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Article ; Online: Theonella

Festa, Carmen / De Marino, Simona / Zampella, Angela / Fiorucci, Stefano

2023 Volume 21, Issue 5

Abstract: The marine environment is considered a vast source in the discovery of structurally unique bioactive secondary metabolites. Among marine invertebrates, the ... ...

Abstract	The marine environment is considered a vast source in the discovery of structurally unique bioactive secondary metabolites. Among marine invertebrates, the sponge
MeSH term(s)	Animals ; Humans ; Theonella ; Sterols/pharmacology ; Sterols/chemistry ; Receptors, Cytoplasmic and Nuclear ; Phytosterols
Chemical Substances	Sterols ; Receptors, Cytoplasmic and Nuclear ; Phytosterols
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21050291
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Article ; Online: Intentional treatment with tofacitinib in a patient with severe refractory ulcerative colitis and concomitant Sars-CoV-2 infection.

Festa, Stefano / De Biasio, Fabiola / Aratari, Annalisa / Papi, Claudio

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2022 Volume 54, Issue 11, Page(s) 1598–1599

MeSH term(s)	Humans ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; COVID-19 ; SARS-CoV-2 ; Pyrimidines/therapeutic use
Chemical Substances	tofacitinib (87LA6FU830) ; Pyrimidines
Language	English
Publishing date	2022-09-06
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2022.08.038
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Article: Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review.

Ratajczak, Alicja Ewa / Festa, Stefano / Aratari, Annalisa / Papi, Claudio / Dobrowolska, Agnieszka / Krela-Kaźmierczak, Iwona

Frontiers in nutrition

2023 Volume 9, Page(s) 1088693

Abstract: Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the ... ...

Abstract	Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the course of IBD. It is known that the group of beneficial bacteria was reduced in the IBD and that the Mediterranean diet (MD)-which is defined as eating habits characterized by high consumption of plant foods, mainly cereals, vegetables, fruit as well as olive oil, and small portions of dairy products, sweets, sugar and meat products-affects gut microbiota, enriching beneficial bacteria, which support gut barrier function and reduce inflammation. Although several studies support different favorable effects of MD on IBD, adherence to MD by IBD patients is generally low, including patients from the Mediterranean Basin. Patients avoid many products which are elements of MD because there cause gastrointestinal symptoms. Patients should be encouraged to have a healthy and well-balanced diet according to individual tolerance of products. A good option seems to be good modified MD, changing hard-to-digest products to easy digest.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1088693
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Article ; Online: Cephalometric changes of pushing splints 3 compared to rapid maxillary expansion and facemask therapy on the airway space in class III growing patients: A randomized clinical trial.

Galeotti, Angela / Viarani, Valeria / Franchi, Lorenzo / Martina, Stefano / Rongo, Roberto / D'Antò, Vincenzo / Uomo, Roberto / Aristei, Francesco / Festa, Paola

Orthodontics & craniofacial research

2024

Abstract: Background: Early orthopaedic treatment with rapid maxillary expansion (RME) associated with facemask (FM) has been shown to be effective in correcting Class III malocclusions in children. Treatment with pushing splints 3 (PS3) has shown to correct ... ...

