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Book: Shen jing nei ke ji bing ying xiang zhen duan si wei

Fang, Yannan

2014

Author's details	zhu bian Fang Yannan , Luo Boning, Chen Shaoqiong, Zhang Aiwu
MeSH term(s)	Nervous System Diseases/diagnosis ; Diagnostic Imaging/methods
Language	Chinese
Size	2, 2, 293 pages :, illustrations
Edition	Di 2 ban.
Document type	Book
ISBN	9787535958891 ; 7535958893
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: The Diagnostic Accuracy of Xpert Xpress to SARS-CoV-2: A systematic review.

Cao, Xun-Jie / Fang, Ke-Ying / Li, Ya-Ping / Zhou, Jie / Guo, Xu-Guang

Journal of virological methods

2022 Volume 301, Page(s) 114460

Abstract: The SARS-CoV-2 infection rate, as well as mortality rate, is high. There is an urgent need for a high-throughput, accurate and reliable method of diagnosing COVID-19 pneumonia. We included references from databases, such as PubMed, Cochrane Library, Web ... ...

Abstract	The SARS-CoV-2 infection rate, as well as mortality rate, is high. There is an urgent need for a high-throughput, accurate and reliable method of diagnosing COVID-19 pneumonia. We included references from databases, such as PubMed, Cochrane Library, Web of Science, and Embase, and extracted data. Then, MetaDisc and STATA were used to establish forest plots and funnel plots for meta-analysis. We collected 14 articles and performed a systematic review. The following results were obtained: sensitivity and specificity were 0.97 (0.96 to 0.98) and 0.97 (0.96 to 0.98) respectively; PLR and NLR were 24.51 (16.63-36.12) and 0.03 (0.01 to 0.10) respectively, DOR was 975.15 (430.11-2210.88), and AUC was 0.9926. When Xpress detects SARS-CoV-2 in different samples, the heterogeneity is small and the specificity and sensitivity are extremely high. We recommend the employment of Xpert Xpress analysis in rapid screening.
MeSH term(s)	COVID-19 ; COVID-19 Testing ; Humans ; Molecular Diagnostic Techniques/methods ; SARS-CoV-2 ; Sensitivity and Specificity
Language	English
Publishing date	2022-01-12
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2022.114460
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Diagnostic Accuracy of Xpert Xpress to SARS-CoV-2: A systematic review

Cao, Xun-Jie / Fang, Ke-Ying / Li, Ya-Ping / Zhou, Jie / Guo, Xu-Guang

Journal of Virological Methods. 2022 Mar., v. 301 p.114460-

2022

Abstract	The SARS-CoV-2 infection rate, as well as mortality rate, is high. There is an urgent need for a high-throughput, accurate and reliable method of diagnosing COVID-19 pneumonia. We included references from databases, such as PubMed, Cochrane Library, Web of Science, and Embase, and extracted data. Then, MetaDisc and STATA were used to establish forest plots and funnel plots for meta-analysis. We collected 14 articles and performed a systematic review. The following results were obtained: sensitivity and specificity were 0.97 (0.96 to 0.98) and 0.97 (0.96 to 0.98) respectively; PLR and NLR were 24.51 (16.63–36.12) and 0.03 (0.01 to 0.10) respectively, DOR was 975.15 (430.11–2210.88), and AUC was 0.9926. When Xpress detects SARS-CoV-2 in different samples, the heterogeneity is small and the specificity and sensitivity are extremely high. We recommend the employment of Xpert Xpress analysis in rapid screening.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; forests ; meta-analysis ; mortality ; pneumonia ; systematic review ; Xpert Xpress ; COVID-19 pneumonia ; SARS-CoV-2 ; Diagnostic accuracy ; Systemic review
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2022.114460
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis.

Fang, Ke-Ying / Liang, Gui-Ning / Zhuang, Zhuo-Qing / Fang, Yong-Xin / Dong, Yu-Qian / Liang, Chuang-Jia / Chen, Xin-Yan / Guo, Xu-Guang

Journal of clinical laboratory analysis

2022 Volume 36, Issue 7, Page(s) e24495

Abstract: Background: After encountering COVID-19 patients who test positive again after discharge, our study analyzed the pathogenesis to further assess the risk and possibility of virus reactivation.: Methods: A separate microarray was acquired from the Gene ...

