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Article ; Online: Feline Comorbidities: Balancing hyperthyroidism and concurrent chronic kidney disease.

Geddes, Rebecca / Aguiar, Joana

2022 Volume 24, Issue 7, Page(s) 641–650

Abstract: Practical relevance: Both hyperthyroidism and chronic kidney disease (CKD) are common long-term conditions in older cats, which might be diagnosed concurrently or develop at different times. Hyperthyroidism may mask the presence of CKD, and vice versa, ... ...

Abstract	Practical relevance: Both hyperthyroidism and chronic kidney disease (CKD) are common long-term conditions in older cats, which might be diagnosed concurrently or develop at different times. Hyperthyroidism may mask the presence of CKD, and vice versa, by various mechanisms that are described in this review. Hyperthyroidism treatment options should be carefully considered when CKD has also been diagnosed. Clinical challenges: Although it can be difficult to diagnose hyperthyroidism and CKD simultaneously, given that one condition may mask the other, it is important to consider the presence of both diseases when examining an older cat presenting with vomiting, weight loss, polyuria/ polydipsia, anorexia or sarcopenia. The concurrent presence of hyperthyroidism and CKD requires careful monitoring of glomerular filtration rate biomarkers, and adequate and prompt support of kidney function when normal thyroid function is re-established. Iatrogenic hypothyroidism is a recognised complication of all of the treatment options for hyperthyroidism, and increases the risk of azotaemia. Therapy with levothyroxine is recommended for cats that are hypothyroid and azotaemic. Evidence base: The information in this review draws on current literature and guidelines related to the pathophysiology, diagnosis and treatment recommendations for feline hyperthyroidism and CKD.
MeSH term(s)	Animals ; Cat Diseases/diagnosis ; Cat Diseases/epidemiology ; Cat Diseases/therapy ; Cats ; Glomerular Filtration Rate ; Hyperthyroidism/complications ; Hyperthyroidism/therapy ; Hyperthyroidism/veterinary ; Hypothyroidism/veterinary ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/veterinary ; Thyroxine
Chemical Substances	Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2022-04-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2049047-1
ISSN	1532-2750 ; 1098-612X
ISSN (online)	1532-2750
ISSN	1098-612X
DOI	10.1177/1098612X221090390
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Article ; Online: Proteomic Profiling of Host Response in the Cereal Crop Triticum aestivum to the Mycotoxin, 15-Acetyldeoxynivalenol, Produced by the Fungal Pathogen, Fusarium graminearum.

Buchanan, Reid / Serajazari, Mitra / Geddes-McAlister, Jennifer

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2659, Page(s) 161–169

Abstract: Deoxynivalenol (DON) is a destructive mycotoxin produced by the fungal pathogen Fusarium graminearum in the devastating cereal disease Fusarium head blight (FHB). Host resistance to FHB has been identified within some of these crops (e.g., wheat, barley, ...

Abstract	Deoxynivalenol (DON) is a destructive mycotoxin produced by the fungal pathogen Fusarium graminearum in the devastating cereal disease Fusarium head blight (FHB). Host resistance to FHB has been identified within some of these crops (e.g., wheat, barley, corn); however, identification of how the host reduces the production of, and tolerates, DON to lessen the effects of the disease still requires further discovery. The field of quantitative proteomics is an effective tool for measuring and quantifying host defense responses to external factors, including the presence of pathogens and toxins. Success within this area of research has increased through recent technological developments (e.g., instrument sensitivity) and the accessibility of data analysis programs. One advancement we leverage is the ability to label peptides with isobaric mass tags to allow for sample multiplexing, reducing mass spectrometer run times, and providing accurate quantification. In this protocol, we exemplify this methodology to identify protein-level responses to DON within both FHB-resistant and FHB-susceptible Triticum aestivum cultivars using tandem mass tags for quantitative labeling combined with liquid-chromatography-MS/MS (LC-MS/MS) analysis. Furthermore, this protocol can be extrapolated for the identification of host responses under various conditions, including infection and environmental fluctuations, to elucidate changes in proteomic profiling in diverse biological contexts.
MeSH term(s)	Mycotoxins ; Fusarium/physiology ; Triticum/microbiology ; Edible Grain/microbiology ; Chromatography, Liquid ; Proteomics ; Tandem Mass Spectrometry ; Plant Diseases/microbiology
Chemical Substances	15-acetyldeoxynivalenol (88337-96-6) ; Mycotoxins
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3159-1_12
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Article: Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems.

