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  1. Article ; Online: Clinical competency of dental health professionals and students in diagnosing oral mucosal lesions.

    Idrees, Majdy / Halimi, Rodwan / Gadiraju, Shashank / Frydrych, Agnieszka M / Kujan, Omar

    Oral diseases

    2023  

    Abstract: Objective: Proper identification of oral potentially malignant disorders (OPMDs) provides an opportunity for oral cancer prevention. This study aims to assess the competency of dental health professionals in identifying OPMDs and, in turn, reducing the ... ...

    Abstract Objective: Proper identification of oral potentially malignant disorders (OPMDs) provides an opportunity for oral cancer prevention. This study aims to assess the competency of dental health professionals in identifying OPMDs and, in turn, reducing the incidence of oral malignancy by early detection.
    Methods: A 26-case online questionnaire of oral mucosal lesions was distributed to cohorts of 363 dental health professionals and dental students in Australia. The participants were asked to provide their provisional diagnosis for each case based on the available information.
    Results: The overall accuracy in identifying oral mucosal lesions was 65.9%. There were no significant differences in the overall diagnostic accuracies between dental specialists, general dental practitioners and final-year dental students (p > 0.05). The lowest diagnostic accuracies were associated with normal mucosal variations and OPMDs. The predoctoral dental curriculum showed statistically significant values in terms of improving skills in diagnosing oral mucosal lesions.
    Conclusions: Lack of adequate knowledge in identifying OPMDs was evident among the participants, highlighting a non-promising figure in reducing the incidence of oral cancers in Australia. Comprehensive modifications of the current continuing professional development system are required to ensure adequate knowledge among dental health providers in Australia.
    Language English
    Publishing date 2023-09-20
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: A Curcumin-Based Oral Gel Has Potential Protective Efficacy against Oral Mucositis: In Vitro Study.

    Idrees, Majdy / Kujan, Omar

    Journal of personalized medicine

    2023  Volume 14, Issue 1

    Abstract: Oral mucositis is a common distressing complication of cancer therapy, characterised by painful sores within the oral cavity. Current management options offer limited symptomatic relief. Curcumin, a natural polyphenolic compound with recognised anti- ... ...

    Abstract Oral mucositis is a common distressing complication of cancer therapy, characterised by painful sores within the oral cavity. Current management options offer limited symptomatic relief. Curcumin, a natural polyphenolic compound with recognised anti-inflammatory and antioxidant properties, has emerged as a potential protective agent against oral mucositis. This study explores the therapeutic potential of curcumin in mitigating the impact of oral mucositis by investigating a commercially available curcumin-based oral gel, PerioGold
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: When single-inhaler triple therapy is a preferred option in asthma management?

    Al-Moamary, Mohamed S / Al-Lehebi, Riyad / Idrees, Majdy M / Zeitouni, Mohammed O

    Annals of thoracic medicine

    2022  Volume 17, Issue 4, Page(s) 185–188

    Abstract: Asthma control is the main goal of management. Unfortunately, most asthma patients with moderate-severe asthma remain uncontrolled despite receiving standard treatment of inhaled corticosteroids (ICS) with long-acting β2 agonists (LABA). The addition of ... ...

    Abstract Asthma control is the main goal of management. Unfortunately, most asthma patients with moderate-severe asthma remain uncontrolled despite receiving standard treatment of inhaled corticosteroids (ICS) with long-acting β2 agonists (LABA). The addition of long-acting antimuscarinic agents (LAMA) has been shown to improve different aspects of asthma control, including symptoms, lung functions, and probably exacerbations. Such an option could be considered for low-T2 asthma phenotype. Umeclidinium and glycopyrronium bromide are other LAMA agents that have been recently made available in combination with ICS and LABA in single-inhaler triple therapy (SITT) devices. Here, we discuss the position of SITT as a new novel therapeutic option in asthma management and its clinical benefits, potential cost saving, and improved compliance.
    Language English
    Publishing date 2022-10-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.atm_341_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical and physiological characteristics of, medically treated, chronic thromboembolic pulmonary hypertension patients in Saudi Arabia: A single center experience.

