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Article: Comparative Analysis of Human Body Temperatures Measured with Noncontact and Contact Thermometers.

Dolibog, Patrycja / Pietrzyk, Barbara / Kierszniok, Klaudia / Pawlicki, Krzysztof

2022 Volume 10, Issue 2

Abstract: Body temperature measurement is one of the basic methods in clinical diagnosis. The problems of thermometry-interpretation of the accuracy and repeatability of various types of thermometers-are still being discussed, especially during the current ... ...

Abstract	Body temperature measurement is one of the basic methods in clinical diagnosis. The problems of thermometry-interpretation of the accuracy and repeatability of various types of thermometers-are still being discussed, especially during the current pandemic in connection with the SARS-CoV-2 virus responsible for causing the COVID-19 disease. The aim of the study was to compare surface temperatures of the human body measured by various techniques, in particular a noncontact thermometer (infrared) and contact thermometers (mercury, mercury-free, electronic). The study included 102 randomly selected healthy women and men (age 18-79 years). The Bland-Altman method was used to estimate the 95% reproducibility coefficient, i.e., to assess the degree of conformity between different attempts. Temperatures measured with contact thermometers in the armpit are higher than temperatures measured without contact at the frontal area of the head. The methods used to measure with contact thermometers and a noncontact infrared thermometer statistically showed high measurement reliability. In order to correctly interpret the result of measuring human body temperature, it is necessary to indicate the place of measurement and the type of thermometer used.
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10020331
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Article ; Online: Continuous glucose monitoring systems in well-controlled children with type 1 diabetes mellitus.

M Kowalczyk, Emilia / Adamczyk, Marta / Pietrzyk, Justyna / Jastrzębska, Barbara / Szypowska, Agnieszka

Pediatric endocrinology, diabetes, and metabolism

2023 Volume 27, Issue 3, Page(s) 151–158

Abstract: Introduction: Numerous studies have demonstrated the clinical benefits of using continuous glucose monitoring (CGM) systems among patients with type 1 diabetes (T1D). Aim of the study was to assess the effectiveness of CGM on metabolic control in ... ...

Title translation	Zastosowanie systemu ciągłego monitorowania glikemii u dzieci z dobrze kontrolowaną cukrzycą typu 1.
Abstract	Introduction: Numerous studies have demonstrated the clinical benefits of using continuous glucose monitoring (CGM) systems among patients with type 1 diabetes (T1D). Aim of the study was to assess the effectiveness of CGM on metabolic control in children with T1D and well-controlled disease prior to the study. Material and methods: This prospective analysis included 99 children (46 girls) at the median age of 11.23 years and diabetes duration of at least 1 year (median: 5.16 years), generally well controlled metabolically (median HbA1c: 7.0%), and treated with continuous subcutaneous insulin infusion (CSII). The patients had used CGM for at least 150 days. We analysed the participants in subgroups based on baseline HbA1c < 7%, ≥ 7%, age, and sex. Results: Children with baseline HbA1c < 7% were characterized by significantly increased HbA1c after the median of 273 days (217; 320) of CGM usage (6.3% vs. 6.6%, respectively; p = 0.002). No significant change in HbA1c was noted in children with baseline HbA1c ≥ 7% (7.5% vs. 7.4%, respectively; p = 0.191), but 20% of the group reached the target of HbA1c < 7.0%. The analysis of CGM data revealed that no group achieved the CGM targets of good metabolic control. Total daily insulin requirements remained stable in both groups (p = 0.752; p = 0.274), but the amount of basal insulin increased statistically in both groups (p = 0.009; p ≤ 0.001). Conclusions: The application of CGM provides detailed information concerning glycaemic control and is beneficial in some, but not all, T1D children with good diabetes control.
MeSH term(s)	Blood Glucose ; Blood Glucose Self-Monitoring ; Child ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Glycated Hemoglobin/analysis ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin Infusion Systems
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2023-02-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2617120-X
ISSN	2083-8441 ; 2083-8441
ISSN (online)	2083-8441
ISSN	2083-8441
DOI	10.5114/pedm.2021.107717
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Article ; Online: The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells.

Jaworska, Martyna / Szczudło, Julia / Pietrzyk, Adrian / Shah, Jay / Trojan, Sonia E / Ostrowska, Barbara / Kocemba-Pilarczyk, Kinga A

Pharmacological reports : PR

2023 Volume 75, Issue 4, Page(s) 876–890

Abstract: Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate fermentation in oxygen presence of oxygen was made a century ago, it is still an area of intense research and development of new hypotheses that, layer by layer, ... ...

