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Article ; Online: Screening for Covid-19 in Skilled Nursing Facilities.

Huber, Douglas H

2020 Volume 383, Issue 2, Page(s) 191–192

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Skilled Nursing Facilities
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2017362
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Article ; Online: From knowledge gaps to career opportunities: The early- to Mid-Career Committee's impact on increasing resources for bipolar disorder professionals.

Jiménez-Pavón, Joanna / Dean, Olivia M / Hosang, Georgina M / Douglas, Katie M / Huber, Rebekah S / Mitchell, Rachel H B

Bipolar disorders

2023 Volume 25, Issue 8, Page(s) 698–699

Language	English
Publishing date	2023-11-20
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/bdi.13395
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Article: Screening for Covid-19 in Skilled Nursing Facilities

Huber, Douglas H

N. Engl. j. med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32469482
Database	COVID19

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Article ; Online: Supporting career development for early- and mid-career professionals working in the bipolar disorder field: Key initiatives to be implemented by the International Society for Bipolar Disorders Early- and Mid-Career Committee.

Douglas, Katie M / Sperry, Sarah H / Dean, Olivia M / Fries, Gabriel R / Gomes, Fabiano A / Pavón, Joanna Jiménez / Morton, Emma / Mitchell, Rachel H B / Van Rheenen, Tamsyn E / Verdolini, Norma / Xu, Ni / Hosang, Georgina M / Huber, Rebekah S

Bipolar disorders

2024

Language	English
Publishing date	2024-04-15
Publishing country	Denmark
Document type	Editorial
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/bdi.13416
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Zs.A 5604: Show issues

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Article ; Online: Barriers to and facilitators of success for early and Mid-Career professionals focused on bipolar disorder: A global needs survey by the International Society for Bipolar Disorders.

Sperry, Sarah H / Douglas, Katie M / Dean, Olivia M / Fries, Gabriel R / Gomes, Fabiano A / Hosang, Georgina M / Morton, Emma / Sandorffy, Bronya / Van Rheenen, Tamsyn E / Xu, Ni / Huber, Rebekah S

Bipolar disorders

2023 Volume 25, Issue 5, Page(s) 379–390

Abstract: Introduction: The International Society for Bipolar Disorders created the Early Mid-Career Committee (EMCC) to support career development of the next generation of researchers and clinicians specializing in bipolar disorder (BD). To develop new ... ...

Abstract	Introduction: The International Society for Bipolar Disorders created the Early Mid-Career Committee (EMCC) to support career development of the next generation of researchers and clinicians specializing in bipolar disorder (BD). To develop new infrastructure and initiatives, the EMCC completed a Needs Survey of the current limitations and gaps that restrict recruitment and retention of researchers and clinicians focused on BD. Methods: The EMCC Needs Survey was developed through an iterative process, relying on literature and content expertise of workgroup members. The survey included 8 domains: navigating transitional career stages, creating and fostering mentorship, research activities, raising academic profile, clinical-research balance, networking and collaboration, community engagement, work-life balance. The final survey was deployed from May to August 2022 and was available in English, Spanish, Portuguese, Italian, and Chinese. Results: Three hundred participants across six continents completed the Needs Survey. Half of the participants self-identified as belonging to an underrepresented group in health-related sciences (i.e., from certain gender, racial, ethnic, cultural, or disadvantaged backgrounds including individuals with disabilities). Quantitative results and qualitative content analysis revealed key barriers to pursuing a research career focused on BD with unique challenges specific to scientific writing and grant funding. Participants highlighted mentorship as a key facilitator of success in research and clinical work. Conclusion: The results of the Needs Survey are a call to action to support early- and midcareer professionals pursuing a career in BD. Interventions required to address the identified barriers will take coordination, creativity, and resources to develop, implement, and encourage uptake but will have long-lasting benefits for research, clinical practice, and ultimately those affected by BD.
MeSH term(s)	Humans ; Bipolar Disorder/therapy ; Surveys and Questionnaires ; Mentors
Language	English
Publishing date	2023-06-30
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/bdi.13365
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Article: Controlling the toxicity of biomass-derived difunctional molecules as potential pharmaceutical ingredients for specific activity toward microorganisms and mammalian cells.

Chang, Hochan / Chang, Douglas H / Stamoulis, Alexios G / Huber, George W / Lynn, David M / Palecek, Sean P / Dumesic, James A

Green chemistry : an international journal and green chemistry resource : GC

2023 Volume 25, Issue 14, Page(s) 5416–5427

Abstract: A biomass-derived difuran compound, denoted as HAH (HMF-Acetone-HMF), synthesized by aldol-condensation of 5-hydroxyfurfural (HMF) and acetone, can be partially hydrogenated to provide an electron-rich difuran compound (PHAH) for Diels-Alder reactions ... ...