Abstract	Background: After encountering COVID-19 patients who test positive again after discharge, our study analyzed the pathogenesis to further assess the risk and possibility of virus reactivation. Methods: A separate microarray was acquired from the Gene Expression Omnibus (GEO), and its samples were divided into two groups: a "convalescent-RTP" group consisting of convalescent and "retesting positive" (RTP) patients (group CR) and a "healthy-RTP" group consisting of healthy control and RTP patients (group HR). The enrichment analysis was performed with R software, obtaining the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the protein-protein interaction (PPI) networks of each group were established, and the hub genes were discovered using the cytoHubba plugin. Results: In this study, 6622 differentially expressed genes were identified in the group CR, among which RAB11B-AS1, DISP1, MICAL3, PSMG1, and DOCK4 were up-regulated genes, and ANAPC1, IGLV1-40, SORT1, PLPPR2, and ATP1A1-AS1 were down-regulated. 7335 genes were screened in the group HR, including the top 5 up-regulated genes ALKBH6, AMBRA1, MIR1249, TRAV18, and LRRC69, and the top 5 down-regulated genes FAM241B, AC018529.3, AL031963.3, AC006946.1, and FAM149B1. The GO and KEGG analysis of the two groups revealed a significant enrichment in immune response and apoptosis. In the PPI network constructed, group CR and group HR identified 10 genes, respectively, and TP53BP1, SNRPD1, and SNRPD2 were selected as hub genes. Conclusions: Using the messenger ribonucleic acid (mRNA) expression data from GSE166253, we found TP53BP1, SNRPD1, and SNRPD2 as hub genes in RTP patients, which is vital to the management and prognostic prediction of RTP patients.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/genetics ; COVID-19 Testing ; Computational Biology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks/genetics ; Humans ; Patient Discharge ; Recurrence
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Renal Involvement in IPEX Syndrome With a Novel Mutation of

Ke, Ruijuan / Zhu, Ying / Deng, Fang / Xu, Daliang

Frontiers in genetics

2022 Volume 12, Page(s) 752775

Abstract: The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare genetic disease characterized by multiple immune disorders. Different mutations of ... ...

Abstract	The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare genetic disease characterized by multiple immune disorders. Different mutations of the
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.752775
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review.

Mei, Youwen / Lin, Yonghong / Chen, Ying / Zheng, Jiafeng / Ke, Xue / Liang, Xuefei / Wang, Fang

Frontiers in medicine

2024 Volume 11, Page(s) 1233962

Abstract: Introduction: Recurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples. The leading cause of RRF is believed to be aneuploid embryo, which could be solved ... ...

Abstract	Introduction: Recurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples. The leading cause of RRF is believed to be aneuploid embryo, which could be solved by preimplantation genetic testing for aneuploidy (PGT-A) in theory. With molecular genetic development, PGT-A based on comprehensive chromosomal screening (CCS) procedures and blastocyst biopsy is widely applied in clinical practice. However, its effects in RRF were not defined yet. Methods: A systematic bibliographical search was conducted without temporal limits up to June, 2023. Studies about the effects of PGT-A based on CCS procedures and blastocyst biopsy in RRF were included. Results: Twenty studies about the effects of PGT-A based on CCS procedures and blastocyst biopsy in RRF were included. It revealed that PGT-A could optimise the reproductive outcomes of RRF sufferers, especially in those with advanced age. However, in patients with multiple occurrences of pregnancy losses, the benefits of PGT-A were limited. Discussion: More randomized controlled trials with large sample size are required to evaluate the benefits of PGT-A in RRF sufferers and identify which population would benefit the most.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1233962
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adropin inhibits the progression of atherosclerosis in ApoE

Ying, Teng / Wu, LingZhen / Lan, TingXiang / Wei, ZhiXiong / Hu, DanQing / Ke, YiLang / Jiang, Qiong / Fang, Jun

Cell death discovery

2023 Volume 9, Issue 1, Page(s) 402

Abstract: Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate ... ...

Abstract	Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate atherosclerosis by regulating EndMT. We found that an intraperitoneal injection of adropin [105 μg/(kg·d) for 13 weeks] inhibited the progression of high-fat diet (HFD)-induced aortic atherosclerosis in apolipoprotein E-deficient mice (ApoE
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01697-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multimodal neural probes for combined optogenetics and electrophysiology

Huihui Tian / Ke Xu / Liang Zou / Ying Fang

iScience, Vol 25, Iss 1, Pp 103612- (2022)

2022

Abstract: Summary: To understand how brain functions arise from interconnected neural networks, it is necessary to develop tools that can allow simultaneous manipulation and recording of neural activities. Multimodal neural probes, especially those that combine ... ...

