LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 73

Search options

  1. Article ; Online: Air quality and COVID-19: Much more than six feet. Evidence about SARS-COV-2 airborne transmission in indoor environments and polluted areas.

    Miani, Alessandro / Piscitelli, Prisco / Setti, Leonardo / De Gennaro, Gianluigi

    Environmental research

    2022  Volume 210, Page(s) 112949

    MeSH term(s) Air Pollution ; Air Pollution, Indoor ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-02-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.112949
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.

    Taliani, Valeria / Buonaiuto, Giulia / Desideri, Fabio / Setti, Adriano / Santini, Tiziana / Galfrè, Silvia / Schirone, Leonardo / Mariani, Davide / Frati, Giacomo / Valenti, Valentina / Sciarretta, Sebastiano / Perlas, Emerald / Nicoletti, Carmine / Musarò, Antonio / Ballarino, Monica

    eLife

    2023  Volume 12

    Abstract: Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA whose ...

    Abstract Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA whose functional knockout in mice results in defective myogenesis and morphological remodeling of the cardiac muscle. Here, we combined Cap-Analysis of Gene Expression (CAGE), single-cell (sc)RNA sequencing, and whole-mount in situ hybridization analyses to study pCharme cardiac expression. Since the early steps of cardiomyogenesis, we found the lncRNA being specifically restricted to cardiomyocytes, where it assists the formation of specific nuclear condensates containing MATR3, as well as important RNAs for cardiac development. In line with the functional significance of these activities, pCharme ablation in mice results in a delayed maturation of cardiomyocytes, which ultimately leads to morphological alterations of the ventricular myocardium. Since congenital anomalies in myocardium are clinically relevant in humans and predispose patients to major complications, the identification of novel genes controlling cardiac morphology becomes crucial. Our study offers unique insights into a novel lncRNA-mediated regulatory mechanism promoting cardiomyocyte maturation and bears relevance to Charme locus for future theranostic applications.
    MeSH term(s) Animals ; Humans ; Mice ; Cell Differentiation/genetics ; Heart Ventricles/metabolism ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Nuclear Matrix-Associated Proteins/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA-Binding Proteins/metabolism
    Chemical Substances MATR3 protein, human ; Nuclear Matrix-Associated Proteins ; RNA, Long Noncoding ; RNA-Binding Proteins
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.81360
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani / Giulia Buonaiuto / Fabio Desideri / Adriano Setti / Tiziana Santini / Silvia Galfrè / Leonardo Schirone / Davide Mariani / Giacomo Frati / Valentina Valenti / Sebastiano Sciarretta / Emerald Perlas / Carmine Nicoletti / Antonio Musarò / Monica Ballarino

    eLife, Vol

    2023  Volume 12

    Abstract: Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA whose ...

    Abstract Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA whose functional knockout in mice results in defective myogenesis and morphological remodeling of the cardiac muscle. Here, we combined Cap-Analysis of Gene Expression (CAGE), single-cell (sc)RNA sequencing, and whole-mount in situ hybridization analyses to study pCharme cardiac expression. Since the early steps of cardiomyogenesis, we found the lncRNA being specifically restricted to cardiomyocytes, where it assists the formation of specific nuclear condensates containing MATR3, as well as important RNAs for cardiac development. In line with the functional significance of these activities, pCharme ablation in mice results in a delayed maturation of cardiomyocytes, which ultimately leads to morphological alterations of the ventricular myocardium. Since congenital anomalies in myocardium are clinically relevant in humans and predispose patients to major complications, the identification of novel genes controlling cardiac morphology becomes crucial. Our study offers unique insights into a novel lncRNA-mediated regulatory mechanism promoting cardiomyocyte maturation and bears relevance to Charme locus for future theranostic applications.
    Keywords ncRNA ; lncRNA ; cardiomyogenesis ; heart ; muscle ; development ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: Assessment of a metal-organic framework catalyst in air cathode microbial fuel cells over time with different buffers and solutions.

    Rossi, Ruggero / Yang, Wulin / Setti, Leonardo / Logan, Bruce E

    Bioresource technology

    2017  Volume 233, Page(s) 399–405

    Abstract: Metal-organic framework (MOF) on activated carbon (AC) enhanced the performance of cathodes but longevity needs to be considered in the presence of metal chelators or ligands, such as phosphate, present in wastewaters. MOF catalysts on AC initially ... ...

