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  1. Book ; Online ; E-Book: Self-assessment Q&A in clinical laboratory science / III /

    Wu, Alan H. B.

    2021  

    Author's details edited by Alan H.B. Wu
    Keywords Clinical chemistry
    Subject code 616.0756076
    Language English
    Size 1 online resource (492 pages)
    Publisher Elsevier ; AACC Press
    Publishing place Amsterdam, Netherlands ; Kidlington, Oxford ; Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-822094-5 ; 0-12-822093-7 ; 978-0-12-822094-8 ; 978-0-12-822093-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: Biomarkers for traumatic brain injury

    Wu, Alan H. B. / Peacock, William Frank

    2020  

    Author's details edited by Alan H. B. Wu, W. Frank Peacock
    Keywords Brain/Wounds and injuries/Diagnosis ; Biochemical markers/Diagnostic use
    Subject code 617.481044
    Language English
    Size 1 Online-Ressource (xix, 466 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020534728
    ISBN 978-0-12-816730-4 ; 9780128163467 ; 0-12-816730-0 ; 0128163461
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article: Biological Variation: An Important but Unappreciated Clinical Laboratory Test Metric.

    Wu, Alan H B

    The journal of applied laboratory medicine

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfae018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Poisoning and Drug Overdose, Eighth Edition

    Anderson, Ilene B / Benowitz, Neal L / Blanc, Paul D / Kim-Katz, Susan Y / Lewis, Justin C / Wu, Alan H B / Olson, Kent R / Smollin, Craig

    2022  

    Author's details Kent R. Olson, MD, FACEP Medical Director California Poison ontrol System, San Francisco Division San Francisco General Hospital Attenting Emergency Physician Elden Hospital Medcial Center Clinical Professor of Medicine, Pediatrics, and Pharmacy University of California, San Francisco
    Language English
    Size 784 p.
    Edition 8
    Publisher McGraw Hill LLC
    Document type Book
    Note PDA Manuell_16
    Format 136 x 209 x 30
    ISBN 9781264259083 ; 1264259085
    Database PDA

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  5. Article ; Online: Using Biomarkers for Traumatic Brain Injury: Are There Lessons That Can Be Learned from Implementing Cardiac Troponin?

    Wu, Alan H B

    Clinical chemistry

    2023  Volume 69, Issue 6, Page(s) 548–550

    MeSH term(s) Humans ; Brain Injuries, Traumatic/diagnosis ; Biomarkers ; Troponin ; Troponin T
    Chemical Substances Biomarkers ; Troponin ; Troponin T
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvac194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: AACC Academy's Pain Management LMPG: Verification of Drug Dosing with Quantitative Urine Drug Testing?

    Wu, Alan H B

    The journal of applied laboratory medicine

    2021  Volume 2, Issue 4, Page(s) 475–477

    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1373/jalm.2017.025361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Untargeted High-Resolution Mass Spectrometry for Detection of Natural Products and Confiscated Powders and Pills.

    Beckerdite, Erica / Wu, Alan H B

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2737, Page(s) 185–193

    Abstract: Drug testing for clinical toxicology purposes is difficult given the variety of drugs and substances that can be abused. High-resolution mass spectrometry is a powerful tool for the qualitative identification of compounds in the blood and urine of ... ...

    Abstract Drug testing for clinical toxicology purposes is difficult given the variety of drugs and substances that can be abused. High-resolution mass spectrometry is a powerful tool for the qualitative identification of compounds in the blood and urine of exposed individuals. The interpretation of results can be greatly improved if caregivers and/or laboratorians are able to communicate with patients, family members, friends, or law enforcement (where appropriate), in order to obtain and test the drugs, plants, herbals, or chemicals that were taken. Methods are needed for the extraction, purification, and untargeted mass spectral analysis of drugs from the donated or seized materials.
    MeSH term(s) Humans ; Powders ; Biological Products ; Mass Spectrometry/methods ; Substance Abuse Detection/methods ; Substance-Related Disorders
    Chemical Substances Powders ; Biological Products
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3541-4_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined?

    Wu, Alan H B / Wang, Chia-Ching

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

    2024  Volume 29, Issue 2, Page(s) 100–104

    Abstract: Background: Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed ... ...

    Abstract Background: Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked.
    Methods: We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio.
    Results: As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children.
    Conclusion: We suggest that the Κ/λ free light chains may be genetically linked.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Infant, Newborn ; Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains ; Immunoglobulin Light Chains ; Paraproteinemias/diagnosis ; Placenta ; Siblings ; Twins
    Chemical Substances Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains ; Immunoglobulin Light Chains
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Twin Study ; Journal Article
    ZDB-ID 1324372-x
    ISSN 1366-5804 ; 1354-750X
    ISSN (online) 1366-5804
    ISSN 1354-750X
    DOI 10.1080/1354750X.2024.2319308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4864: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Potential medical impact of unrecognized

    Wu, Alan H B / Peacock, W Franklin

    Clinical chemistry and laboratory medicine

    2024  

    Abstract: Objectives: The destruction of red cells during blood collection or with the processing of the sample continues to occur at a high rate, especially among emergency department (ED) patients. This can produce pre-analytical laboratory errors, particularly ...

    Abstract Objectives: The destruction of red cells during blood collection or with the processing of the sample continues to occur at a high rate, especially among emergency department (ED) patients. This can produce pre-analytical laboratory errors, particularly for potassium. We determined the incidence of hemolyzed samples and discuss the potential medical impact for hypokalemic patients who potassium level is artificially normal (pseudoeukalemia).
    Methods: Potassium results were obtained for a 6-month period. Using a measured hemolysis index (HI), hemolysis was present in 3.1 % for all potassium ordered (n=94,783) and 7.5 % for ED orders (n=22,770). Most of these samples were reported as having high normal result or were hyperkalemic. There were 22 hemolytic samples with a potassium of <3.5 mmol/L, and 57 hemolytic samples with a potassium in lower limit of normal (3.5-3.8 mmol/L). From this group, we examined the medical histories of 8 selected patients whose initially normal potassium levels were subsequently confirmed to have a potassium values that were below, at, or just above the lower limit of normal due to hemolysis.
    Results: The primary complaint for these patients were: necrotizing soft tissue infection, pancreatitis, volume overload from heart failure with reduced ejection fraction, hypertension treated with hydrochlorothiazide, and presence of a short bowel syndrome. A subsequent non-hemolyzed sample was collected demonstrating hypokalemia in all of these patients. Within these cases, there was a potential for harm had hemolysis detection not been performed.
    Conclusions: We demonstrate the medical importance of detecting hemolysis for patients who have pseudoeukalemia. This is relevant because the HI cannot be obtained when electrolytes are tested using whole blood samples, and a normal potassium may lead to inappropriate patient management.
    Language English
    Publishing date 2024-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2024-0351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Kappa/Lambda Ratio for Early Detection of Multiple Myeloma Relapse Using the Reference Change Value from Biological Variation Studies.

    Wu, Alan H B

    The journal of applied laboratory medicine

    2021  Volume 6, Issue 6, Page(s) 1683–1687

    MeSH term(s) Humans ; Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains ; Immunologic Tests ; Multiple Myeloma/diagnosis ; Neoplasm Recurrence, Local/diagnosis
    Chemical Substances Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains
    Language English
    Publishing date 2021-09-17
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfab093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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