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  1. Article ; Online: Reply.

    Vintzileos, William S / Muscat, Jolene / Hoffmann, Eva / John, Nicole S / Vo, Duc / Vintzileos, Anthony

    American journal of obstetrics and gynecology

    2020  Volume 223, Issue 3, Page(s) 471–472

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Female ; Humans ; Pandemics ; Pneumonia, Viral ; Pregnancy ; Pregnancy Complications, Infectious ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.05.041
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  2. Article ; Online: Impact of cesarean delivery due to maternal choice on perinatal outcome in term nulliparous patients with a singleton fetus in a vertex presentation.

    Hoffmann, Eva / Vintzileos, William S / Akerman, Meredith / Vertichio, Rosanne / Sicuranza, Genevieve B / Vintzileos, Anthony M

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2020  Volume 35, Issue 21, Page(s) 4156–4161

    Abstract: Objective: The objectives of our study were to: (1) evaluate the prevalence of cesarean delivery due to maternal request among nulliparous, term, singleton, vertex (NTSV) patients; (2) identify the clinical profile, if any, of these patients; and (3) ... ...

    Abstract Objective: The objectives of our study were to: (1) evaluate the prevalence of cesarean delivery due to maternal request among nulliparous, term, singleton, vertex (NTSV) patients; (2) identify the clinical profile, if any, of these patients; and (3) compare the perinatal outcomes between NTSV patients who requested a cesarean delivery versus patients who did not request cesarean delivery.
    Study design: This was a retrospective case control study performed at a single institution between November 2018 and July 2019. All NTSV patients who had a cesarean delivery due to maternal choice were identified and compared to the next two NTSV patients in labor who delivered vaginally or by medically indicated cesarean delivery following a cesarean delivery by maternal choice. The primary outcome was composite neonatal morbidity. Secondary outcomes were individual components of composite neonatal and maternal morbidity.
    Results: Of 1138 NTSV patients, 61 (5.4%) patients opted for cesarean delivery by maternal choice. There were significant differences in the demographic/clinical profile between cases and controls including BMI (35.3 kg/m
    Conclusion: Cesarean delivery by maternal choice in NTSV patients is not associated with improved neonatal outcomes; in contrast, it is associated with increased composite maternal morbidity and increased transfusion rate.
    MeSH term(s) Case-Control Studies ; Cesarean Section ; Female ; Fetus ; Humans ; Infant, Newborn ; Parturition ; Pregnancy ; Retrospective Studies
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2020.1847078
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  3. Article ; Online: Adverse Pregnancy Outcomes Among Individuals With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review and Meta-analysis.

    Huntley, Benjamin J F / Mulder, Isabelle A / Di Mascio, Daniele / Vintzileos, William S / Vintzileos, Anthony M / Berghella, Vincenzo / Chauhan, Suneet P

    Obstetrics and gynecology

    2021  Volume 137, Issue 4, Page(s) 585–596

    Abstract: Objective: To compare the risk of intrauterine fetal death (20 weeks of gestation or later) and neonatal death among individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with those who tested negative ...

    Abstract Objective: To compare the risk of intrauterine fetal death (20 weeks of gestation or later) and neonatal death among individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with those who tested negative for SARS-CoV-2 on admission for delivery.
    Data sources: MEDLINE, Ovid, EMBASE, Cumulative Index to Nursing and Allied Health, and Cochrane Library were searched from their inception until July 17, 2020. Hand search for additional articles continued through September 24, 2020. ClinicalTrials.gov was searched on October 21, 2020.
    Methods of study selection: The inclusion criteria were publications that compared at least 20 cases of both pregnant patients who tested positive for SARS-CoV-2 on admission to labor and delivery and those who tested negative. Exclusion criteria were publications with fewer than 20 individuals in either category or those lacking data on primary outcomes. A systematic search of the selected databases was performed, with co-primary outcomes being rates of intrauterine fetal death and neonatal death. Secondary outcomes included rates of maternal and neonatal adverse outcomes.
    Tabulation, integration, and results: Of the 941 articles and completed trials identified, six studies met criteria. Our analysis included 728 deliveries to patients who tested positive for SARS-CoV-2 and 3,836 contemporaneous deliveries to patients who tested negative. Intrauterine fetal death occurred in 8 of 728 (1.1%) patients who tested positive and 44 of 3,836 (1.1%) who tested negative (P=.60). Neonatal death occurred in 0 of 432 (0.0%) patients who tested positive and 5 of 2,400 (0.2%) who tested negative (P=.90). Preterm birth occurred in 95 of 714 (13.3%) patients who tested positive and 446 of 3,759 (11.9%) who tested negative (P=.31). Maternal death occurred in 3 of 559 (0.5%) patients who tested positive and 8 of 3,155 (0.3%) who tested negative (P=.23).
    Conclusion: The incidences of intrauterine fetal death and neonatal death were similar among individuals who tested positive compared with negative for SARS-CoV-2 when admitted to labor and delivery. Other immediate outcomes of the newborns were also similar among those born to individuals who tested positive compared with negative for SARS-CoV-2.
    Systematic review registration: PROSPERO, CRD42020203475.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; Fetal Mortality ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Mortality ; Patient Admission ; Perinatal Mortality ; Pregnancy ; Premature Birth/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004320
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  4. Article ; Online: Screening all pregnant women admitted to labor and delivery for the virus responsible for coronavirus disease 2019.

