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Article ; Online: Biological therapy in elderly patients with acute myeloid leukemia.

Ciotti, Giulia / Marconi, Giovanni / Sperotto, Alessandra / Giannini, Maria B / Gottardi, Michele / Martinelli, Giovanni

Expert opinion on biological therapy

2023 Volume 23, Issue 2, Page(s) 175–194

Abstract: Introduction: The introduction of target molecules and immunological therapies is changing the treatment landscape of acute myeloid leukemia (AML).: Areas covered: We recapitulate the biological therapies that can be employed in the treatment of ... ...

Abstract	Introduction: The introduction of target molecules and immunological therapies is changing the treatment landscape of acute myeloid leukemia (AML). Areas covered: We recapitulate the biological therapies that can be employed in the treatment of elderly patients with AML. Alongside small molecules inhibitors that target specific gene mutations, antibodies, tumor microenvironment modulators, and cellular therapies are being developed for the cure of the disease. Here, we report the biological activities, the efficacy and toxicities of humanized antibodies and antibody-drug conjugates that targets surface antigens as CD33 (gemtuzumab ozogamicine) or CD123 (pivekimab sunirine). We further explore mechanisms and effectiveness of medications that modify the microenvironment, such as glasdegib, or that harness the immune system against leukemia, such as CD47 antibody magrolimab, PD1/PDL1 inhibitors pembrolizumab and nivolumab, TIM3 inhibitor sabatolimab, T-cell and NK-cell engagers. Cellular therapies are considered, even if a large trial is still pending for the feasibility of the approach. In this scenario, a brief overview of the mechanism of action of target agents is provided, particularly with respect to their biological mechanisms. Expert opinion: Overall, this therapeutic armamentarium will constitute the basis for multimodal and personalized combinations that, in the idea of precision medicine, will enormously benefit elderly AML patients.
MeSH term(s)	Humans ; Aged ; Immunotherapy/methods ; Killer Cells, Natural ; T-Lymphocytes ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Tumor Microenvironment
Chemical Substances	sabatolimab
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2023.2174015
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Article ; Online: Haploidentical transplant after failure of a first allogeneic transplant: A long and winding road.

Tiribelli, Mario / Sperotto, Alessandra / Patriarca, Francesca / Damiani, Daniela / Fanin, Renato

European journal of haematology

2021 Volume 106, Issue 6, Page(s) 871–872

MeSH term(s)	Adult ; Aged ; Allografts ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Letter
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13611
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Article: CPX-351 and allogeneic stem cell transplant for a therapy-related acute myeloid leukemia that developed after treatment of acute promyelocytic leukemia: a case report and review of the literature.

Sperotto, Alessandra / Stanghellini, Maria Teresa Lupo / Peccatori, Jacopo / De Marchi, Roberta / Piemontese, Simona / Ciotti, Giulia / Basso, Marco / Pierdomenico, Elisabetta / Fiore, Paolo / Ciceri, Fabio / Gottardi, Michele

Frontiers in oncology

2024 Volume 13, Page(s) 1291457

Abstract: Therapy-related myeloid neoplasms (t-MNs), which develop after cytotoxic, radiation, or immunosuppressive therapy for an unrelated disease, account for 7%-8% of acute myeloid leukemia (AML). Worse outcomes and consequently shortened survival are ... ...

Abstract	Therapy-related myeloid neoplasms (t-MNs), which develop after cytotoxic, radiation, or immunosuppressive therapy for an unrelated disease, account for 7%-8% of acute myeloid leukemia (AML). Worse outcomes and consequently shortened survival are associated with t-MNs as compared with
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1291457
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Article ; Online: Primary school children and nutrition: lifestyles and behavioral traits associated with a poor-to-moderate adherence to the Mediterranean diet. A cross-sectional study.

Buja, Alessandra / Grotto, Giulia / Brocadello, Filippo / Sperotto, Milena / Baldo, Vincenzo

European journal of pediatrics

2020 Volume 179, Issue 5, Page(s) 827–834

Abstract: The Mediterranean diet has consistently shown a beneficial influence on health and longevity. The aim of this cross-sectional study was to identify all the various factors-such as socio-demographics, lifestyles, and behavioral traits-associated with the ... ...