Djoneva, Luba / Lawson, Jack / Rutherford, Lynda / Geddes, Rebecca

Veterinary record open

2023 Volume 10, Issue 2, Page(s) e69

Abstract: Objectives: Distinguishing bacterial cystitis from subclinical bacteriuria is necessary for feline treatment protocols and antimicrobial stewardship. This can be challenging in cats with subcutaneous ureteral bypass (SUB) systems because they may ... ...

Abstract	Objectives: Distinguishing bacterial cystitis from subclinical bacteriuria is necessary for feline treatment protocols and antimicrobial stewardship. This can be challenging in cats with subcutaneous ureteral bypass (SUB) systems because they may present with lower urinary tract signs without bacteriuria. We investigated the relationship between positive urine culture and lower urinary tract signs in cats with SUBs, including factors associated with each. Methods: Clinical records were retrospectively reviewed to identify cats presenting with ureteral obstruction that underwent placement of a SUB device(s). The relationship between a positive urine culture and lower urinary tract signs was determined by chi-squared analysis. Univariable and multivariable logistic regression models were performed to identify factors associated with positive urine cultures and lower urinary tract signs. Results: Two hundred and thirty visits were recorded for 61 cats, with 36 of 230 (16%) positive cultures in 21 of 61 (34%) cats. Lower urinary tract signs were documented at 97 of 230 (42%) visits, with 37 of 61 (61%) cats demonstrating lower urinary tract signs at some point. No relationship was found between culture results and lower urinary tract signs. Risk factors for a positive culture were higher urine pH, higher urine white blood cells and the presence of bacteriuria on microscopy. Risk factors for lower urinary tract signs were younger age and being a purebred cat (vs. non-purebred). Conclusions: A high proportion of cats with SUBs exhibited sterile lower urinary tract signs, making differentiation between bacterial cystitis and subclinical bacteriuria difficult. This highlights the need for clearer guidelines on when to treat bacteriuria in cats with SUBs.
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2782580-2
ISSN	2052-6113
ISSN	2052-6113
DOI	10.1002/vro2.69
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Article ; Online: Female empowerment to improve sexual and reproductive health outcomes and prevent violence in adolescent girls and young women in Uganda: evidence reviews for policy.

Lewington, Jessica / Geddes, Rosemary / Gabagaya, Grace

African health sciences

2022 Volume 22, Issue 4, Page(s) 413–427

Abstract: Background: Adolescent girls and young women in Uganda face numerous public health challenges including high HIV prevalence, teenage pregnancies, poor sexual and reproductive health rights, child marriage, and violence.: Objectives: This evidence ... ...

Abstract	Background: Adolescent girls and young women in Uganda face numerous public health challenges including high HIV prevalence, teenage pregnancies, poor sexual and reproductive health rights, child marriage, and violence. Objectives: This evidence review explores which interventions focusing on the empowerment of adolescent girls and young women to address these challenges are suitable for Ugandan policy. Methods: We reviewed the literature to identify experimental studies and systematic reviews of interventions which improve sexual and reproductive health outcomes and/or prevent violence in adolescent girls and young women in low- and middle-income countries (LMICs). Two authors independently reviewed the studies identified through a comprehensive search strategy and assessed their quality. From this evidence base, two policy options were explored in depth considering benefits, harms, equity impacts, and costs, given the Ugandan context. Results: The screen yielded 47 studies, of which 12 remained after applying inclusion and exclusion criteria and relevance, applicability and quality assessment. Feasible policy options included: a vertical cash-incentive approach at a national or local level to support girls' attainment of education; and a horizontal integrated community approach focusing on skills and knowledge building. A combination of both is recommended for young female empowerment in Uganda, allowing for the full range of socio-cultural and economic drivers to be targeted. Conclusion: Research into the link between female empowerment and sexual and reproductive health outcomes is still in early development. This review contributes to evidence on this topic and outlines an approach that is potentially suitable for adoption across similar LMICs in Africa.
MeSH term(s)	Adolescent ; Female ; Humans ; Young Adult ; Empowerment ; Human Rights ; Reproductive Health ; Sex Factors ; Sexual Health ; Uganda ; Violence/prevention & control ; Women's Rights ; Social Determinants of Health ; Sociodemographic Factors ; Socioeconomic Factors
Language	English
Publishing date	2022-05-05
Publishing country	Uganda
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v22i4.47
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Article ; Online: Phosphoproteomic Sample Preparation for Global Phosphorylation Profiling of a Fungal Pathogen.