    Abstract Metal-organic framework (MOF) on activated carbon (AC) enhanced the performance of cathodes but longevity needs to be considered in the presence of metal chelators or ligands, such as phosphate, present in wastewaters. MOF catalysts on AC initially produced 2.78±0.08Wm
    MeSH term(s) Bioelectric Energy Sources ; Buffers ; Catalysis ; Electrodes ; Metals
    Chemical Substances Buffers ; Metals
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2017.02.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Interspecific rootstock can enhance yield of processing tomatoes (Solanum lycopersicum L.) in organic farming

    Caradonia, Federica / Francia, Enrico / Barbieri, Riccardo / Setti, Leonardo / Hagassou, Djangsou / Ronga, Domenico

    Biological agriculture & horticulture. 2020 July 02, v. 36, no. 3

    2020  

    Abstract: At present, consumer concern about the impact of food production on the environment is driving increased demand for high quality and healthy tomatoes. However, the yield of processing tomatoes in organic systems are generally lower than that in ... ...

    Abstract At present, consumer concern about the impact of food production on the environment is driving increased demand for high quality and healthy tomatoes. However, the yield of processing tomatoes in organic systems are generally lower than that in conventional systems and only a limited number of genotypes suitable for low input or organic systems are available for farmers. The technique of grafting commercial genotypes onto selected rootstocks offers a faster alternative to the classic breeding process. Therefore, in this study, the use of the interspecific rootstock RS01658654 (RT1) was assessed, aiming to improve the marketable yield of processing tomatoes grown in an organic cropping system. The non-commercial processing tomato genotype TC266 was grafted onto the interspecific rootstock RT1 and the plants were then grown under organic conditions. In two growing seasons, morphological, physiological and agronomic performances of grafted processing tomato plants were compared to non-grafted and self-grafted plants. TC226 grafted onto RT1 had a higher number of flowers and leaves compared with the non-grafted and the self-grafted plants. In addition, the marketable yield (significant in 2017 only), the number of fruits and the fruit dry weight were higher for plants grown on the interspecific rootstock RT1, without affecting the quality of the fruit. The results of this study showed that the use of the interspecific rootstock RT1 could provide a good option for improving the production of processing tomatoes in organic farming.
    Keywords Solanum lycopersicum ; agriculture ; consumer attitudes ; food production ; fruits ; genotype ; horticulture ; rootstocks ; tomatoes
    Language English
    Dates of publication 2020-0702
    Size p. 156-171.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 408953-4
    ISSN 2165-0616 ; 0144-8765
    ISSN (online) 2165-0616
    ISSN 0144-8765
    DOI 10.1080/01448765.2020.1756407
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  6. Article ; Online: Searching for SARS-COV-2 on Particulate Matter: A Possible Early Indicator of COVID-19 Epidemic Recurrence.

    Setti, Leonardo / Passarini, Fabrizio / De Gennaro, Gianluigi / Barbieri, Pierluigi / Pallavicini, Alberto / Ruscio, Maurizio / Piscitelli, Prisco / Colao, Annamaria / Miani, Alessandro

    International journal of environmental research and public health

    2020  Volume 17, Issue 9

    Abstract: A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in ...

    Abstract A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in many countries a "Phase-2" is approaching and many activities will re-open soon, although with some differences depending on the severity of the outbreak experienced and SARS-COV-2 estimated diffusion in the general population. At the present, possible relapses of the epidemic cannot be excluded until effective vaccines or immunoprophylaxis with human recombinant antibodies will be properly set up and commercialized. COVD-19-related quarantines have triggered serious social challenges, so that decision makers are concerned about the risk of wasting all the sacrifices imposed to the people in these months of quarantine. The availability of possible early predictive indicators of future epidemic relapses would be very useful for public health purposes, and could potentially prevent the suspension of entire national economic systems. On 16 March, a Position Paper launched by the Italian Society of Environmental Medicine (SIMA) hypothesized for the first time a possible link between the dramatic impact of COVID-19 outbreak in Northern Italy and the high concentrations of particulate matter (PM
    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Humans ; Italy/epidemiology ; Pandemics ; Particulate Matter ; Pneumonia, Viral/epidemiology ; Public Health ; Quarantine ; Recurrence ; SARS-CoV-2
    Chemical Substances Aerosols ; Particulate Matter
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17092986
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Determination of Free Soluble Phenolic Compounds in Grains of Ancient Wheat Varieties ( Triticum sp. pl.) by Liquid Chromatography-Tandem Mass Spectrometry.