Abstract	The Mediterranean diet has consistently shown a beneficial influence on health and longevity. The aim of this cross-sectional study was to identify all the various factors-such as socio-demographics, lifestyles, and behavioral traits-associated with the risk of a poor adherence to the Mediterranean diet in a sample of Italian primary school children. The study sample included 267 children in their first year of primary school. Their mothers were asked to answer an anonymous, self-administered questionnaire that investigated their children's adherence to the Mediterranean diet (using the KidMed score) and variables related to their lifestyles, behavioral traits, and socio-economic factors. A multivariate logistic regression was performed to test the association between adherence to the Mediterranean diet and the other variables investigated. Most of the children involved in this study (73.9%) were classifiable as having a poor-to-moderate adherence to the Mediterranean diet. Higher odds of a poor adherence to the Mediterranean diet were associated with videogame playing for more than 1 h a day and lower levels of mothers' health consciousness. On the other hand, the odds were lower in association with more time spent practicing sport, higher levels of prosocial behavior, and with mothers having a high school education as opposed to fewer years of schooling.Conclusions: These results point to the need to consider the role of mothers' health consciousness and formal education in influencing their children's diets. Health promotion interventions should focus on the importance of a healthy overall lifestyle, which includes not only appropriate nutrition but also time spent on physical activity and leisure activities (such as playing videogames).What is Known:• Most of the children were classified as having a poor or moderate adherence to the Mediterranean diet. This result reflects a trend common to numerous countries of the Mediterranean area in recent years.• A mother's level of formal education influences her child's diet.What is New:• Higher levels of prosocial traits coincided with lower odds of a poor adherence to the Mediterranean diet.
MeSH term(s)	Attitude to Health ; Child ; Cross-Sectional Studies ; Diet, Mediterranean ; Feeding Behavior/psychology ; Female ; Healthy Lifestyle ; Humans ; Italy ; Male ; Mothers/psychology ; Screen Time ; Social Interaction ; Surveys and Questionnaires
Language	English
Publishing date	2020-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-020-03577-9
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Article ; Online: WT1 - Gene expression driven pre-emptive treatment with decitabine for molecular relapse of acute myeloid leukemia after allogeneic stem cell transplant.

Sperotto, Alessandra / Gottardi, Michele / Candoni, Anna / Toffoletti, Eleonora / De Marchi, Roberta / Petruzzellis, Giuseppe / Pizzano, Umberto / Fanin, Renato

Leukemia research

2021 Volume 108, Page(s) 106587

Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Letter
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2021.106587
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Article ; Online: Adolescent gambling behavior: a gender oriented prevention strategy is required?

Buja, Alessandra / Sperotto, Milena / Genetti, Bruno / Vian, Paolo / Vittadello, Fabio / Simeoni, Elisabetta / Zampieri, Chiara / Baldo, Vincenzo

Italian journal of pediatrics

2022 Volume 48, Issue 1, Page(s) 113

Abstract: Background: Studies published on gender-related differences in the gambling behavior of adolescents have focused mainly on psychological and social factors. The aim of this study was to develop separate risk factor models for male and female adolescents, ...

Abstract	Background: Studies published on gender-related differences in the gambling behavior of adolescents have focused mainly on psychological and social factors. The aim of this study was to develop separate risk factor models for male and female adolescents, considering the environmental, psychological, behavioral and socio-economic factors related to their gambling. Methods: A survey was conducted through a questionnaire developed on a dedicated web site in 2014 on a representative sample of the Italian 15-19-years-old population, including 34,922 students attending 438 secondary schools. The SOGS-RA questionnaire was used to measure gambling behavior. To verify the risk factors associated with gambling a logistic regression stratified by gender was performed. Results: In our representative sample of Italian adolescents nationwide, the prevalence of each level of gambling was higher in males than in females. The logistic regression stratified by gender found that for both genders, gambling was positively associated with internet surfing, playing sports, getting into a fight, having unprotected sex, pulling stunts, drinking alcohol at least once in the previous month, having not a satisfactory relationship with teachers, receiving pocket money from parents, spending each week much money and having someone in the family (father, sister/brother, other relatives) who gambles. On the other hand, having poor or average school marks, going to ED in the previous year, smoking at least once in the previous month, having dissatisfied with relationships with father and having a lower family income than their friends was only associated with gambling in boys. Having an accident or injury in the previous year and having a mother who gambled was associated only in girls with higher odd of at risk or problem gambling behavior. A low psychological distress is protective only in girls for risk of gambling. Conclusions: Understanding the gender-related differences, and how they emerge in younger people at the start of their gambling careers, can suggest how best to educate individuals, families and the community on the topic of gambling. Programs to prevent substance use and abuse should be multifaceted, and include efforts to prevent gambling with a gender perspective approach.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Adult ; Female ; Gambling/epidemiology ; Gambling/prevention & control ; Humans ; Male ; Risk Factors ; Students/psychology ; Substance-Related Disorders/epidemiology ; Young Adult
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-022-01309-3
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Article: Measurable Residual Disease and Clonal Evolution in Acute Myeloid Leukemia from Diagnosis to Post-Transplant Follow-Up: The Role of Next-Generation Sequencing.

Sperotto, Alessandra / Bochicchio, Maria Teresa / Simonetti, Giorgia / Buccisano, Francesco / Peccatori, Jacopo / Piemontese, Simona / Calistri, Elisabetta / Ciotti, Giulia / Pierdomenico, Elisabetta / De Marchi, Roberta / Ciceri, Fabio / Gottardi, Michele

Biomedicines

2023 Volume 11, Issue 2

Abstract: It has now been ascertained that acute myeloid leukemias-as in most type of cancers-are mixtures of various subclones, evolving by acquiring additional somatic mutations over the course of the disease. The complexity of leukemia clone architecture and ... ...