Abstract	Background: Early orthopaedic treatment with rapid maxillary expansion (RME) associated with facemask (FM) has been shown to be effective in correcting Class III malocclusions in children. Treatment with pushing splints 3 (PS3) has shown to correct skeletal discrepancies in Class III growing patients. However, the effects of orthopaedic treatment on the upper airways in children with Class III malocclusion is controversial. Objectives: The aim of this study was to evaluate the cephalometric changes in the airways of PS3 compared to the RME/FM protocol. Materials and methods: In this study, 48 patients with Class III malocclusion (age range 5.5-8.5 years old) were selected for this study, and 24 were treated with PS3 appliance and 24 with RME/FM therapy. Lateral cephalograms before (T0) and at the end of the treatment (T1) were analysed to compare pharyngeal spaces. Paired and unpaired t tests were used for data analysis (P < .05). Results: A total of 41 patients (21 patients for the PS3 group, 11 males and 10 females, mean age 7.0 ± 1.2 years; 20 patients for the RME/FM group, 10 males and 10 females, mean age 7.2 ± 1.3 years) were included. The results showed a statistically significant (P < .05) increase in the nasopharyngeal space after both therapies. However, the effects were similar considering that there were no differences between groups for the assessed variables at T0-T1. Conclusions: Early treatment of Class III malocclusion with PS3 does not induce a statistically significant increase in the sagittal airway space compared to RME/FM. The absence of untreated group could not define the role of growth in the increase of space.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2076514-9
ISSN	1601-6343 ; 1601-6335
ISSN (online)	1601-6343
ISSN	1601-6335
DOI	10.1111/ocr.12767
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Article: Immune-Mediated Inflammatory Diseases Awareness and Management among Physicians Treating Patients with Inflammatory Bowel Disease: An IG-IBD Survey.

Vernero, Marta / Bezzio, Cristina / Ribaldone, Davide G / Caprioli, Flavio A / Fantini, Massimo C / Festa, Stefano / Macaluso, Fabio S / Orlando, Ambrogio / Pugliese, Daniela / Renna, Sara / Rispo, Antonio / Savarino, Edoardo V / Variola, Angela / Saibeni, Simone

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: 1) ...

Abstract	(1)
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13071857
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Article ; Online: Use of biologics for the management of Crohn's disease: IG-IBD technical review based on the GRADE methodology.

Bonovas, Stefanos / Piovani, Daniele / Pansieri, Claudia / Macaluso, Fabio Salvatore / Orlando, Ambrogio / Festa, Stefano / Papi, Claudio / Pugliese, Daniela / Armuzzi, Alessandro

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 55, Issue 6, Page(s) 695–703

Abstract: The therapeutic armamentarium for the management of Crohn's disease (CD) is rapidly expanding. Several biologic therapies (e.g. infliximab, adalimumab, vedolizumab, and ustekinumab) have been regulatory approved, and there is considerable practice ... ...

Abstract	The therapeutic armamentarium for the management of Crohn's disease (CD) is rapidly expanding. Several biologic therapies (e.g. infliximab, adalimumab, vedolizumab, and ustekinumab) have been regulatory approved, and there is considerable practice variability in the treatment of patients with CD. This technical review systematically searched and identified the current evidence, synthesized it using meta-analytic methodology, appraised its quality, and concisely presented it, thus forming the basis for developing clinical practice recommendations on the use of biologic treatments in adult patients with CD.
MeSH term(s)	Adult ; Humans ; Crohn Disease/drug therapy ; Infliximab/therapeutic use ; Adalimumab/therapeutic use ; Ustekinumab/therapeutic use ; Biological Products/therapeutic use
Chemical Substances	Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842) ; Ustekinumab (FU77B4U5Z0) ; Biological Products
Language	English
Publishing date	2023-03-22
Publishing country	Netherlands
Document type	Systematic Review ; Practice Guideline ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.02.019
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Article: Dual-Energy Computed Tomography Applications to Reduce Metal Artifacts in Hip Prostheses: A Phantom Study.

Conti, Daniele / Baruffaldi, Fabio / Erani, Paolo / Festa, Anna / Durante, Stefano / Santoro, Miriam

Diagnostics (Basel, Switzerland)

2022 Volume 13, Issue 1

Abstract: Metal components of hip prostheses cause severe artifacts in CT images, influencing diagnostic accuracy. Metal artifact reduction (MAR) software and virtual monoenergetic reconstructions on dual-energy CT (DECT) systems are possible solutions that should ...

