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  1. Article ; Online: A new predictive formula for calculation of equilibrium pH: a step back in time.

    Wooten, E Wrenn

    American journal of physiology. Renal physiology

    2010  Volume 298, Issue 2, Page(s) F471

    MeSH term(s) Acid-Base Equilibrium ; Buffers ; Hydrogen-Ion Concentration ; Models, Biological ; Models, Chemical ; Protons ; Solutions/chemistry
    Chemical Substances Buffers ; Protons ; Solutions
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00240.2009
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  2. Article: Proprotein Convertase Subtilisin Kexin 9 (PCSK9) and nonHDL particles rise during normal pregnancy and differ by BMI.

    Wild, R A / Weedin, E / Cox, K / Zhao, Y D / Wrenn, D S / Lopez, D / Wooten, C J / Melendez, Q M / Myers, D / Hansen, K R

    Journal of clinical lipidology

    2022  Volume 16, Issue 4, Page(s) 483–490

    Abstract: Background: Serum lipids, including total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c), increase during pregnancy. Serum Proprotein Convertase Subtilisin Kexin 9 (PCSK9) is a vital regulator in lipoprotein ... ...

    Abstract Background: Serum lipids, including total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c), increase during pregnancy. Serum Proprotein Convertase Subtilisin Kexin 9 (PCSK9) is a vital regulator in lipoprotein metabolism. Circulating PCSK9 downregulates the LDL receptor on the surface of liver cells inhibiting clearance of LDL-c.
    Objective: To determine the influence of weeks of pregnancy and obesity on circulating levels of essential lipid lipoproteins and PCSK9 in women with normal, uncomplicated pregnancies and deliveries.
    Methods: We performed a comprehensive lipid and lipoprotein profile during each trimester of pregnancy in 70 mostly Caucasian women with uncomplicated normal pregnancies and deliveries. Based on their first trimester BMI, we placed them into one of three categories: (<25 kg/m
    Results: Total and active PCSK9, LDL-c, and nonHDL particle concentrations were higher than reported for non-pregnant normal values, increased after the first trimester of pregnancy, and were highest from mid-gestation to the last trimester of pregnancy in the overweight and the obese.
    Conclusion: PCSK9 levels rise as normal pregnancy progresses. Levels are higher in persons who are obese, even after adjustment for insulin resistance. Defining normal PCSK9 levels during pregnancy must adjust for gestational age and BMI.
    MeSH term(s) Body Mass Index ; Cholesterol ; Cholesterol, LDL ; Female ; Humans ; Insulin Resistance ; Lipoproteins ; Obesity ; Pregnancy ; Proprotein Convertase 9 ; Proprotein Convertases ; Subtilisins ; Triglycerides
    Chemical Substances Cholesterol, LDL ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2022.05.070
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  3. Article ; Online: The standard strong ion difference, standard total titratable base, and their relationship to the Boston compensation rules and the Van Slyke equation for extracellular fluid.

    Wooten, E Wrenn

    Journal of clinical monitoring and computing

    2010  Volume 24, Issue 3, Page(s) 177–188

    Abstract: A general formalism for calculating physiological acid-base balance in multiple compartments is extended to the combined interstitial, plasma, and erythrocyte multicompartment system in humans using the Siggaard-Andersen approximation for interstitial ... ...

    Abstract A general formalism for calculating physiological acid-base balance in multiple compartments is extended to the combined interstitial, plasma, and erythrocyte multicompartment system in humans using the Siggaard-Andersen approximation for interstitial fluid. The resulting equations for total titratable base and strong ion difference reproduce the experimental in vivo carbon dioxide titration curve as well as the experimental strong ion difference value of the interstitial, plasma, and erythrocyte system in normal man. The "Boston rules" for compensation in acute respiratory acidosis and alkalosis are then derived analytically from the model. The Van Slyke equation for the interstitial, plasma, and erythrocyte system is also derived and shown to approximate the Van Slyke equation for standard base excess.
    MeSH term(s) Acid-Base Equilibrium/physiology ; Acidosis, Respiratory/metabolism ; Alkalosis, Respiratory/metabolism ; Biostatistics ; Computer Simulation ; Erythrocytes/metabolism ; Extracellular Fluid/metabolism ; Humans ; Mathematical Concepts ; Models, Biological ; Plasma/metabolism
    Language English
    Publishing date 2010-03-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-010-9231-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Science review: quantitative acid-base physiology using the Stewart model.