Abstract	It has now been ascertained that acute myeloid leukemias-as in most type of cancers-are mixtures of various subclones, evolving by acquiring additional somatic mutations over the course of the disease. The complexity of leukemia clone architecture and the phenotypic and/or genotypic drifts that can occur during treatment explain why more than 50% of patients-in hematological remission-could relapse. Moreover, the complexity and heterogeneity of clone architecture represent a hindrance for monitoring measurable residual disease, as not all minimal residual disease monitoring methods are able to detect genetic mutations arising during treatment. Unlike with chemotherapy, which imparts a relatively short duration of selective pressure on acute myeloid leukemia clonal architecture, the immunological effect related to allogeneic hematopoietic stem cell transplant is prolonged over time and must be overcome for relapse to occur. This means that not all molecular abnormalities detected after transplant always imply inevitable relapse. Therefore, transplant represents a critical setting where a measurable residual disease-based strategy, performed during post-transplant follow-up by highly sensitive methods such as next-generation sequencing, could optimize and improve treatment outcome. The purpose of our review is to provide an overview of the role of next-generation sequencing in monitoring both measurable residual disease and clonal evolution in acute myeloid leukemia patients during the entire course of the disease, with special focus on the transplant phase.
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11020359
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Article ; Online: Screening procedure for SARS-CoV-2 infection combining triage, nasopharyngeal swab and serological test in allogeneic stem cell transplantation recipients undergoing outpatient posttransplant follow-up.

Sperotto, Alessandra / Candoni, Anna / Petruzzellis, Giuseppe / Mullai, Rikard / Patriarca, Francesca / Tascini, Carlo / Fanin, Renato

Journal of medical virology

2020 Volume 93, Issue 3, Page(s) 1244–1246

MeSH term(s)	Adult ; Aged ; COVID-19/diagnosis ; COVID-19/immunology ; Diagnostic Tests, Routine/methods ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Middle Aged ; Nasopharynx/virology ; Outpatients ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Serologic Tests/methods ; Triage/methods ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26586
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Article: Risk Factors and Outcome of

Rosignoli, Chiara / Petruzzellis, Giuseppe / Radici, Vera / Facchin, Gabriele / Girgenti, Marco / Stella, Rossella / Isola, Miriam / Battista, Martalisa / Sperotto, Alessandra / Geromin, Antonella / Cerno, Michela / Arzese, Alessandra / Deias, Paola / Tascini, Carlo / Fanin, Renato / Patriarca, Francesca

Journal of clinical medicine

2020 Volume 9, Issue 11

Abstract: Patients who undergo hematopoietic stem cell transplants (HSCT) are at major risk ... ...

Abstract	Patients who undergo hematopoietic stem cell transplants (HSCT) are at major risk of
Language	English
Publishing date	2020-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9113673
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Article: Effectiveness of individually tailored exercise on functional capacity and mobility in nursing home residents.

Bertoncello, Chiara / Sperotto, Milena / Bellio, Stefania / Pistellato, Ilaria / Fonzo, Marco / Bigolaro, Chiara / Ramon, Roberto / Imoscopi, Alessandra / Baldo, Vincenzo

British journal of community nursing

2021 Volume 26, Issue 3, Page(s) 144–149

Abstract: Deterioration of physical and functional capacities is often seen in nursing homes. The present study aimed at assessing the effectiveness of an individually tailored physical exercise intervention on mobility and functional decline in nursing home ... ...

Abstract	Deterioration of physical and functional capacities is often seen in nursing homes. The present study aimed at assessing the effectiveness of an individually tailored physical exercise intervention on mobility and functional decline in nursing home residents in a 1-year follow-up period. Information on gender, age, education, profession and cognitive status was collected at baseline and at 6 and 12 months of the intervention. The decline in functional capacity and mobility was assessed using the Barthel index. Some 221 participants were included. Results from the multivariate logistic regression showed how residents who never participated in physical activities had a five-fold higher risk of mobility decline compared with residents who did engage for the whole follow-up time. A lower effect was seen in residents who participated for only 6 months. Although dementia appeared to be a significant predictor of decline, a substantial stabilisation in mobility capacity was noted in patients with both mild and severe dementia performing exercise. The findings suggest that preventing or slowing physical decline in nursing home residents is an achievable goal, and even those with a higher degree of cognitive decline may benefit from a tailored physical activity plan.
MeSH term(s)	Activities of Daily Living ; Dementia ; Exercise ; Exercise Therapy ; Humans ; Infant ; Nursing Homes
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2146386-4
ISSN	1462-4753
ISSN	1462-4753
DOI	10.12968/bjcn.2021.26.3.144
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