Abstract	Summary: To understand how brain functions arise from interconnected neural networks, it is necessary to develop tools that can allow simultaneous manipulation and recording of neural activities. Multimodal neural probes, especially those that combine optogenetics with electrophysiology, provide a powerful tool for the dissection of neural circuit functions and understanding of brain diseases. In this review, we provide an overview of recent developments in multimodal neural probes. We will focus on materials and integration strategies of multimodal neural probes to achieve combined optogenetic stimulation and electrical recordings with high spatiotemporal precision and low invasiveness. In addition, we will also discuss future opportunities of multimodal neural interfaces in basic and translational neuroscience.
Keywords	Neuroscience ; Biotechnology ; Materials science ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic changes of key metabolites in Longjing green tea during processing revealed by widely targeted metabolomic profiling and sensory experiments.

Zeng, Lin / Fu, Yan-Qing / Gao, Ying / Wang, Fang / Liang, Shuang / Yin, Jun-Feng / Fauconnier, Marie-Laure / Ke, Lijing / Xu, Yong-Quan

Food chemistry

2024 Volume 450, Page(s) 139373

Abstract: In this study, widely targeted metabolomics and chemometrics were utilized to comprehensively analyse the formation of taste compounds in Longjing green tea. A total of 580 non-volatile metabolites were identified by using ultra-performance liquid ... ...

Abstract	In this study, widely targeted metabolomics and chemometrics were utilized to comprehensively analyse the formation of taste compounds in Longjing green tea. A total of 580 non-volatile metabolites were identified by using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry, and alterations in three metabolic pathways were investigated. Notably, the fixation process reduced phosphatidic acid levels, resulting in the formation of lyso-phosphatidylcholine and lyso-phosphatidylethanolamine, as well as the release of esterified polyunsaturated fatty acids. Baiye No.1 had high levels of L-glutamic acid and l-glutamine, while Longjing 43 showed elevated levels of flavones. Correlation analysis and sensory verification indicated that the specific concentration of L-leucine could decrease the umami of the tea. These findings advance our understanding of Longjing green tea quality improvement and cultivar development.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139373
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Superior Attentional Efficiency of Auditory Cue via the Ventral Auditory-thalamic Pathway.

Wang, Ke / Fang, Ying / Guo, Qiang / Shen, Lu / Chen, Qi

Journal of cognitive neuroscience

2023 Volume 36, Issue 2, Page(s) 303–326

Abstract: Auditory commands are often executed more efficiently than visual commands. However, empirical evidence on the underlying behavioral and neural mechanisms remains scarce. In two experiments, we manipulated the delivery modality of informative cues and ... ...

Abstract	Auditory commands are often executed more efficiently than visual commands. However, empirical evidence on the underlying behavioral and neural mechanisms remains scarce. In two experiments, we manipulated the delivery modality of informative cues and the prediction violation effect and found consistently enhanced RT benefits for the matched auditory cues compared with the matched visual cues. At the neural level, when the bottom-up perceptual input matched the prior prediction induced by the auditory cue, the auditory-thalamic pathway was significantly activated. Moreover, the stronger the auditory-thalamic connectivity, the higher the behavioral benefits of the matched auditory cue. When the bottom-up input violated the prior prediction induced by the auditory cue, the ventral auditory pathway was specifically involved. Moreover, the stronger the ventral auditory-prefrontal connectivity, the larger the behavioral costs caused by the violation of the auditory cue. In addition, the dorsal frontoparietal network showed a supramodal function in reacting to the violation of informative cues irrespective of the delivery modality of the cue. Taken together, the results reveal novel behavioral and neural evidence that the superior efficiency of the auditory cue is twofold: The auditory-thalamic pathway is associated with improvements in task performance when the bottom-up input matches the auditory cue, whereas the ventral auditory-prefrontal pathway is involved when the auditory cue is violated.
MeSH term(s)	Humans ; Cues ; Auditory Pathways ; Auditory Perception ; Attention ; Thalamus
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1007410-7
ISSN	1530-8898 ; 0898-929X ; 1096-8857
ISSN (online)	1530-8898
ISSN	0898-929X ; 1096-8857
DOI	10.1162/jocn_a_02090
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