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  1. Article ; Online: Saudi Oncology Society clinical management guidelines for prostate cancer.

    Abusamra, Ashraf J / Bazarbashi, Shouki / Bahader, Yasser / Kushi, Hussain / Rabah, Danny / Rabbah, Dany / Al Bogami, Naser / Al Ghamdi, Khalid / Al Ghamdi, Abdullah / Balaraj, Khaled / Seyam, Raouf / Al Otaibi, Mohammed / Al Saeed, Eyad

    Urology annals

    2011  Volume 3 Suppl, Page(s) S10–6

    Abstract: In this report, guidelines for the evaluation, medical and surgical management of testicular germ cell tumors is presented. It is categorized according to the stage of the disease using the tumor node metastasis staging system, 7th edition. The ... ...

    Abstract In this report, guidelines for the evaluation, medical and surgical management of testicular germ cell tumors is presented. It is categorized according to the stage of the disease using the tumor node metastasis staging system, 7th edition. The recommendations are presented with supporting level of evidence.
    Language English
    Publishing date 2011-05-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 2557851-0
    ISSN 0974-7834 ; 0974-7834
    ISSN (online) 0974-7834
    ISSN 0974-7834
    DOI 10.4103/0974-7796.78550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Saudi Oncology Society clinical management guidelines for prostate cancer

    Ashraf J Abusamra / Shouki Bazarbashi / Yasser Bahader / Hussain Kushi / Dany Rabbah / Naser Al Bogami / Khalid Al Ghamdi / Abdullah Al Ghamdi / Khaled Balaraj / Raouf Seyam / Mohammed Al Otaibi / Eyad Al Saeed

    Urology Annals, Vol 3, Iss 4, Pp 10-

    2011  Volume 16

    Abstract: In this report, guidelines for the evaluation, medical and surgical management is presented. It is categorized according to the stage of the disease using the tumor node metastasis staging system, 7 th edition. The recommendations are presented with ... ...

    Abstract In this report, guidelines for the evaluation, medical and surgical management is presented. It is categorized according to the stage of the disease using the tumor node metastasis staging system, 7 th edition. The recommendations are presented with supporting level of evidence.
    Keywords Prostate ; cancer ; guidelines ; Saudi ; management ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis.

    Abusamra, Ashraf J / Zhong, Zhaohui / Zheng, Xiufen / Li, Mu / Ichim, Thomas E / Chin, Joseph L / Min, Wei-Ping

    Blood cells, molecules & diseases

    2005  Volume 35, Issue 2, Page(s) 169–173

    Abstract: Tumor-derived immune suppression is considered to be a major mechanism of tumor evasion from the immune system destruction, however, little is known regarding the induction of T-cell functional suppression by tumor-derived exosomes. Herein, we ... ...

    Abstract Tumor-derived immune suppression is considered to be a major mechanism of tumor evasion from the immune system destruction, however, little is known regarding the induction of T-cell functional suppression by tumor-derived exosomes. Herein, we investigate tumor-derived exosomes involved in normal immunological communications as means of inhibiting an antitumor T-cell response. Exosomes derived from LNCaP, a human prostate cancer cell line, were visualized by FACS and identified based on size (80-200 nm) in comparison to marker beads. Exosomes from tumor cell line inhibited T-cell proliferation. Dose-dependent apoptosis of T cells was induced by co-culture with tumor exosomes. Addition of anti-FasL antibody blocked the apoptosis induction by tumor exosomes. This study suggests that induction of T-cell apoptosis by tumor-derived exosomes appears to be a novel mechanism of tumor immune evasion.
    MeSH term(s) Antigens, Neoplasm/immunology ; Antigens, Neoplasm/physiology ; Apoptosis ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Cell Proliferation ; Coculture Techniques ; Endosomes/immunology ; Endosomes/pathology ; Fas Ligand Protein ; Humans ; Lymphocyte Activation ; Male ; Membrane Glycoproteins/physiology ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/pathology ; Tumor Necrosis Factors/physiology
    Chemical Substances Antigens, Neoplasm ; FASLG protein, human ; Fas Ligand Protein ; Membrane Glycoproteins ; Tumor Necrosis Factors
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2005.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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