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Article ; Online: Recalling the Usefulness of Conebeam CT in Temporal Bone Imaging: Higher Resolution with Lower Radiation Dose.

Quintas-Neves, M / Saraiva, J

AJNR. American journal of neuroradiology

2022 Volume 43, Issue 11, Page(s) E43–E44

MeSH term(s)	Humans ; Temporal Bone/diagnostic imaging ; Cone-Beam Computed Tomography ; Radiation Dosage
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7564
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Article ; Online: Decreased expression of S100A8/A9 in V30M related ATTRv amyloidosis.

Moreira, João / Martins, Sofia / Saraiva, Margarida / Saraiva, Maria João

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2023 Volume 30, Issue 3, Page(s) 327–334

Abstract: Introduction: Hereditary Transthyretin Amyloidosis is a rare, progressive and life-threatening systemic disease with predominant peripheral and autonomic nervous system involvement caused by mutation of the transthyretin protein. The most common TTR ... ...

Abstract	Introduction: Hereditary Transthyretin Amyloidosis is a rare, progressive and life-threatening systemic disease with predominant peripheral and autonomic nervous system involvement caused by mutation of the transthyretin protein. The most common TTR mutation regarding to ATTRv is a substitution of a Methionine for a Valine at position 30 that predisposes TTR to form aggregates and fibrils. Methods: S100A8 protein levels were measured in plasma samples from ATTRV30M patients and healthy donors. Additionally, S100A8/9 levels were measured in Schwann cells after incubation with human WT or V30M TTR. Moreover, bone marrow derived macrophages of either genetic background were generated and the expression of S100A8/9 was measured in response to toll like receptors agonists. Results: S100A8/A9 mRNA levels are decreased in HSF V30M mice as compared with the WT. Moreover, S100A8 protein levels were found downregulated in plasma samples from ATTRV30M patients. Furthermore, we provide evidence for a dysregulated S100 expression by Schwann cells in response to TTRV30M and by mutated macrophages in response to toll like receptors agonists. Conclusion: The presence of TTRV30M impacts S100 expression, possibly contributing to the impaired immune activation of Schwann cells in nerves from ATTRV30M patients. This may be linked to the diminished immune cellular infiltration in these nerves, contributing in this way for the neuronal dysfunction present in the disease.
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Amyloid Neuropathies, Familial/metabolism ; Amyloid Neuropathies, Familial/pathology ; Calgranulin A/genetics ; Calgranulin B/genetics ; Down-Regulation ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Peripheral Nervous System/metabolism ; Prealbumin/genetics ; Schwann Cells/metabolism
Chemical Substances	Calgranulin A ; Calgranulin B ; Lipopolysaccharides ; Prealbumin ; S100A8 protein, human ; S100A9 protein, human ; TTR protein, human
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2023.2185755
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Zs.A 4114: Show issues

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Article ; Online: TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines.

Moreira, João / Martins, Helena / Saraiva, Margarida / Saraiva, Maria João

Clinical science (London, England : 1979)

2023 Volume 137, Issue 5, Page(s) 355–366

Abstract: Hereditary amyloid transthyretin (ATTRv) amyloidosis is a fatal neurodegenerative disorder, first identified in Portugal. The most common transthyretin (TTR) mutation in ATTRv results from an exchange of a methionine for a valine at position 30 (V30M). ... ...

Abstract	Hereditary amyloid transthyretin (ATTRv) amyloidosis is a fatal neurodegenerative disorder, first identified in Portugal. The most common transthyretin (TTR) mutation in ATTRv results from an exchange of a methionine for a valine at position 30 (V30M). ATTRv is characterized by the extracellular deposition of aggregates and fibrils of mutant forms of TTR, particularly in the nerves and ganglia of the peripheral nervous system (PNS). This phenotype is often accompanied by the lack of inflammatory infiltrates, despite the importance of macrophages in removal of TTR deposits in ATTRv patients. The mechanisms underlying this impairment of inflammatory responses in ATTRv patients are poorly understood. Here, we show a significant down-regulation in the expression of several chemokines by bone marrow-derived macrophages (BMDM) generated from V30M TTR mice upon stimulation with toll-like receptor 4 (TLR4) and TLR2 agonists. The phosphorylation of the MAP kinase p38, important for TLR4 and TLR2 signaling pathways, was also down-regulated in V30M macrophages, as compared with wild-type (WT) ones. The present study contributes with new insights to unravel the molecular mechanisms underlying the lack of inflammatory immune responses observed in ATTRv patients and may help in the development of new immune therapeutic strategies for the disease.
MeSH term(s)	Mice ; Animals ; Prealbumin/genetics ; Prealbumin/metabolism ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/metabolism ; Macrophages/metabolism
Chemical Substances	Prealbumin ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Tlr2 protein, mouse
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20220656
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Article: The High Pressure Preservation of Honey: A Comparative Study on Quality Changes during Storage.