    Montevecchi, Giuseppe / Setti, Leonardo / Olmi, Linda / Buti, Matteo / Laviano, Luca / Antonelli, Andrea / Sgarbi, Elisabetta

    Journal of agricultural and food chemistry

    2018  Volume 67, Issue 1, Page(s) 201–212

    Abstract: A method of liquid chromatography coupled with tandem mass spectrometry was developed and validated for the determination of free soluble phenolic compounds in eight ancient varieties of wheat ( Triticum sp. pl.): Autonomia, Gentil rosso, Inallettabile, ... ...

    Abstract A method of liquid chromatography coupled with tandem mass spectrometry was developed and validated for the determination of free soluble phenolic compounds in eight ancient varieties of wheat ( Triticum sp. pl.): Autonomia, Gentil rosso, Inallettabile, Leone aristato, Mentana, Poulard di Ciano, Risciola, and Terminillo. Trace compounds such as two conjugated flavones, vitexin (17.13-34.32 μg/kg) and isovitexin (9.76-30.01 μg/kg), were also determined. Poulard di Ciano, presumably an autochthonous wheat of the Reggio Emilia province (northern Italy), showed a peculiar quali/quantitative phenolic profile (7097.03 μg/kg sum of total phenolic compounds and 1.97 sum of hydroxycinnamic acids to sum of hydroxybenzoic acids ratio) along with a tetraploid genome. Terminillo, Risciola, Gentil rosso, Mentana, and Leone aristato showed hexaploid genomes and high concentrations of phenolic compounds (ranging from 6796.12 to 7605.78 μg/kg), also in comparison with two modern varieties of bread wheat, Bolero and Blasco. The targeted metabolomic approach proved to be effective to determine some secondary metabolites of wheat. The richness in phenolic compounds combined with high rusticity and adaptability to marginal soils showed by ancient wheat varieties make them suitable for sustainable agricultural and organic cultivation.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Genome, Plant ; Genotype ; Phenols/analysis ; Plant Extracts/analysis ; Tandem Mass Spectrometry/methods ; Triticum/chemistry ; Triticum/classification ; Triticum/genetics
    Chemical Substances Phenols ; Plant Extracts
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.8b05629
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Use of black soldier fly (Hermetia illucens (L.), Diptera: Stratiomyidae) larvae processing residue in peat-based growing media.

    Setti, Leonardo / Francia, Enrico / Pulvirenti, Andrea / Gigliano, Silvia / Zaccardelli, Massimo / Pane, Catello / Caradonia, Federica / Bortolini, Sara / Maistrello, Lara / Ronga, Domenico

    Waste management (New York, N.Y.)

    2019  Volume 95, Page(s) 278–288

    Abstract: The Black Soldier Fly (Hermetia illucens (L.), Diptera: Stratiomyidae) is an insect whose larvae thrive on agro-industrial by-products. This study reports the first use of black soldier fly larvae processing residue (BSPR) as an innovative ingredient for ...

    Abstract The Black Soldier Fly (Hermetia illucens (L.), Diptera: Stratiomyidae) is an insect whose larvae thrive on agro-industrial by-products. This study reports the first use of black soldier fly larvae processing residue (BSPR) as an innovative ingredient for growing media. BSPR was characterized and evaluated to partially replace commercial peat (CP) in the production of potted plants. Chemical and microbiological analysis showed the suitability of BSPR for soilless production. Hence, six growing media mixtures (CP 100% + slow acting synthetic solid fertilizer, CP 90% + BSPR 10%, CP 80% + BSPR 20%, CP 70% + BSPR 30%, CP 60% + BSPR 40% and CP 100% without fertilizer) were assessed for the production of baby leaf lettuce, basil and tomato potted plants. Using BSPR in a proportion up to 20%, all investigated crops showed values significantly greater than or comparable to those obtained using CP 100% + slow acting synthetic solid fertilizer. In general, BSPR used in a proportion up to 20% increased the crop growth of baby leaf lettuce, basil and tomato, recording a high total dry weight (+31%, compared to the total average) and the measured leaf parameters (+39% of leaf area, +14% of leaf number), without showing abiotic stresses. This study indicates that BSPR used in a proportion up to 20% might be a valid approach for soilless production of potted baby leaf lettuce, basil and tomato plants.
    MeSH term(s) Animals ; Diptera ; Fertilizers ; Larva ; Simuliidae ; Soil
    Chemical Substances Fertilizers ; Soil
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2019.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Book ; Online: Searching for SARS-COV-2 on Particulate Matter

    Leonardo Setti / Fabrizio Passarini / Gianluigi De Gennaro / Pierluigi Barbieri / Alberto Pallavicini / Maurizio Ruscio / Prisco Piscitelli / Annamaria Colao / Alessandro Miani

    International Journal of Environmental Research and Public Health ; Volume 17 ; Issue 9

    A Possible Early Indicator of COVID-19 Epidemic Recurrence

    2020  

    Abstract: A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in ...