    Imtiaz, Sadia / Saaedeldin, Ahmed I / Alqahtani, Nayef H / Idrees, Majdy M

    Annals of thoracic medicine

    2021  Volume 16, Issue 4, Page(s) 347–353

    Abstract: Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is uncommon but well-known sequel of venous thromboembolism (VTE). At present, it is the only potential curable subtype of pulmonary hypertension. The aim of this study is to describe the ...

    Abstract Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is uncommon but well-known sequel of venous thromboembolism (VTE). At present, it is the only potential curable subtype of pulmonary hypertension. The aim of this study is to describe the medically treated-CTEPH patients' characteristics in a single specialized PH center in Saudi Arabia.
    Methods: This study presents demographic, clinical, physiological, and hemodynamic characteristics of medically treated-CTEPH patients in a single PH center, namely Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Both incident and prevalent cases are included.
    Results: A total of 20 patients with a confirmed diagnosis of CTEPH were included. Mean age at diagnosis was 43 years with a female preponderance of 75%. Most common presenting symptom was dyspnea (100%) followed by syncope (58%). At diagnosis, a mean of 15 ± 10 months had passed since symptoms onset. About 45% of patients were in WHO functional class IV. At baseline, mean 6-min walk distance was 354.3 meters. Overall, VTE was the most frequent risk factor identified (65% of all patients). Nearly 30% of patients had sickle cell disease. 13 out of 20 patients had radiographic (i.e., computed tomography [CT] pulmonary angiogram) features of chronic thromboembolism. About 75% of patients were found to have distal disease on radiographic imaging. At the time of diagnosis, 7 out of 20 (35%) patients demonstrated right ventricular failure on echocardiography. Mean tricuspid annular plane systolic excursion was 17.7 ± 1.20. Median NT-proBNP levels were found to be 688 pg/ml. Mean diffusing capacity for carbon monoxide was 74.8%.
    Conclusions: Diagnosis of CTEPH was established at a relatively younger age. Majority of patients had advanced but distal disease on radiographic imaging, not amenable to surgery.
    Language English
    Publishing date 2021-10-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.atm_738_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Generic orphan drug substitution: a critical analysis of global practices and Saudi Arabia's perspective.

    Alakeel, Yousif S / Rampakakis, Emmanouil / AlRumaih, Ali / AlRuwaisan, Rana / Abushal, Maha / AlDalaan, Abdullah M / Idrees, Majdy M / Alanazi, Zaid D / AlKoait, Hanouf / Muaadi, Abdulrahman / AlAfra, Majed Ali M / AlShaya, Shaya A / AlHomida, Suliman

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1376009

    Abstract: In an era of cost pressure, substituting generic drugs represents one of the main cost-containment strategies of healthcare systems. Despite the obvious financial benefits, in a minority of cases, substitution may require caution or even be ... ...

    Abstract In an era of cost pressure, substituting generic drugs represents one of the main cost-containment strategies of healthcare systems. Despite the obvious financial benefits, in a minority of cases, substitution may require caution or even be contraindicated. In most jurisdictions, to obtain approval, the bioequivalence of generic products with the brand-name equivalent needs to be shown via bioavailability studies in healthy subjects. Rare diseases, defined as medical conditions with a low prevalence, are a group of heterogenous diseases that are typically severe, disabling, progressive, degenerative, and life-threatening or chronically debilitating, and disproportionally affect the very young and elderly. Despite these unique features of rare diseases, generic bioequivalence studies are typically carried out with single doses and exclude children or the elderly. Furthermore, the excipients and manufacturing processes for generic/biosimilar products can differ from the brand products which may affect the shelf-life of the product, its appearance, smell, taste, bioavailability, safety and potency. This may result in approval of generics/biosimilars which are not bioequivalent/comparable in their target population or that meet bioequivalence but not therapeutic equivalence criteria. Another concern relates to the interchangeability of generics and biosimilars which cannot be guaranteed due to the phenomenon of biocreep. This review summarizes potential concerns with generic substitution of orphan drugs and discusses potentially problematic cases including narrow therapeutic index drugs or critical conditions where therapeutic failure could lead to serious complications or even death. Finally, we put forward the need for refining regulatory frameworks, with emphasis on Saudi Arabia, for generic substitution and recent efforts toward this direction.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1376009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pulmonary hypertension: more to be done.

