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  1. Article ; Online: Journal of Cardiovascular Pharmacology Welcomes New Associates.

    Booz, George W

    Journal of cardiovascular pharmacology

    2024  Volume 83, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proteinopathy: Shared Feature Between the Heart and Brain in Alzheimer's Disease.

    Amin, Ghadir / Booz, George W / Zouein, Fouad A

    Journal of cardiovascular pharmacology

    2024  Volume 83, Issue 1, Page(s) 4–7

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Brain ; Proteostasis Deficiencies ; Heart
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Central role for BRAF in cardiac hypertrophy: rethinking the pathological-physiological divide.

    Altara, Raffaele / Booz, George W

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 2, Page(s) 143–148

    Abstract: The RAF/MEK/ERK1/2 signaling cascade has been implicated in pathological cardiac hypertrophy downstream of some Gq-coupled receptors. The RAF family of kinases consists of three isoforms (ARAF, BRAF, and CRAF) and until recently most studies on this ... ...

    Abstract The RAF/MEK/ERK1/2 signaling cascade has been implicated in pathological cardiac hypertrophy downstream of some Gq-coupled receptors. The RAF family of kinases consists of three isoforms (ARAF, BRAF, and CRAF) and until recently most studies on this signaling pathway in the heart have focused on RAF1 (CRAF). In a recent issue of Clinical Science, Alharbi et al. utilized an inducible cardiac myocyte targeted knockout mouse model to define the role of BRAF in pathological versus physiological hypertrophy using angiotensin II and phenylephrine (PE) infusion, respectively. They reported that loss of BRAF attenuated both pathological cardiac hypertrophy and interstitial fibrosis. BRAF knockout decreased cardiac function with PE in male mice and enhanced both interstitial and perivascular cardiac fibrosis but had no effect on hypertrophy. In contrast, loss of BRAF attenuated physiological hypertrophy in female mice but had no effect on fibrosis or contractility. These observations extend those previously made by this group assessing the consequences of expressing an inducible activating mutant of BRAF in the heart and the benefit of enhancing RAF/MEK/ERK1/2 signaling by exploiting the 'RAF paradox'. Additional studies are needed to better define the role of BRAF under conditions reflective of chronic stress on the heart due to the biomechanical stimulation exerted by hypertension. In addition, the role of BRAF and its activation in overt heart failure remains to be established. Nevertheless, the new findings highlight the potential importance of additional signaling events, perhaps related to RAF1 or ERK1/2 activation, in shaping BRAF signaling in a sex- and context-dependent manner.
    MeSH term(s) Male ; Mice ; Female ; Animals ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Cardiomegaly/pathology ; MAP Kinase Signaling System ; Mice, Knockout ; Mitogen-Activated Protein Kinase Kinases ; Fibrosis ; Myocytes, Cardiac/metabolism
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Non-coding RNAs in heart failure.

    Booz, George W / Theofilatos, Konstantinos A

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 1016139

    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1016139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: G Protein-Coupled Receptors-Receptors With New Tricks Up Their Sleeves.

    Steinberg, Susan F / Booz, George W

    Journal of cardiovascular pharmacology

    2022  Volume 80, Issue 3, Page(s) 325–327

    MeSH term(s) Arthroplasty, Replacement, Knee ; Receptors, G-Protein-Coupled
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the Promise and Challenges of Artificial Intelligence in Biomedical Research and Clinical Practice.

    Altara, Raffaele / Basson, Cameron J / Biondi-Zoccai, Giuseppe / Booz, George W

    Journal of cardiovascular pharmacology

    2024  

    Abstract: Artificial intelligence (AI) is poised to revolutionize how science, and biomedical research in particular, are done. With AI, problem solving and complex tasks using massive data sets can be performed at a much higher rate and dimensionality level ... ...

    Abstract Artificial intelligence (AI) is poised to revolutionize how science, and biomedical research in particular, are done. With AI, problem solving and complex tasks using massive data sets can be performed at a much higher rate and dimensionality level compared to humans. With the ability to handle huge data sets and self-learn, AI is already being exploited in drug design, drug repurposing, toxicology, and material identification. AI could also be used in both basic and clinical research in study design, defining outcomes, analyzing data, interpreting findings, and even identifying the most appropriate areas of investigation and funding sources. State-of-the-art AI-based large language models (LLM), such as ChatGPT and Perplexity, are positioned to change forever how science is communicated and how scientists interact with one another and their profession, including post-publication appraisal and critique. Like all revolutions, upheaval will follow and not all outcomes can be predicted, necessitating guardrails at the onset, especially to minimize the untoward impact of the many drawbacks of LLMs, which include lack of confidentiality, risk of hallucinations, and propagation of mainstream albeit potentially mistaken opinions and perspectives. In this review, we highlight areas of biomedical research that are already being reshaped by AI and how AI is likely to impact it further in the near future. We discuss the potential benefits of AI in biomedical research and address possible risks, some surrounding the creative process, that warrant further reflection.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction: Noureddine et al. Impact of the Renin-Angiotensin System on the Endothelium in Vascular Dementia: Unresolved Issues and Future Perspectives.

    Noureddine, Fatima Y / Altara, Raffaele / Fan, Fan / Yabluchanskiy, Andriy / Booz, George W / Zouein, Fouad A

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: The authors would like to make the following correction to the publication dealing with Reference #3 [ ... ]. ...

    Abstract The authors would like to make the following correction to the publication dealing with Reference #3 [...].
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Few Initial Thoughts on Receiving the Baton.

    Booz, George W

    Journal of cardiovascular pharmacology

    2018  Volume 72, Issue 1, Page(s) 2

    MeSH term(s) Biomedical Research/trends ; Cardiotonic Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Editorial Policies ; Humans ; Periodicals as Topic/trends
    Chemical Substances Cardiotonic Agents
    Language English
    Publishing date 2018-07-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000000601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Immunomodulatory Approaches in Cardiovascular Diseases.

    Booz, George W / Altara, Raffaele / Zouein, Fouad A

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 873452

    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.873452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Seizing the Future: What's Next for the Journal of Cardiovascular Pharmacology?

    Booz, George W

    Journal of cardiovascular pharmacology

    2018  Volume 73, Issue 1, Page(s) 1–2

    MeSH term(s) Animals ; Biomedical Research/trends ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/therapeutic use ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Diffusion of Innovation ; Editorial Policies ; Forecasting ; Humans ; Periodicals as Topic/trends ; Pharmacology/trends
    Chemical Substances Cardiovascular Agents
    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000000630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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