    Vintzileos, William S / Muscat, Jolene / Hoffmann, Eva / John, Nicole S / Vertichio, Rosanne / Vintzileos, Anthony M / Vo, Duc

    American journal of obstetrics and gynecology

    2020  Volume 223, Issue 2, Page(s) 284–286

    MeSH term(s) Adult ; COVID-19 ; Coronavirus Infections/diagnosis ; Delivery, Obstetric ; Female ; Humans ; Labor, Obstetric ; Mass Screening/methods ; Pandemics ; Patient Admission ; Pneumonia, Viral/diagnosis ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Retrospective Studies
    Keywords covid19
    Language English
    Publishing date 2020-04-26
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: External funding of obstetrical publications: citation significance and trends over 2 decades.

    Vintzileos, William S / Ananth, Cande V / Vintzileos, Anthony M

    American journal of obstetrics and gynecology

    2013  Volume 209, Issue 2, Page(s) 150.e1–6

    Abstract: Objective: The objective of the study was to identify the external funding status of the most frequently cited obstetrical publications (citation classics) and to assess trends in funded vs nonfunded manuscripts as well as each publication's type of ... ...

    Abstract Objective: The objective of the study was to identify the external funding status of the most frequently cited obstetrical publications (citation classics) and to assess trends in funded vs nonfunded manuscripts as well as each publication's type of external funding.
    Study design: For the first objective, the citation classics, which were reported in a previous publication, were reviewed to identify their funding status. For the second objective, all pregnancy-related and obstetrical publications from the 2 US-based leading journals, the American Journal of Obstetrics and Gynecology and Obstetrics and Gynecology, were reviewed to identify the funding status and trends between 1989 and 2012.
    Results: Twenty-seven of 44 of the citation classics (61%) had external funding, whereas only 43% of the reviewed regular (non-citation classic) obstetrical publications had external funding. There was a decreasing trend in the number of obstetrical manuscripts associated with a decreasing trend in the number and proportion of nonfunded manuscripts and an increasing trend in the number and proportion of National Institutes of Health (NIH)-funded manuscripts. Relative to 1989, in 2012 there was a 34.8% decrease in the number of published obstetrical manuscripts, a 59.6% decrease in the number of nonfunded manuscripts, and a 6.8% increase in the number of funded manuscripts accompanied by an 8.2% increase in the number of NIH-funded publications. In the last 9 years (2004-2012), there was a 35.1% increase in the proportion of NIH-funded manuscripts accompanied by an 18.8% decrease in the proportion of non-NIH-funded manuscripts.
    Conclusion: Our findings provide useful data regarding the importance of securing NIH-based funding for physicians contemplating academic careers in obstetrics.
    MeSH term(s) Journal Impact Factor ; Manuscripts as Topic ; National Institutes of Health (U.S.)/economics ; Obstetrics ; Periodicals as Topic/economics ; Periodicals as Topic/trends ; Time Factors ; United States
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2013.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Screening all pregnant women admitted to labor and delivery for the virus responsible for coronavirus disease 2019

    Vintzileos, William S / Muscat, Jolene / Hoffmann, Eva / John, Nicole S / Vertichio, Rosanne / Vintzileos, Anthony M / Vo, Duc

    Am J Obstet Gynecol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #125546
    Database COVID19

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  8. Article ; Online: Fallopian tube endometriosis in women undergoing operative video laparoscopy and its clinical implications.

    McGuinness, Bailey / Nezhat, Farr / Ursillo, Lauren / Akerman, Meredith / Vintzileos, William / White, Michael

    Fertility and sterility

    2020  Volume 114, Issue 5, Page(s) 1040–1048

    Abstract: ... surgery practice.: Patient(s): All patients who underwent surgery for endometriosis from July 2015 ... infertility, or cystic adnexal mass.: Intervention(s): Subjects were divided by those who did and ... those who did not have a salpingectomy at the time of surgery.: Main outcome measure(s): Diagnosis of tubal ...