    Idrees, Majdy M

    Annals of thoracic medicine

    2009  Volume 4, Issue 3, Page(s) 107–108

    Language English
    Publishing date 2009-07-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/1817-1737.53343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Saudi initiative for asthma - 2024 update: Guidelines for the diagnosis and management of asthma in adults and children.

    Al-Moamary, Mohamed Saad / Alhaider, Sami A / Allehebi, Riyad / Idrees, Majdy M / Zeitouni, Mohammed O / Al Ghobain, Mohammed O / Alanazi, Abdullah F / Al-Harbi, Adel S / Yousef, Abdullah A / Alorainy, Hassan S / Al-Hajjaj, Mohamed S

    Annals of thoracic medicine

    2023  Volume 19, Issue 1, Page(s) 1–55

    Abstract: The Saudi Initiative for Asthma 2024 (SINA-2024) is the sixth version of asthma guidelines for the diagnosis and management of asthma for adults and children that was developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main ... ...

    Abstract The Saudi Initiative for Asthma 2024 (SINA-2024) is the sixth version of asthma guidelines for the diagnosis and management of asthma for adults and children that was developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up-to-date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA Panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5-12 years, and children aged <5 years. SINA guidelines have focused more on personalized approaches reflecting a better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. The medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient-doctor partnership in the management that also includes a self-management plan.
    Language English
    Publishing date 2023-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.atm_248_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acute pulmonary embolism risk stratification.

    Idrees, Majdy M

    Saudi medical journal

    2008  Volume 29, Issue 7, Page(s) 941–945

    MeSH term(s) Humans ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/etiology ; Pulmonary Embolism/therapy ; Risk Assessment
    Language English
    Publishing date 2008-07
    Publishing country Saudi Arabia
    Document type Editorial
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2330: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 6: Show issues

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  9. Article: Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary hypertension due to lung diseases and/or hypoxia.

    Sakkijha, Husam / Idrees, Majdy M

    Annals of thoracic medicine

    2014  Volume 9, Issue Suppl 1, Page(s) S56–61

    Abstract: Chronic lung diseases are common causes of pulmonary hypertension. It ranks second after the left heart disease. Both obstructive and restrictive lung diseases are know to cause pulmonary hypertension. The pathophysiology of the disease is complex, and ... ...

    Abstract Chronic lung diseases are common causes of pulmonary hypertension. It ranks second after the left heart disease. Both obstructive and restrictive lung diseases are know to cause pulmonary hypertension. The pathophysiology of the disease is complex, and includes factors affecting the blood vessels, airways, and lung parenchyma. Hypoxia and the inhalation of toxic materials are another contributing factors. Recent guidelines have further clarified the association between pulmonary hypertension and chronic lung disease and made general guidelines concerning the diagnosis and management. In this article, we will provide a detailed revision about the new classification and give general recommendations about the management of pulmonary hypertension in chronic lung diseases.
    Language English
    Publishing date 2014-07-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/1817-1737.134030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension.

    Saleemi, Sarfraz / Idrees, Majdy M

    Annals of thoracic medicine

    2014  Volume 9, Issue Suppl 1, Page(s) S42–6

    Abstract: Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output ... ...

    Abstract Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pressures (PAP). However, patients with POPH develop a progressive increase in pulmonary vascular resistance (PVR), which is generally lower than that observed in other forms of PAH. The prognosis of untreated patients with POPH is very poor and the outcome of liver transplant (LT) in those patients is determined by the degree of severity of the associated pulmonary hemodynamics. In this narrative review, we describe the clinical presentation of POPH, the pathobiology, and the clinical implication of pulmonary hemodynamics. We also provide evidence-based recommendations for the diagnosic and management approaches of POPH.
    Language English
    Publishing date 2014-07-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/1817-1737.134021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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