Scepankova, Hana / Majtan, Juraj / Estevinho, Leticia M / Saraiva, Jorge A

Foods (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: In commercially available honey, the application of a heat treatment to prevent spoilage can potentially compromise its beneficial properties and quality, and these effects worsen with extended storage. The high-pressure processing (HPP) of honey is ... ...

Abstract	In commercially available honey, the application of a heat treatment to prevent spoilage can potentially compromise its beneficial properties and quality, and these effects worsen with extended storage. The high-pressure processing (HPP) of honey is being explored, but its long-term impact on honey quality has not been characterised yet. This study evaluated the effects of HPP and thermal processing on the microbial load, physicochemical quality (i.e., hydroxymethylfurfural content and diastase activity), and antioxidant capacity of honey after treatment and following extended storage (6, 12, and 24 months) at 20 °C. Pasteurization (78 °C/6 min) effectively eliminated the microorganisms in honey but compromised its physicochemical quality and antioxidant activity. HPP initially showed sublethal inactivation, but storage accelerated the decrease in yeasts/moulds and aerobic mesophiles in honey (being <1 log CFU/g after 24 months of storage) compared to unprocessed honey and honey thermally treated under mild conditions (55 °C/15 min). The physicochemical characteristics of the quality of HPP-treated honey and raw unprocessed honey did change after long-term storage (24 months) but remained within regulatory standards. In conclusion, HPP emerged as a more suitable and safe preservation method for
Language	English
Publishing date	2024-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13070989
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Article: Evaluation of Claw Lesions in Beef Cattle Slaughtered in Northern Portugal: A Preliminary Study.

Seixas, Mafalda / Moura, Dina / Grispoldi, Luca / Cenci-Goga, Beniamino / Saraiva, Sónia / Silva, Filipe / Pires, Isabel / Saraiva, Cristina / García-Díez, Juan

Animals : an open access journal from MDPI

2024 Volume 14, Issue 3

Abstract: Claw diseases have a profound impact on cattle welfare, affecting behaviors such as grazing, rumination, rest, decubitus, and water consumption. This study aimed to assess the prevalence of claw lesions and classify them according to the ICAR Claw Health ...

Abstract	Claw diseases have a profound impact on cattle welfare, affecting behaviors such as grazing, rumination, rest, decubitus, and water consumption. This study aimed to assess the prevalence of claw lesions and classify them according to the ICAR Claw Health Atlas (International Committee of Animal Recording) in two slaughterhouses. The influence of claw lesions on carcass weight, classification, and fat deposition was also examined. Involving 343 crossbreed cattle from 103 different extensive or semi-intensive farms, this study found an animal prevalence of claw disorders at 65.8%, with a higher incidence in females (n = 207, 60.35%) compared to males (n = 136, 39.65%). Despite the observed prevalence, claw lesions were not influenced by age or sex (
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14030514
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Article ; Online: Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2.

Couto, Joana / Gonçalves, Rute / Lamas, Sofia / Saraiva, Margarida

STAR protocols

2023 Volume 4, Issue 2, Page(s) 102303

Abstract: Intranasal infection of k18-hACE2 mice with SARS-CoV-2 recapitulates the clinical characteristics present in severe COVID-19. Here, we present a protocol for intranasal administration of SARS-CoV-2 to k18-hACE2 mice and their subsequent daily monitoring. ...

Abstract	Intranasal infection of k18-hACE2 mice with SARS-CoV-2 recapitulates the clinical characteristics present in severe COVID-19. Here, we present a protocol for intranasal administration of SARS-CoV-2 to k18-hACE2 mice and their subsequent daily monitoring. We describe steps for intranasal inoculation of SARS-CoV-2 and the collection of clinical scores on weight, body condition, hydration, appearance, neurological symptoms, behavior, and respiratory movements. This protocol contributes to the establishment of a model of severe SARS-CoV-2 infection that minimizes animal suffering. For complete details on the use and execution of this protocol, please refer to Gonçalves et al. (2023).
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102303
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Article ; Online: The Expression of Chemokines Is Downregulated in a Pre-Clinical Model of TTR V30M Amyloidosis.

Moreira, João / Costelha, Susete / Saraiva, Margarida / Saraiva, Maria João

Frontiers in immunology

2021 Volume 12, Page(s) 650269

Abstract: Inflammation is a hallmark of several neurodegenerative disorders including hereditary amyloidogenic transthyretin amyloidosis (ATTRv). ATTRv is an autosomal dominant neurodegenerative disorder with extracellular deposition of mutant transthyretin (TTR) ... ...

