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  1. Article ; Online: Osteoporosis Treatment: Not Easy.

    Ott, Susan M

    Annals of internal medicine

    2023  Volume 176, Issue 2, Page(s) 278–279

    MeSH term(s) Humans ; Osteoporosis/drug therapy ; Bone Density
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-3580
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  2. Article ; Online: In osteoporosis or osteopenia, exercise interventions improve BMD; effects vary by exercise type and BMD site.

    Ott, Susan M

    Annals of internal medicine

    2022  Volume 175, Issue 4, Page(s) JC46

    Abstract: Source citation: Zhang S, Huang X, Zhao X, et al. ...

    Abstract Source citation: Zhang S, Huang X, Zhao X, et al.
    MeSH term(s) Bone Density ; Bone Diseases, Metabolic/therapy ; Exercise Therapy ; Humans ; Lumbar Vertebrae ; Osteoporosis/therapy
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Consider the Bisphosphonate Dose.

    Ott, Susan M

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2021  Volume 37, Issue 1, Page(s) 1–2

    MeSH term(s) Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4479
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  4. Article ; Online: In women, bisphosphonate use for ≥3 years vs. <3 months was linked to increased atypical femur fracture risk.

    Ott, Susan M

    Annals of internal medicine

    2021  Volume 174, Issue 1, Page(s) JC9

    Abstract: Source citation: Black DM, Geiger EJ, Eastell R, et al. ...

    Abstract Source citation: Black DM, Geiger EJ, Eastell R, et al.
    MeSH term(s) Diphosphonates/adverse effects ; Female ; Femoral Fractures/chemically induced ; Femoral Fractures/epidemiology ; Femur ; Humans ; Osteoporotic Fractures/chemically induced ; Osteoporotic Fractures/epidemiology
    Chemical Substances Diphosphonates
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202101190-009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Not etched in bone: the role of osteoclast proton-sensing receptors.

    Ott, Susan M

    Kidney international

    2021  Volume 99, Issue 3, Page(s) 542–545

    Abstract: The osteoclast proton-sensing receptors may play a role in osteoclastogenesis or bone resorption. The current study by Kreiger et al. found that in female mice, osteoclast-specific deletion of the gene for OGR1 resulted in increased bone mass, which ... ...

    Abstract The osteoclast proton-sensing receptors may play a role in osteoclastogenesis or bone resorption. The current study by Kreiger et al. found that in female mice, osteoclast-specific deletion of the gene for OGR1 resulted in increased bone mass, which demonstrates that in some situations this receptor is playing a role. However, there are some inconsistencies because the bone resorption was not reduced in their global knockout mice, and the effects are not seen in both genders or by other investigators. More work should be done to better define the role of OGR1 because acidosis is an important cause of bone loss.
    MeSH term(s) Acidosis ; Animals ; Bone Resorption/genetics ; Female ; Male ; Mice ; Mice, Knockout ; Osteoclasts ; Protons ; Receptors, G-Protein-Coupled
    Chemical Substances Protons ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates.

    Ott, Susan M / Heckbert, Susan R

    The New England journal of medicine

    2020  Volume 383, Issue 22, Page(s) 2188–2189

    MeSH term(s) Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects ; Femoral Fractures/chemically induced ; Femoral Fractures/prevention & control ; Femur ; Humans
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2029828
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  7. Article ; Online: Renal insufficiency and bone loss.

    Ott, Susan M

    Current opinion in rheumatology

    2019  Volume 31, Issue 4, Page(s) 394–399

    Abstract: Purpose of review: Patients with chronic kidney disease have a high risk of fractures and no established treatments that have been shown to prevent the bone disease. The physiology of renal osteodystrophy is complex and recently more factors have been ... ...

    Abstract Purpose of review: Patients with chronic kidney disease have a high risk of fractures and no established treatments that have been shown to prevent the bone disease. The physiology of renal osteodystrophy is complex and recently more factors have been found that complicate the mineral metabolism. The recognition that vascular calcifications are related to bone disease has made treatment even more challenging.
    Recent findings: The most exciting new findings relate to the signaling pathways that are seen in kidney disease and how they cause abnormalities in bone physiology. In particular, wnt and activin signaling pathways are seen early in the course of renal disease. The bones react by increasing FGF-23, which targets both renal phosphate secretion and a variety of other systemic effects. Secreted klotho is another newly described hormone with effects on several systems.Clinical studies have focused on treatments for hyperparathyroidism and phosphate, and frustrating limitations of the treatments used for ordinary osteoporosis.
    Summary: Treatment of bone disease in patients with chronic kidney disease is challenging, and understanding the physiological pathways could lead to novel therapies.
    MeSH term(s) Activins/metabolism ; Bone and Bones/metabolism ; Chronic Kidney Disease-Mineral and Bone Disorder/etiology ; Chronic Kidney Disease-Mineral and Bone Disorder/metabolism ; Disease Progression ; Fibroblast Growth Factors/metabolism ; Humans ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Wnt Proteins/metabolism
    Chemical Substances Wnt Proteins ; Activins (104625-48-1) ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE)
    Language English
    Publishing date 2019-05-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Guideline: USPSTF recommends against menopausal estrogen for primary prevention of chronic conditions.

    Ott, Susan M

    Annals of internal medicine

    2018  Volume 168, Issue 6, Page(s) JC26

    MeSH term(s) Estrogens ; Female ; Humans ; Menopause ; Postmenopause ; Primary Prevention
    Chemical Substances Estrogens
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJC-2018-168-6-026
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  9. Article ; Online: Cortical or Trabecular Bone: What's the Difference?

    Ott, Susan M

    American journal of nephrology

    2018  Volume 47, Issue 6, Page(s) 373–375

    MeSH term(s) Bone and Bones ; Cancellous Bone ; Chronic Kidney Disease-Mineral and Bone Disorder ; Cortical Bone ; Humans
    Language English
    Publishing date 2018-05-22
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000489672
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  10. Article ; Online: Review: Osteoporosis drugs may improve BMD and reduce fractures in some patients with CKD.

    Ott, Susan M

    Annals of internal medicine

    2017  Volume 167, Issue 4, Page(s) JC19

    Language English
    Publishing date 2017-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJC-2017-167-4-019
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