Ball, Brianna / Krieger, Jonathan R / Geddes-McAlister, Jennifer

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2456, Page(s) 141–151

Abstract: Phosphorylation is a key post-translational modification central to the biological behavior of proteins. This reversible modification specifically regulates cell signaling mechanisms to control survival and growth. Moreover, microbial pathogens, ... ...

Abstract	Phosphorylation is a key post-translational modification central to the biological behavior of proteins. This reversible modification specifically regulates cell signaling mechanisms to control survival and growth. Moreover, microbial pathogens, including both fungi and bacteria, rely on this modification to coordinate protein production and functioning during infection and dissemination within a host. Understanding phosphorylation and its involvement with effector proteins and complex networks are now possible with the recent technological advancements of mass spectrometry. Herein, we describe a phosphopeptide enrichment strategy optimized for the invasive mycosis-causing fungal pathogen Cryptococcus neoformans. Our protocol details proper sample preparation for efficient lysis and protein extraction with minimal phosphorylation losses followed by outlined steps for enrichment, instrumentation handling, and data analysis to permit deep profiling of the global phosphoproteome. The high-throughput versatility of bottom-up proteomics combined with our sample preparation approach facilitates opportunities for in-depth phosphorylation mapping and novel biological discoveries.
MeSH term(s)	Cryptococcosis/microbiology ; Cryptococcus neoformans ; Phosphopeptides/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Proteome/metabolism ; Proteomics/methods
Chemical Substances	Phosphopeptides ; Phosphoproteins ; Proteome
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2124-0_10
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Article ; Online: Differential follow-up patterns in COVID-19 and comparison cohorts - Authors' reply.

Taquet, Maxime / Luciano, Sierra / Geddes, John R / Harrison, Paul J

The lancet. Psychiatry

2021 Volume 8, Issue 5, Page(s) 360–361

MeSH term(s)	COVID-19 ; Follow-Up Studies ; Humans ; Mental Disorders ; Retrospective Studies ; SARS-CoV-2 ; United States
Language	English
Publishing date	2021-03-10
Publishing country	England
Document type	Letter ; Comment
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(21)00076-6
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Article ; Online: Disentangling the complex bidirectional associations between COVID-19 and psychiatric disorder - Authors' reply.

Taquet, Maxime / Luciano, Sierra / Geddes, John R / Harrison, Paul J

The lancet. Psychiatry

2021 Volume 8, Issue 3, Page(s) 179

MeSH term(s)	COVID-19 ; Humans ; Mental Disorders/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; United States
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Letter ; Comment
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(21)00028-6
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Article ; Online: Neurobehavioral mechanisms influencing the association between generativity, the desire to promote well-being of younger generations, and purpose in life in older adults at risk for Alzheimer's disease.

Walker, Caitlin S / Li, Linda / Baracchini, Giulia / Tremblay-Mercier, Jennifer / Spreng, R Nathan / Geddes, Maiya R

The journals of gerontology. Series B, Psychological sciences and social sciences

2024

Abstract: Objectives: Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in ...

Abstract	Objectives: Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in life remain unknown. This study aims to identify the functional neuroanatomy of generativity and mechanisms linking generativity with purpose in life in at-risk older adults. Methods: Fifty-eight older adults (mean age = 70.8, SD = 5.03, 45 females) with a family history of Alzheimer's disease (AD) were recruited from the PREVENT-AD cohort. Participants underwent brain imaging and completed questionnaires assessing generativity, social support, and purpose in life. Mediation models examined whether social support mediated the association between generativity and purpose in life. Seed-to-voxel analyses investigated the association between generativity and resting-state functional connectivity (rsFC) to the ventromedial prefrontal cortex (vmPFC) and ventral striatum (VS), and whether this rsFC moderated the relationship between generativity and purpose in life. Results: Affectionate social support mediated the association between generative desire and purpose in life. Generative desire was associated with rsFC between VS and precuneus, and, vmPFC and right dorsolateral prefrontal cortex (rdlPFC). The vmPFC-rdlPFC rsFC moderated the association between generative desire and purpose in life. Discussion: These findings provide insight into how the brain supports complex social behavior and, separately, purpose in life in at-risk aging. Affectionate social support may be a putative target process to enhance purpose in life in older adults. This knowledge contributes to future developments of personalized interventions that promote healthy aging.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223664-0
ISSN	1758-5368 ; 1079-5014
ISSN (online)	1758-5368
ISSN	1079-5014
DOI	10.1093/geronb/gbae060
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Article ; Online: Postural orthostatic tachycardia syndrome explained using a baroreflex response model.