Abstract	Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate fermentation in oxygen presence of oxygen was made a century ago, it is still an area of intense research and development of new hypotheses that, layer by layer, unravel the complexities of neoplastic transformation. This seemingly simple metabolic reprogramming of cancer cells reveals an intriguing, multi-faceted nature that may link various phenomena including cell signaling, cell proliferation, ROS generation, energy supply, macromolecules synthesis/biosynthetic precursor supply, immunosuppression, or cooperation of cancerous cells with cancer-associated fibroblasts (CAFs), known as reversed Warburg effect. According to the current perception of the causes and consequences of the Warburg effect, PI3K/Akt/mTOR are the main signaling pathways that, in concert with the transcription factors HIF-1, p53, and c-Myc, modulate the activity/expression of key regulatory enzymes, including PKM2, and PDK1 to tune in the most optimal metabolic setting for the cancer cell. This in turn secures adequate levels of biosynthetic precursors, NADPH, NAD
MeSH term(s)	Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Neoplasms/metabolism ; Signal Transduction ; Oxygen/metabolism ; Glycolysis ; Lactates
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Oxygen (S88TT14065) ; Lactates
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2186248-5
ISSN	2299-5684 ; 1734-1140
ISSN (online)	2299-5684
ISSN	1734-1140
DOI	10.1007/s43440-023-00504-1
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Article ; Online: Knowledge and Attitudes of Dialysis Patients Toward Kidney Transplantation: Preliminary Report from a Pilot Study Preceding a Cross-Sectional Nationwide Evaluation.

Kurleto, Paulina / Kiersztejn, Maciej / Szumańska, Nina / Milaniak, Irena / Tomaszek, Lucyna / Dębska, Grażyna / Turkanik, Edyta / Siekierska, Barbara / Michalski, Rajmund / Tomaszek, Aleksandra / Pietrzyk, Jacek A

Transplantation proceedings

2024

Abstract: Background: The knowledge and attitudes of dialyzed patients toward the best method of renal replacement treatment (ie, kidney transplantation [KTx]) may be the main factor motivating them to apply and be put on the national kidney transplant waiting ... ...

Abstract	Background: The knowledge and attitudes of dialyzed patients toward the best method of renal replacement treatment (ie, kidney transplantation [KTx]) may be the main factor motivating them to apply and be put on the national kidney transplant waiting list, resulting in a better prognosis. Objective: Assessment of the knowledge and attitudes of dialyzed patients toward KTx. Methods: A pilot study is considered an introductory step before the nationwide project, which will cover dialysis centers in Poland from 2023 to 2024. The authorship 4-part questionnaire, including self-assessment knowledge, attitude dimension, pain and mental evaluation section, was made available to 30 patients with hemodialysis aged 30 to 75 years. Results: The median age of the patients was 59 years. The primary cause of end-stage renal disease (ESRD) was glomerulonephritis (33%). Most of the patients stayed on hemodialysis for 2 years or less (57%); 43% of the patients declared insufficient knowledge in the field of KTx, 41% of the patients were not informed at the nephrology clinic that KTx remains one of the methods of renal replacement therapy, and 65% did not receive information about the possibility of preemptive or early transplantation from a relative donor. Only 34% of the patients considered KTx to be a much better treatment option than dialysis, but only 20% of those were on the national waiting list for KTx. Conclusions: The pilot study showed insufficient knowledge of patients with ESRD regarding kidney transplantation as a method of renal replacement therapy. There is a need to introduce an effective educational program.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.02.004
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Article: High rates of undiagnosed and untreated osteoporosis in postmenopausal women receiving medical services in the area of Upper Silesia.

Hachuła, Marcin / Pietrzyk, Barbara / Gruszka, Wojciech / Cedrych, Ida / Chudek, Jerzy

Przeglad menopauzalny = Menopause review

2020 Volume 19, Issue 2, Page(s) 72–79

Abstract: Introduction: High social cost and high risk of disability make postmenopausal osteoporosis one of major public health problem in the 21: Material and methods: The survey included 450 postmenopausal women (age 65 ±11 years). A detailed questionnaire ... ...

