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  1. Article ; Online: Grain Intake and Human Health.

    Zingone, Fabiana

    Nutrients

    2020  Volume 12, Issue 12

    Abstract: Wheat is one of the most consumed cereal grains worldwide and represents an important part of the human diet [ ... ]. ...

    Abstract Wheat is one of the most consumed cereal grains worldwide and represents an important part of the human diet [...].
    MeSH term(s) Ataxia ; Celiac Disease ; Dermatitis Herpetiformis ; Diet ; Diet, Gluten-Free ; Edible Grain ; Glutens ; Health Status ; Humans ; Triticum ; Wheat Hypersensitivity ; Whole Grains
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2020-12-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12123733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Celiac Disease-Related Conditions: Who to Test?

    Zingone, Fabiana / Bai, Julio C / Cellier, Christophe / Ludvigsson, Jonas F

    Gastroenterology

    2024  

    Abstract: Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous and, despite ...

    Abstract Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous and, despite growing awareness among physicians and the public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD is proactive case finding through serologic testing in high-risk groups. We reviewed the most recent evidence on the association between CeD and more than 20 conditions. In light of this review, CeD screening is recommended in individuals with (1) autoimmune disease and accompanying symptoms suggestive of CeD; (2) diseases that may mimic CeD (eg, irritable bowel syndrome [IBS], inflammatory bowel disease [IBD], and microscopic colitis); and (3) among patients with (conditions with a high CeD prevalence: first-degree relatives, idiopathic pancreatitis, unexplained liver enzyme abnormalities, autoimmune hepatitis, primary biliary cholangitis, hyposplenism or functional asplenia with severe bacterial infection, type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease, Sjögren's syndrome, dermatitis herpetiformis, recurrent aphthous syndrome and enamel defects, unexplained ataxia, peripheral neuropathy, delayed menarche or premature menopause, Down syndrome, Turner syndrome, Williams syndrome, chronic fatigue syndrome, IgA nephropathy, and IgA deficiency. CeD serology should be the initial step in the screening process. However, for patients with any of the aforementioned disorders who are undergoing upper endoscopy, biopsies should be performed to rule out CeD.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.02.044
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  3. Article: Editorial: Challenges in Inflammatory Bowel Disease: Current, Future and Unmet Needs.

    Gravina, Antonietta Gerarda / Pellegrino, Raffaele / Zingone, Fabiana

    Frontiers in medicine

    2022  Volume 9, Page(s) 979535

    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.979535
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  4. Article ; Online: Viral screening before initiation of biologics in patients with inflammatory bowel disease during the COVID-19 outbreak.

    Zingone, Fabiana / Savarino, Edoardo Vincenzo

    The lancet. Gastroenterology & hepatology

    2020  Volume 5, Issue 6, Page(s) 525

    MeSH term(s) Betacoronavirus ; Biological Products ; COVID-19 ; Coronavirus Infections ; Humans ; Inflammatory Bowel Diseases ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Biological Products
    Keywords covid19
    Language English
    Publishing date 2020-03-25
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(20)30085-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Crosstalk between MicroRNAs and Oxidative Stress in Coeliac Disease.

    Pelizzaro, Filippo / Cardin, Romilda / Sarasini, Giulia / Minotto, Milena / Carlotto, Chiara / Fassan, Matteo / Palo, Michela / Farinati, Fabio / Zingone, Fabiana

    Inflammatory intestinal diseases

    2024  Volume 9, Issue 1, Page(s) 11–21

    Abstract: MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in regulating gene expression. Many studies, mostly conducted on pediatric patients, suggested that oxidative stress and several miRNAs may play an important role in coeliac disease (CeD) ... ...

    Abstract MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in regulating gene expression. Many studies, mostly conducted on pediatric patients, suggested that oxidative stress and several miRNAs may play an important role in coeliac disease (CeD) pathogenesis. However, the interplay between oxidative stress and miRNA regulatory functions in CeD remains to be clarified. In this review, we aimed to perform a literature review on the role of miRNAs and oxidative stress in adult CeD patients and to analyze their potential interactions. In this direction, we also reported the preliminary results of a pilot study we recently performed.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2817967-5
    ISSN 2296-9365 ; 2296-9365
    ISSN (online) 2296-9365
    ISSN 2296-9365
    DOI 10.1159/000536107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Primary sclerosing cholangitis and inflammatory bowel disease: a complicated yet unique relationship.

    Peviani, Matteo / Cazzagon, Nora / Gambato, Martina / Bertin, Luisa / Zingone, Fabiana / Savarino, Edoardo V / Barberio, Brigida

    Minerva gastroenterology

    2024  

    Abstract: Primary sclerosing cholangitis (PSC) is a rare liver disorder characterized by biliary ducts inflammation, fibrosis and consequently chronic cholestasis, which progressively lead to liver cirrhosis. The main feature of PSC is the frequent association ... ...