Geddes, Justen R / Ottesen, Johnny T / Mehlsen, Jesper / Olufsen, Mette S

Journal of the Royal Society, Interface

2022 Volume 19, Issue 193, Page(s) 20220220

Abstract: Patients with postural orthostatic tachycardia syndrome (POTS) experience an excessive increase in heart rate (HR) and low-frequency (∼0.1 Hz) blood pressure (BP) and HR oscillations upon head-up tilt (HUT). These responses are attributed to increased ... ...

Abstract	Patients with postural orthostatic tachycardia syndrome (POTS) experience an excessive increase in heart rate (HR) and low-frequency (∼0.1 Hz) blood pressure (BP) and HR oscillations upon head-up tilt (HUT). These responses are attributed to increased baroreflex (BR) responses modulating sympathetic and parasympathetic signalling. This study uses a closed-loop cardiovascular compartment model controlled by the BR to predict BP and HR dynamics in response to HUT. The cardiovascular model predicts these quantities in the left ventricle, upper and lower body arteries and veins. HUT is simulated by letting gravity shift blood volume (BV) from the upper to the lower body compartments, and the BR control is modelled using set-point functions modulating peripheral vascular resistance, compliance, and cardiac contractility in response to changes in mean carotid BP. We demonstrate that modulation of parameters characterizing BR sensitivity allows us to predict the persistent increase in HR and the low-frequency BP and HR oscillations observed in POTS patients. Moreover, by increasing BR sensitivity, inhibiting BR control of the lower body vasculature, and decreasing central BV, we demonstrate that it is possible to simulate patients with neuropathic and hyperadrenergic POTS.
MeSH term(s)	Baroreflex/physiology ; Blood Pressure/physiology ; Heart Rate/physiology ; Humans ; Postural Orthostatic Tachycardia Syndrome ; Posture/physiology
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2022.0220
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Article ; Online: Quantitative Phosphoproteome Analysis of the Interaction Between Fusarium graminearum and Triticum aestivum.

Liu, Boyan / Johal, Danisha / Buchanan, Reid / Ball, Brianna / Serajazari, Mitra / Geddes-McAlister, Jennifer

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2659, Page(s) 171–182

Abstract: Quantitative proteomics is a powerful method for distinguishing protein abundance changes in a biological system across conditions. In addition to recent advances in computational power and bioinformatics methods, improvements to sensitivity and ... ...

Abstract	Quantitative proteomics is a powerful method for distinguishing protein abundance changes in a biological system across conditions. In addition to recent advances in computational power and bioinformatics methods, improvements to sensitivity and resolution of mass spectrometry (MS) instrumentation provide an innovative approach for studying host-pathogen interaction dynamics and posttranslational modifications. In this protocol, we provide a workflow for state-of-the-art MS-based proteomics to assess changes in phosphorylated protein abundance upon interaction between the worldwide cereal crop, Triticum aestivum (wheat), and the global cereal crop fungal pathogen, Fusarium graminearum, during infection. This protocol mimics a time course of infection of T. aestivum by F. graminearum in the greenhouse, and the harvested samples undergo Fe-NTA phosphoenrichment combined with label-free quantification (LFQ) for detection by liquid-chromatography (LC)-coupled with tandem MS/MS. Our approach provides an in-depth view of changes in phosphorylation from both the host and pathogen perspectives in a single experiment across infection time points and different host cultivars.
MeSH term(s)	Triticum/microbiology ; Tandem Mass Spectrometry ; Plant Diseases/microbiology ; Proteomics ; Fusarium/metabolism ; Proteome/metabolism
Chemical Substances	Proteome
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3159-1_13
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