    Abstract A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in many countries a “

    Phase-2”

    is approaching and many activities will re-open soon, although with some differences depending on the severity of the outbreak experienced and SARS-COV-2 estimated diffusion in the general population. At the present, possible relapses of the epidemic cannot be excluded until effective vaccines or immunoprophylaxis with human recombinant antibodies will be properly set up and commercialized. COVD-19-related quarantines have triggered serious social challenges, so that decision makers are concerned about the risk of wasting all the sacrifices imposed to the people in these months of quarantine. The availability of possible early predictive indicators of future epidemic relapses would be very useful for public health purposes, and could potentially prevent the suspension of entire national economic systems. On 16 March, a Position Paper launched by the Italian Society of Environmental Medicine (SIMA) hypothesized for the first time a possible link between the dramatic impact of COVID-19 outbreak in Northern Italy and the high concentrations of particulate matter (PM10 and PM2.5) that characterize this area, along with its well-known specific climatic conditions. Thereafter, a survey carried out in the U.S. by the Harvard School of Public Health suggested a strong association between increases in particulate matter concentration and mortality rates due to COVID-19. The presence of SARS-COV-2 RNA on the particulate matter of Bergamo, which is not far from Milan and represents the epicenter of the Italian epidemic, seems to confirm (at least in case of atmospheric stability and high PM concentrations, as it usually occurs in Northern Italy) that the virus can create clusters with the particles and be carried and detected on PM10. Although no assumptions can be made concerning the link between this first experimental finding and COVID-19 outbreak progression or severity, the presence of SARS-COV-2 RNA on PM10 of outdoor air samples in any city of the world could represent a potential early indicator of COVID-19 diffusion. Searching for the viral genome on particulate matter could therefore be explored among the possible strategies for adopting all the necessary preventive measures before future epidemics start.
    Keywords COVID-19 ; RNA ; Particulate Matter ; Indicator ; Epidemic ; Relapse ; covid19
    Language English
    Publishing date 2020-04-25
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: Searching for SARS-COV-2 on Particulate Matter

    Leonardo Setti / Fabrizio Passarini / Gianluigi De Gennaro / Pierluigi Barbieri / Alberto Pallavicini / Maurizio Ruscio / Prisco Piscitelli / Annamaria Colao / Alessandro Miani

    International Journal of Environmental Research and Public Health, Vol 17, Iss 2986, p

    A Possible Early Indicator of COVID-19 Epidemic Recurrence

    2020  Volume 2986

    Abstract: A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in ...

    Abstract A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in many countries a “Phase-2” is approaching and many activities will re-open soon, although with some differences depending on the severity of the outbreak experienced and SARS-COV-2 estimated diffusion in the general population. At the present, possible relapses of the epidemic cannot be excluded until effective vaccines or immunoprophylaxis with human recombinant antibodies will be properly set up and commercialized. COVD-19-related quarantines have triggered serious social challenges, so that decision makers are concerned about the risk of wasting all the sacrifices imposed to the people in these months of quarantine. The availability of possible early predictive indicators of future epidemic relapses would be very useful for public health purposes, and could potentially prevent the suspension of entire national economic systems. On 16 March, a Position Paper launched by the Italian Society of Environmental Medicine (SIMA) hypothesized for the first time a possible link between the dramatic impact of COVID-19 outbreak in Northern Italy and the high concentrations of particulate matter (PM 10 and PM 2.5 ) that characterize this area, along with its well-known specific climatic conditions. Thereafter, a survey carried out in the U.S. by the Harvard School of Public Health suggested a strong association between increases in particulate matter concentration and mortality rates due to COVID-19. The presence of SARS-COV-2 RNA on the particulate matter of Bergamo, which is not far from Milan and represents the epicenter of the Italian epidemic, seems to confirm (at least in case of atmospheric stability and high PM concentrations, as it usually occurs in Northern Italy) that the virus can create clusters with the particles and be carried and detected on PM 10 . ...
    Keywords COVID-19 ; RNA ; Particulate Matter ; Indicator ; Epidemic ; Relapse ; Medicine ; R
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top