    Abstract Primary sclerosing cholangitis (PSC) is a rare liver disorder characterized by biliary ducts inflammation, fibrosis and consequently chronic cholestasis, which progressively lead to liver cirrhosis. The main feature of PSC is the frequent association with inflammatory bowel disease (IBD), with an estimated prevalence of around 70% of the cases. This strong relationship seems due to the presence of shared pathogenetic mechanisms, which seem to involve the intestinal barrier function, the human gut microbiota and the immune innated and adaptative response to antigens derived from the bowel. Of relevance, PSC-IBD have specific clinical and pathological features that differ from PSC and IBD as separate entities, explaining the diversity in outcomes among these categories, and therefore the distinct clinical management that is required. The aim of this review is to present recent data regarding the epidemiology, pathobiology and clinical features of PSC-IBD.
    Language English
    Publishing date 2024-02-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062713-8
    ISSN 2724-5365
    ISSN (online) 2724-5365
    DOI 10.23736/S2724-5985.23.03605-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Therapy in elderly IBD patients.

    Castiglione, Fabiana / Imperatore, Nicola / Zingone, Fabiana / D'Incà, Renata

    Minerva gastroenterology

    2021  Volume 70, Issue 1, Page(s) 89–97

    Abstract: Introduction: Appropriate treatment is critical in elderly inflammatory bowel disease (IBD) subjects since they are at higher risk of complications such as infections, malignancies and mortality.: Evidence acquisition: We conducted an extensive ... ...

    Abstract Introduction: Appropriate treatment is critical in elderly inflammatory bowel disease (IBD) subjects since they are at higher risk of complications such as infections, malignancies and mortality.
    Evidence acquisition: We conducted an extensive PubMed search for guidelines, systematic reviews and primary studies to perform a critical analysis of the existing literature on the efficacy and safety of conventional and biological therapies for elderly IBD patients.
    Evidence synthesis: Due to the exclusion of elderly population from clinical trials, most evidences comes from real-life studies. While aminosalicylates remain a cornerstone treatment of elderly patients with ulcerative colitis (UC), for their effectiveness and safety, their use in Crohn's disease (CD) should not be further supported. Corticosteroid use should be limited for the induction of remission, while as maintenance treatment it should be avoided, due to the low safety profile. Although as efficacious as in the younger population, immunosuppressant use has been associated with higher risk of infective/malignant issues and further use should be carefully evaluated. Biologics have demonstrated high effectiveness in the elderly. However, due to increased morbidity and mortality described in elderly subjects treated with anti-TNF alpha agents, vedolizumab and ustekinumab should be favoured over anti-TNF alpha agents.
    Conclusions: Treatment of elderly IBD patients remains challenging, since comorbidities and the risk of adverse events can complicate the effectiveness and safety of therapy. Close monitoring of such patients in a multidisciplinary team is advocated to reduce the risk of infections and optimize the treatment, choosing a suitable agent.
    MeSH term(s) Aged ; Humans ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Remission Induction ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease/drug therapy ; Colitis, Ulcerative/drug therapy
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2021-06-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062713-8
    ISSN 2724-5365
    ISSN (online) 2724-5365
    DOI 10.23736/S2724-5985.21.02895-3
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  8. Article ; Online: Assessment of Nutritional Status by Bioelectrical Impedance in Adult Patients with Celiac Disease: A Prospective Single-Center Study.

    Maniero, Daria / Lorenzon, Greta / Marsilio, Ilaria / D'Odorico, Anna / Savarino, Edoardo Vincenzo / Zingone, Fabiana

    Nutrients

    2023  Volume 15, Issue 12

    Abstract: The gluten-free diet [GFD] has been linked to an increased risk of weight gain and the development of metabolic disorders. Most of the studies have focused on the effect of GFD on the Body Mass Index [BMI]. We aimed to evaluate the nutritional status ... ...

    Abstract The gluten-free diet [GFD] has been linked to an increased risk of weight gain and the development of metabolic disorders. Most of the studies have focused on the effect of GFD on the Body Mass Index [BMI]. We aimed to evaluate the nutritional status using specific nutritional parameters in patients with celiac disease [CeD] at diagnosis and on a GFD compared to healthy controls. We recruited subjects at our outpatient clinic at the University of Padua. We collected demographic and clinical data and values obtained with bioelectrical impedance analysis. A total of 24 CeD patients and 28 healthy controls were enrolled. CeD patients at diagnosis had a lower body cell mass index [BCMI,
    MeSH term(s) Humans ; Adult ; Nutritional Status ; Celiac Disease ; Electric Impedance ; Prospective Studies ; Body Mass Index ; Weight Loss ; Diet, Gluten-Free/adverse effects
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15122686
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  9. Article ; Online: The Role of the FODMAP Diet in IBS.