    Abstract Objective: To determine the incidence of fallopian tube endometriosis in patients undergoing laparoscopic surgery with a preoperative diagnosis of endometriosis, pelvic pain, infertility, or cystic adnexal mass.
    Design: Retrospective cross-sectional study.
    Setting: Gynecologic oncology and minimally invasive surgery practice.
    Patient(s): All patients who underwent surgery for endometriosis from July 2015 to June 2018 were included. Exclusion criteria were age ≥55 years, diagnosis of cancer, laparotomy, previous bilateral salpingectomy, and preoperative diagnosis other than endometriosis, pelvic pain, infertility, or cystic adnexal mass.
    Intervention(s): Subjects were divided by those who did and those who did not have a salpingectomy at the time of surgery.
    Main outcome measure(s): Diagnosis of tubal endometriosis was based on macroscopic evidence of endometrial implants on the fallopian tube(s) noted within the operative report and microscopic evidence of endometriosis noted within the pathology report.
    Result(s): A total of 444 surgeries were performed and 185 met the study criteria. Among those, 153 (82.7%) had histologically diagnosed endometriosis within the abdominopelvic cavity. The incidence of tubal endometriosis was 11%-12% macroscopically and 42.5% microscopically after salpingectomy. Patients with tubal endometriosis were more likely to have severe disease.
    Conclusion(s): Among patients with endometriosis, the incidence of microscopic tubal endometriosis was significantly greater than that of macroscopic disease.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Endometriosis/diagnosis ; Endometriosis/surgery ; Fallopian Tubes/pathology ; Fallopian Tubes/surgery ; Female ; Humans ; Laparoscopy/methods ; Middle Aged ; Retrospective Studies ; Video-Assisted Surgery/methods
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2020.05.026
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  9. Article ; Online: Amniotic fluid inflammatory score is associated with pregnancy outcome in patients with mid trimester short cervix.

    Kiefer, Daniel G / Keeler, Sean M / Rust, Orion / Chow, Sharon S W / Craig, Maria E / Peltier, Morgan R / Vintzileos, Anthony M / Rawlinson, William D / Hanna, Nazeeh

    American journal of obstetrics and gynecology

    2012  Volume 206, Issue 1, Page(s) 68.e1–6

    Abstract: Objective: We propose a novel amniotic fluid inflammatory score from a comprehensive cytokine analysis of patients with mid-trimester short cervix.: Study design: Amniotic fluid from singleton gestations (n = 44) with a cervical length of ≤25 mm ... ...

    Abstract Objective: We propose a novel amniotic fluid inflammatory score from a comprehensive cytokine analysis of patients with mid-trimester short cervix.
    Study design: Amniotic fluid from singleton gestations (n = 44) with a cervical length of ≤25 mm between 16-24 weeks was assayed for 25 inflammatory mediators. Patient data were stratified according to gestational age at delivery (<34 vs ≥34 weeks). Mediators that reached statistical significance were included in the amniotic fluid inflammatory score. Patients were assigned 1 point for each significant mediator if their level was in the upper quartile. The amniotic fluid inflammatory score was determined, and its relationship to other clinical characteristics was examined.
    Results: Fourteen mediators met the criteria. A score of ≥8 was predictive of delivery at <34 weeks' gestation (sensitivity, 87.0%; specificity, 100%; positive predictive value, 100%; negative predictive value, 87.5%). Twenty patients had a high inflammatory score (≥8); 24 patients had a low score. All patients with a high inflammatory score delivered at <30 weeks' gestation.
    Conclusion: The amniotic fluid inflammatory score is related to delivery outcome and clinical characteristics.
    MeSH term(s) Adult ; Amniotic Fluid/chemistry ; Cervix Uteri/physiopathology ; Cytokines/analysis ; Female ; Humans ; Inflammation/diagnosis ; Predictive Value of Tests ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Outcome ; Premature Birth/diagnosis ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Young Adult
    Chemical Substances Cytokines
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2011.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia.

    Smulian, John / Shen-Schwarz, Susan / Scorza, William / Kinzler, Wendy / Vintzileos, Anthony

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2004  Volume 16, Issue 5, Page(s) 287–293

    Abstract: Objective: To determine whether differences in the clinical entities of HELLP syndrome and severe preeclampsia are associated with different placental lesions.: Study design: This was a case control study of singleton pregnancies with HELLP syndrome ... ...

    Abstract Objective: To determine whether differences in the clinical entities of HELLP syndrome and severe preeclampsia are associated with different placental lesions.
    Study design: This was a case control study of singleton pregnancies with HELLP syndrome or severe preeclampsia. Archived pathology slides were retrieved and reviewed. Clinical and histopathological features were compared between the two groups.
    Results: There were 31 women with HELLP syndrome and 56 with severe preeclampsia. HELLP syndrome was associated with epigastric pain and higher levels of LDH, bilirubin, liver enzymes and fibrin degradation products. Hemoglobin, hematocrit and platelet counts were lower. Abruption lesions of the placenta were less common with HELLP syndrome (Odds Ratio 0.1 95% Confidence Interval 0.01,0.8). None of the other 22 placental features examined were different between the two conditions.
    Conclusion: The significant overlap between HELLP syndrome and severe preeclampsia for both clinical and placental features suggests that the two conditions represent a spectrum of essentially the same pathophysiologic process.
    MeSH term(s) Adult ; Biomarkers/blood ; Case-Control Studies ; Female ; HELLP Syndrome/diagnosis ; HELLP Syndrome/pathology ; Humans ; Liver/pathology ; Placenta/pathology ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/pathology ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/pathology ; Statistics, Nonparametric
    Chemical Substances Biomarkers
    Language English
    Publishing date 2004-11
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1476-7058 ; 1057-0802
    ISSN (online) 1476-4954
    ISSN 1476-7058 ; 1057-0802
    DOI 10.1080/14767050400018015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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