Abstract	Introduction: High social cost and high risk of disability make postmenopausal osteoporosis one of major public health problem in the 21 Material and methods: The survey included 450 postmenopausal women (age 65 ±11 years). A detailed questionnaire included demographic and anthropometric data, comorbidity, history of previous low-energy fractures, family medical history, and treatment for osteoporosis. The FRAX calculator was used to estimate the risk of MOF and HF. Results: Osteoporosis was previously diagnosed in 23.7% women. Of those 70.2% were receiving vitamin D, 27% calcium preparations, 33% bisphosphonates, and 22% were untreated. Only 42.2% women with previous fractures had been diagnosed with osteoporosis and 42.8% received any treatment. 12.5% women with FRAX-BMD ≥ 10% had no risk factors of osteoporosis and < 10% risk of MOF and HF in FRAX without BMD. Conclusions: Osteoporosis often remains undiagnosed and untreated in postmenopausal women. There is a great need to popularize FRAX without BMD calculator among physicians, especially GPs, as the risk calculation justify the implementation of antiosteoporotic therapy. Women with burden of risk factors of fractures and borderline FRAX without BMD values, should be referred to a densitometry examination, as having greater risk of fracture than shown by FRAX without BMD.
Language	English
Publishing date	2020-07-13
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596140-8
ISSN	2299-0038 ; 1643-8876
ISSN (online)	2299-0038
ISSN	1643-8876
DOI	10.5114/pm.2020.97844
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Article ; Online: High rates of undiagnosed and untreated osteoporosis in postmenopausal women receiving medical services in the area of Upper Silesia

Marcin Hachuła / Barbara Pietrzyk / Wojciech Gruszka / Ida Cedrych / Jerzy Chudek

Menopause Review, Vol 19, Iss 2, Pp 72-

2020 Volume 79

Keywords	osteoporosis ; postmenopausal women ; undiagnosed osteoporosis ; untreated osteoporosis ; frax calculator ; Medicine ; R
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
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Article: Sclerostin: Intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders.

Pietrzyk, Barbara / Smertka, Mike / Chudek, Jerzy

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2017 Volume 26, Issue 8, Page(s) 1283–1291

Abstract: Sclerostin is a glycoprotein involved in the regulation of bone metabolism, exclusively secreted by osteocytes. It affects the activity of bone morphogenetic proteins (BMPs) and is an inhibitor of the Wnt/β-catenin metabolic pathway in bone cells. ... ...

Abstract	Sclerostin is a glycoprotein involved in the regulation of bone metabolism, exclusively secreted by osteocytes. It affects the activity of bone morphogenetic proteins (BMPs) and is an inhibitor of the Wnt/β-catenin metabolic pathway in bone cells. Osteocytes reduce the release of sclerostin in response to mechanical stimuli acting on bone, and thus promote the activation of osteogenic pathway Wnt/β-catenin in osteoblasts. This signaling pathway plays a key role in osteogenesis and bone turnover. Loss of sclerostin gene function is related to 3 different craniotubular hyperostosis processes: sclerosteosis, craniodiaphyseal dysplasia, and van Buchem disease. Additionally, experimental and clinical studies suggest that sclerostin may promote vascular calcification. Antibodies directed against sclerostin stimulate bone formation and represent a new therapeutic option in the treatment of diseases with increased bone resorption, such as osteoporosis and inflammatory diseases where there is generalized bone loss, periarticular osteoporosis, and cartilage damage, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and glucocorticoid-induced osteoporosis (GIO). Antibody use has the potential to offer new therapeutic approaches in the therapy of mineral and bone disorders resulting from chronic kidney disease (CKD-MBD) and vascular calcifications.
MeSH term(s)	Bone Density ; Bone Diseases/etiology ; Bone Morphogenetic Proteins/antagonists & inhibitors ; Bone Morphogenetic Proteins/blood ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/physiology ; Bone Remodeling ; Genetic Markers/genetics ; Genetic Markers/physiology ; Humans ; Osteoporosis/etiology ; Renal Insufficiency, Chronic/complications ; Vascular Diseases/etiology
Chemical Substances	Bone Morphogenetic Proteins ; Genetic Markers ; SOST protein, human
Language	English
Publishing date	2017-11
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/68739
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Article ; Online: Approach to tap water safety analysis in terms of biostability

Tchórzewska-Cieślak Barbara / Papciak Dorota / Pietrucha-Urbanik Katarzyna / Pietrzyk Andżelika

E3S Web of Conferences, Vol 59, p

2018 Volume 00005

Abstract: The subject of the work is the analysis and assessment of the risk of biological instability of water. The lack of water stability causes the increased susceptibility of the distribution system to secondary microbial contamination of water and ... ...