Abstract	Inflammation is a hallmark of several neurodegenerative disorders including hereditary amyloidogenic transthyretin amyloidosis (ATTRv). ATTRv is an autosomal dominant neurodegenerative disorder with extracellular deposition of mutant transthyretin (TTR) aggregates and fibrils, particularly in nerves and ganglia of the peripheral nervous system. Nerve biopsies from ATTRv patients show increased cytokine production, but interestingly no immune inflammatory cellular infiltrate is observed around TTR aggregates. Here we show that as compared to Wild Type (WT) animals, the expression of several chemokines is highly downregulated in the peripheral nervous system of a mouse model of the disease. Interestingly, we found that stimulation of mouse Schwann cells (SCs) with WT TTR results in the secretion of several chemokines, a process that is mediated by toll-like receptor 4 (TLR4). In contrast, the secretion of all tested chemokines is compromised upon stimulation of SCs with mutant TTR (V30M), suggesting that V30M TTR fails to activate TLR4 signaling. Altogether, our data shed light into a previously unappreciated mechanism linking TTR activation of SCs and possibly underlying the lack of inflammatory response observed in the peripheral nervous system of ATTRv patients.
MeSH term(s)	Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/immunology ; Amyloid Neuropathies, Familial/pathology ; Animals ; Cells, Cultured ; Chemokines/metabolism ; Disease Models, Animal ; Down-Regulation/immunology ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Mice ; Mice, Transgenic ; Mutation ; Prealbumin/genetics ; Prealbumin/isolation & purification ; Prealbumin/metabolism ; Primary Cell Culture ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Schwann Cells/immunology ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Sciatic Nerve/immunology ; Sciatic Nerve/pathology ; Toll-Like Receptor 4/metabolism
Chemical Substances	Chemokines ; Prealbumin ; Recombinant Proteins ; TTR protein, human ; Tlr4 protein, mouse ; Toll-Like Receptor 4
Language	English
Publishing date	2021-05-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.650269
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Article: Antimicrobial Effects and Antioxidant Activity of

Moura, Dirce / Vilela, Joana / Saraiva, Sónia / Monteiro-Silva, Filipe / De Almeida, José M M M / Saraiva, Cristina

Foods (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: The aim of this study was to assess the antimicrobial effects of myrtle ( ...

Abstract	The aim of this study was to assess the antimicrobial effects of myrtle (
Language	English
Publishing date	2023-09-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12183390
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Article ; Online: Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.

Moreira, João / Saraiva, Margarida / Saraiva, Maria João

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2019 Volume 26, Issue sup1, Page(s) 63–64

MeSH term(s)	Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/pathology ; Animals ; Cathepsin E/genetics ; Cathepsin E/metabolism ; Gene Expression Regulation/genetics ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Transgenic ; Prealbumin/genetics
Chemical Substances	Prealbumin ; Cathepsin E (EC 3.4.23.34)
Language	English
Publishing date	2019-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2019.1585342
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Zs.A 4114: Show issues

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Conference proceedings ; Online: The BELSHAKE database of earthquake ground motion in Belgium

Onvani, M. / Vanneste, K. / Saraiva Esteves Pacheco De Almeida, J.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The BELSHAKE project aims to compile a database of ground motion in Belgium and to develop the capacity to model earthquake ground motion based on that. This database contributes to existing databases by increasing the coverage of low-seismicity regions. ...

Abstract	The BELSHAKE project aims to compile a database of ground motion in Belgium and to develop the capacity to model earthquake ground motion based on that. This database contributes to existing databases by increasing the coverage of low-seismicity regions. The current BELSHAKE database contains ~7000 records from 362 natural and induced earthquakes in Belgium and adjacent areas since 1985 with ML≥2. It includes records from broadband, accelerometric, and short-period sensors operated by the Royal Observatory of Belgium. For each event, the relevant source parameters and station metadata are extracted from the ROB database, event-station metadata computed and waveforms capturing the complete event downloaded. The waveform library is structured in folders corresponding to each event, containing one file for each station. The metadata and ground-motion parameters are collected in a relational database. A dedicated python library provides a programming interface with the database and waveform archive, allowing reading and writing of metadata, and streamlining data import. All records have been visually checked to correct or eliminate problematic waveforms such as low signal-to-noise ratio, timing problems, disturbances, clipping, missing or incomplete phase windows, interruptions, and the presence of foreshocks or aftershocks. We use a combination of two windowing procedures, one to define P, S and coda windows, and the other to define noise windows. We are currently implementing a semi-automatic workflow to process the waveforms in a uniform way, which will allow to determine ground-motion parameters following international standards. In this contribution, we discuss the database and processing steps in more detail.
Subject code	005
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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