Abstract	A biomass-derived difuran compound, denoted as HAH (HMF-Acetone-HMF), synthesized by aldol-condensation of 5-hydroxyfurfural (HMF) and acetone, can be partially hydrogenated to provide an electron-rich difuran compound (PHAH) for Diels-Alder reactions with maleimide derivatives. The nitrogen (N) site in the maleimide can be substituted by imidation with amine-containing compounds to control the hydrophobicity of the maleimide moiety in adducts of furans and maleimide by Diels-Alder reaction, denoted as norcantharimides (Diels-Alder adducts). The structural effects on the toxicity of various biomass-derived small molecules synthesized in this manner to regulate biological processes, defined as low molecular weight (≤ 1000 g/mol) organic compounds, were investigated against diverse microbial and mammalian cell types. The biological toxicity increased when hydrophobic N-substitutions and C=C bonds were introduced into the molecular structure. Among the synthesized norcantharamide derivatives, some compounds demonstrated pH-dependent toxicities against specific cell types. Reaction kinetics analyses of the norcantharimides in biological conditions suggest that this pH-dependent toxicity of norcantharimides could arise from retro Diels-Alder reactions in the presence of a Br
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d3gc00188a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cell Therapy Informatics: Updates on the Integration of HCT/IEC Functionalities into an Electronic Medical Record System in the US to Promote Efficiency, Patient Safety, Research, and Data Interoperability.

Ho, Vincent T / Klumpp, Thomas R / Liang, Wayne H / Prestegaard, Matt / Horwitz, Mitchell / Hamilton, Betty K / Page, Kristin / Jaglowski, Samantha / Huber, John / Martinez, Charles / Shenoy, Vinaya / Chen, Allen / Rizzo, Douglas

Transplantation and cellular therapy

2023 Volume 29, Issue 9, Page(s) 539–547

Abstract: The use of electronic health/medical record (EMR) systems has streamlined medical practice and improved efficiency of clinical care in recent years. However, EMR systems are not generally well designed to support research and tracking of longitudinal ... ...

Abstract	The use of electronic health/medical record (EMR) systems has streamlined medical practice and improved efficiency of clinical care in recent years. However, EMR systems are not generally well designed to support research and tracking of longitudinal outcomes across populations, which are particularly important in hematopoietic stem cell transplantation (HCT) and immune effector cell therapy (IEC), where data reporting to registries and regulatory agencies are often required. Since its formation in 2014, the HCT EMR user group has worked with a large EMR vendor (Epic) to develop many functionalities within the EMR to improve the care of HCT/IEC patients and facilitate the capture of HCT/IEC data in an easily interoperable format. Awareness and the widespread adoption of these new tools among transplant centers remains a challenge, however. In this report, we aim to increase awareness and adoption of these new features in the Epic EMR across the transplantation community, advocate for the use of data standards, and promote future collaboration with other commercial EMRs to develop standardized HCT/IEC content to improve patient care and facilitate interoperable data exchange.
MeSH term(s)	Humans ; Electronic Health Records ; Patient Safety ; Software ; Informatics ; Hematopoietic Stem Cell Transplantation
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2023.06.014
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Zs.A 5082: Show issues

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Article ; Online: Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE.

Acta neuropathologica

2024 Volume 147, Issue 1, Page(s) 45

Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. Cross- ... ...

Abstract	Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. Cross-sectional studies suggest that tau inclusions follow a stereotyped pattern that begins in the neocortex in low stage disease, followed by involvement of the medial temporal lobe and subcortical regions with significant neocortical burden in high stage CTE. Here, we define a subset of brain donors with high stage CTE and with a low overall cortical burden of tau inclusions (mean semiquantitative value ≤1) and classify them as cortical-sparing CTE (CSCTE). Of 620 brain donors with pathologically diagnosed CTE, 66 (11%) met criteria for CSCTE. Compared to typical high stage CTE, those with CSCTE had a similar age at death and years of contact sports participation and were less likely to carry apolipoprotein ε4 (p < 0.05). CSCTE had less overall tau pathology severity, but a proportional increase of disease burden in medial temporal lobe and brainstem regions compared to the neocortex (p's < 0.001). CSCTE also had lower prevalence of comorbid neurodegenerative disease. Clinically, CSCTE participants were less likely to have dementia (p = 0.023) and had less severe cognitive difficulties (as reported by informants using the Functional Activities Questionnaire (FAQ); p < 0.001, meta-cognitional index T score; p = 0.002 and Cognitive Difficulties Scale (CDS); p < 0.001,) but had an earlier onset age of behavioral (p = 0.006) and Parkinsonian motor (p = 0.013) symptoms when compared to typical high stage CTE. Other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent Alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for FAQ (p = 0.042), meta-cognition index T score (p = 0.014) and age of Parkinsonian motor symptom onset (p = 0.046). Overall, CSCTE appears to be a distinct subtype of high stage CTE with relatively greater involvement of subcortical and brainstem regions and less severe cognitive symptoms.
MeSH term(s)	Humans ; Chronic Traumatic Encephalopathy ; Neurodegenerative Diseases ; Cross-Sectional Studies ; Brain ; Alzheimer Disease
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1079-0
ISSN	1432-0533 ; 0001-6322
ISSN (online)	1432-0533
ISSN	0001-6322
DOI	10.1007/s00401-024-02690-5
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Article ; Online: Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy.