    Bertin, Luisa / Zanconato, Miriana / Crepaldi, Martina / Marasco, Giovanni / Cremon, Cesare / Barbara, Giovanni / Barberio, Brigida / Zingone, Fabiana / Savarino, Edoardo Vincenzo

    Nutrients

    2024  Volume 16, Issue 3

    Abstract: The low FODMAP (fermentable oligosaccharide, disaccharide, monosaccharide, and polyol) diet is a beneficial therapeutic approach for patients with irritable bowel syndrome (IBS). However, how the low FODMAP diet works is still not completely understood. ... ...

    Abstract The low FODMAP (fermentable oligosaccharide, disaccharide, monosaccharide, and polyol) diet is a beneficial therapeutic approach for patients with irritable bowel syndrome (IBS). However, how the low FODMAP diet works is still not completely understood. These mechanisms encompass not only traditionally known factors such as luminal distension induced by gas and water but also recent evidence on the role of FOMAPs in the modulation of visceral hypersensitivity, increases in intestinal permeability, the induction of microbiota changes, and the production of short-chain fatty acids (SCFAs), as well as metabolomics and alterations in motility. Although most of the supporting evidence is of low quality, recent trials have confirmed its effectiveness, even though the majority of the evidence pertains only to the restriction phase and its effectiveness in relieving abdominal bloating and pain. This review examines potential pathophysiological mechanisms and provides an overview of the existing evidence on the effectiveness of the low FODMAP diet across various IBS subtypes. Key considerations for its use include the challenges and disadvantages associated with its practical implementation, including the need for professional guidance, variations in individual responses, concerns related to microbiota, nutritional deficiencies, the development of constipation, the necessity of excluding an eating disorder before commencing the diet, and the scarcity of long-term data. Despite its recognized efficacy in symptom management, acknowledging these limitations becomes imperative for a nuanced comprehension of the role of a low FODMAP diet in managing IBS. By investigating its potential mechanisms and evidence across IBS subtypes and addressing emerging modulations alongside limitations, this review aims to serve as a valuable resource for healthcare practitioners, researchers, and patients navigating the intricate landscape of IBS.
    MeSH term(s) Humans ; Irritable Bowel Syndrome ; FODMAP Diet ; Fermentation ; Disaccharides ; Oligosaccharides/therapeutic use ; Diet ; Monosaccharides ; Diet, Carbohydrate-Restricted
    Chemical Substances Disaccharides ; Oligosaccharides ; Monosaccharides
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16030370
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  10. Article ; Online: Women in Gastroenterology: What Is the Current Situation? Results of an Italian National Survey.

    Venezia, Ludovica / Labarile, Nunzia / Maselli, Roberta / Benedetti, Antonio / Annibale, Bruno / Parodi, Maria Caterina / Soncini, Marco / Zingone, Fabiana

    Digestive diseases and sciences

    2024  

    Abstract: Background: Many women grow up dreaming of becoming doctors, preferring specialties that allow more focus on time outside the hospital and on family life. Nowadays, specialties, like gastroenterology, have still a significant gender gap.: Methods: ... ...

    Abstract Background: Many women grow up dreaming of becoming doctors, preferring specialties that allow more focus on time outside the hospital and on family life. Nowadays, specialties, like gastroenterology, have still a significant gender gap.
    Methods: Based on this known discrepancy, a web-based questionnaire was designed by the Young Component of the Scientific Committee of the Federation of Italian Scientific Societies of Digestive Diseases 2023 (FISMAD) to examine the current situation of female gastroenterologists in Italy. The survey, designed specifically for this study, was sent by email to all female gastroenterologists and residents gastroenterologists, members of the three major Italian societies of Gastroenterology.
    Results: A total of 423 female physicians responded to the survey: 325 (76.8%) had full-time employment, and only a few had an academic career (7.2%). The main occupations were outpatient clinics (n = 288, 68%) and diagnostic endoscopy (n = 289, 68.3%); only 175 (41.3%) performed interventional endoscopy. One hundred and forty-seven (34.7%) had the chance to attend a master in advanced or interventional endoscopy, while 133 (31.4%) faced disadvantages that enabled them to attend. Of the 244 (58%) who reported feeling underappreciated, 194 (79.5%) said it was due to gender bias. We found that women doctors considered themselves disadvantaged compared with men doctors due to career opportunities (n = 338), salary negotiations (n = 64), and training opportunities (n = 144).
    Conclusions: In conclusion, gastroenterology still has a long way to go before approaching greater gender parity.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-024-08407-8
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