Abstract	Metal components of hip prostheses cause severe artifacts in CT images, influencing diagnostic accuracy. Metal artifact reduction (MAR) software and virtual monoenergetic reconstructions on dual-energy CT (DECT) systems are possible solutions that should be considered. In this study, we created a customized adjustable phantom to quantify the severity of artifacts on periprosthetic tissues (cortical and spongious bone, soft tissues) for hip prostheses. The severity of artifacts was classified by different thresholds of deviation from the CT numbers for reference objects not affected by artifacts. The in vitro setup was applied on four unilateral and three bilateral configurations of hip prostheses (made of titanium, cobalt, and stainless steel alloys) with a DECT system, changing the energy of virtual monoenergetic reconstructions, with and without MAR. The impact of these tools on the severity of artifacts was scored, looking for the best scan conditions for the different configurations. For titanium prostheses, the reconstruction at 110 keV, without MAR, always minimized the artifacts. For cobalt and stainless-steel prostheses, MAR should always be applied, while monoenergetic reconstruction alone did not show clear advantages. The available tools for reducing metal artifacts must therefore be applied depending on the examined prosthetic configuration.
Language	English
Publishing date	2022-12-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13010050
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Article: Stricturing Crohn's disease: what is the role of endoscopic stenting? A systematic review.

Scotti, Giorgia Burrelli / Lorenzetti, Roberto / Aratari, Annalisa / Lamazza, Antonietta / Fiori, Enrico / Papi, Claudio / Festa, Stefano

Clinical endoscopy

2023 Volume 56, Issue 6, Page(s) 726–734

Abstract: Background/aims: Endoscopic stenting for stricturing Crohn's disease (CD) is an emerging treatment that achieves more persistent dilatation of the stricture over time than endoscopic balloon dilatation (EBD). We aimed to explore the efficacy and safety ... ...

Abstract	Background/aims: Endoscopic stenting for stricturing Crohn's disease (CD) is an emerging treatment that achieves more persistent dilatation of the stricture over time than endoscopic balloon dilatation (EBD). We aimed to explore the efficacy and safety of stenting for the treatment of CD strictures. Methods: A systematic electronic literature search was performed (PROSPERO; no. CRD42022308033). The primary outcomes were technical success, efficacy, complication rate, and the need for further interventions due to reobstruction. The outcomes of partially covered self-expanding metal stents (PCSEMS) with scheduled retrieval after seven days were also analyzed. Results: Eleven eligible studies were included in the review. Overall, 173 patients with CD were included in this study. Mean percentage of technical success was 95% (range, 80%-100%), short-term efficacy was 100% in all studies, and long-term efficacy was 56% (range, 25%-90%). In patients with a scheduled PCSEMS retrieval, the long-term efficacy was 76% (range, 59%-90%), the mean complication rate was 35% (range, 15%-57%), and the major complication rate was 11% (range, 0%-29%). Conclusion: Endoscopic stenting with scheduled PCSEMS retrieval may be considered a feasible second-line treatment for short CD strictures to postpone surgery. However, larger head-to-head prospective studies are needed to understand the role of stenting as an alternative or additional treatment to EBD in CD.
Language	English
Publishing date	2023-10-24
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2023.059
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Article ; Online: Impact of 4D-Flow CMR Parameters on Functional Evaluation of Fontan Circulation.

Ait Ali, Lamia / Martini, Nicola / Listo, Elisa / Valenti, Elisa / Sotelo, Julio / Salvadori, Stefano / Passino, Claudio / Monteleone, Angelo / Stagnaro, Nicola / Trocchio, Gianluca / Marrone, Chiara / Raimondi, Francesca / Catapano, Giosuè / Festa, Pierluigi

Pediatric cardiology

2024 Volume 45, Issue 5, Page(s) 998–1006

Abstract: We sought to evaluate the potential clinical role of 4D-flow cardiac magnetic resonance (CMR)-derived energetics and flow parameters in a cohort of patients' post-Fontan palliation. In patients with Fontan circulation who underwent 4D-Flow CMR, ... ...