Culhane, Julia E / Jackson, Colleen E / Tripodis, Yorghos / Nowinski, Christopher J / Dams-O'Connor, Kristen / Pettway, Erika / Uretsky, Madeline / Abdolmohammadi, Bobak / Nair, Evan / Martin, Brett / Palmisano, Joseph / Katz, Douglas I / Dwyer, Brigid / Daneshvar, Daniel H / Goldstein, Lee E / Kowall, Neil W / Cantu, Robert C / Stern, Robert A / Huber, Bertrand Russell /

Crary, John F / Mez, Jesse / Stein, Thor D / McKee, Ann C / Alosco, Michael L

Journal of neurotrauma

2024

Abstract: Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear whether a history of traumatic brain injury (TBI) is sufficient to precipitate CTE neuropathology. We ... ...

Abstract	Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear whether a history of traumatic brain injury (TBI) is sufficient to precipitate CTE neuropathology. We examined the association between TBI and CTE neuropathology in 580 deceased individuals exposed to RHIs from football. TBI history was assessed using a modified version of the Ohio State University TBI Identification Method Short Form administered to informants. There were 22 donors who had no TBI, 213 who had at least one TBI without loss of consciousness (LOC), 345 who had TBI with LOC, and, of those with a history of TBI with LOC, 36 who had at least one moderate-to-severe TBI (msTBI, LOC >30 min). CTE neuropathology was diagnosed in 405. There was no association between CTE neuropathology status or severity and TBI with LOC (odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.64-1.41; OR = 1.22, 95% CI = 0.71-2.09) or msTBI (OR = 0.70, 95% CI = 0.33-1.50; OR = 1.01, 95% CI = 0.30-3.41). There were no associations with other neurodegenerative or cerebrovascular pathologies examined. TBI with LOC and msTBI were not associated with CTE neuropathology in this sample of brain donors exposed to RHIs from American football.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0391
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Zs.A 2016: Show issues

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Article ; Online: Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy.

Alosco, Michael L / White, Micaela / Bell, Carter / Faheem, Farwa / Tripodis, Yorghos / Yhang, Eukyung / Baucom, Zachary / Martin, Brett / Palmisano, Joseph / Dams-O'Connor, Kristen / Crary, John F / Goldstein, Lee E / Katz, Douglas I / Dwyer, Brigid / Daneshvar, Daniel H / Nowinski, Christopher / Cantu, Robert C / Kowall, Neil W / Stern, Robert A /

Alvarez, Victor E / Huber, Bertrand Russell / Stein, Thor D / McKee, Ann C / Mez, Jesse

Molecular neurodegeneration

2024 Volume 19, Issue 1, Page(s) 10

Abstract: Background: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain donors with autopsy-confirmed CTE, ...

Abstract	Background: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain donors with autopsy-confirmed CTE, we investigated the association of CTE p-tau pathology density and location with cognitive, functional, and neuropsychiatric symptoms. Methods: In 364 brain donors with autopsy confirmed CTE, semi-quantitative p-tau severity (range: 0-3) was assessed in 10 cortical and subcortical regions. We summed ratings across regions to form a p-tau severity global composite (range: 0-30). Informants completed standardized scales of cognition (Cognitive Difficulties Scale, CDS; BRIEF-A Metacognition Index, MI), activities of daily living (Functional Activities Questionnaire), neurobehavioral dysregulation (BRIEF-A Behavioral Regulation Index, BRI; Barratt Impulsiveness Scale, BIS-11), aggression (Brown-Goodwin Aggression Scale), depression (Geriatric Depression Scale-15, GDS-15), and apathy (Apathy Evaluation Scale, AES). Ordinary least squares regression models examined associations between global and regional p-tau severity (separate models for each region) with each clinical scale, adjusting for age at death, racial identity, education level, and history of hypertension, obstructive sleep apnea, and substance use treatment. Ridge regression models that incorporated p-tau severity across all regions in the same model assessed which regions showed independent effects. Results: The sample was predominantly American football players (333; 91.2%); 140 (38.5%) had low CTE and 224 (61.5%) had high CTE. Global p-tau severity was associated with higher (i.e., worse) scores on the cognitive and functional scales: MI ([Formula: see text] Conclusion: Accumulation of p-tau aggregates, especially in the frontal cortex, are associated with cognitive, functional, and certain neurobehavioral symptoms in CTE.
MeSH term(s)	Humans ; Activities of Daily Living ; Autopsy ; Brain/metabolism ; Chronic Traumatic Encephalopathy/pathology ; Cognition ; Neurodegenerative Diseases/pathology ; tau Proteins/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2244557-2
ISSN	1750-1326 ; 1750-1326
ISSN (online)	1750-1326
ISSN	1750-1326
DOI	10.1186/s13024-023-00697-2
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