hyperthyroidism. Case description and literature review: A 48-year-old woman who underwent cosmetic blepharoplasty with undiagnosed hyperthyroidism claimed that the lagophthalmos that occurred some months after the procedure was due to medical malpractice, due to an over-resection of the exuberant lower eyelid tissue. The review question was, "Are thyroid disfunctions usually considered contraindications to be communicated to patients who undergo blepharoplasty?", and the databases MEDLINE via PubMed, Embase, Scopus, Ovid, ISI Web of Science, Cochrane, and Google Scholar were used. Results and discussion: There were 21 eligible papers. The case highlights the importance and complexity of causal inference (such as unknown thyroid dysfunctions), related informed consent involving information on possible complications unrelated to malpractice, and guidelines recommending endocrinological consultation for cosmetic/functional blepharoplasty in patients at risk (e.g., female patients with a known history of thyroid disease).
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases12040075
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Article: Four-years experience with the preferential derivation care model for multidisciplinary care in patients with psoriasis and psoriatic arthritis.

Burlando, Martina / Craviotto, Chiara / Carmisciano, Luca / Bianchi, Gerolamo / Parodi, Aurora

Dermatology reports

2021 Volume 14, Issue 2, Page(s) 9111

Language	English
Publishing date	2021-10-08
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2568735-9
ISSN	2036-7406 ; 2036-7392
ISSN (online)	2036-7406
ISSN	2036-7392
DOI	10.4081/dr.2021.9111
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Article ; Online: Preliminary Results of Laser Ablation during In Vivo Experiments: Comparison of Thermal Effects Obtained with Bare and Diffuser Tip Applicators.

Korganbayev, Sanzhar / De Landro, Martina / Bianchi, Leonardo / Verde, Juan / Saccomandi, Paola

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–4

Abstract: This work is a step towards the analysis of the effect of different laser applicator tips used for laser ablation of liver for in vivo experiments. As the thermal outcome of this minimally invasive treatment for tumors depends upon the interaction ... ...

Abstract	This work is a step towards the analysis of the effect of different laser applicator tips used for laser ablation of liver for in vivo experiments. As the thermal outcome of this minimally invasive treatment for tumors depends upon the interaction between the tissue and the light, the emission pattern of the laser applicator has a key role in the shape and size of the final treated region. Hence, we have compared two different laser applicators: a bare tip fiber (emitting light from the tip and forward) and a diffuser tip fiber (emitting light at 360° circumferentially from the side of the fiber). The experiments have been carried out percutaneously in a preclinical scenario (anesthetized pigs), under computed tomography (CT) guidance. The thermal effects of the two applicators have been assessed in terms of real-time temperature distribution, by means of an array of 40 fiber Bragg grating (FBG) sensors, and in terms of cavitation and ablation volumes, measured through CT post-temperature due to breathing motion has been analyzed and filtered out. Results show that the maximum temperature reached 50.5 °C for the bare tip fiber experiment (measured at 6.24 mm distance from the applicator) and 60.9 °C for the diffuser tip fiber experiment (measured at 5.23 mm distance from the applicator). The diffuser tip fiber allowed to achieve a more symmetrical heat distribution than the bare tip fiber, and without cavitation volume.Clinical Relevance-This work shows the analysis of the thermal effects of different laser fiber tips to improve laser ablation treatment. The results obtained in the preclinical scenario well represent the expected clinical outcome in the treatment of hepatic tumors. Moreover, these findings can be applied to other fields in which laser ablation is the optimal therapeutic choice, such as neurosurgery.
MeSH term(s)	Swine ; Animals ; Laser Therapy ; Lasers ; Liver/diagnostic imaging ; Liver/surgery ; Neoplasms/pathology ; Light
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340179
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