Abstract	The subject of the work is the analysis and assessment of the risk of biological instability of water. The lack of water stability causes the increased susceptibility of the distribution system to secondary microbial contamination of water and constitutes a hazard for consumers’ health. The risk is expressed as the loss of water supply safety and distinguishes a failure of not meeting certain water quality parameters that can influence physico-chemical parameters and the bacteriological quality of the water supplied to the consumers. In the paper the method of analysing and evaluating the risk of loss of biostability of tap water is presented. The presented analysis was performed on the basis of the operating data from the water treatment plant.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Coexisting Conditions Modifying Phenotypes of Patients with 22q11.2 Deletion Syndrome.

Smyk, Marta / Geremek, Maciej / Ziemkiewicz, Kamila / Gambin, Tomasz / Kutkowska-Kaźmierczak, Anna / Kowalczyk, Katarzyna / Plaskota, Izabela / Wiśniowiecka-Kowalnik, Barbara / Bartnik-Głaska, Magdalena / Niemiec, Magdalena / Grad, Dominika / Piotrowicz, Małgorzata / Gieruszczak-Białek, Dorota / Pietrzyk, Aleksandra / Crowley, T Blaine / Giunta, Victoria / McGinn, Daniel E / Zackai, Elaine H / Tran, Oanh /

Emanuel, Beverly S / McDonald-McGinn, Donna M / Nowakowska, Beata A

Genes

2023 Volume 14, Issue 3

Abstract: 22q11.2 deletion syndrome (22q11.2DS) is the most common genomic disorder with an extremely broad phenotypic spectrum. The aim of our study was to investigate how often the additional variants in the genome can affect clinical variation among patients ... ...

Abstract	22q11.2 deletion syndrome (22q11.2DS) is the most common genomic disorder with an extremely broad phenotypic spectrum. The aim of our study was to investigate how often the additional variants in the genome can affect clinical variation among patients with the recurrent deletion. To examine the presence of additional variants affecting the phenotype, we performed microarray in 82 prenatal and 77 postnatal cases and performed exome sequencing in 86 postnatal patients with 22q11.2DS. Within those 159 patients where array was performed, 5 pathogenic and 5 likely pathogenic CNVs were identified outside of the 22q11.2 region. This indicates that in 6.3% cases, additional CNVs most likely contribute to the clinical presentation. Additionally, exome sequencing in 86 patients revealed 3 pathogenic (3.49%) and 5 likely pathogenic (5.81%) SNVs and small CNV. These results show that the extension of diagnostics with genome-wide methods can reveal other clinically relevant changes in patients with 22q11 deletion syndrome.
MeSH term(s)	Humans ; DiGeorge Syndrome/genetics ; DiGeorge Syndrome/complications ; Phenotype ; Microarray Analysis
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14030680
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Article ; Online: Coexisting Conditions Modifying Phenotypes of Patients with 22q11.2 Deletion Syndrome

Smyk, Marta / Geremek, Maciej / Ziemkiewicz, Kamila / Gambin, Tomasz / Kutkowska-Kaźmierczak, Anna / Kowalczyk, Katarzyna / Plaskota, Izabela / Wiśniowiecka-Kowalnik, Barbara / Bartnik-Głaska, Magdalena / Niemiec, Magdalena / Grad, Dominika / Piotrowicz, Małgorzata / Gieruszczak-Białek, Dorota / Pietrzyk, Aleksandra / Crowley, T. Blaine / Giunta, Victoria / McGinn, Daniel E. / Zackai, Elaine H. / Tran, Oanh /

Emanuel, Beverly S. / McDonald-McGinn, Donna M. / Nowakowska, Beata A.

Genes (Basel). 2023 Mar. 09, v. 14, no. 3

2023

Abstract	22q11.2 deletion syndrome (22q11.2DS) is the most common genomic disorder with an extremely broad phenotypic spectrum. The aim of our study was to investigate how often the additional variants in the genome can affect clinical variation among patients with the recurrent deletion. To examine the presence of additional variants affecting the phenotype, we performed microarray in 82 prenatal and 77 postnatal cases and performed exome sequencing in 86 postnatal patients with 22q11.2DS. Within those 159 patients where array was performed, 5 pathogenic and 5 likely pathogenic CNVs were identified outside of the 22q11.2 region. This indicates that in 6.3% cases, additional CNVs most likely contribute to the clinical presentation. Additionally, exome sequencing in 86 patients revealed 3 pathogenic (3.49%) and 5 likely pathogenic (5.81%) SNVs and small CNV. These results show that the extension of diagnostics with genome-wide methods can reveal other clinically relevant changes in patients with 22q11 deletion syndrome.
Keywords	diagnostic techniques ; genome ; genomics ; microarray technology ; phenotype
Language	English
Dates of publication	2023-0309
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14030680
Database	NAL-Catalogue (AGRICOLA)

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