Abstract	We sought to evaluate the potential clinical role of 4D-flow cardiac magnetic resonance (CMR)-derived energetics and flow parameters in a cohort of patients' post-Fontan palliation. In patients with Fontan circulation who underwent 4D-Flow CMR, streamlines distribution was evaluated, as well a 4D-flow CMR-derived energetics parameters as kinetic energy (KE) and energy loss (EL) normalized by volume. EL/KE index as a marker of flow efficiency was also calculated. Cardiopulmonary exercise test (CPET) was also performed in a subgroup of patients. The population study included 55 patients (mean age 22 ± 11 years). The analysis of the streamlines revealed a preferential distribution of the right superior vena cava flow for the right pulmonary artery (62.5 ± 35.4%) and a mild preferential flow for the left pulmonary artery (52.3 ± 40.6%) of the inferior vena cave-pulmonary arteries (IVC-PA) conduit. Patients with heart failure (HF) presented lower IVC/PA-conduit flow (0.75 ± 0.5 vs 1.3 ± 0.5 l/min/m
MeSH term(s)	Humans ; Fontan Procedure ; Female ; Male ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/physiopathology ; Young Adult ; Exercise Test/methods ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/physiopathology ; Adolescent ; Adult ; Magnetic Resonance Imaging, Cine/methods ; Child ; Vena Cava, Superior/diagnostic imaging ; Blood Flow Velocity/physiology ; Heart Failure/physiopathology ; Heart Failure/surgery ; Vena Cava, Inferior/diagnostic imaging
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-024-03446-4
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Article ; Online: Crohn's disease after surgery: Changes in post-operative management strategies over time and their impact on long-term re-operation rate-A retrospective multicentre real-world study.

Aratari, Annalisa / Scribano, Maria Lia / Pugliese, Daniela / Baccolini, Valentina / De Biasio, Fabiola / Verna, Serena / Morretta, Chiara / Festa, Stefano / Armuzzi, Alessandro / Papi, Claudio

Alimentary pharmacology & therapeutics

2024

Abstract: Background: Few data are available addressing the impact of post-operative management of Crohn's disease (CD) on long-term clinical course.: Aim: To assess the evolution of post-operative management strategies over the last 40 years and their impact ... ...

Abstract	Background: Few data are available addressing the impact of post-operative management of Crohn's disease (CD) on long-term clinical course. Aim: To assess the evolution of post-operative management strategies over the last 40 years and their impact on the re-operation rate of CD. Methods: We included 657 patients with CD who had undergone their first radical ileo-caecal resection between 1980 and 2020. Three cohorts were defined according to year of surgery: cohort 1 (1980-1998; n = 198), cohort 2 (1999-2009; n = 218) and cohort 3 (2010-2020; n = 241). We estimated exposure to immunomodulators and anti-TNFα agents after surgery and rates of re-operation using Kaplan-Meier survival analyses. We used Cox proportional hazards regression to assess the association of clinical variables with time to re-operation. Results: Immunosuppressants, (IMMs) and anti-TNFα exposure within 5 years after surgery increased significantly from cohort 1 to cohort 2 and cohort 3 (IMMs: 1.6%, 38.2% and 28.0%, respectively, p < 0.001; anti-TNFα: 0.0%, 20.7% and 52.0%, respectively, p < 0.001). There was no significant difference across cohorts regarding the cumulative probability of re-operation within 5 and 10 years. Multivariate analysis identified IMMs/anti-TNFα exposure before the first surgery (HR 9.15; 95% CI 2.77-30.21) and post-operatively (HR: 0.24; 95% CI 0.07-0.74) as variables associated with the risk of re-operation. However, these associations had a time-varying effect and become non-significant after 5 and 2 years after surgery, respectively. Conclusion: Despite increased post-operative use of IMMs and anti-TNFα agents in the last two decades, the impact of these strategies on the risk of long-term re-operation rate has been modest.
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.18001
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