    Wooten, E Wrenn

    Critical care (London, England)

    2004  Volume 8, Issue 6, Page(s) 448–452

    Abstract: There has been renewed interest in quantifying acid-base disorders in the intensive care unit. One of the methods that has become increasingly used to calculate acid-base balance is the Stewart model. This model is briefly discussed in terms of its ... ...

    Abstract There has been renewed interest in quantifying acid-base disorders in the intensive care unit. One of the methods that has become increasingly used to calculate acid-base balance is the Stewart model. This model is briefly discussed in terms of its origin, its relationship to other methods such as the base excess approach, and the information it provides for the assessment and treatment of acid-base disorders in critically ill patients.
    MeSH term(s) Acid-Base Equilibrium/physiology ; Acidosis/diagnosis ; Acidosis/metabolism ; Albumins/analysis ; Critical Illness ; Humans ; Intensive Care Units ; Models, Biological ; Phosphates/blood
    Chemical Substances Albumins ; Phosphates
    Language English
    Publishing date 2004-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/cc2910
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  5. Article: Calculation of physiological acid-base parameters in multicompartment systems with application to human blood.

    Wooten, E Wrenn

    Journal of applied physiology (Bethesda, Md. : 1985)

    2003  Volume 95, Issue 6, Page(s) 2333–2344

    Abstract: A general formalism for calculating parameters describing physiological acid-base balance in single compartments is extended to multicompartment systems and demonstrated for the multicompartment example of human whole blood. Expressions for total ... ...

    Abstract A general formalism for calculating parameters describing physiological acid-base balance in single compartments is extended to multicompartment systems and demonstrated for the multicompartment example of human whole blood. Expressions for total titratable base, strong ion difference, change in total titratable base, change in strong ion difference, and change in Van Slyke standard bicarbonate are derived, giving calculated values in agreement with experimental data. The equations for multicompartment systems are found to have the same mathematical interrelationships as those for single compartments, and the relationship of the present formalism to the traditional form of the Van Slyke equation is also demonstrated. The multicompartment model brings the strong ion difference theory to the same quantitative level as the base excess method.
    MeSH term(s) Acid-Base Equilibrium/physiology ; Albumins/chemistry ; Algorithms ; Amino Acids/blood ; Bicarbonates/chemistry ; Bicarbonates/metabolism ; Blood Chemical Analysis ; Blood Gas Analysis ; Blood Proteins/chemistry ; Body Fluid Compartments ; Erythrocytes/chemistry ; Hemoglobins/chemistry ; Hemoglobins/metabolism ; Humans ; Hydrogen-Ion Concentration ; Membranes/physiology ; Models, Biological ; Oxyhemoglobins/chemistry
    Chemical Substances Albumins ; Amino Acids ; Bicarbonates ; Blood Proteins ; Hemoglobins ; Oxyhemoglobins
    Language English
    Publishing date 2003-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
    ISSN (online) 1522-1601
    ISSN 8750-7587 ; 0021-8987 ; 0161-7567
    DOI 10.1152/japplphysiol.00560.2003
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  6. Article: Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein).

    Wooten, M W / Nel, A E / Goldschmidt-Clermont, P J / Galbraith, R M / Wrenn, R W

    FEBS letters

    1985  Volume 191, Issue 1, Page(s) 97–101

    Abstract: A major 56 kDa substrate for phospholipid/Ca2+-dependent kinase (C-kinase) in pancreatic acinar cells is physicochemically and immunologically indistinguishable from the vitamin D-binding protein, Gc or group-specific component. Cellular Gc was also ... ...

    Abstract A major 56 kDa substrate for phospholipid/Ca2+-dependent kinase (C-kinase) in pancreatic acinar cells is physicochemically and immunologically indistinguishable from the vitamin D-binding protein, Gc or group-specific component. Cellular Gc was also phosphorylated in intact cells following treatment with carbachol as a physiological stimulus. These findings indicate the potential usefulness of Gc as a defined substrate for further studies of the biological role of C-kinase activity in pancreatic acini and possibly in other cells.
    MeSH term(s) Animals ; Calcium/pharmacology ; Pancreas/enzymology ; Phosphorylation ; Protein Kinase C/analysis ; Rats ; Vitamin D-Binding Protein/isolation & purification
    Chemical Substances Vitamin D-Binding Protein ; Protein Kinase C (EC 2.7.11.13) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1985-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1016/0014-5793(85)81001-2
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